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English printer William Caxton produces the first book ever printed in the English language — Recuyell of the Historyes of Troye or Recueil des Histoires de Troye, a translation by William Caxton of a French courtly romance written by Raoul Lefèvre, chaplain to Philip III, Duke of Burgundy. Recuyell (recueil in Modern French) simply means "collection" in English. Hence, the work in Modern English would read "A Collection of the Histories of Troy". Caxton's translations and sometimes his titles incorporated words from other European languages. Caxton, probably with the assistance of Colard Mansion and Johann Veldener, printed his translation in 1473 or 1474 (traditionally "ca. 1475") in Bruges. Just 18 copies still exist, and when the Duke of Northumberland sold one in 2014, it fetched more than £1 million.

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Campanus of Novara (an Italian mathematician, astronomer, astrologer, and physician) publishes a Latin edition of Euclid's Elementa in fifteen books. This work by Campanus was influential and was the most frequently used compilation of Euclid until the 16th century. It was based on a compilation by Robert of Chester and also includes material from: Arithmetica by Jordanus de Nemore, commentary on Euclid by Anaritius, and additions by Campanus himself. It would later become the first printed edition of Euclid, published by Erhard Ratdolt in Venice in 1482 as Preclarissimus liber elementorum Euclidis perspicacissimi.

Leonardo da Vinci sketches a design for a parachute — a pyramid shaped design that was held in shape by a wooden frame. The tent-like design was to be made out of linen and be as large as 23 meters in length. Da Vinci's intent for this invention was to allow people to be able to jump from great heights and land smoothly without injury. More than 500 years after Leonardo da Vinci sketched his design, a Briton has proved that the renaissance genius was indeed the inventor of the first working parachute. Adrian Nicholas, a 38-year-old skydiver from London, fulfilled his life's ambition to prove the aerodynamics experts wrong when he used a parachute based on Da Vinci's design to float almost one and a half miles down from a hot air balloon. Ignoring warnings that it would never work, he built the 187lb contraption of wooden poles, canvas and ropes from a simple sketch that Da Vinci had scribbled in a notebook in 1485. And at 7am on Monday, over the Mpumalanga province of South Africa, Mr Nicholas proved in a 7,000ft descent that the design could indeed be looked upon as a prototype for the modern parachute. Yesterday he said: "It took one of the greatest minds who ever lived to design it, but it took 500 years to find a man with a brain small enough to actually go and fly it. "All the experts agreed it wouldn't work — it would tip over or fall apart or spin around and make you sick — but Leonardo was right all along. It's just that no one else has ever bothered trying to build it before."

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Leonardo da Vinci offers an explanation for capillary action — the ability of rise up in a narrow tube.

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Christopher Columbus left Castile in August 1492 with three ships and made landfall in the Americas on 12 October, ending the period of human habitation in the Americas now referred to as the pre-Columbian era. His landing place was an island in the Bahamas, known by its native inhabitants as Guanahani. He then visited the islands now known as Cuba and Hispaniola, establishing a colony in what is now Haiti. Columbus returned to Castile in early 1493, with captured natives. Word of his voyage soon spread throughout Europe.

Italian explorer Christopher Columbus observes that Native Americans use tobacco as a medicinal herb. Columbus acquires some dried tobacco leaves from the Natives, personally tests the leaves for efficacy, and then (as a satisfied customer) transports samples back to Europe.

Leonardo da Vinci is the first the theorize seriously about flying machines.

Tobacco plant and smoking first introduced in Europe. Human health will be changed for centuries.

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Summa de arithmetica, geometria, proportioni et proportionalita (Summary of arithmetic, geometry, proportions and proportionality) is a book on mathematics written by Luca Pacioli and first published in 1494. It contains a comprehensive summary of Renaissance mathematics, including practical arithmetic, basic algebra, basic geometry and accounting, written for use as a textbook and reference work. Written in vernacular Italian, the Summa is the first printed work on algebra, and it contains the first published description of the double-entry bookkeeping system. It set a new standard for writing and argumentation about algebra, and its impact upon the subsequent development and standardization of professional accounting methods was so great that Pacioli is sometimes referred to as the "father of accounting".

Whiskey invented in Scotland.

French gunners begin using cast-iron cannonballs rather than stones.

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Polish astronomer Nicolaus Copernicus records a star being occluded by the moon.

Portuguese navigator Vasco de Gama sails around the Cape of Good Hope and crosses the Indian Ocean to reach India.

German Benedictine abbot and polymath Johannes Trithemius writes Steganographia, a major work on cryptography. The book is published in 1606. This book is in three volumes, and appears to be about magic — specifically, about using spirits to communicate over long distances. However, since the publication of a decryption key to the first two volumes in 1606, they were discovered to be actually concerned with cryptography and steganography. Until recently, the third volume was widely believed to be solely about magic, but the "magical" formulas have now been shown to be covertexts for yet more material on cryptography. The book was placed on the Index Librorum Prohibitorum in 1609 and removed in 1900.

Pedro Álvares Cabral, a Portuguese nobleman, military commander, navigator and explorer, sailed far into the western Atlantic Ocean, perhaps intentionally, and made landfall (April 1500) on what he initially assumed to be a large island. As the new land was within the Portuguese sphere according to the 1494 Treaty of Tordesillas, Cabral claimed it for the Portuguese Crown. He explored the coast, realizing that the large land mass was probably a continent, and dispatched a ship to notify King Manuel I of the new territory. The continent was South America, and the land he had claimed for Portugal later came to be known as Brazil. The fleet reprovisioned and then turned eastward to resume the journey to India.

The Castilian navigator and cartographer, Juan de la Cosa, creates a world map that includes the earliest known representation of the New World and the first depiction of the equator and the Tropic of Cancer on a nautical chart. Juan de la Cosa's map is a manuscript nautical chart of the world drawn on two joined sheets of parchment sewn onto a canvas backing. It measures 96 cm high by 183 cm wide. A legend written in Spanish at the western edge of the map translates as "Juan de la Cosa made this (map) in the port of Santa Maria in the year 1500". The overall style is similar to other contemporary charts of the Mediterranean, especially maps produced in Majorca, an important center of map making at the time.

Chinese legendary adventurer Wan Hu attempts to leave the Earth by sitting on a chair with 47 rockets tied to it, holding a kite in each of his hands, and flying into the sky after his servants were ordered to light the fuses to the rockets. But the rockets exploded and Wan Hu was gone when the air cleared. While most authorities consider the story apocryphal, some Chinese scholars believe that foreigners from several different countries in the west were unlikely to fabricate such a story out of thin air. The tale may be based on the stories told by European missionaries who arrived in China since the late Ming dynasty, and then passed on by word of mouth. Alternatively, these European and American scholars may have indirectly relied on records in an ancient Chinese document that has been subsequently lost.

Leonardo da Vinci, finding many fossils in canal building sites, proposes that fossil shells of marine animals are found on mountains because Earth undergoes transformations that cause areas once submerged to become exposed.

Leonardo da Vinci as comparative anatomist: human leg vs. canine leg.

Amerigo Vespucci maps the two stars Alpha Centauri and Beta Centauri, as well as the stars of the constellation Crux, which are below the horizon in Europe.

Christopher Columbus leaves Cadiz, Spain for his fourth and final voyage to the New World.

Portuguese explorers, led by Pedro Álvares Cabral, sail into Guanabara Bay, Brazil, mistaking it for the mouth of a river, which they name Rio de Janeiro.

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Christopher Columbus uses his knowledge of a lunar eclipse this night (February 29) to convince Jamaican tribesmen to provide him with supplies. Three days before the eclipse, Columbus requested a meeting with the Arawak chief and informed him that his Christian god was very angry with his people for no longer supplying him and his men with food. Therefore, he was about to provide a clear sign of his displeasure: Three nights hence, he would all but obliterate the rising full moon, making it appear "inflamed with wrath," which would signify the evils that would soon be inflicted upon all of them. On the appointed evening, as the sun set in the west and the moon started emerging from beyond the eastern horizon, it was plainly obvious to all that something was terribly wrong. By the time the moon appeared in full view, a small but noticeable dark scallop had been removed from its lower edge. And, just over an hour later, as evening twilight ended and full darkness descended, the moon indeed exhibited an eerily inflamed and "bloody" appearance: In place of the normally brilliant late winter full moon there now hung a dim red ball in the eastern sky. According to Columbus' son, Ferdinand, the Arawaks were terrified at this sight and "with great howling and lamentation came running from every direction to the ships laden with provisions and beseeching the admiral to intercede with his god on their behalf." They promised that they would happily cooperate with Columbus and his men if only he would restore the moon back to its normal self.

Leonardo da Vinci produces his Codex on the Flight of Birds, a relatively short codex. It comprises 18 folios and measures 21 × 15 centimetres. Now held at the Royal Library of Turin, the codex begins with an examination of the flight behavior of birds and proposes mechanisms for flight by machines. Leonardo constructed a number of these machines, and attempted to launch them from a hill near Florence. However, his efforts failed. In the codex, Leonardo notes for the first time that the center of gravity of a flying bird does not coincide with its center of pressure.

Bermuda is discovered by Spanish explorer Juan de Bermúdez. Bermúdez made 11 registered trips to the New World from 1495 to 1519.

Christopher Columbus dies.

First publication of the Waldseemüller map or Universalis Cosmographia ("Universal Cosmography") is a printed wall map of the world by German cartographer Martin Waldseemüller. It is known as the first map to use the name "America". The name America is placed on South America on the main map. As explained in Cosmographiae Introductio, the name was bestowed in honor of the Italian Amerigo Vespucci. The map is drafted on a modification of Ptolemy's second projection, expanded to accommodate the Americas and the high latitudes. A single copy of the map survives, presently housed at the Library of Congress in Washington, D.C.

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The Constantinople earthquake occurs in the Sea of Marmara on 10 September 1509 at about 22:00. The earthquake had an estimated magnitude of 7.2 ± 0.3 on the surface-wave magnitude scale. A tsunami and 45 days of aftershocks followed the earthquake. The death toll of this earthquake is poorly known; estimates range between 1,000 and 13,000.

Luca Pacioli's De divina proportione, concerning the golden ratio, is published in Venice, with illustrations by Leonardo da Vinci. Its subject was mathematical proportions (the title refers to the golden ratio) and their applications to geometry, to visual art through perspective, and to architecture. The clarity of the written material and Leonardo's excellent diagrams helped the book to achieve an impact beyond mathematical circles, popularizing contemporary geometric concepts and images.

An acute respiratory disease emerged in Asia before spreading through North Africa and Europe during the first chronicled, inter-regional flu pandemic generally recognized by medical historians and epidemiologists. Influenza-like illnesses had been documented in Europe since at least Charlemagne, with 1357's outbreak the first to be called influenza, but the 1510 flu pandemic is the first to be pathologically described following communication advances brought about by the printing press. Flu became more widely referred to as coqueluche and coccolucio in France and Sicily during this pandemic, variations of which became the most popular names for flu in early modern Europe. The pandemic caused significant disruption in government, church, and society with near-universal infection and a mortality rate of around 1%.

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Hieronymus Brunschwygk's book, Liber de arte Distillandi de Compositis, describes medicinal herbs and the construction of stills for processing them.

Juan Ponce de León becomes the first European definitely known to sight the modern-day territory of the United States, specifically Florida, mistaking it for another island. He landed somewhere along Florida's east coast, then charted the Atlantic coast down to the Florida Keys and north along the Gulf coast; historian John R. Swanton believed that he sailed perhaps as far as Apalachee Bay on Florida's western coast. Though in popular culture he was supposedly searching for the Fountain of Youth, there is no contemporary evidence to support the story, which most modern historians consider a myth.

Detailed world map produced by Muhiddin Piri (c. 1470–1553), better known as Piri Reis, an Ottoman corsair, navigator, geographer, and cartographer. He is primarily known today for his cartographic works, including his 1513 world map and the Book of the Sea, a book with detailed information on early navigational techniques as well as relatively accurate charts for their time, describing the ports and cities of the Mediterranean Sea.

Vasco Núñz de Balboa first sees what will become known as the Pacific Ocean.

The earliest printed textbook for midwifes was written by Eucharius Rösslin (d.1526?) of Worms. First published in Germany, Die Rosengarten was dedicated to Princess Katherine of Saxony and was granted a copyright by Emperor Maximilian in 1513. The book was an immediate success. It then appeared in English in 1540 as The Birth of Mankind. By the mid-16th century, it had been translated into all the main European languages and had gone through numerous editions. It survived 40 editions, being used as late as 1730.

Johannes Werner publishes his translation of Ptolemy's Geography, Nova Translatio Primi Libri Geographicae Cl. Ptolomaei, containing the Werner map projection and proposing use of the cross-staff for marine navigation.

The first Johannes Schöner Globe, a printed globe, was made. Two exemplars survive, one at the Historisches Museum in Frankfurt and the other at the Herzogin Anna Amalia Bibliothek, at Weimar. There can be little doubt that Schöner was familiar with the globe made in Nuremberg by Martin Behaim in 1492. An inscription across the northern part of America, says: "This part of the island has been discovered by order of the King of Castile". This is matched by another inscription off America's east coast: "The more southerly part of this island was discovered by order of the King of Portugal"; that is, America is called in both an island. A strait between the southern tip of America and the land to the south can be found on Schöner's globe before its "official discovery" by Ferdinand Magellan in 1520. The actual strait is at 53 degrees south, whereas in the 1515 globe its southernmost tip is shown at about 45 degrees south. Schöner accompanied his globe with an explanatory treatise, Luculentissima quaedam terrae totius descriptio ("A Most Lucid Description of All Lands"). It contained a description of America.

An Indian rhinoceros arrives in Lisbon, the first to be seen in Europe since Roman times.

The fall of the Nantan meteorite is possibly observed near the city of Nantan, Nandan County, Guangxi (China).

A third epidemic of sweating sickness in England hits Oxford and Cambridge.

German surgeon Hans von Gersdorff publishes his Feldbuch der Wundarzney ("Field book of surgery").

Henricus Grammateus (also known as Henricus Scriptor, Heinrich Schreyber or Heinrich Schreiber)publishes Ayn neu Kunstlich Buech in Vienna, containing the earliest printed use of plus and minus signs for arithmetic. He also publishes Libellus de compositione regularum pro vasorum mensuratione. Deque arte ista tota theoreticae et practicae and a new musical temperament, which is now named after him, for the harpsichord. It was a precursor of the equal temperament.

Dancing plague, a case of dancing mania, breaks out in Strasbourg. Somewhere between 50 and 400 people took to dancing for weeks. There are many theories behind the phenomenon, the most popular being stress-induced mass hysteria, suggested by John Waller. Other theories include ergot and religious explanations. There is controversy concerning the number of deaths.

The Miller Atlas, also known as Lopo Homem-Reineis Atlas, a richly illustrated Portuguese partial world atlas is published. It is a joint work of the cartographers Lopo Homem, Pedro Reinel and Jorge Reinel, and illustrated by miniaturist António de Holanda. The regions represented are the North Atlantic Ocean, Northern Europe, the Azores Archipelago, Madagascar, Horn of Africa, the Indian Ocean, Indonesia, the China Sea, the Moluccas, Brazil and the Mediterranean Sea. It was acquired by the librarian Bénigne Emmanuel Clement Miller in 1855 at a bookseller in Santarém, Portugal, hence the name Miller Atlas. In 1897, his widow sold it to the National Library of France, where it has stayed ever since.

A pandemic spreads from the Greater Antilles into Central America, and perhaps as far as Peru, killing much of the indigenous populations in these areas.

Ferdinand Magellan passes through a navigable sea route in southern Chile separating mainland South America to the north and Tierra del Fuego to the south. The strait is considered the most important natural passage between the Atlantic and Pacific oceans. The strait is approximately 570 km (310 nmi; 350 mi) long and 2 km (1.1 nmi; 1.2 mi) wide at its narrowest point. Magellan was the first European to discover it. Magellan's original name for the strait was Estrecho de Todos los Santos ("Strait of All Saints"). The King of Spain, Emperor Charles V, who sponsored the Magellan-Elcano expedition, changed the name to the Strait of Magellan in honor of Magellan.

Jacopo Berengario da Carpi publishes Commentaria cum amplissimus additionibus super anatomiam Mundini in Bologna, containing the first printed anatomical illustrations taken from nature and including observation of the vermiform appendix. His book Isagoge breves published in 1522 made him the most important anatomist before Andreas Vesalius.

Francisco de Cordillo explores the American coast up to South Carolina.

The Victoria (nau Vittoria), one of the surviving ships of the Magellan expedition, returns to Sanlúcar de Barrameda in Spain under the command of Juan Sebastián Elcano, becoming the first ship to circumnavigate the world. It carries the first (dead) examples of the bird-of-paradise ever to be seen in Europe. Venetian cardinal Gasparo Contarini, in Spain at this time, is the first European to give a correct explanation of the one-day discrepancy in dates observed by the crew on their return.

Anthony Fitzherbert publishes The Boke of Husbandry (Book of Husbandry), one of the classics of English agriculture, containing directions for draining, clearing, and enclosing a farm; and for enriching and reducing the soil to tillage. Lime, marl, and fallowing are strongly recommended. The landlords are advised to grant leases to farmers who will surround their farms, and divide them by hedges into proper enclosures. The Boke of Husbandry gives a clear and minute description of the rural practices of that period.

Giovanni da Verrazzano becomes the first European to explore the Atlantic coast of North America between Florida and New Brunswick in 1524, including New York Bay and Narragansett Bay.

First publication of Galen's Of the method of curing diseases in the original Greek, by the Aldine Press in Venice.

Publication of Richard Banckes' Herball, the first true herbal printed in Britain.

Christoff Rudolff introduces the mathematical sign designating square root.

Albrecht Dürer's book on geometry and perspective, Underweysung der Messung (Instructions on Measurement) is published at Nuremberg. It is the first book for adults to be published on mathematics in German.

First publication of the collected works of Hippocrates translated into Latin, in Rome.

Transit of Venus occurs. A transit of Venus takes place when Venus passes directly between the Sun and the Earth (or any other superior planet), becoming visible against (and hence obscuring a small portion of) the solar disk. During a transit, Venus is visible as a small black circle moving across the face of the Sun.

Publication of Peter Treveris's The Grete Herball (a translation of Le Grant Herbier) in England.

Petrus Apianus publishes a handbook of commercial arithmetic, Ein newe und wolgegründete underweisung aller Kauffmanns Rechnung in dreyen Büchern, mit schönen Regeln und fragstücken begriffen, at Ingolstadt.

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Italian Girolamo Fracastoro describes syphilis, introduced to Spain by sailors returning from the Americas.

Sebastian Münster publishes Horologiographia, a treatise on the construction of sun dials.

Europeans start cultivation of the tobacco plant in Central America.

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De Principis Astronomiae et Cosmographie by Gemma Frisius (a Dutch physician, mathematician, cartographer, philosopher, and instrument maker) gives the first published explanation of the use of triangulation in surveying and mapmaking. Having established a baseline (e.g., in the figure the cities of Brussels and Antwerp), the location of other cities (e.g. Middelburg, Ghent etc.) can be found by taking a compass direction from each end of the baseline, and plotting where the two directions cross. This was only a theoretical presentation of the concept — due to topographical restrictions, it is impossible to see Middelburg from either Brussels or Antwerp. Nevertheless, the figure soon became well known all across Europe.

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The one-man diving bell is invented by Guglielmo de Lorena. De Lorena's device boasted a revolutionary air-supply mechanism which would exchange the air inside while maintaining pressure, allowing the diver to remain underwater for hours. In July 1535, set on exploring a sunken Roman vessel in Lake Nemi, Guglielmo de Lorna and partner Francesco de Marchi used the invention to examine and document sunken barges which had lain at the bottom of Lake Nemi.

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Niccolò Tartaglia publishes Nova Scientia, a treatise on gunnery science. This was Tartaglia's first published work and was described by Matteo Valleriani as: ... one of the most fundamental works on mechanics of the Renaissance, indeed, the first to transform aspects of practical knowledge accumulated by the early modern artillerists into a theoretical and mathematical framework. Then dominant Aristotelian physics preferred categories like "heavy" and "natural" and "violent" to describe motion, generally eschewing mathematical explanations. Tartaglia brought mathematical models to the fore. One of his findings was that the maximum range of a projectile was achieved by directing the cannon at a 45-degree angle to the horizon.

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Georg Joachim Rheticus publishes De Libris Revolutionum Copernici Narratio Prima in Danzig, an abstract of Copernicus' as yet unpublished De revolutionibus orbium coelestium and the first printed publication of Copernican heliocentrism.

Valerius Cordus discovers and describes a method of synthesizing ether ("oleum dulci vitrioli") by adding sulfuric acid to ethyl alcohol.

Publication in London of the first printed book in English on obstetrics, The Byrth of Mankynde, a translation attributed to Richard Jonas from Rösslin's De partu hominis. It will continue to be issued in new editions for more than a century.

Gerardus Mercator makes his first terrestrial globe, for Charles V, Holy Roman Emperor.

Leonhart Fuchs publishes his new herbal De historia stirpium commentarii insignes in Basel. It was illustrated by: Albrecht Meyer, who made drawings based on the actual plants; Heinrich Füllmaurer, who transferred the drawings to woodblock; and Vitus Rudolph Speckle, who cut the blocks and printed the drawings. It covers about 497 plants and has over 500 woodcut illustrations. Over 100 of the plants in the book were first descriptions. The University of Glasgow states that it is considered a landmark work in its field. Stanford University Press considers it one of the best illustrated books of all time and a masterpiece of the German Renaissance. It set a new standard for accuracy and quality, as well as being the first known publication of plants from the Americas, such as pumpkin, maize, marigold, potato, and tobacco. Plants were identified in German, Greek, and Latin, and sometimes English. The book was initially published in Latin and Greek and quickly translated into German. Just during Fuchs' lifetime the book went through 39 printings in Dutch, French, German, Latin, and Spanish and 20 years after his death was translated into English.

Jean Fernel publishes De naturali parte medicinae, presenting human physiology as integral to the study of medicine.

In a brief work titled On Meteorology, Fausto da Longiano argues that Noah's flood "cannot have been universal, according to natural reasons," and endorses a 36,000-year cycle of Earth history accepted by some other scholars.

De revolutionibus orbium coelestium (On the Revolutions of the Heavenly Spheres) by the Renaissance astronomer Nicolaus Copernicus is published. The book presents the notion that the Earth revolves around the sun (a heliocentric theory) as opposed to Ptolemy's geocentric system (the Earth at the center of the universe), which had been widely accepted since ancient times.

Andreas Vesalius (Andries van Wesel) publishes the anatomy treatise De humani corporis fabrica (On the Workings of the Human Body).

Niccol Fontana Tartaglia publishes a translation of Euclid's Elements into Italian, the first into any modern European language.

Robert Recorde publishes The Grounde of Artes, teaching the Worke and Practise of Arithmeticke, both in whole numbers and fractions, one of the first printed elementary arithmetic textbooks in English and the first to cover algebra. It will go through around forty-five editions in the following century and a half. In this work, the use of the equal sign ("=") is first introduced into mathematical symbology.

Orto botanico di Pisa botanical garden established by Cosimo I de' Medici, Grand Duke of Tuscany, under the direction of Luca Ghini, who also creates the first herbarium.

William Turner's Avium praecipuarum, quarum apud Plinium et Aristotelem mentio est, brevis et succincta historia is published in Cologne, the first printed book devoted entirely to ornithology.

Georgius Agricola publishes De ortu et causis subterraneorum, laying the foundations of modern physical geology.

Thomas Phaer publishes The Boke of Chyldren, the first book on paediatrics written in English.

Gerolamo Cardano publishes his algebra text Ars Magna, including the first published solutions to cubic and quartic equations.

German minerologist Georgius Agricola publishes De Natura Fossilium (On the Nature of Fossils), the first published paleontological treatise.

Girolamo Fracastoro, in his De Contagione et Contagiosis Morbis (published in Venice), discusses the transmission of infectious diseases and gives the first description of typhus.

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Publication of Erasmus Reinhold's ephemeris (collection of astronomical tables), the Tabulae Prutenicae, helping to disseminate Copernican methods of astronomical calculation.

Cornelius Gemma publishes the first illustration of a human tapeworm.

Thierry de Hery publishes La Méthode Curatoire de la Maladie Vénérienne, Vulgairement Appellée Grosse Vairolle, & de la Diuersité de Ses Symptomes, the first work in French on syphilis.

Publication in Spain of Libro del Exercicio, considered the first book on the benefits of physical exercise for health.

Guillaume Rondelet publishes a volume on Mediterranean fish — De Piscibus — and includes the assertion that glossopetrae, or tongue stones, resemble shark teeth. The hypothesis attracts little attention.

Roman naturalist Ippolito Salviani publishes History of Aquatic Animals.

Venetian mathematician Giambattista Benedetti publishes two editions of Demonstratio proportionum motuum localium, developing his new doctrine of the speed of bodies in free fall.

Pierre Belon publishes L'Histoire de la nature des oyseaux, a pioneering work in the comparative anatomy of birds.

The first edition of Alessio Piemontese's Secreti is published, listing about 350 medical recipes along with observations of nature. The publisher, Girolamo Ruscelli, will later claim authorship. Enormously popular, the book will total 104 editions through 1699.

Great Comet of 1556 becomes visible in Europe. The comet, known as C/1556 D1 in modern nomenclature, appears to have been seen in some places before the end of February; but it was not generally observed until the middle of the first week in March. Its apparent diameter was equal to half that of the Moon, and the tail resembled " the flame of a torch agitated by the wind," — an expression doubtless referring to the coruscations which are sometimes visible in the tails of comets

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Jean Nicot, French ambassador to Portugal 1559–61, describes the medicinal properties of tobacco which he introduces in the form of snuff to the French court. The plant was also an instant success and soon many of the fashionable people of Paris began to use the plant, making Nicot a celebrity. The tobacco plant, Nicotiana, also a flowering garden plant, was named after him by Carl Linnaeus, as was nicotine.

A total solar eclipse visible in Europe occurred on August 21. The prediction of this solar eclipse helped to inspire Tycho Brahe's (1546–1601) interest in astronomy at the age of 13. The announcement of this forthcoming eclipse in France caused many Frenchmen to panic, fighting one another to be next in line at the confessional. One beleaguered parish priest tried to calm the populace by announcing that since there were so many waiting to confess, a decision had been made to postpone the eclipse for two weeks.

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Diego Gutiérrez and Hieronymus Cock published the map Americae Sive Quartae Orbis Partis Nova Et Exactissima Descriptio (A New and Most Exact Description of America or The Fourth Part of the World). The map (an ornate geographical map of the Americas) encompasses the eastern coast of North America, the entire Central and South America and parts of the western coasts of Europe and Africa. Americae Sive Quartae Orbis Partis Nova Et Exactissima Descriptio is the earliest scale wall map of the New World and the first to use the name "California".

Outbreak of bubonic plague — The Black Death — in London kills over 20,000. Plague epidemics ravaged London in 1563, 1593, 1603, 1625, 1636, and 1665, reducing its population by 10 to 30% during those years.

Galileo Galilei is born born in Pisa (then part of the Duchy of Florence), Italy, on 15 February 1564.

Conrad Gessner publishes De Omni Rerum Fossilium ("A Book of Fossil Objects").

Antwerp doctor Samuel Quiccheberg publishes a description of the curiosity cabinet of Hans Jakob Fugger, including items from the animal, vegetable and mineral world.

College of Physicians of London empowered to carry out human dissections.

Roger Taverner writes his Arte of Surveyinge.

Danish astronomer Tycho Brahe, while studying at the University of Rostock in Mecklenburg, loses part of his nose in a duel with fellow nobleman and relation Manderup Parsberg over a mathematical formula.

Paracelsus (Philippus Aureolus Theophrastus Bombastus von Hohenheim) publishes On the Miners' Sickness and Other Diseases of Miners, a pioneering example of occupational medicine.

Fabrizio Mordente publishes a single sheet treatise in Venice showing illustrations of his "proportional eight-pointed compass" which has two arms with cursors that allow the solution of problems in measuring the circumference, area and angles of a circle.

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The Mercator projection is first used in Gerardus Mercator's world map Nova et Aucta Orbis Terrae Descriptio ad Usum Navigantium Emendata.

London haberdasher Henry Billingsley makes the first translation of Euclid's Elements into English (from the Greek).

Giovanni Padovani publishes a detailed treatise on the construction of sundials, Opus de compositione et usu multiformium horologiorum solarium, in Venice.

European doctors start publishing works on healthy properties of the tobacco plant, claiming it can cure a myriad of diseases, from toothache to lockjaw and cancer.

A supernova, now designated as SN 1572, is first observed in the constellation Cassiopeia by Cornelius Gemma. Tycho Brahe, who notes it two days later, will use it to challenge the prevailing view that stars do not change.

Girolamo Mercuriale of Forl (Italy) writes the work De morbis cutaneis ("On the diseases of the skin"), the first scientific tract on dermatology.

French surgeon Ambroise Paré publishes the first edition of Des Monstres et Prodiges. At this time, surgeons are not regarded as real doctors, and Paré is roundly criticized for discussing larger issues of medicine and philosophy, considered well beyond his purview.

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The Great Comet of 1577 (official designation: C/1577 V1) was a comet that passed close to Earth during the year 1577 AD. It was viewed by people all over Europe, including the famous Danish astronomer Tycho Brahe and Turkish astronomer Taqi ad-Din. From his observations of the comet, Brahe was able to discover that comets and similar objects travel above the Earth's atmosphere. The best fit using JPL Horizons suggests that the comet is currently about 320 AU from the Sun (based on 24 of Brahe's observations spanning 74 days from 13 November 1577 to 26 January 1578).

Li Shizhen completes the first draft of the materia medica Bencao Gangmu.

English seaman William Bourne publishes a manual, Inventions or Devises, Very Necessary for all Generalles and Captaines, as wel by Sea as by Land, including an early theoretical description of a submarine.

Hieronymus Fabricius discovers the membranous folds that serve as valves in the veins.

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Andrea Cesalpino publishes De Plantis, ordering plants in families. In his works he classified plants according to their fruits and seeds, rather than alphabetically or by medicinal properties. In 1555, he succeeded Luca Ghini as director of the botanical garden in Pisa.

Agostino Michele publishes On the Magnitude of the Water and of the Earth, calling himself "determined to follow Aristotle and Plato only as much as Moses and Christ allow," and arguing that huge subterranean reservoirs made the universal deluge of Noah's flood possible.

Thomas Fincke's Geometria rotundi is published, introducing the terms tangent and secant for trigonometric functions.

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Michele Mercati establishes one of the first mineralogical curiosity cabinets in Europe. Mercati was a physician who was superintendent of the Vatican Botanical Garden under Popes Pius V, Gregory XIII, Sixtus V, and Clement VIII. He was one of the first scholars to recognise prehistoric stone tools as human-made rather than natural or mythologically created thunderstones.

Giordano Bruno uses Fabrizio Mordente's "proportional eight-pointed compass" to refute Aristotle's hypothesis on the incommensurability of infinitesimals, thus confirming the existence of the "minimum" which lays the basis of his own atomic theory. Bruno publishes his proofs as Figuratio Aristotelici Physici auditus.

Simon Stevin publishes De Thiende, introducing a form of decimal fraction.

Jacques Dal champs publishes Historia generalis plantarum in Lyon, describing 2,731 plants, a record number for this time.

Galileo publishes La Billancetta, describing an accurate balance to weigh objects in air or water.

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Ferdinando I de Medici, Grand Duke of Tuscany, appoints Galileo to the professorship of mathematics at the University of Pisa.

Pietro Cataldi discovers the sixth and seventh Mersenne primes by this year.

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José de Acosta publishes Natural and Moral History of the Indies describing such weird creatures as iguanas.

Glass lenses are developed in the Netherlands and used for the first time in microscopes and telescopes.

Girolamo Porro produces a plan for a botanical garden at Padua, arguably expecting to assemble all the world's plants. Over the next century, well- traveled naturalists will abandon such goals as unrealistic.

François Viète publishes In Artem Analyticem Isagoge, introducing the new algebra with innovative use of letters as parameters in equations.

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The tulip bulbs planted by Carolus Clusius in the Hortus Botanicus Leiden, Holland, first flower.

Francis Bacon pens Gesta Grayorum, a staged debate related to science.

Bevis Bulmer sets up a system at Blackfriars, London, for pumping a public water supply.

Bartholomaeus Pitiscus publishes Trigonometria: sive de solutione triangulorum tractatus brevis et perspicuus in Heidelberg, introducing the term trigonometry to Western European languages.

Johannes Kepler's Mysterium Cosmographicum is the first published defense of the Copernican (heliocentric) system of planetary motion. This book explains Kepler's cosmological theory, based on the Copernican system, in which the five Pythagorean regular polyhedra dictate the structure of the universe and reflect God's plan through geometry. This was the first attempt since Copernicus to say that the theory of heliocentrism is physically true.

Abraham Ortelius, in the last edition of his Thesaurus geographicus, considers the possibility of continental drift.

Andreas Libavius's chemistry textbook Alchemia published. Libavius was a staunch believer in chrysopoeia, or the ability to transmute a base metal into gold. This viewpoint was a matter of much debate for alchemists of the time and he defended it in several of his writings. Though he did discover several new chemical processes, he tended to be more of a theoretician and he leaned toward traditional Aristotelianism rather than Paracelsian alchemy.

Tycho Brahe's star catalogue Astronomiae instauratae mechanica, listing the positions of 1,004 stars, is published.

Jean Bauhin, a former student of Conrad Gesner's, publishes a monograph of the medicinal waters and surrounding environment of the German fountains at Boll, the first publication of a complete set of fossils from a specific location.

After being separated from the main Second Dutch Expedition to Indonesia fleet of Admiral Wybrand Van Warwyck, three ships under Jacob Cornelisz. van Neck land on the island which they name Mauritius and sight the dodo bird (Raphus cucullatus); it will become extinct around 1681.

Lawyer Carlo Ruini's Anatomia del cavallo is published posthumously in Venice. This anatomy of the horse is the first published of any non-human animal.

Ferrante Imperato publishes Dell'Historia Naturale (Natural History) attempting to catalog all of nature's animal, vegetable and mineral forms. He illustrated the book with his own cabinet of curiosities displayed at Palazzo Gravina in Naples. The engraving became the first pictorial representation of a Renaissance humanist's displayed natural history research collection.

William Gilbert, court physician to Elizabeth I, describes the Earth's magnetism in De Magnete.

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Ulisse Aldrovandi publishes De Animalibus Insectis.

Prince Federico Cesi establishes the Lincean, or Lyncean, Academy in Rome, perhaps the first scientific academy of the modern era.

King James I condemns tobacco in his treatise A Counterblast to Tobacco.

The German mathematician and astronomer Johannes Kepler establishes his three Laws of Planetary Motion, mathematical laws that describe the motion of planets in the Solar System, including the ground-breaking idea that the planets follow elliptical, not circular, paths around the Sun. Newton later used them to deduce his own Laws of Motion and his Law of Universal Gravitation.

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Galileo constructs the first telescope.

The Italian mathematician and physicist Galileo Galilei develops an astronomical telescope powerful enough to indentify moons orbiting Jupiter, sunspots on the Sun and the different phases of Venus, all of which are instrumental in convincing the scientific community of the day that the heliocentric Copernican model of the Solar System is superior to the geocentric Ptolemiac model.

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The first flintlock musket likely created for Louis XIII of France by gunsmith Marin Bourgeois.

Richard Braithwaite coined the phrase ‘computer’.

Tobacco shops open across Britain, selling the Virginia blend tobacco.

Logarithms presented by John Napier in his book Mirifici Logarithmorum Canonis Descriptio (A Description of the Wonderful Law of Logarithms), which contained fifty-seven pages of explanatory matter and ninety pages of tables of numbers related to natural logarithms (see Napierian logarithm). The book also has an excellent discussion of theorems in spherical trigonometry, usually known as Napier's Rules of Circular Parts.

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Fabio Colonna publishes "Dissertation on Tongue Stones" arguing that "nobody is so stupid" that he or she will not agree that tongue stones are really shark teeth. Like Rondelet several decades earlier, he attracts little attention.

Italian philosopher Lucilio Vanini suggests that humans descended from apes. In 1618 Vanini is arrested and, after a prolonged trial, condemned to have his tongue cut out, to be strangled at the stake and to have his body burned to ashes. The sentence was executed on 9 February 1619.

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English philosopher Francis Bacon publishes Novum Organum (New Instrument), which seeks to add inductive reasoning to the tools of deductive inquiry that had been outlined in Aristotle's treatises of logic known as the Organum.

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Slide Rule invented by William Oughtred

Gaspard Bauhin publishes Pinax Theatri Botanici describing some 6,000 plants.

Francis Bacon develops a method of steganography that used an underlying binary code for the letters of the alphabet.

Wilhelm Schickard designs a calculating machine.

Galileo presents to Cesi, founder of the Lincean Academy, a "little eyeglass" (a microscope). The invention will enable the Linceans to study natural objects with unprecedented precision. They will start with bees, then move on to flies and dust mites.

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Aurochs go extinct.

William Harvey publishes Exercitatio Anatomica de Motu Cordis et Sanguinis in Animalibus (Latin for "An Anatomical Exercise on the Motion of the Heart and Blood in Living Beings"). The book established the circulation of the blood and was a landmark in the history of physiology. Just as important as its substance was its method. Harvey combined observations, experiments, measurements, and hypotheses in extraordinary fashion to arrive at his doctrine. His work is a model of its kind. It had an immediate and far-reaching influence on Harvey's contemporaries. In the book, Harvey investigated the effect of ligatures on blood flow. The book also argued that blood was pumped around the body in a "double circulation", where after being returned to the heart, it is recirculated in a closed system to the lungs and back to the heart, where it is returned to the main circulation.

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Galileo Galilei first describes the Principle of Relativity, the idea that the fundamental laws of physics are the same in all inertial frames and that, purely by observing the outcome of mechanical experiments, one cannot distinguish a state of rest from a state of constant velocity.

Under compulsion, Galileo rejects the Copernican system.

The French philosopher Ren Descartes outlines a model of a static, infinite universe made up of tiny corpuscles of matter, a viewpoint not dissimilar to ancient Greek atomism. Descartes universe shares many elements of Sir Isaac Newton s later model, although Descartes vacuum of space is not empty but composed of huge swirling whirlpools of ethereal or fine matter, producing what would later be called gravitational effects.

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Francesco Stelluti publishes a summary of research on fossil wood conducted by himself and fellow Lincean Academy member Federico Cesi. Though resulting from meticulous research, the work reaches the wrong conclusion, describing the origin of fossil wood as inorganic.

Pierre de Fermat formulates his so-called Last Theorem, unsolved until 1995. In number theory, Fermat's Last Theorem (sometimes called Fermat's conjecture, especially in older texts) states that no three positive integers a, b, and c satisfy the equation aⁿ + bⁿ = cⁿ for any integer value of n greater than 2. The cases n = 1 and n = 2 have been known to have infinitely many solutions since antiquity. This theorem was first conjectured by Pierre de Fermat in 1637 in the margin of a copy of Arithmetica where he claimed he had a proof that was too large to fit in the margin.

Galileo Galilei demonstrates that unequal weights would fall with the same finite speed in a vacuum, and that their time of descent is independent of their mass. Thus, freely falling bodies, heavy or light, have the same constant acceleration, due to the force of gravity.

Jeremiah Horrox observes the first transit of Venus. Horrox (or Horrocks) was an English astronomer. He was the first person to demonstrate that the Moon moved around the Earth in an elliptical orbit; and he was the only person to predict the transit of Venus of 1639, an event which he and his friend William Crabtree were the only two people to observe and record.

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Calvinist lawyer Isaac La Peyrère seeks permission to publish his manuscript claiming that people have existed before Adam, and that Chaldeans can legitimately trace their civilization back 470,000 years. Permission is denied, but he will publish Men Before Adam anonymously 14 years later, inciting both outrage and mild amusement among religious leaders.

Dutch anatomist Nicolaas Tulp produces the first formal description of an ape (a chimp, bonobo or orangutan).

René Descartes publishes Principles of Philosophy arguing that the universe is governed by simple laws and that natural processes could have shaped the Earth.

Pascal's calculator or the Pascaline constructed

The mezzotint printmaking method was invented by the German amateur artist Ludwig von Siegen. Mezzotint is a printmaking process of the intaglio family, technically a drypoint method. It was the first tonal method to be used, enabling half-tones to be produced without using line- or dot-based techniques like hatching, cross-hatching or stipple. Mezzotint achieves tonality by roughening the plate with thousands of little dots made by a metal tool with small teeth, called a "rocker." In printing, the tiny pits in the plate hold the ink when the face of the plate is wiped clean. A high level of quality and richness in the print can be achieved.

Workers dig up a skeleton in Flanders. A court physician to the Danish king observes the excavation, measures the skeleton in "Brabantian cubits," and attributes the skeleton to a giant. It will later be identified as a fossil proboscidian.

Evangelista Torricelli invents the barometer.

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Christiaan Huygens invents the pendulum and applies its workings to create highly accurate pendulum clocks.

Franciscus Hackius publishes a lavish book on the natural history and medicines available from Brazil, Historia Naturalis Brasileae.

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Irish archbishop James Ussher calculates the date of creation, based on the ages of biblical prophets. Using his calculations, theologians will identify the date of creation as on October 26, 4004 BC.

Tobacco arrives in Africa — European settlers grow it and use it as a currency.

William Harvey publishes Exercitationes de generatione animalium (On Animal Generation) explaining that all animal life begins as eggs, whether in birds, amphibians or mammals. According to Joseph Needham, in this work Harvey: (1) presented a doctrine of omne vivum ex ovo (all life comes from the egg), the first definite statement against the idea of spontaneous generation; (2) denied the possibility of generation from excrement and from mud, and pointed out that even worms have eggs; (3) identified the citricula as the point in the yolk from which the embryo develops and the blastoderm surrounding the embryo; (4) destroyed once and for all the Aristotelian (semen-blood) and Epicurean (semen-semen) theories of early embryogeny; and (5) settled the long controversy about which parts of the egg were nutritive and which was formative, by demonstrating the unreality of the distinction.

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Otto von Guericke invents a vacuum pump consisting of a piston and an air gun cylinder with two-way flaps designed to pull air out of whatever vessel it was connected to, and used it to investigate the properties of the vacuum in many experiments. This pump is described in Chapters II and III of Book III of the Experimenta Nova and in the Mechanica Hydraulico-pneumatica. Guericke demonstrated the force of air pressure with dramatic experiments. In 1657, he machined two 20-inch diameter hemispheres and pumped all the air out of them, locking them together with a vacuum seal. The air pressure outside held the halves together so tightly that sixteen horses, eight harnessed to each side of the globe, could not pull the halves apart. It would have required more than 4,000 pounds of force to separate them.

Danish scholar Ole Worm publishes Musei Wormiani Historia, a successful book about his cabinet of natural curiosities.

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Jesuit missionary Martino Martini publishes a manuscript explaining that documented Chinese history predates the time generally understood to mark Noah's flood (2,300 BC).

John Tradescant deeds his family treasures to fellow collector Elias Ashmole. Ashmole will later donate the collection to Oxford University, stipulating that a separate building is to be constructed for it.

Foundation of the Royal Society, London, for the promotion of mathematical and physical science.

Robert Boyle publishes The Sceptical Chymist helping to transform alchemy into chemistry. Though an alchemist himself with his own cache of secret notebooks, Boyle begins writing up experiments for use by others.

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German physician Otto von Guericke pieces together bones from different species to make a fossil "unicorn."

In his private museum in Rome, Virgilio Romano exhibits a Hippopotamus major canine tooth found in Pleistocene gravels along the Via Nomentana.

Thomas Willis publishes The Anatomy of the Brain and Nerves.

Isaac Newton discovers that white light is composed of different colors.

Robert Hooke observes cork under a microscope and uses the word cells to describe the tiny chambers that he sees. He publishes drawings of these cells, of fleas, and of other small creatures, in his book Micrographia.

Le Journal des Savants is first published in France, and Philosophical Transactions of the Royal Society is first published in England.

Samuel Morland builds a mechanical calculator that will add and subtract

Gravity is discovered.

Niels Stensen (Steno) describes his dissection of the head of a giant white shark and correctly identifies shark teeth, still generally thought (despite arguments to the contrary from Rondelet and Colonna in the preceding century) to be serpent tongues.

Natural historian John Somner finds woolly rhino teeth near Canterbury in Kent, and figures they might be the remains of a sea monster. As he will die before he can publish his conclusions, his brother William will print his article A Brief Relation of Some Strange Bones There Lately Digged Up In Some Grounds of Mr. John Somner.

Francesco Redi publishes Esperienze Intorno alla Generazione degli Insetti (Experiments on the Generation of Insects), which is regarded as his masterpiece and a milestone in the history of modern science. At the time, prevailing wisdom was that maggots arose spontaneously from rotting meat. Redi took six jars and divided them into two groups of three: In one experiment, in the first jar of each group, he put an unknown object; in the second, a dead fish; in the last, a raw chunk of veal. Redi covered the tops of the first group of jars with fine gauze so that only air could get into it. He left the other group open. After several days, he saw maggots appear on the objects in the open jars, on which flies had been able to land, but not in the gauze-covered jars. In the second experiment, meat was kept in three jars. One of the jars was uncovered, and two of the jars were covered, one with cork and the other one with gauze. Flies could only enter the uncovered jar, and in this, maggots appeared. In the jar that was covered with gauze, maggots appeared on the gauze but did not survive. Knowing full well the terrible fates of out-spoken thinkers such as Giordano Bruno and Galileo Galilei, Redi was careful to express his new views in a manner that would not contradict theological tradition of the Church; hence, his interpretations were always based on biblical passages, such as his famous adage: omne vivum ex vivo ("All life comes from life").

Jan Swammerdam dissects a caterpillar for Cosimo de Medici, demonstrating that the butterfly wings already exist inside the caterpillar's body. A year later, he will publish Historia Insectorum Generalis.

Robert Hooke presents a lecture to the Royal Society claiming that earthquakes, not the biblical flood, have caused fossils to be found on mountaintops and buried in stone.

Niels Stensen (Steno) publishes Forerunner, showing diagrammatic sections of the Tuscany area geology, making the important point that sediments are deposited in horizontal layers.

Brandt discovers phosphorus.

Agostino Scilla publishes Vain Speculation Undeceived by Sense arguing for the organic origin of fossils.

The Greenwich Observatory is built.

Isaac Newton completes his book, The Methods of Fluxions and Infinite Series, with its Application to the Geometry of Curve-lines (which was not published until 1736). The book describes Newton's analytic methods, which would now be called calculus.

Gottfried Wilhelm von Leibniz invents the Staffelwalze (stepped drum, or stepped reckoner), the first mechanical calculator that could perform all four mathematical operations. Its intricate precision gearwork, however, was somewhat beyond the fabrication technology of the time; mechanical problems, in addition to a design flaw in the carry mechanism, prevented the machines from working reliably. Despite the mechanical flaws, it suggested possibilities to future calculator builders. The operating mechanism, invented by Leibniz, called the stepped cylinder or Leibniz wheel, was used in many calculating machines for 200 years, and into the 1970s with the Curta hand calculator. In discussing his invention, Leibniz wrote Indignum enim est excellentium virorum horas servii calculandi labore perire, qui Machina adhibita vilissimo cuique secure transcribi posset — For it is unworthy of distinguished men to waste their time with slavish calculations, which can be done safely with the use of this machine by anyone else.

Apothecary and antiquary John Conyers finds an elephant tusk and a nearby handaxe about 12 feet below ground at Gray's Inn Lane, London. The Gray's Inn Lane handaxe will later be dated at 350,000 years old.

Leeuwenhoek begins corresponding with the Royal Society of London describing his discoveries under the microscope.

Antonie van Leeuwenhoek creates a simple microscope with only one lens. He developed glass-handling techniques that allowed him to create lenses with magnifying power up to 270x — by far the most powerful magnifying lenses available. Although compound microscopes had been invented in the 1590s, nearly forty years before Leeuwenhoek was born, there were technical difficulties in building them, meaning that early compound microscopes (such as used by Robert Hooke) had a maximum magnification of only 20x or 30x. Leeuwenhoek's more powerful lenses allowed him to discover protozoa and other single-celled organisms and to be the first to observe bacteria.

Jan Swammerdam publishes a treatise on the mayfly entitled A Figure of Man's Miserable Life.

The English physicist Sir Isaac Newton argues that light is composed of particles, which are refracted by acceleration toward a denser medium, and posits the existence of aether to transmit forces between the particles.

The first quantitative estimate of the speed of light was made in 1676 by Danish astronomer Ole R mer. From the observation that the periods of Jupiter's innermost moon Io appeared to be shorter when the Earth was approaching Jupiter than when receding from it, he concluded that light travels at a finite speed, and estimated that it takes light 22 minutes to cross the diameter of Earth's orbit. Christiaan Huygens combined this estimate with an estimate for the diameter of the Earth's orbit to obtain an estimate of speed of light of 220000 km/s, 26% lower than the actual value.

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Royal Society member Neremiah Grew examines the "sea serpent teeth" found by John Somner in 1668 and recognizes that they are rhino teeth.

Amsterdam physician Gerard Blasius publishes Anatome Animalium examining animals' internal anatomy and skeletal structure.

The first museum of natural history is established in London.

Neremiah Grew publishes The Anatomy of Plants with microscopic observations of plant features.

Oxford opens the Ashmolean Museum, the world's first public museum. The museum's practice of allowing entry to anyone who pays the admission fee horrifies scholars from continental Europe.

Dublin doctor Thomas Molyneux shows that a "giant's tooth" from the collection of Ole Worm really belongs to a whale, and a "giant's hand" shown in London is really the fin of a porpoise.

Filippo Buonanni publishes Ricreatione dell' occhio e della mente. — perhaps the first book devoted entirely to shells, for which he is considered a founder of conchology.

Gottfried Wilhelm von Leibniz publishes a description of his invention of the differential calculus.

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Timothy Nourse anticaptes eugenics with the argument that a gentleman "ought at least to be as careful of his race as he is of that of his horses, where the fairest and most beautiful are made choice of for breed."

Robert Boyle composes Free Inquiry into the Vulgarly Received Notion of Nature criticizing the notion that nature is capable of autonomy from God.

Sir Isaac Newton publishes his Philosophi Naturalis Principia Mathematica (or just Principia), which describes an infinite, steady state, static, universe, in which matter on the large scale is uniformly distributed. In the work, he establishes the three Laws of Motion ( a body persists its state of rest or of uniform motion unless acted upon by an external unbalanced force ; force equals mass times acceleration ; and to every action there is an equal and opposite reaction ) and the Law of Universal Gravitation (that every particle in the universe attracts every other particle according to an inverse-square formula) that were not to be improved upon for more than two hundred years. He is credited with introducing the idea that the motion of objects in the heavens (such as planets, the Sun and the Moon) can be described by the same set of physical laws as the motion of objects on the ground (like cannon balls and falling apples).

Giovanni Ciampini describes remains of the extinct straight-tusked elephant, Elephas antiquus, found in the town of Vitorchiano in the region of Latium.

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Naturalist John Ray publishes Three Physicotheological Discourses about the Creation, the Deluge and the Conflagration, discussing conflicting theories about the nature of fossils.

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Scandinavian historian Olof Rudbeck publishes his attempt to chronologically measure sedimentary deposits, laying the foundations for the field of stratigraphy.

Edward Lhwyd publishes a description of a "flatfish" in the Philosophical Transactions of the Royal Society. (The flatfish is really a trilobite, an ancient marine arthropod.)

Edward Lhwyd publishes a book devoted to British fossils. In it, he describes ichthyosaur remains as those of a fish.

Based on a dissection he performed the year before, Edward Tyson publishes Orang Outan, sive Homo sylvestris pointing out similarities between chimpanzee and human anatomy. (Although he has dissected an infant chimp, Tyson uses the term "orang-outan.")

African slaves are first forced to work on tobacco plantations, years before they become a workforce in the cotton fields.

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Gottfried Wilhelm Leibniz invents the Binary System

Isaac Newton is elected president of the Royal Society.

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A giant fossil tooth is found along the banks of the Hudson River. It will initially be identified (by Cotton Mather) as that of a human giant who perished in Noah's flood, then correctly identified (by Georges Cuvier) as that of a mastodon.

Maria Sibylla Merian publishes Metamorphosis Insectorum Surinamensium describing insect species and other animals she has studied in Surinam.

The Ambonese Curiosity Cabinet by G.E. Rumphius is published. It provides detailed descriptions of soft and hard shellfish, minerals, rocks and fossils from Indonesia.

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Hans Sloane publishes the first of two volumes describing the natural wonders of Jamaica. (The second volume will be published in 1725.)

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George Berkeley publishes "A Treatise Concerning the Principles of Human Knowledge."

Jakob Christoph Le Blon, an engraver, invents three-color printing.

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In Physico-theology, or a demonstration of the being and attributes of God from His works of creation William Derham tries to show that this is the best of all possible worlds.

Daniel Gabriel Fahrenheit constructs a mercury thermometer with a temperature scale.

On the advice of Leibniz, Peter the Great opens a public museum in Saint Petersburg.

Edmund Halley lectures the Royal Society that the age of the Earth could be calculated by measuring the ocean's salinity since ocean salts result from sediments carried by rivers and streams.

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William Stukely publishes An Account of the Almost Entire Sceleton of a Large Animal in a Very Hard Stone. The fossil is a plesiosaur, but is identified as a crocodile.

Dutch pharmacist Albertus Seba inventories his wonder cabinet for the avid collector Peter the Great, including 1,000 European insects and 400 animal specimens. The czar buys the inventory, and Seba begins his second collection, which he will describe in print starting in 1734.

Johann Heinrich Schulze makes fleeting sun prints of words by using stencils, sunlight, and a bottled mixture of chalk and silver nitrate in nitric acid, simply as an interesting way to demonstrate that the substance inside the bottle darkens where it is exposed to light.

Porcelain is first manufactured in Vienna.

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René Réaumur submits a report to the Paris Academy of Sciences proposing that a brief Noachian flood cannot account for the thick sedimentary layers (composed largely of broken shells) underlying the region of Tours. He suggests instead that the region was once covered by the sea.

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Benoît de Maillet anonymously publishes Telliamed, named after an oriental sage who says that the Earth must be at least 2 billion years old, based on measurements of falling sea level. (In fact, no sage exists; the title is really the author's name spelled backward.)

Antoine de Jussieu addresses a paper to the Académie des Sciences suggesting that an ancient object, e.g., a stone tool, made of the same material and by the same process as those used by a modern population probably has the same function.

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Balthasar Ehrhart identifies belemnites as fossil cephalopods.

Johann Heinrich Schulze discovered that silver nitrate darkened upon exposure to light.

Hans Sloane publishes two papers on fossils found in Siberia and North America arguing that they are fossil elephants, not giants or monsters.

In An Attempt towards a Natural History of England, John Woodward describes three "pinecones" that, upon later examination, will prove to be coprolites.

Louis Bourget's Lettres philosophiques sur la formation des sels et de cristaux et sur la génération et la méchanique organique (Philosophical letters on the formation of salts and crystals and on generation and organic mechanisms) makes the distinction between organic and inorganic growth.

Otto Müller is among the first to see bacteria since Leeuwenhoek and the first to classify them into types.

First American tobacco companies open their doors in Virginia.

Jethro Tull's Horse-hoeing husbandry advocates the use of manure, pulverization of the soil, growing crops in rows, and hoeing to remove weeds.

Johann Jakob Scheuchzer publishes Sacred Physics, a pictorial account of Earth's history based on the Old Testament. Included is a description of what he believes is a fossilized victim of the biblical flood.

Nöel-Antoine Pluche publishes the first of eight volumes of Le spectacle de la nature (Spectacle of nature), popularizing "natural theology" in France.

Stephen Hales' Statical essays, containing haemastatics, etc., two volumes, reports his investigations on blood flow and pressure in animals and the hydrostatics of sap in plants.

The Swedish scientist and philosopher Emanuel Swedenborg proposes a hierarchical universe, still generally based on a Newtonian static universe, but with matter clustered on ever larger scales of hierarchy, endlessly being recycled. This idea of a hierarchical universe and the nebular hypothesis were developed further (independently) by Thomas Wright (1750) and Immanuel Kant (1775).

René de Réamure's Mémaoires pour servir à l'histoire des insects (History of insects) is one of the foundation works in entomology.

Systema Naturae (System of Nature) by Carolus Linnaeus introduces the system of classification for organisms that is still in use today.

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Hermann Boerhaave prints Jan Swammerdam's Biblia naturae (Bible of nature), which was originally published to little notice in 1658. It contains his reports on the dissection of insects under a microscope.

Linnaeus's Genera Plantorum (Genera of Plants) explains his method of systematic botany and classifies 18,000 species of plants.

(no entry for this year)

Native Americans traveling with French soldiers find mastodon fossils along the Ohio River. The bones will be shipped back to France and become the first American fossils studied by scientists.

David Hume publishes A Treatise of Human Nature.

(no entry for this year)

(no entry for this year)

Abraham Trembley makes the first permanent graft of animal tissue, using the Hydra.

The Microscope Made Easy, by Henry Baker, introduces the construction and use of the microscope to the layman.

(no entry for this year)

Abraham Trembley's Mémoires summarizes his research on the hydra and his discovery of regeneration in polyps.

Scholar and teacher Abraham Trembley publishes Mémoires Concerning the Natural History of a Type of Freshwater Polyp with Arms Shaped Like Horns. After watching them move and eat, he has concluded that the simple creatures (later to be classified as cnidarians) are animals, not plants.

Traité d'insectologie (Treatise on insect ecology) by Charles Bonnet describes his observations on parthenogenetic reproduction and metamorphosis of aphids.

Bologna physician Vincenzo Menghini roasts the blood of fish, birds and mammals (including humans) then sifts through the residue with a magnetic blade, noting that roasted-blood particles adhere to it. The experiment provides evidence that blood contains iron.

(no entry for this year)

Andreas Marggraf discovers sugar in beets, laying the foundation for Europe's sugar-beet industry.

L'homme Machine (Man the Machine) by Julien Offray de la Mettrie describes humans as machines, without freedom or will.

Georges-Louis Leclerc de Buffon publishes the first volume of Historie Naturelle. Thirty-six volumes came out between 1749 and 1789, followed by eight more after his death. The Histoire Naturelle was meant to address the whole of natural history, but actually covers only minerals, birds, and the quadrupeds among animals. It is accompanied by some discourses and a theory of the earth by way of introduction, and by supplements including an elegantly written account of the epochs of nature. The Histoire Naturelle had a distinctly mixed reception in the eighteenth century. Wealthy homes in both England and France purchased copies, and the first edition was sold out within six weeks. But Buffon was criticised by some priests for suggesting (in the essay Les Epoques de Nature, Volume XXXIV) that the earth was more than 6,000 years old and that mountains had arisen in geological time. The Paris faculty of theology, acting as the official censor, wrote to Buffon with a list of statements in the Histoire Naturelle that were contradictory to Roman Catholic Church teaching. In June, 2017, an antiquarian book deal offered a complete second edition of the Historie Naturelle for 14500 .

Carolus Linnaeus's Philosophia Botanica rejects any notion of evolution and continues his work in classifying plants.

John Needham publishes Nouvelles Observations Microscopiques arguing that decomposing plant and animal matter can spontaneously generate new life. Fifteen years later, Italian polymath Lazzaro Spallanzani will conduct a more careful set of experiments then publish a report rejecting Needham's conclusions.

Linnaeus's Species Plantarum completes his development of the use of binary nomenclature in botany. The work still provides the foundation for the modern classification of species.

Pierre-Louis de Maupertuis's Système de la Nature provides a theoretical speculation on heredity and the origin of species by chance.

Étienne Bonnot de Condillac's Traité de sensations claims that knowledge reaches humans only through the senses.

Benjamin Franklin describes electricity as a single fluid and distinguishes between positive and negative electricity in Experiments and Observations on Electricity. He shows that electricity can magnetize and demagnetize iron needles.

Encyclopedists Diderot and d'Alembert publish the first volume of the Encyclopedia, or Classified Dictionary of Sciences, Arts and Trades emphasizing a dispassionate presentation of factual information rather than reliance on age-old "wisdom."

The lightning conductor is invented by Benjamin Franklin, whose experiments with lightning include a flying a kite in a thunderstorm. The kite experiment shows that lightning is a form of electricity, similar to the discharge from a Leyden jar.

Stung by satires of its Philosophical Transactions, the Royal Society of London forms a committee that will vote on which papers merit publication.

Tobacco genus named by a Swedish botanist Carolus Linnaeus — Nicotiana rustica and Nicotiana tabacum named for the first time.

Russian scientist Georg Wilhelm Richmann is killed performing a lightning experiment in St. Petersburg. Richmann is electrocuted in while trying to quantify the response of an insulated rod to a nearby storm. The incident, reported worldwide, underscored the dangers inherent in experimenting with insulated rods and in using protective rods with faulty ground connections.

The British Museum opens.

(no entry for this year)

(no entry for this year)

William Cullen observes the cooling effect of evaporating liquids and publishes the results in An Essay on the Cold Produced by Evaporating Fluids and Other Means of Producing Cold.

(no entry for this year)

Henri-Louis Duhamel du Monceau discovers that when he turns a seedling upside down, its roots and shoots reorient so that the root continues to grow downward while the shoot continues to grow upward.

In Theoria Generationis (his MD dissertation), Caspar Friedrich Wolff claims the existence of a vis essentialis — an essential force — that is at the heart of all living matter. He also describes the differentiation of tissues in a developing embryo, refuting the preformation concept — the idea that development consists in the growth of a fully formed, but miniature individual. His views were not well received.

The Kew Botanical Gardens open in London.

Joseph Gottlieb Kölreuter'S Vorläufige nachricht von einigen das geschlecht der pflantzen betreffende versuche and beobachtungen describes his research in heredity in plants.

Giovanni Arduino proposes a naming system for geologic strata, in order of oldest to youngest: Primary: lacking fossils; Secondary: tilted with fossils; Tertiary: horizontal with fossils; Quaternary: sands and gravels overlying Tertiary strata. Although he does not relate these systems to scripture, many people will interpret them in terms of biblical events.

Photometria by German physicist Johann Lambert is an investigation of light reflections from planets, introducing the term ALBEDO (whiteness) for the differing reflectivities of planetary bodies.

In experiments with primitive apparatus, Daniel Bernoulli decides that the electrical force obeys an inverse square law similar to that of gravity.

The Swiss physicist Johann Heinrich Lambert supports Wright and Kant s hierarchical universe and nebular hypothesis, and also hypothesizes that the stars near the Sun are part of a group which travel together through the Milky Way, and that there are many such groupings or star systems throughout the galaxy.

Jean-Baptiste Robinet's five-volume De la nature claims that organic species form a linear scale of progress, without gaps.

Between 1761 and 1766, Joseph Gottlieb Kölreuter (Germany) demonstrates that hybrid offspring receive traits from both parents (pollen and ovule transmit genetic information), and are intermediate in most traits. First scientific hybrid produced (tobacco). Demonstrates the identity of reciprocal crosses. Notes hybrid vigor, segregation of offspring (parental and non-parental types) from a hybrid.

Joseph Black discovers latent heat by finding that ice, when melting, absorbs heat without changing in temperature. Later he measures the latent heat of steam — that is, the heat required to keep water boiling without raising its temperature.

Charles Bonnet's Considerations sur les corps organisées gives his theory of "preformation" — the idea that each creature is already preformed in miniature in the egg, and that the egg contains all future generations in even smaller scale, ad infinitum.

George III purchases the Paper Museum of Cassiano Dal Pozzo, a 17th- century patron of arts and sciences. Preserved by the Albani family, this "museum" contains more than 7,000 science illustrations, including highly accurate depictions from the Lincean Academy that will prove invaluable to later science historians.

(no entry for this year)

(no entry for this year)

Italian biologist Lazzaro Spallanzani suggests preserving food by sealing it in containers that do not permit air to penetrate.

Leonhard Euler gives a general treatment of the motion of rigid bodies, including the precession and nutation of earth, in Theoria motus corporum solidorum seu rigidorum (Theory of the motion of solid and rigid bodies).

Albrecht von Haller is the first to show that nerves stimulate muscles to contract and that all nerves lead to the spinal cord and the brain.

Horace-Bénédict de Saussure invents the electrometer, a device for measuring the electric potential by means of the attraction or repulsion of charged bodies.

Bifocal spectacles are invented by Benjamin Franklin.

First fire escape patented, consisting of a wicker basket on a pulley and chain.

Benjamin Franklin writes a thank-you letter to a wealthy Irish trader for a box of proboscidian "tusks and grinders." Franklin believes the remains belong to elephants but makes astute observations about how their climate must have differed from the present.

Lazzaro Spallanzani's Prodromo d'un ouvrage sur les reproductions animales (Foreword to a work on animal reproduction) tells of his demonstration that spontaneous generation of animals does not take place in tightly closed bottles that have been boiled for more than 30 minutes.

Caspar Friedrich Wolff's De formatione intestinarum establishes principles of the formation of organs in embryos.

James Cook sets sail on the Endeavour bound for the South Pacific. Accompanying Cook is naturalist Joseph Banks, who will collect tens of thousands of plant and animal specimens and initiate the exchange of flora and fauna between Europe, the Americas and the South Seas.

Charles Bonnet's Philosophical palingenesis, or ideas on the past and future states of living beings contains his view that the females of every species contain the germs of all future generations.

John Robison measures the repulsion between two charged bodies and shows that this force is inversely proportional to the distance between the two bodies.

James Watt patents the modern steam engine, which finds wide use in manufacturing. It is an early milestone of the Industrial Revolution.

Erasmus Darwin has the allegorical motto E conchis omnia or "Everything from shells" painted on his carriage, promoting the idea of common descent. Bowing to social pressure, he removes it shortly thereafter.

In Gailenreuth Cave in Germany, Father Johann Esper finds human bones underlying those of extinct animals. He concludes that the bones got there by accident, an opinion Cuvier will share.

Italian anatomist Luigi Galvani discovers accidentally the action of electricity on the muscles of the dissected frog: it causes a twitch.

Joseph Priestly discovers that a plant can produce enough breathable air to sustain a mouse and keep a candle burning. Though he describes it in different terms, he has discovered oxygen.

New Jersey passes bill requiring a license to practice medicine.

Swedish scientist Johan Carl Wilcke calculates the latent heat of ice (the amount of heat absorbed when ice turns into water).

(no entry for this year)

Joseph Priestley discovers oxygen.

Franz Anton Mesmer suggests that "animal magnetism" causes attractions between certain persons. Mesmer's name becomes the root of the English verb "mesmerize".

Johann Christian Fabricius's Systema Entomologiae classifies insects based on the structure of mouth organs rather than wings.

Alessandro Volta describes his electrofore perpetuo device for producing and storing a charge of static electricity. This device replaces the Leyden jar and eventually leads to modern electrical condensers.

Grand duke Pietro Leopoldo establishes the Royal Museum of Physics and Natural History (La Specola) in Florence. Unlike many older natural history repositories, this institution will admit any visitor, at least anyone meeting the museum's standards for dress and hygiene. The museum includes a stuffed hippopotamus, that once belonged to Cosimo III, a member of the Medici who had a penchant for exotic animals. The hippo once roamed the Boboli Gardens. After its death, the hippo was inexpertly stuffed, and later displayed in Florence s Museum of Zoology and Natural History (La Specola), where it can still be seen today.

Abbé Jacques-François Dicquemare describes reptilian fossils in Journal de Physique but refrains from speculating about their sources.

Pierre-Simon Laplace states that if all of the forces on all objects in any one time are known, then the future can be completely predicted.

Charles-Augustin Coulomb invents the torsion balance.

Buffon publishes Les Epoques de la Nature, asserting that the Earth is a staggering 74,832 years old, and has existed long before the arrival of humans or any other form of life.

Jan Ingenhousz discovers two distinct respiratory cycles in plants: at night oxygen is absorbed and carbon dioxide is exhaled; during the day carbon dioxide is absorbed and oxygen is exhaled. The exact nature of the exhaled gases becomes clear with the later discoveries by Lavoisier.

Jan Ingenhousz discovers photosynthesis: In Experiments on Vegetables Ingenhousz shows that sunlight is essential for the production of oxygen by leaves.

The peculiar inheritance of human color-blindness reported to The Royal Society of London by Michael Lort.

Lazzaro Spallanzani studies the role of semen in fertilization and learns that the sperm must make physical contact with the egg for fertilization to take place.

William Herschel discovers first binary star, Xi Ursae Majoris.

Abraham Gottlob Werner asserts that all rocks have been deposited by a primordial ocean. This "Neptunian" view is accepted with little question.

Pierre François André Méchain discovers M80 (globular cluster in Scorpio).

Johan Carl Wilcke introduces the concept of SPECIFIC HEAT.

Coloumb's Théorie des machiones simple (Theory of simple machines) is a study of friction.

(no entry for this year)

The amateur British astronomer John Michell proposes the theoretical idea of an object massive enough that its gravity would prevent even light from escaping (which has since become known as a black hole). He realizes that such an object would not be directly visible, but could be identified by the motions of a companion star if it was part of a binary system. A similar idea was independently proposed by the Frenchman Pierre-Simon Laplace in 1795.

Horace-Bénédict de Saussure's Essais sur l'hygromé (Essay on measuring humidity) describes how to construct a hygrometer from human hair that can measure relative humidity.

Joseph and Jacques Montgolfier make first public balloon flight.

Historian and naturalist Cosimo Alessandro Collini publishes a description of the first known pterosaur.

George Atwood accurately determines the acceleration of a free-falling body.

Charles Willson Peale establishes a natural history museum in Philadelphia, one of the first successful American museums.

Lazzaro Spallanzani performs artificial insemination on a dog.

In his Theory of the Earth, James Hutton explains the principle of uniformitarianism: all geological features can be explained by changes that can be observed now, taking place over very long periods of time.

Couloumb makes precise measurements of the forces of attraction and repulsion between charged bodies and between magnetic poles, using a torsion balance, demonstrating conclusively that electric charge and magnetism obey inverse-square laws like that of gravity. He also discovers that electrically charged bodies discharge spontaneously. In the 20th century, it is found that cosmic radiation is responsible for this discharge.

First balloon flight across English Channel (Jean-Pierre Blanchard and John Jeffries).

French balloonists Jean-François Pilatre de Rozier and Jules Romain are killed when their Royal Balloon crashes near Boulogne, France, June 15, 1785, in what is considered the first aerial disaster.

(no entry for this year)

Herschel discovers Enceladus, a moon of Saturn, and Titania and Oberon, moons of Uranus.

Jacques-Alexandre Charles shows that different gases expand by the same amount for a given rise in temperature (Charles Law).

Thomas Jefferson publishes Notes on the State of Virginia refuting Buffon's claim that America's harsh, moist climate stunts the growth of its inhabitants. He also addresses the issue of race, describing Native Americans favorably, but African slaves unfavorably.

Juan-Bautista Bru mounts the first relatively accurate fossil reconstruction of an extinct animal from South America. Georges Cuvier classifies it as a giant sloth.

Gilbert White's The Natural History and Antiquities of Selborne, a series of notes about animal and plant life in Selborne, England, is the first recognizable work of ecology. It goes through about 300 different editions and is still in print today.

Johann Wolfgang Goethe's Versuch, die Metamorphose der Pflanzen zu erklären (Attempt to explain the metamorphosis of plants) claims incorrectly that all plant structures are modified leaves, but clearly espouses evolution.

French polymath Antoine Lavoisier publishes a paper on French geology defining peacefully deposited pelagic sediments and violently deposited littoral sediments. He argues that these sediments illustrate a fluctuating sea level on an ancient planet.

The French chemist Antoine-Laurent de Lavoisier definitively states the Law of Conservation of Mass (although others had previously expressed similar ideas, including the ancient Greek Epicurus, the medieval Persian Nasir al-Din al-Tusi and the 18th Century scientists Mikhail Lomonosov, Joseph Black, Henry Cavendish and Jean Rey), and identifies (albeit slightly incorrectly) 23 elements which he claims can not be broken down into simpler substances.

Bourbon Whiskey is first created by Elijah Craig in Bourbon, Kentucky.

German poet Johann Wolfgang von Goethe writes The Morphology of Plants stating that all plant organs, flowers included, began as leaves — an assertion that will enjoy some support from 21st-century genetic research.

British doctors find that snuff leads to increased risk of nose cancer.

Luigi Galvani announces that electricity applied to severed frog's legs causes them to twitch and that frogs legs twitch in the presence of two different metals with no electric current present. The latter discovery eventually leads to Alessandro Volta's developing the electric battery.

Pierre Prévost develops his theory of exchanges of radiation of heat. He correctly shows that cold is merely the absence of heat and that all bodies continually radiate heat. If they seem not to radiate heat, it means that they are in heat equilibrium with their environment.

Charles Babbage is Born

John Stone, Concord, Massachusetts, patents a pile driver.

New York City traffic regulation creates first one-way street.

Guillotine first used (to execute highwayman Nicolas J. Pelletier).

Reverend James Douglas publishes Nenia Britannica; or, A Sepulchral History of Great Britain providing perhaps the first record of a fossil (sea urchin) at an archaeological site.

France becomes first country to use the metric system.

Eli Whitney invents the cotton gin (cotton enGINe), a machine that quickly and easily separates cotton fibers from their seeds, allowing for much greater productivity than manual cotton separation. By reducing the labor of removing seeds, the cotton gin made cotton growing more profitable, thereby raising demand for slave labor. The first federal census of 1790 counted 697,897 slaves; by 1810, there were 1.2 million slaves, a 70 percent increase. Slavery spread from the seaboard to some of the new western territories and states as new cotton fields were planted, and by 1830 it thrived in more than half the continent. Within 10 years after the cotton gin was put into use, the value of the total United States crop leaped from $150,000 to more than $8 million.

John Frere describes and illustrates handaxes from Hoxne that will turn out to be some 400,000 years old.

Erasmus Darwin (Charles' grandfather) publishes Zoonomia, or the Laws of Organic Life.

James Hutton publishes An Investigation of the Principles of Knowledge. Buried in the 2,138-page philosophical tome is a chapter about variety in nature in which Hutton anticipates Charles Darwin's theory of natural selection.

John Dalton's Extraordinary facts relating to the vision of colors gives an early account of red-green color blindness, which he refers to as Daltonism, since he is afflicted with the condition.

Zoonomia, or the Laws of Organic Life by Erasmus Darwin (grandfather of Charles Darwin) contains his ideas about evolution, which are Lamarckian in that they assume the environment has a direct influence on organisms, causing permanent changes in the germ line.

Alessandro Volta demonstrates that the electric force observed by Galvani is not connected with living creatures, but can be obtained whenever two different metals are placed in a conducting fluid.

James Hutton's Theory of the Earth published, interpreting certain geological strata as former sea beds. Hutton proposes geological theory of gradualism.

Johann Friedrich Blumenbach publishes De generis humani varietate nativa liber arguing that humans comprise a single species with five varieties: Caucasian, Mongolian, Ethiopian, (American) Indian and Malayan.

James Hutton overturns the "Neptunian" view of rock formation in his Theory of the Earth, suggesting instead that forces of rock creation are balanced by forces of rock destruction.

(no entry for this year)

(no entry for this year)

Publication of Thomas Malthus' Essay on the Principle of Population, a work that Darwin asserted helped him frame the principle of evolution by natural selection.

Henry Cavendish determines the mass of Earth by measuring the gravity between two small masses and two large masses. This gives the gravitational constant G, which was the only unknown in Newton's equations. Solving for G enables Cavendish to establish that Earth is about 5.5 times as dense as water.

Enquiry concerning the source of heat which is excited by friction by Count Rumford (Benjamin Thompson) describes his experiments with boring cannons that show that the caloric theory of heat cannot be true, and that heat should be considered a kind of motion.

The first mammoth fossil fully documented by modern science is discovered near the delta of the Lena River in 1799 by Ossip Schumachov, a Siberian hunter. Schumachov allows it to thaw (a process taking several years) until he can retrieve the tusks for sale to the ivory trade in Yakutsk. He then abandons the specimen, allowing it to decay before its recovery. In 1806, Russian botanist Mikhail Adams rescues what remained of the specimen and brought it to the Zoological Museum of the Zoological Institute of the Russian Academy of Sciences in St. Petersburg. The specimen, which became known as the Adams Mammoth, is stuffed and mounted, and continues to be on display at the Zoological Institute.

Charles White publishes An Account of the Regular Gradation in Man, and in Different Animals and Vegetables, a treatise on the great chain of being, showing people of color at the bottom of the human chain.

Faujas publishes a description of the Maastricht animal, a spectacular mosasaur found in chalk quarries in the Netherlands, describing it as a crocodile.

Thomas Jefferson publishes a paper describing Megalonyx, a North American fossil ground sloth similar to the one found in South America.

George Shaw publishes a description of a platypus even though he suspects the odd animal might be a hoax.

Alexander von Humboldt names the Jurassic System, after the Jura Mountains. This time period will later be identified as the "middle period" for the dinosaurs.

William Smith maps rock formations in the vicinity of Bath, England, making perhaps the world's first geologic map. The same year, Smith, Joseph Townsend and Benjamin Richardson recognize rocks containing the Permian and Triassic, though not necessarily by those names. (These periods will later be identified as spanning the Earth's most catastrophic mass extinction.)

The British government purchases the collection of Scottish anatomist John Hunter, forming the Hunterian Museum.

Between 1800 and 1803, naturalist Alexander von Humboldt visits Mexico and writes influential accounts of his observations.

Karl Friedrich Burdach coins the term BIOLOGY to denote the study of human morphology, physiology and psychology.

Erasmus Darwin publishes Phytologia declaring that leaves breathe air through tiny pores, sugar and starch are the products of plant "digestion," and nitrates and phosphorus promote vegetation.

Alessandro Volta announces his invention, made in 1799, of the electric battery, also known as the Voltaic pile. It consists of a stack of alternating zinc and silver discs separated by felt soaked in brine. It is the first source of a steady electric current.

William Herschel's "An investigation of the powers of prismatic colors to heat and illuminate objects" tells of his discovery of infrared radiation. While investigating the power of different parts of the spectrum to heat a thermometer, he finds that invisible light beyond the red produces the most heat.

Thomas Wedgwood conceives of making permanent pictures of camera images by using a durable surface coated with a light-sensitive chemical. He succeeds only in producing silhouettes and other shadow images, and is unable to make them permanent.

Giuseppe Piazzi discovers first asteroid, which is later named Ceres.

Jean-Baptiste Lamarck's Système de Animaux sans Vertèbres (System for Animals without Vertebrae) includes a classification system for invertebrates and a preliminary view of his ideas of evolution.

The English scientist Thomas Young demonstrates, in his famous double-slit experiment, the interference of light and concludes that light is a wave, not a particle as Sir Isaac Newton had ruled.

In Natural Theology, William Paley uses the analogy of a watch requiring a watchmaker to argue that the universe implies an intelligent designer.

Gottfried Treviranus and Jean Baptiste de Lamarck independently broaden the meaning of BIOLOGY to include the study of all living things.

Considered the father of modern scientific education in America, Benjamin Silliman, Sr., teaches the first modern science course (chemistry at Yale) in the United States. Silliman later becomes a founder in 1818 of the American Journal of Science, one of the oldest scientific journals in the world.

Thomas Young's On the theory of light and colors is the first of three pivotal papers describing his wave theory of light.

(no entry for this year)

Georges Cuvier suggests that fossils found in the area around Paris are "thousands of centuries" old. This casual observation pushes the age of the Earth well beyond its commonly accepted limits. Cuvier also publishes a paper explaining that the fossil animals he has studied bear no resemblance to anything still living, an unambiguous endorsement of the theory of extinction.

James Parkinson publishes the first of a three-volume work entitled Organic Remains of a Former World. In this volume, he describes fossils as the remains of Noah's Flood. In the next several years, he will recognize fossils as the remains of a world before people, and acknowledge as much in the third volume, published in 1811.

Nicolas-Théodore de Saussure's Recherches chimiques sur la végétation "Chemical researches on vegetation" shows that plants require carbon dioxide from the air and nitrogen from the soil. Earlier researchers had assumed the plants got carbon from the soil instead of from the air.

John Leslie's An experimental inquiry into the nature and propagation of heat establishes that the transmission of heat through radiation has the same properties as the propagation of light.

The field of comparative anatomy begins, with the publications of Baron Georges Cuvier's Lesson in Comparative Anatomy

Pierre-Simon Laplace measures molecular forces in liquids and announces his theory of capillary forces.

The English chemist John Dalton develops his atomic theory, proposing that each chemical element is composed of atoms of a single unique type, and that, though they are both immutable and indestructible, they can combine to form more complex structures.

(no entry for this year)

Thomas Young introduces the concept of, and is the first to use the word, ENERGY.

Robert Fulton develops the first practical steamboat, the Clermont, which sails from New York City to Albany and back.

Étienne-Louis Malus discovers that reflected light is polarized and introduces the term POLARIZATION.

12 Feb 1809

Charles Darwin is born

Jean Baptiste de Lamarck's theory of evolution presented with the publication of his Philosophie Zoologique, which emphasized the fundamental unity of life and the capacity of species to vary.

Mary Anning's brother Joseph discovers the world's first recognized fossil ichthyosaur. Mary Anning will collect the fossil the next year.

Georges Cuvier identifies the "biblical flood" victim, described by Johann Jakob Scheuchzer in 1731, as a giant salamander.

Georges Cuvier correctly identifies pterosaurs as flying reptiles. His conclusions will be largely ignored for many years.

William Hyde Wollaston invents the camera lucida, a device for projecting an image onto a flat surface, such as drawing paper, on which the object can then be traced.

Swiss-French botanist Augustin Pyramus de Candolle introduces the word TAXONOMY in his lifelong project of a 21-volume plant encyclopedia. Seven volumes are published during his lifetime, the remainder after his death.

(no entry for this year)

Relying largely on fossils to identify strata, civil engineer William Smith publishes a geologic map of England, Wales and part of Scotland, the largest region so far documented. Four years later, Smith will be arrested and sent to debtors' prison.

Ada, Lady Lovelace, is Born

Augustin Fresnel demonstrates with his mirror experiment the wave nature of light. He also gives an explanation of polarization.

Nic phore Ni pce succeeds in making negative photographs of camera images on paper coated with silver chloride, but cannot adequately "fix" them to stop them from darkening all over when exposed to light for viewing.

Russian biologist Heinz Christian Pander studies the chick embryo and discovers the germ layers (i.e., three distinct regions of the embryo that give rise to the specific organ systems). Because of these findings, he is considered by many to be the "founder of embryology".

Georges Cuvier's Le règne animal distribué d'après son organisation (The animal kingdom, distributed according to its organization) gives an account of the whole animal kingdom, dividing it into four distinct groups.

Thomas Young and Augustin Fresnel demonstrated that light waves must be transverse vibrations.

(no entry for this year)

A baby, who would later become Queen Victoria of England, is born carrying a new genetic mutation. Three generations later, that mutation may have changed the course of history.

Christian Friedrich Nasse formulated Nasse's law: hemophilia occurs only in males and is passed on by unaffected females.

Gideon Mantell discovers, in England, a fossil trunk of a tree resembling that of a tropical palm, evidence of a much warmer climate.

André-Marie Ampère formulates one of the basic laws of electromagnetism, the right-hand rule for the influence of an electric current on the magnet and demonstrates that two wires that are carrying an electric current will attract or repel each other, depending on whether the occurrence are in opposite where the same directions.

Dominique-François Arago discovers the magnetic effect of electricity passing through a copper wire, demonstrating that iron is not necessary for magnetism.

Augustin-Jean Fresnel invents the so-called Fresnel lens, a lens used in lighthouses.

The science of electrodynamics is born with the announcement of Hans Christian Ørsted's discovery of electromagnetism.

The Arithmometer was the first commercially successful mechanical calculator patented

Michael Faraday invents the electric motor and generator.

Etienne Geoffroy publishes Anatomical Philosophy discussing similarities between skeletal structures — such as bat wings, paws and hands — that support the evolutionary claims of Lamarck. He also argues that arthropods and vertebrates have similar but inverse body plans, an assertion that will ultimately be widely accepted.

Between 1822-1824, Thomas Andrew Knight, John Goss, and Alexander Seton all independently perform crosses with the pea and observe dominance in the immediate progeny, and segregation of various hereditary characters in the next generation. However, they do not study later generations or determine the numerical ratios in which the characters are transmitted.

William Buckland publishes an account of how ancient hyenas lived and fed in Kirkdale Cave, based on their fossil remains. This is one of the first descriptions of living habits based on fossil evidence.

Omalius d'Halloy names the Cretaceous System, after massive chalk deposits. This time period will later be identified with the last dinosaurs and the first flowering plants.

William Conybeare and William Phillips name the Carboniferous System, a period associated with coal deposits. This time period will also become known as the Mississippian and Pennsylvanian Periods in the United States.

Charles Babbage takes first steps in the construction of machines that would compute numbers

Nic phore Ni pce abandons silver halide photography as hopelessly impermanent and tries using thin coatings of Bitumen of Judea on metal and glass. He creates the first fixed, permanent photograph, a copy of an engraving of Pope Pius VII, by contact printing in direct sunlight without a camera or lens. It is later destroyed; the earliest surviving example of his "heliographic process" is from 1825.

Thomas Andrew Knight confirms reports of dominance, recessivity, and segregation in peas, but does not detect regularities.

William Buckland finds a skeleton covered in ocher. Called the Red Lady, it will later be identified as Cro-Magnon (and male).

Physicist Michael Faraday (1791-1867) describes the liquification of chlorine in On fluid chlorine. Faraday finds that gasses of certain kinds, when kept under constant pressure, will condense until they cool. This latter discovery ushers in the beginning of mechanical methods of refrigeration.

Small-scale drilling for oil begins at Baku, a Russian port city on the west coast of the Caspian Sea, now the capital of Azerbaijan. The drilling marks the beginning of the modern petroleum industry, and by 1900 nearly half the world's oil will come from the Baku oil fields.

William Buckland publishes Notice on the Megalosaurus ("giant lizard"), the first dinosaur fossil to be described and named, although the term "dinosaur" doesn't yet exist. Buckland also announces the discovery of the first fossil mammal from the Mesozoic.

Réflexions sur la puissance motrice du feu (On the motive power of fire) by Nicolas Léonard Sadi Carnot shows that work is done as heat passes from a high temperature to a low temperature; defines work; hints at the second law of thermodynamics; and suggests internal combustion engines.

Nic phore Ni pce makes the first durable, light-fast camera photograph, similar to his surviving 1826-1827 photograph on pewter but created on the surface of a lithographic stone. It is destroyed in the course of subsequent experiments.

Father John MacEnery starts digging in Kent's Cave in Devon. He'll eventually find human remains in the same layer as those of extinct mammals, a finding that will be dismissed by Buckland.

Gideon Mantell publishes Notice on the Iguanodon, the second description of a dinosaur and the first description of an herbivorous fossil reptile.

The Erie Canal (from Albany to Buffalo, New York) opens on October 26, connecting the Midwestern U.S. with the Atlantic Ocean, via the Great Lakes, and stimulating the development of Fort Dearborn (know today as Chicago), Cleveland and Columbus Ohio, and upstate New York cities like Rochester, Syracuse and Little Falls.

The first passenger steam railway opens, between Stockton and Darlington, England.

Photograph by Joseph Ni pce: View from the Window at Le Gras, the world's first permanent photograph.

The first photographic images produced by Joseph-Nicéphore Ni pce

Karl Ernst von Baer first demonstrated the mammalian ovum; he regarded the sperm cells as "Entozoa," i.e., parasites, and named them spermatozoa.

Theory of systems of rays by William Rowan Hamilton is a unification of the study of optics through the principle of "varying action". It contains his correct prediction of conical refraction. When his prediction is verified, he becomes a well-known and is knighted.

While studying the behavior of fluids under a microscope, botanist Robert Brown (1773-1858) discovers what is today called "Brownian motion".

A year after discovering the mammalian egg cell, Karl Ernst von Baer publishes Entwickelungsgeschichte der Thiere tracing the developmental history of animals.

Publication of Karl Ernst von Baer's The Embryology of Animals which strongly opposed preformationism.

Adolphe Brongniart publishes Prodrome d'une histoire des Végétaux Fossils, a study of fossil plants. He outlines four distinct phases in plant prehistory: (1) primitive plants from the Coal Measures, (2) the first conifers, (3) domination by cycads and conifers, and (4) flowering plants.

Mary Anning discovers Britain's first recognized pterosaur fossil. (Gideon Mantell has already found pterosaur remains, but has attributed them to a bird).

Chemist Friedrich Wöhler (1800-1882) synthesizes the organic compound urea, a feat previously thought impossible because of the vital force thought to be a part of organic substances.

Philippe-Charles Schmerling discovers a Neanderthal fossil, the partial cranium of a small child. The fossil will not be accurately identified as Neanderthal, however, for a century, though Charles Lyell will illustrate it in Antiquity of Man in 1863.

Jules Desnoyers names the Quaternary System, a time in which humans have lived.

Gustave-Gaspard Coriolis coins the term KINETIC ENERGY in On the calculation of mechanical action.

Joseph Henry shows that passing an electric current through a wire wrapped into coils produces a greater magnetic field than is produced when that same current is passed through a straight wire, and that an insulated wire wrapped around an iron core can produce a powerful electromagnet.

The first steam locomotive to operate on a U.S. railroad begins service between Carbondale and Honesdale, Pennsylvania. The engine, "The Stourbridge Lion", has been imported from the Stephenson Engine Works in London.

Charles Lyell's multi-volume Principles of Geology appear (between 1830 amd 1833), advancing the theory of uniformitarianism, i.e., the view that geological formations are explainable in terms of forces and conditions observable at present.

Georg Goldfuss announces that he sees "hairs" on a pterosaur fossil. This outlandish assertion will be supported by later finds.

The first edition of Birds of America, by the painter and ornithologist John James Audubon (1785-1851), appears.

Charles Darwin joins the crew of the HMS Beagle as the ship's naturalist. The Beagle plans a two-year voyage to map the coast of South America. This turns out to be a five-year trip.

Patrick Matthew publishes On Naval Timber and Arboriculture with an appendix describing what Charles Darwin will later name natural selection. After becoming aware of Matthew's hypothesis, Darwin will acknowledge it in a reprint of On the Origin of Species.

Robert Brown published his observations reporting the discovery and widespread occurrence of nuclei in cells.

Independently, Michael Faraday and Joseph Henry discover that electricity can be induced by changes in a magnetic field (electromagnetic induction), a discovery leading to the first electric generators.

Encouraged by Cambridge professor William Whewell, the Royal Society of London commissions reports of manuscripts received. This move will later be cited as the beginning of the peer-review process.

Gideon Mantell finds the first fossil Hylaeosaurus, an ankylosaur. He will formally name it the following year, making it the third identified dinosaur species.

In November, the New York and Harlem Railroad begins service, and heralds the start of rapid mass transit in New York City. Two horse-drawn rail cars operate every 15 minutes between 14th Street and Prince Street, along the Bowery. The fare is 25 cents.

Solicitor André Brouillet discovers a reindeer bone with an engraved illustration of two female deer in Chaffaud Cave. He assumes the carving was made by the Celts. Later research will show the artwork to be about 13,000 years old.

The first volume of the five-volume Recherches sur les poissons fossiles (Researches on Fossil Fishes) by Jean-Louis-Rodolphe Agassiz is published.

The English term SCIENTIST is coined by the philosopher William Whewell (1794-1866 ), during a meeting of the British Association for the Advancement of Science.

In correspondence, Michael Faraday and William Whewell introduce the terms ELECTRODE, ANODE, ION, CATHODE, ANION, CATION, ELECTROLYTE, and ELECTROLYSIS.

Ada Lovelace Meets Charles Babbage

Based on a vertebrae and other fragments from Alabama, anatomist Richard Harlan identifies Basilosaurus as a fossil reptile. It will later be identified as a fossil whale.

Friedrich von Alberti names the Triassic System. This time period will later by identified with the first dinosaurs.

Mathematician Carl Friedrich Gauss (1777-1855) shows that the origin of the Earth's magnetic field must lie deep inside the Earth. He makes use of the measurements of the magnetic field made by the physicist Paul Erman in 1828.

H rcules Florence, a French-Brazilian painter and the isolate inventor of photography in Brazil, coined the word photographie for his technique, at least four years before John Herschel coined the English word photography.

Charles Babbage invents the "analytical engine" — the forerunner of the modern computer.

While serving as scientific officer on the HMS Beagle, Charles Darwin visits the Galapagos Islands. He observes that the many varieties of finches on the islands seem to have developed from a common ancestor found on the mainland of South America.

Adam Sedgwick names the Cambrian System, recognizing the first rich assemblage of fossils in the rock record. Roderick Murchison names the Silurian System. He believes (not entirely accurately) that the Silurian predates the fossils of land plants, and consequently any economically valuable coal seams. Murchison and Sedgwick will later develop a bitter priority dispute over these systems.

Gustave-Gaspard Coriolis's Mémoire sur les equations du mouvement relatif des sytèms de corps (Memoir on the equations of relative movement of systems of bodies) describes the Coriolis effect: the deflection of a moving body caused by Earth's rotation. The Coriolis effect is important in the study of wind. However, the claim that the Coriolis effect determines the direction water rotates when going down a drain is a myth.

Henry Fox Talbot produces durable silver chloride camera negatives on paper and conceives the two-step negative-positive procedure used in most non-electronic photography up to the present.

Mappa Selenographica, a map of the moon's surface, is produced by the astronomers Wilhelm Beer (1797-1850) and Johann Heinrich von Mädler (1794-1874). The two will also be the first to map Mars.

Henry Riley and Samuel Stutchbury name Thecodontosaurus, the fourth named dinosaur species.

Elements of Botany, by the naturalist Asa Gray (1810-1888), is published. It is the first botanical textbook.

German biologist Theodor Schwann discovers the enzyme pepsin — the first known animal enzyme. He reports the discovery in Über das Wesen der Verdauungsprozesses (On the essence of digestion).

John Frederic Danielle invents the Daniell cell, the first reliable source of electric current, based on the interactions of copper and zinc.

Alonzo D. Phillips, a shoemaker from Springfield, Massachusetts, patents the phosphorous match.

Charles Darwin formulates the theory of natural selection to explain evolution. Fearful of the reaction his theory will cause, he delays publishing.

Hermann von Meyer names Plateosaurus, the fifth named dinosaur species.

Louis Agassiz presents the theory of the Ice Age at a meeting of the Swiss Society of Natural Sciences. The shocked audience reacts with hostility.

Mathematician Semèon Denis Poisson (1781-1840) publishes Recherches sur la Probabilitè des Jugements. Poisson's book described what is now known as the Poisson Distribution, for the first time.

Charles Babbage published a paper describing a mechanical computer that is now known as the Analytical Engine

Samuel F. B. Morse sends his first message by electric telegraph — "What hath God wrought!" — on an experimental line between Washington DC and Baltimore, Maryland.

M. J. Schleiden and T. Schwann develop the cell theory. Schleiden notes nucleoli within nuclei.

Chemist Jöns Jakob Berzelius (1779-1848) shows that the presence of iron is what enables blood to absorb as much oxygen as it does.

The word PROTEIN first appears in the chemical literature in a paper by G. J. Mulder. The term, however, was invented by J. J. Berzelius.

The S.S. Sirius and the S. S. Great Western are the first ships powered entirely by steam to cross the Atlantic. Both ships are designed by engineer Isambard Kingdom Brunel (1806-1859).

Czech scientist Jan Evangelista Purkyně (also written Johannes Evangelist Purkinje) coins the word PROTOPLASM to describe the contents of a cell.

Roderick Murchison and Adam Sedgwick name the Devonian System.

The English scientist Michael Faraday concludes from his work on electromagnetism that, contrary to scientific opinion of the time, the divisions between the various kinds of electricity are illusory. He also establishes that magnetism can affect rays of light, and that there is an underlying relationship between the two phenomena.

Louis-Jacques-Mand Daguerre perfects and presents the daguerreotype process as the first publicly available photographic process (which for nearly twenty years was also the one most commonly used). To make the image, a daguerreotypist would polish a sheet of silver-plated copper to a mirror finish, treat it with fumes that made its surface light sensitive, expose it in a camera for as long as was judged to be necessary, which could be as little as a few seconds for brightly sunlit subjects or much longer with less intense lighting; make the resulting latent image on it visible by fuming it with mercury vapor; remove its sensitivity to light by liquid chemical treatment, rinse and dry it, then seal the easily marred result behind glass in a protective enclosure.

Henry Fox Talbot publicly introduces the paper-based process he worked out in 1835, calling it "photogenic drawing", but it requires much longer exposures than the daguerreotype and the results are not as clear and detailed.

John Herschel introduces hyposulfite of soda (now known as sodium thiosulfate but still nicknamed "hypo") as a highly effective fixer for all silver-based processes. He also makes the first glass negative.

Sarah Anne Bright creates a series of photograms, six of which are known to still exist. These are the earliest surviving photographic images created by a woman.

Although a bicycle consisting of a frame and wheels has existed for years, blacksmith Kirkpatrick MacMillan (1813-1878), introduces the first bicycle in its modern form, with brakes and pedals. The bike has iron tires and weighs nearly 60 pounds.

Inventor Erastus Brigham Bigelow (1814-1879) introduces the power loom in Massachusetts.

The first electric clock is built by physicist Carl August Steinheil (1801-1870).

Charles Darwin's Zoology of the Voyage of the Beagle appears.

Martin Barry expressed the belief that the spermatozoon enters the egg.

Alexandre-Edmond Becquerel shows that light can initiate chemical reactions that produce an electric current.

First American patent issued in photography to Alexander Wolcott for his camera.

The first postage stamp, called the "Penny Black" and bearing the image of Queen Victoria, is issued in England.

The oil-immersion microscope is invented by Giovanni Battista Amici (1786-1863), a former professor of mathematics who is now the director of the observatory at the Royal Museum in Florence, and an astronomer to the Grand Duke of Tuscany. The objective lens of this microscope is immersed in a drop of oil which sits on top of the object under study; this helps to minimize aberrations caused by the light source.

Roderick Murchison names the Permian System.

William Smith's nephew John Phillips formally proposes the geologic eras Paleozoic, Mesozoic and Cainozoic (Cenozoic).

Charles Thomas Jackson (1805-1880) discovers the anesthetic properties of ether.

William Henry Talbot patents the Calotype process, the first negative-positive process making possible the first multiple copies.

Henry Fox Talbot introduces his patented calotype (or "talbotype") paper negative process, an improved version of his earlier process that greatly reduces the required exposure time.

In Paris, street lights made from arc lamps are demonstrated.

Charles Darwin's book The Structure and Distribution of Coral Reefs being the first part of the geology of the voyage of the Beagle, is published. During the year Darwin composes an abstract of his theory of species evolution.

Carl Wilhelm von Nägeli (1817-1891) publishes Zur Entwicklungsgeschichte des Pollens. His paper describes cell division in plants with remarkable accuracy, and discusses seed formation in flowering plants.

Richard Owen names Cetiosaurus, the sixth named dinosaur species.

Die Thierchemie, by chemist Baron Justus von Liebig (1803-1873), is published, and the science of biochemistry begins.

The term DINOSAUR is coined by Richard Owen (1804-1892) to describe a class of animals that we now believe were dominant on the Earth for approximately 175 million years.

Based on Agassiz's Ice Age theory, self-taught science enthusiast Charles MacLaren publishes a newspaper article explaining that substantial ice sheets in the northern hemisphere would have lowered global sea level.

German physician and physicist Julius Robert Mayer is the first to state the law of conservation of energy, noting specifically that heat and mechanical energy are two aspects of the same thing.

On the uniform motion of heat in homogeneous solid bodies, by William Thomson, aka Lord Kelvin (1824-1907), is published. Thomson's concern with the physics of cooling bodies will draw him into debates concerning the age of the Earth. In 1846 he calculates that the Earth can be no more than 100 million years old.

The change in the observed frequency of waves emitted from a source, moving relative to the observer, is described by Christian Johann Doppler (1803-1853). This phenomenon is now known as the Doppler Effect.

Louis Agassiz completes Les Poissons Fossiles describing fossil fish of the world. This single monograph increases tenfold the formally described vertebrates known to science.

That the nervous system uses electricity in communicating between different parts of the body is demonstrated by Emil Heinrich du Bois-Reymond (1818-1896). He founds the field of electrophysiology.

John Stuart Mill publishes Logic.

James Prescott Joule determines the mechanical equivalent of heat by measuring the rise in temperature produced in water by stirring it.

Jerome Increase Case, a 24 year-old farmer from Oswego County, New York, introduces the J. I. Case Threshing Machine. The J. I. Case Company will manufacture farm equipment and will become the largest thresher producer in the world.

The first tunnel under the Thames opens on March 25, built by Isambard Kingdom Brunel (1806-1859). {a]The Thames Tunnel{/a} connects Rotherhithe and Wapping, London. Although it was a triumph of civil engineering, the Thames Tunnel was not a financial success. It had cost a fortune to build — £454,000 to dig and another £180,000 to fit out — far exceeding its initial cost estimates. Proposals to extend the entrance to accommodate wheeled vehicles failed owing to cost, and it was only used by pedestrians. It became a major tourist attraction, attracting about two million people a year, each paying a penny to pass through.

Charles Darwin first outlines his thoughts on natural selection in an unpublished essay.

Robert Chambers, a Scottish journalist, publishes (anonymously) his Vestiges of the Natural History of Creation, an early book outlining an evolutionary view of the natural world.

The second part of the Geology of the Beagle, Charles Darwin's Geological Observations on Volcanic Islands Visited During the Voyage of H.M.S. Beagle, is published. Darwin's book claims to supply evidence for the geological theories of Charles Lyell (1797-1875), from areas that Lyell himself had never seen.

That all the cells in an organism are generated from successive divisions of the egg cell is described by Rudolf Albert von Kölliker (1817-1905). Kölliker shows that the egg is itself a cell.

In Hartford, Connecticut, dentist Horace Wells (1815-1848) uses nitrous oxide as an anesthetic; he is the first to do so.

The School of Medicine in Paris creates a gallery of comparative anatomy.

Michael Faraday relates magnetism to light after finding the magnetic field effects the polarization of light in crystals. He proposes that light may be waves of electromagnetism. He also describes the phenomena of diamagnetism and paramagnetism, which he explains in terms of his concept of a magnetic field.

Francis Ronalds invents the first successful camera for continuous recording (the first "movie camera") of the variations in meteorological and geomagnetic parameters over time. A copy of Ronalds' paper describing describing his device maybe obtained HERE.

The bridge spanning the Allegheny River, at Pittsburgh, designed by engineer John Augustus Roebling (1806-1869), opens in May. It is the first wire cable suspension aqueduct bridge in the world.

Karl Wilhelm Von Nägeli shows that plant cells are not formed as buds from the surfaces of existing cells, as was proposed by Theodore Schwann.

Joseph Leidy identifies in pork the parasite that causes trichinosis, a potentially fatal human disease.

James Prescott Joule discovers that the length of an iron bar changes slightly when the bar is magnetized.

Nitroglycerine is discovered by chemist Ascanio Sobrero (1811-1870), although he uses to term "pyroglycerine". Because of the risks involved in its production, it will not be manufactured commercially for more than a decade.

The lock-stitch sewing machine is patented by Elias Howe (1819-1867).

Jakob Mathias Schleiden and Theodor Schwann announce that cells are the basic units of all living structures.

In his Account of a New Anesthetic Agent, obstetrician Sir James Simpson (1811-1870) argues that chloroform, a substance he discovered, is a better anesthetic than nitrous oxide or ether. Simpson has begun to use chloroform as an anesthetic in childbirth.

Über die Erhaltung der Kraft ("On the Conservation of Force"), by Hermann Ludwig von Helmholtz (1821-1894), is published. It articulates what later becomes known as the Conservation of Energy.

The rotary, or "lightning" printing press is patented by Richard March Hoe (1812-1886). It is used first by the Philadelphia Public Ledger.

On the archetype and homologies of the vertebrate skeleton, by Richard Owen (1804-1892), is published. In the book Owen argues that the skull, and other parts of the body, are formed by the modification of the vertebra of different animals.

Richard Owen describes "homologies" — similarities of design in bird wings, fish fins and human hands.

A Neanderthal skull is excavated from Forbes Quarry on the northern side of the Rock of Gibraltar. Over the next few decades, the skull will be stashed in a library cabinet in Gibraltar, dusted off and sent to London, accurately likened to the ancient skullcap from Neander Valley in Germany, nearly named Homo calpicus, and finally stored and largely forgotten in the Royal College of Surgeons.

The American Medical Association is founded in Philadelphia, with a mission "to promote the science and art of medicine and the betterment of public health."

An absolute scale of temperatures is proposed by William Thomson (1824-1907). Thomson will become Baron Kelvin of Largs, in 1892, and the scale will come to bear his name.

Armand Hippolyte Louis Fizeau suggests that light from a source of moving away from the observer will be shifted toward the red end of the spectrum, a phenomenon known as redshift. This is closely related to, but not exactly the same as, the Doppler effect.

Edmond Becquerel makes the first full-color photographs, but they are only laboratory curiosities: an exposure lasting hours or days is required and the colors are so light-sensitive that they sometimes fade right before the viewer's eyes while being examined.

The American Association for the Advancement of Science is founded. Joseph Henry (1797-1898), who had been appointed the first secretary of the Smithsonian in 1846, is the first secretary of the AAAS, which is modeled after The British Association for the Advancement of Science. The British Association has been in existence for 17 years.

The American Association for the Advancement of Science is established.

Botanist Carl Friedrich von Gärtner (1772-1850) publishes Versuche und Beobachtungen über die Bastarderzeugung im Pflanzenreiche. The book describes thousands of experiments, many involving the production of hybrids, on more than 500 species of plants. Mendel will study this book in detail when he attends the University of Vienna in the early 1850s, and will cite the book in the opening of his paper of 1865.

Based on a humerus 58 inches in circumference, Mantell names a new dinosaur species: Pelorosaurus, the first recognized sauropod.

Armand Hippolyte Louis Fizeau measures the velocity of light in error by measuring the time it takes for a beam of light to pass between the teeth of a rotating gear. The light is reflected by a mirror and stopped by the next tooth of the gear. The result, 315,000 km/se4c (196,000 miles/sec), is within 5% of today's accepted value.

In describing Sadi Carnot's theory of heat, published in 1824, William Thomson (1824-1907) uses the term THERMODYNAMICS.

The speed of light is measured by physicist Armand Hippolyte Louis Fizeau (1819-1896) to be approximately 186,000 miles per second.

A unmanned Montgolfier balloon is used to drop bombs on Venice. This is the first time a bombing has been conducted from the air.

German physicist Gustav Theodor Fechner discovers that an increase in the intensity of a stimulus does not produce a one-to-one increase in the intensity of sensation. Instead, the sensation seems to increase as the logarithm of the excitation.

Mathematician Bernard Bolzano's Paradoxien des Unendlichen is published, two years after the Bolzano's death. It is the first work to use the word "set" in a modern mathematical sense, and also treats infinite sets.

In Über die bewegende Kraft der Wärme, mathematical physicist Rudolf Julius Emanuel Clausius articulates what comes to be known as the Second Law of Thermodynamics. The law states that heat can only be transferred from a warmer body to a colder body. In 1865, he'll restate the Law, saying that in the closed system entropy always increases.

"Bibless overalls" made of canvas are sold by the 20 year-old Levi Strauss in San Francisco. Within three years he will switch to denim and dye his pants indigo blue.

Mathematician Joseph Liouville demonstrates the existence of transcendental numbers (transcendentals are numbers that are not the solution to any algebraic equation).

Léon Foucault demonstrates that the Earth rotates using a pendulum, suspended from the ceiling of a church.

Physicist William Thomson proposes a concept of "absolute zero", at which the energy of molecules is zero. He draws on Charles' Law to show that such a condition would hold at -273 degrees Celsius.

Arithmometer: first commercially successful mechanical calculator launched

The fast-acting Collodion process invented by Frederick Scott Archer. Images require only two or three seconds of light exposure. Collodion process, mostly synonymous with the "collodion wet plate process", requires the photographic material to be coated, sensitized, exposed and developed within the span of about fifteen minutes, necessitating a portable darkroom for use in the field. Collodion is normally used in its wet form, but can also be used in humid ("preserved") or dry form, at the cost of greatly increased exposure time. The latter made the dry form unsuitable for the usual portraiture work of most professional photographers of the 19th century. The use of the dry form was therefore mostly confined to landscape photography and other special applications where minutes-long exposure times were tolerable.

Isaac Singer patents the continuous-stitch sewing machine.

The Erie Railroad, now controlled by Daniel Drew, becomes the first rail line connecting the Great Lakes with New York City, and begins to compete with the Erie Canal as a transportation route.

Albrecht von Kölliker publishes the first textbook of histology, Handbuch der Gewebelehre.

Hermann Ludwig von Helmholtz becomes the first to discover how fast a message travels along a nerve, measuring the speed of transmission in a frog nerve cell.

James Prescott Joule and William Thompson, later Lord Kelvin, establish that an expanding gas becomes cooler. This is now known as the Joule-Thompson effect.

In South Bend, Indiana, Clement and Henry Studebaker found Studebaker Brothers. Joined by a third brother, John, in 1858, the company will become the world's largest maker of wagons and carriages.

In Sweden, safety matches are patented by J. E. Lundstrom.

The brown paper bag is invented.

The elevator is invented, facilitating the future development of skyscrapers.

The U.S. state of Pennsylvania adopts a non-standard railroad gauge in order to prevent New York's Erie Railroad from establishing a route, through Pennsylvania, to Ohio.

Rudolph Albert von Kölliker discovers the cellular origin of spermatozoa, which were believed by some to originate from a fermentation process.

In Britain, vaccination against small pox is made compulsory.

Léon Foucault demonstrates that the velocity of light is lesson water than in air, tending to confirm the wave theory of light.

William John Macquorn Rankine introduces the concept of potential energy, or energy of position.

Potato chips are invented.

Mathematician George Boole, whose "Calculus of Logic," appeared in 1848, publishes An Investigation of the Laws of Thought, on Which are Founded the Mathematical Theories of Logic and Probabilities, which articulates a system of "symbolic logic".

Andr -Adolphe-Eug ne Disd ri credited with introduction of the carte de visite (English: visiting card or calling card) format for portraiture. Disd ri uses a camera with multiple lenses that can photograph eight different poses on one large negative. After printing on albumen paper, the images are cut apart and glued to calling-card-size mounts. Photographs had previously served as calling cards, but Disd ri's invention of the paper carte de visite (i.e. "visiting card") enabled the mass production of photographs. On 27 November 1854 he patented the system of printing ten photographs on a single sheet (although there is no evidence that a system printing more than eight actually materialized). Disd ri's's cartes de visite were 6 9 cm, about the size of conventional (nonphotographic) visiting cards of the time, and were made by a camera with four lenses and a sliding plate holder; a design inspired by the stereoscopic cameras. The novelty quickly spread throughout the world. According to a German visitor, Disd ri's studio became "really the Temple of Photography - a place unique in its luxury and elegance. Daily he sells three to four thousand francs worth of portraits". The fact that these photos could be reproduced inexpensively and in great quantity brought about the decline of the daguerreotype and ushered in a carte de visite craze as they became enormously popular throughout Europe and the United States. Disd ri also invented the twin-lens reflex camera.

Alfred Russel Wallace publishes "On the Law which has Regulated the Introduction of New Species," anticipating Darwin's theory of evolution by natural selection.

Rudolf Virchow states the principle that new cells come into being only by division of previously existing cells: Omnis cellula e cellula.

Recherches sur la putréfaction, by Louis Pasteur, is published. The book describes how fermentation is caused by microorganisms.

A mercury pump is developed by inventor Heinrich Geissler, to produce vacuum tubes. The first cathode rays will be observed in these tubes, after they are modified and improved by Sir William Crookes.

Engineer Frederick Taylor carries out "time-motion" studies of workers with the idea of making their labor more efficient. He will pioneer the "scientific management" of the workplace.

The remains of the first known example of what come to be known as the "Neanderthals" is found in a cave near Düsseldorf, in the Neander Valley. The discovery was made by limestone quarry miners and consists of a skullcap, two femora, the three right arm bones, two of the left arm bones, ilium, and fragments of a scapula and ribs. The fossils were given to Johann Carl Fuhlrott, a local teacher and amateur naturalist. The first description of the remains was made by anatomist Hermann Schaaffhausen and the find was announced jointly in 1857.In 1997, the specimen was the first to yield Neanderthal mitochondrial DNA fragments. The description of this discovery represents the beginning of paleoanthropology as a scientific discipline.

Louis Agassiz publishes Essay on Classification advocating a theory of multiple creations and contradicting both evolution and Noah's ark.

Gregor Mendel, a monk at the Augustinian monastery of St. Thomas in Brünn, Austria (now Brno, Czechoslovakia), begins breeding experiments with the garden pea, Pisum sativum.

Heinz Christian Pander describes conodonts — toothy microfossils that will puzzle paleontologists for many years.

A railway bridge spanning the Mississippi opens between Rockville, Illinois, and Davenport, Iowa. Abraham Lincoln, a lawyer, will defend the legality of the bridge before the Supreme Court, in response to a "right of way" suit brought by a steamship company.

During Easter vacation from London's Royal College of Chemistry, 18-year-old William Henry Perkin synthesized mauve, or aniline purple — the first synthetic dyestuff — from chemicals derived from coal tar. Mauve was enthusiastically adopted by the fashion industry in England and synthetic dyes quickly destroyed the market for natural substances derived from plants like indigo and madder. Perkin's creation was an accident — he was trying to synthesize quinine.

The "Bessemer process" for making inexpensive steel, which involves using blasts of cold air to decarbonize melted pig iron, is developed by inventor Henry Bessemer.

The 458-mile Wabash and Erie Canal opens after 24 years, and is the largest canal ever dug in the U.S. By 1860, however, sections will begin to be close, and, unable to compete for railroads, the entire Canal will be closed by 1874.

Über die Art der Bewegung, welche wir Wäe nennen (On the type of motion turned heat) by Rudolf Clausius is establishes his kinetic theory of heat of the mathematical basis. It also explains how evaporation occurs.

In Burrville, Connecticut, commercial production of Gail Borden's patented "condensed milk" begins. The product is made from skim milk, without any fat and without a number of nutrients found in cow's milk.

In California, Tokay, Zinfandel, and Shiraz grapes (all from Hungary) are first planted, and Italian honeybees are introduced. This is the beginning of the U.S. wine and honey industries. In North America, honey bees are an artificially introduced and invasive species.

Robert Wilhelm von Bunsen (along with Henry Roscoe) publish a design for a laboratory burner in Poggendorff's Annalen der Physik und Chemie, 100:84-85.

Rudolf Virchow finalizes the cell theory originally announced by Schleiden and Schwann 11 years earlier by declaring that cells are the basic units of all living things, and all cells are formed by the division of existing cells.

Alfred Russel Wallace sends to Darwin a manuscript — "On the Tendency of Varieties to Depart Indefinitely from the Original Type" — that shows clearly that Wallace has independently formulated a model of evolution by natural selection.

Darwin's and Wallace's ideas are jointly presented to the Linnaean Society of London.

The first relatively complete dinosaur skeleton, of Hadrosaurus foulkii, is found in New Jersey.

Physician Henry Gray publishes Anatomy of the Human Body, Descriptive and Surgical. Gray's Anatomy will be a standard textbook of anatomy for more than a century.

The concept of "bonds" is introduced by chemist Archibald Scott Couper, who believes that carbon atoms are the fundamental building blocks of organic compounds.

Julius Plücker shows that cathode rays bend under the influence of a magnet, suggesting they are connected in some way with charge. This is an early step along the path that will lead in 1897 to the discovery that cathode rays are composed of electrons.

J. Schweppe & Co. Ltd. patents a quinine tonic water that they will begin selling in 1880.

John Landis Mason patents a reusable glass jar.

Charles Darwin publishes On the Origin of Species.

An exceptionally well-preserved skeleton is discovered in Bavaria. Two years later, this bird-like, bipedal dinosaur will be named Compsognathus, meaning "dainty jaw."

Catholic priest Jean-Jacques Pouech describes fossil eggshell fragments. They will eventually prove to be the first described dinosaur eggs.

Matrix algebra begins, as mathematician Arthur Cayley discusses the matrix in the context of a theory of invariant transformations.

Gustav Kirchoff recognizes that sodium is found on the sun and discovers his black-body radiation law.

Physicist Gustav Robert Kirchhoff and chemist R. W. Bunsen explain that when light passes through a gas, or heated material, only certain wavelengths of the light are absorbed. Therefore, an analysis of the spectrum of the light can reveal the chemical makeup of the gas or material.

In Titusville, Pennsylvania, commercial production of petroleum begins, with drilling of the first well by Edwin Laurentine Drake. The well will produce approximately 400 gallons/day.

The first internal combustion engine is developed by Jean-Joseph-Etienne Lenoir. The engine uses coal gas.

Louis Agassiz attacks Darwin's the origin of species, rejecting the idea of evolution of the species and arguing that each species was created separately.

Thomas Henry Huxley (sometimes known as Darwin's bulldog) clashes with Bishop "Soapy Sam" Wilberforce about evolution at the annual meeting of The British Association for the Advancement of Science, in what has come to be known as the Huxley-Wilberforce debate.

Bishop Wilberforce is supposed to have asked Huxley sarcastically whether "it was through his grandfather or his grandmother that he claimed descent from a monkey." Huxley responded, "If then the question is put to me whether I would rather have a miserable ape for a grandfather or a man highly endowed by nature and possessed of great means of influence and yet employs these faculties and that influence for the mere purpose of introducing ridicule into a grave scientific discussion, I unhesitatingly affirm my preference for the ape." Or words to that effect.

John Phillips diagrams the progressive but fluctuating diversity of life on Earth based on the fossil record. His work evidences massive extinctions at the end of the Paleozoic and Mesozoic, and increased diversity in each subsequent age.

Louis Pasteur becomes significantly involved in biological research with the publication of "Mémoir sur la fermentation alcoolique" in which he showed that alcoholic fermentation seemed to be carried out by yeast, which were themselves living organisms.

Herman Hollerith was born 29th February 1860

Emil Erlenmeyer invents the flask.

Between 1861 and 1862, Max Johann Sigismund Schultze (Germany) and Heinrich Anton de Bary (Germany) establish the essential unity of protoplasm in all living cells.

First recognized fossil Archaeopteryx lithographica skeleton is found in the stone quarries of Solnhofen.

In "Mémoires sur les corpuscles organisés qui existent dans l'atmosphère," Pasteur applies heat to bent-neck flasks to show unequivocally that the "organized bodies" (microbes) which drive fermentation originate from "organized bodies" that exist in the atmosphere. In this elegant series of experiments, Pasteur laid to rest the long-held belief in spontaneous generation."

In his presidential address to the Geological Society of London, Leonard Horner proposes removing the world's "creation" date of 4004 BC from the English Bible, citing geological evidence of a much older planet.

Oliver Wendell Holmes invents stereoscope viewer

James Clerk Maxwell presents a projected additive color image of a multicolored ribbon, the first demonstration of color photography by the three-color method he suggested in 1855. It uses three separate black-and-white photographs taken and projected through red, green and blue color filters. The projected image is temporary but the set of three "color separations" is the first durable color photograph.

Lord Kelvin asserts that the Earth and sun are cooling from their initial formation, between 20 and 400 million years ago. He will later adopt the smaller number.

Anti-evolutionist James Hunt, founder of the Anthropological Society of London, gives a presidential address to the society stating that human races were created separately. He further argues that the African species is closer in ability to apes than to Europeans.

Alfred Russel Wallace describes the "Wallace line," the dividing line between Indo-Malayan and Austro-Malayan fauna, in Proceedings of the Royal Geographical Society of London.

Dominique Alexandre Godron and Charles Victor Naudin (France) independently report experiments in plant hybridization. Naudin confirmed Sageret's work, in general discussed work of the early hybridizers, and reported dominance and segregation in Datura (jimsonweed) hybrids. He did not deal with single characters and reported no statistical observations on the second generation. His theoretical explanation of his facts was a forerunner of Mendel's ideas, but inferred rather than deduced.

T. H. Huxley publishes Man's Place in Nature discussing human and primate paleontology, and showing similarities between humans and other animals.

Father-and-son glassworkers Leopold and Rudolf Blaschka begin making glass models of marine invertebrates. Marine biologists will refer to their exquisitely detailed, accurate models 150 years later while trying to see how many of the depicted species can still be found in the wild.

Abraham Lincoln forms the National Academy of Sciences.

Ernst Haeckel (Häckel) outlines the essential elements of modern zoological classification.

James Clerk Maxwell's A dynamical theory of the electromagnetic field is the first of his publications to use Michael Faraday's concept of a field as the basis of the mathematical treatment of electricity and magnetism. It introduces Maxwell's equations to describe electromagnetism.

John Lubbock publishes Prehistoric Times dividing what has previously been understood to be the Stone Age into two parts: the older Paleolithic and the newer Neolithic. In the same book, he also argues that modern Tasmanians and Fuegians are throwbacks to archaic humans.

Franz Schweigger-Seidel and A. von la Valette St. George (Germany) independently prove that a spermatozoon is a single cell and contains nucleus and cytoplasm

Gregor Mendel presents his work on inheritance in peas to the Brünn Natural History Society. The results are published the following year.

Sir John William Dawson of McGill University identifies "shells" of huge foraminiferal protozoans. Known as Eozoön or "dawn animal," this find is used as an argument against evolution because it shows a relatively "modern" animal early in the fossil record. It will prove, however, to be a geologically young pseudofossil formed by heat and pressure on limestone.

Paolo Mantegazza publishes Degli Innesti Animali e della Produzione Artificiale delle Cellule (On Animal Grafts and Artificial Cell Production) describing the results of a series of interspecies animal grafts, such as the transplant of a cockspur onto a cow ear. Grafts described include transplants between dogs, frogs and rodents. Mantegazza reports that some grafts decomposed while others became "pathological tumours."

Rudolf Clausius invents the term ENTROPY to describe the degradation of energy in the closed system.

German zoologist Ernst Haeckel publishes General Morphology of Organisms, the first detailed genealogical tree relating all known organisms, incorporating the principles of Darwinian evolution.

Ernst Heinrich Haeckel (Häckel) hypothesizes that the nucleus of a cell transmits its hereditary information.

Mendel publishes his work on heredity, Versuche über Pflanzen Hybriden.

Ernst Heinrich Haeckel (Häckel) first used the term ECOLOGY to describe the study of living organisms and their interactions with other organisms and with their environment.

Orléans Railway Company employee Peccadeau de l'Isle presents a paper to the French Academy of Sciences on his recent discoveries at Montastruc, including a mammoth carved from a reindeer antler, and two reindeer (found in separate pieces) carved from a mammoth tusk. The finds will eventually be dated at about 13,000 years old.

H. S. Bidwell (United States) reports controlled pollination in maize.

Charles Darwin publishes The Variation of Animals and Plants under Domestication, in which he offers his own theory of heredity, which he called the "Provisional Hypothesis of Pangenesis."

Ernst Haeckel publishes Natürliche Schöpfungsgeschichte, subdividing humanity into 12 separate species. He also asserts that evolution consists of 22 phases, the 21st being the "missing link" between apes and humans.

Thomas Henry Huxley publishes "On the Animals which are Most Nearly Intermediate between Birds and Reptiles," arguing that birds are descendants of dinosaurs. This suggestion will not be taken very seriously for another century.

Three human skulls and other skeletal remains, roughly 30,000 years old, are discovered at a rock shelter called Cro-Magnon (old French for "big hole").

Louis Ducos du Hauron patents his numerous ideas for color photography based on the three-color principle, including procedures for making subtractive color prints on paper. They are published the following year. Their implementation is not technologically practical at that time, but they anticipate most of the color processes that are later introduced.

Wallace Clement Ware Sabine becomes the first acoustical engineer and uses acoustic principles to design Boston's Symphony Hall.

Francis Galton publishes Hereditary Genius. In it he describes a scientific study of human pedigrees from which he concludes that intelligence has a genetic basis.

Huxley, Norman Lockyer and others found Nature Magazine, which becomes one of the world's two most important scientific journals. (The other journal is Science.)

O. C. Marsh discovers the first North American pterosaur, from chalk deposits in Kansas. He calculates the wingspan at 20 feet. The following year, he will collect more fossils that confirm this calculation.

Quarry workers in the Valley Forge area discover the Port Kennedy Bone Cave, under roughly the same site where the Continental Army wintered over a century earlier. The site proves rich in Pleistocene plant and animal fossils, but will be accidentally flooded decades later. The site will be lost to science until its rediscovery after the turn of the 21st century.

The rivalry between fossil collectors O. C. Marsh and E. D. Cope turns ugly when Marsh publicly points out Cope's error in reconstructing a fossil marine reptile (putting its head on the tip of its tail). Their rivalry is the public's gain as they try to outdo each other in identifying new dinosaur species — over 130.

Publication of Charles Darwin's Descent of Man, in which the role of sexual selection in evolution is described for the first time.

Lord Kelvin suggests that "the germs of life might have been brought to the Earth by some meteorite," an idea that will enjoy support a century later.

Johann Friedrich Miescher isolates a substance which he calls NUCLEIN from the nuclei of white blood cells. The substance was soluble in alkalis but not in acids and came to be known as nucleic acid.

Lambert Adolphe Jacques Quetelet showed the importance of statistical analysis for biologists and laid the foundation of biometry.

George Johnstone Stoney notes that the wavelengths of three lines in the hydrogen spectrum are found to have simple ratios, and anticipation of Balmer's formula, an important step towards understanding the structure of the atom.

James Clerk Maxwell explains how his statistical theory of heat works by inventing MAXWELL'S DEMON, a mythical creature that can see and handle individual molecules. By opening a gate between two vessels containing a gas only one of fast molecules passing into one, the demon would make heat flow from cold to hot.

Richard Leach Maddox invents the gelatin dry plate silver bromide process. Negatives no longer had to be developed immediately. Long before his discovery of the dry gelatin photographic emulsion, Maddox was prominent in what was called photomicrography - photographing minute organisms under the microscope. The eminent photomicrographer of the day, Lionel S. Beale, included as a frontispiece images made by Maddox in his manual 'How to work with the Microscope'.

Ferdinand Julius Cohn coined the term BACTERIUM and founded the study of bacteriology.

Anton Schneider observed and described the behavior of nuclear filaments (chromosomes) during cell division in his study of the platyhelminth Mesostoma. His account was the first accurate description of the process of mitosis in animal cells.

Francis Galton publishes a paper entitled "Hereditary Improvement" arguing that people "of really good breed" should be encouraged to reproduce while their inferiors should be discouraged from doing so. This, he argues, will improve humanity the way selective breeding improves livestock.

James Clerk Maxwell's Electricity and Magnetism contains the basic laws of electromagnetism and predicts, in great detail, such phenomena as radio waves and pressure caused by light rays.

QWERTY keyboard invented

Hermann Wilhelm Vogel discovers dye sensitization, allowing the blue-sensitive but otherwise color-blind photographic emulsions then in use to be made sensitive to green, yellow and red light. Technical problems delay the first use of dye sensitization in a commercial product until the mid-1880s; fully panchromatic emulsions are not in common use until the mid-20th century.

The Hamburg Tierpark features an "anthropological-zoological" display of Lapps acting out "daily life" with reindeer. The show draws enthusiastic crowds.

The Mütter Museum buys 139 human skulls from Viennese anatomist Joseph Hyrtl. Hyrtl has compiled the collection to show the remarkable variation within European populations, and to debunk the claims of phrenologists. The collection is unusual for the time, when most skull assemblages are aimed at emphasizing differences between ethnic groups.

Irish physicist George J. Stoney estimates the charge of the then unknown electron to be about 10^-20 coulomb, close to the modern value of 1.6021892 x 10^-19. He also introduces the term ELECTRON.

The Cavendish laboratory at Cambridge is completed. Although widely believed to have been named after the 18th-century physicist Henry Cavendish, it is, in fact, named after the entire Cavendish family, because the 19th century steel-making descendent of Henry, William Cavendish, financed the laboratory. The structure of DNA was worked out at the Cavendish many years later by Watson and Crick.

Thomas J. Watson Sr. is born

The first electric tram operates in New York City.

Eduard Strasburger accurately described the processes of mitotic cell division in plants.

Francis Galton demonstrates the usefulness of twin studies for elucidating the relative influence of nature (heredity) and nurture (environment) upon behavioral traits.

Oscar Hertwig concludes from a study on sea urchins that fertilization in both animals and plants consists of the physical union of the two nuclei contributed by the male and female parents.

Paleontologist Roberto Lawley collects a badly eroded Pliocene whale bone near Pisa, Italy, and donates it to the paleontology museum of Florence. In the 21st century, close examination will indicate boreholes of Osedax, mouthless, gutless marine worms (nicknamed zombie worms) that extract nutrients by drilling into bones.

Charles Doolittle Walcott becomes the first to successfully find and describe elusive trilobite legs, ending speculation about how the animals moved.

Eugen Goldstein shows that the radiation in a vacuum tube produced when an electric current is forced through the tube starts at the cathode. Goldstein introduces the term CATHODE RAY to describe the light emitted.

Ferdinand Hurter and Vero Charles Driffield begin systematic evaluation of sensitivity characteristics of photographic emulsions the science of sensitometry. They also invent a photographic exposure estimation device known as an actinograph. In 1920, William Bates Ferguson edits a memorial volume: The Photographic Researches of Ferdinand Hurter & Vero C. Driffield: Being a Reprint of Their Published Papers, Together With a History of Their Early Work & a Bibliography of Later Work on the Same Subject.

Hermann Fol reports watching the spermatozoan of a starfish penetrate the egg. He was able to see the transfer of the intact nucleus of the sperm into the egg, where it became the male pronucleus.

A new Archaeopteryx fossil is discovered in Solnhofen, complete with a toothy jaw. This well-preserved fossil, which will become known as the Berlin Archaeopteryx, supports Huxley's previous observations about its reptilian affinities.

Comparative anatomy professor François Louis Paul Gervais undertakes thin-section microscopy studies of fossil eggs. His work will be largely forgotten until Roy Chapman Andrews discovers dinosaur eggs in Mongolia in the 1920s.

Germ Theory of Disease: Louis Pasteur presented his Germ Theory of disease. Joseph Lister went on to initiate the practice of insuring that surgeons were clean before they conducted surgery.

Phonograph Invented by Edison On December 15th, Thomas Edison applied for a patent for his phonograph. Edison initially believed it would be used to record business sessions, or family voices. Edison became famous with this invention and was invited to the White House for a demonstration.

Wilhelm Friedrich Kühne proposed the term ENZYME (meaning "in yeast") and distinguished enzymes from the micro-organisms that produce them.

Charlotte Hill collects a well-preserved fossil butterfly, later named Prodryas persephone, from the Florissant Formation in Colorado. The fossil is about 35 million years old.

Entire skeletons of Iguanodon are discovered in Belgium, enabling a more accurate reconstruction of this dinosaur than those of Owen and Waterhouse Hawkins in the 1850s. Engineer-turned-paleontologist Louis Dollo will publish the first of several papers on these fossils in 1882.

Willgodt T. Odhner granted a patent for a calculating machine

Eadweard Muybridge uses a row of cameras with trip-wires to make a high-speed photographic analysis of a galloping horse. Each picture is taken in less than the two-thousandth part of a second, and they are taken in sufficiently rapid sequence (about 25 per second) that they constitute a brief real-time "movie" that can be viewed by using a device such as a zoetrope, a photographic "first".

Heat ripening of gelatin emulsions is discovered. This greatly increases sensitivity and makes possible very short "snapshot" exposures.

The world's first oil tanker — the Zoroaster — is launched, in the Caspian Sea. The ship was designed by Ludvig Nobel, the brother of Alfred Nobel.

The first electric street lighting appears, in London.

From 1879 through 1882, Walther Flemming describes and names CHROMATIN, MITOSIS, and the SPIREME. He makes the first accurate counts of chromosome numbers and accurately drew the "longitudinal splitting" of chromosomes.

Eight-year-old Maria de Sautuola finds a Paleolithic cave drawing of bison on her father's property in Spain. It is the oldest artwork yet discovered, but it will be dismissed as a forgery for years, considered too beautiful to be the work of prehistoric savages.

Charles Lapworth resolves a priority dispute between Adam Sedgwick and Roderick Murchison by assigning older rocks to the Cambrian (named by Sedgwick), younger rocks to the Silurian (named by Murchison), and naming the Ordivician System in between.

The United States Geological Survey is formed.

Throughout the decade of 1880-1890, Walther Flemming, Eduard Strasburger, Edouard van Beneden, and others elucidate the essential facts of cell division and stressed the importance of the qualitative and quantitative equality of chromosome distribution to daughter cells.

Charles Darwin and his son Francis publish the results of their studies on plant responses to light, explaining that phototropism (bending toward the light) results from light reaching the top of a plant's shoot.

Pierre Curie discovers the piezoelectric effect: certain substances produce an electric current when they are physically distorted, and conversely they are physically distorted when an electric current is applied to them. This effect has many applications, including, in the 21st century, the construction of high-end tweeters in stereo systems.

James Albert Bonsack invents the first automated cigarette-rolling machine after seeing a tobacco company offer a prize for the first machine to roll and cut a cigarette. The Bonsack machine could roll up to 210 cigarettes per minute, compared to the average of four cigarettes per minute that could be rolled by hand. The Bonsack machine revolutionized the cigarette industry by making it possible to mass-produce inexpensive cigarettes.

Hermann Ludwig von Helmholtz shows that the electrical charges in atoms are divided into definite integral portions, suggesting the idea that there is a smallest unit of electricity.

Walther Flemming publishes accurate depictions of cell division (mitosis) in Zellsubstanz, Kern und Zelltheilung.

Eduard Strasburger coins the terms CYTOPLASM and NUCLEOPLASM.

W. Flemming discovers lampbrush chromosomes and coins the term MITOSIS.

Karl Alfred von Zittel describes an exceptionally well-preserved pterosaur wing showing flight membranes in detail.

Charles Darwin publishes his final letter to Nature, on the dispersal of freshwater bivalves. His obituary appears the same month. In this paper, Darwin acknowledges the assistance of W. D. Crick or Northampton. Later, Crick's grandson — Francis Crick — will be one of the co- discoverers of the structure of DNA.

John William Strutt, Lord Rayleigh, discovers that the ratio of the atomic mass of oxygen to that of hydrogen is not 16 exactly, as had been assumed, but 15.882.

The first hydro-electric plant opens, in Wisconsin.

August Weismann points out the distinction in animals between the somatic cell line and the germ cells, stressing that only changes in germ cells are transmitted to further generations.

Edouard van Beneden announced the principles of genetic continuity of chromosomes and reported the occurrence of chromosome reduction at germ cell formation. The sperm and egg are haploid and fertilization restores the diploid chromosome number.

Wilhelm Roux offers a possible explanation for the function of mitosis.

William Keith Brooks, a professor at The Johns Hopkins University, publishes The Law of Heredity: A Study of the Cause of Variation and the Origin of Living Organisms. Although this speculative work did not significantly advance the understanding of heredity, brooks' thinking is important because during his career he provided instruction to and supervised the early research of Thomas H. Morgan, Edmund Beecher Wilson, and William Bateson — ultimately some of the most important contributors to the new science of genetics.

Pierre Émile Duclaux introduces the custom of designating an enzyme by the by the name of the substrate on which its action was first reported and adding the suffix -ase.

Geologist James Hall names Cryptozoon, based on cabbagelike rocks up to meter across. Although Hall's biologic interpretation of these structures will be heavily criticized, it will ultimately prove correct.

Scheutz invents the first printing calculator

German engineer Gottlieb Daimler creates a portable engine that leads to the age of the automobile.

During 1884-88, identification of the cell nucleus as the basis for inheritance was independently reported by Oscar Hertwig, Eduard Strasburger, Albrecht von Kölliker, and August Weismann.

Gregor Mendel dies on January 6th, without ever knowing that his work on peas would lead to the transformation of biological research.

Walther Flemming, Eduard Strasburger and Edouard van Beneden demonstrate that chromosome doubling occurs by a process of longitudinal splitting. Strasburger describes and names the PROPHASE, METAPHASE, and ANAPHASEstages of chromosomal division.

George Eastman invents flexible, paper-based photographic film.

August Weismann formulates the germ-plasm theory which held that the germ plasm was separate from the somatoplasm and was continuous from generation to generation.

Carl Rabl theorized the individuality of chromosomes in all stages of the cell cycle.

Walther Flemming observed sister chromatids passing to opposite poles of the cell during mitosis.

Johann Jakob Balmer discovers the formula for the hydrogen spectrum that will later inspire Niels Bohr to develop his model of the atom.

James Dewar invents a thermos bottle in which heat is prevented from leaking via vacuum between two glass walls. The model becomes known as the Dewar Flask.

The world's first skyscraper, the Home Insurance Company Building, is erected in Chicago.

Francis Galton devised a new useful statistical tool, the correlation table.

Hugo de Vries (Holland) discovers aberrant evening primrose plants at Hilversum, Holland. Experiments with these extending over 15 years formed the basis for his mutation theory of evolution.

A. Ficatier publishes an account of the discovery of a trilobite perforated with two holes (perhaps to hang on a thread) at a Magdalenian- age site in France. The fossil lends the site its name of La Grotte du Trilobite.

John Bell Hatcher develops the "ant hill method of collecting minute fossils," collecting hundreds of tiny fossil teeth and jaws pushed to the surface by ants. He even carries shovelfuls of ants and sediment to other fossil localities in need of excavation by the arthropods.

William Crookes proposes that atomic weights measured by chemists are averages of the weights of different kinds of atoms of the same element (although it will not be until 1910 that Frederick Soddy identifies these different kinds of atoms as isotopes).

Worthington George Smith excavates a Bronze Age grave of a mother and child, surrounded by at least 200 fossil sea urchins, on Dunstable Downs. He nicknames the mother Maud.

August Weismann elaborated an all-encompassing theory of chromosome behavior during cell division and fertilization and predicted the occurrence of a reduction division (meiosis) in all sexual organisms.

Edouard van Beneden demonstrated chromosome reduction in gamete maturation, thereby confirming August Weismann's predictions.

Wilhelm Roux put forth the suggestion that the linearly arranged qualities of the chromosomes were equally transmitted to both daughter cells at meiosis.

Harry Govier Seeley determines that dinosaurs consist of "lizard- hipped" (saurischian) and "bird-hipped" (ornithischian) branches.

Albert Michelson and Edward Morley measure the velocity of light in two directions, attempting to detect the proper motion of Earth through the ether (a hypothesized fluid that was assumed to fill all space, providing a medium for the transport of electromagnetic waves). The Michelson Morley experiment reveals no evidence of motion.

Ernst Mach notes that airflow becomes disturbed at the speed of sound.

Dorr E. Felt was granted a patent for the Comptometer.

Introduction of the Comptometer by Felt & Tarrant Co

Celluloid film base introduced.

German anatomist W. von Waldeyer names chromosomes.

Heinrich Wilhelm Gottfried von Waldeyer names the CHROMOSOME.

Theodor Boveri verifies August Weismann's predictions of chromosome reduction by direct observation in Ascaris.

Heinrich Rudolf Hertz produces and detects radio waves for the first time. Radio waves will be called Hertzian waves until renamed by Marconi, who calls them radiotelegraphy waves.

Babbage's Analytical Engine Operates For The First Time

Burroughs Receives Patent for Calculating Machine

Introduction of its adder-lister by William Seward Burroughs

Eastman patents Kodak roll-film camera.

Louis Le Prince makes Roundhay Garden Scene. It is believed to be the first-ever motion picture on film.

John Boyd Dunlop, trained as a veterinary surgeon, devises the first practical pneumatic tire in response to a request from his son for a more comfortable tricycle. His first effort involved an inflated section of garden hose, fitted to the rear wheels of the tricycle. Although born in Scotland, Dunlop spent most of his life in Northern Ireland, where his image occurs on the current £10 note, issued by the Northern Bank.

Francis Galton publishes Natural Inheritance. In it he describes the quantitative measurement of metric traits in populations. He thus founds biometry and the statistical study of variation. Ultimately, he formulates the Law of Ancestral Inheritance, a statistical description of the relative contributions to heredity made by one's ancestors.

George Francis Fitzgerald formulates the principle that objects shrink slightly in the direction they are traveling, now known as the Fitzgerald-Lorenz contraction, since Hendrik Antoon Lorentz reaches the same conclusion a few years later.

Nintendo is founded as Nintendo Koppai on 23 September 1889 by craftsman Fusajiro Yamauchi in Shimogyo-ku, Kyoto, Japan, as an unincorporated establishment, to produce and distribute Japanese playing cards, or karuta (from Portuguese carta, 'card'), most notably hanafuda ('flower cards').

Herman Hollerith lodges patent for Punch Card technology

The first commercially available transparent celluloid roll film is introduced by the Eastman Company, later renamed the Eastman Kodak Company and commonly known as Kodak.

The numerical equality of paternal and maternal chromosomes at fertilization was established by Theodor Boveri and Jean-Louis-Léon Guignard.

Herman Hollerith designs tabulating machines for 1890 U.S. Census

Hypertext Pioneer Vannevar Bush Is Born

US Census Bureau announces results using Herman Hollerith's machine

Gabriel Lippmann announces a "method of reproducing colors photographically based on the phenomenon of interference".

William Kennedy Laurie Dickson develops the "kinetoscopic" motion picture camera while working for Thomas Edison.

Publication of August Weismann's book Das Keimplasma (The Germ Plasm) emphasized meiosis as an exact mechanism of chromosome distribution.

Joseph Whiteaves describes Anomalocaris, meaning "anomalous shrimp," from the Cambrian. The fossil that Whiteaves identifies as a shrimp will later prove to be part of a much larger animal.

Entomologist E.B. Poulton studies caterpillars from the species Gastropacha quercifolia, noting how siblings look different depending on where they live and what they eat. His discovery will become known as phenotypic plasticity.

Wilhelm Wien discovers that the maximum wavelength emitted by hot body varies inversely with its absolute temperature. Wien's law becomes useful in establishing the temperature of stars. The problems he has with deriving an equation to describe black-body radiation lead to Max Planck's introduction of the quantum in 1900.

Hans Driesch expounded the view that all nuclei of an organism were equipotential but varied in their activity in accordance with the differentiation of tissues.

Karl Pearson published the first in a long series of contributions to the mathematical theory of evolution. Methods for analyzing statistical frequency distributions were developed in detail.

William Bateson's Materials for the Study of Variation emphasized the importance of discontinuous variations, foreshadowing the rediscovery of Mendel's work.

Eugène Dubois publishes his monograph of Pithecanthropus erectus, or Java Man, a missing link between humans and apes.

French paleontologist Charles Brongniart describes a fossil dragonfly from the Carboniferous with a 2-foot (63-centimeter) wingspan. The find implies a higher oxygen content in the Earth's ancient atmosphere.

The intricately carved mammoth ivory figurine known as the Lady (or Venus) of Brassempouy is discovered in France. At roughly 25,000 years old, it ranks among the earliest known depictions of a human face.

Joseph John (J.J.) Thomson announces that he has found that the velocity of cathode rays is much lower than that of light.

A team of paleontologists, including Samuel Williston, Elmer Riggs and Barnum Brown, successfully excavates a Triceratops fossil in Wyoming.

Charles Thomson Rees Wilson develops the CLOUD CHAMBER, a box containing a gas that is saturated. When a charged particle passes through the gas, small droplets are formed that make the track of the particle visible. The cloud chamber becomes a powerful tool in particle physics.

Pierre Curie shows that as the temperature of the magnet is increased, there is a level at which the magnetism is disrupted and ceases to exist. This temperature is still called the Curie point.

Wilhelm Konrad Röntgen (Roentgen) discovers X-rays, which will soon be applied in the visualization of bodily structures and in the induction of genetic mutations (both intentionally and accidentally).

Auguste and Louis Lumi re invent the cin matographe.

Cornflakes are invented in Battle Creek, Michigan, by John Harvey Kellogg — the chief medical officer of the Battle Creek sanitarium.

E. B. Wilson publishes The Cell in Development and Heredity. This influential treatise (ultimately reprinted in several editions) distills the information compiled concerning cytology in the half-century since Schleiden and Schwann put forth the cell theory.

Dublin anatomist Daniel Cunningham concludes that Neanderthals represent an intermediate step between Pithecanthropus erectus and modern humans.

J. de Morgan describes nine pierced fossil urchins found in a Chalcolithic tomb at Toukh.

Less than three months after the discovery of x-rays, Dartmouth College Professor of Physics Edwin Frost and his brother, the then physician in chief of Mary Hitchcock Hospital, Gilman Frost, MD, take the first clinical X-ray in the US — an image of Eddie McCarthy's fractured left wrist.

Antoine-Henri Becquerel discovers rays produced by uranium — the first observation of natural radioactivity.

Gabriel Bertrand coined the term COENZYME to designate inorganic substances which were necessary to activate certain enzymes.

Renowned physicist Lord Kelvin gives a lecture at London's Victoria Institute claiming that the sun, which is cooling from its initial formation, can be no more than 20 million years old.

Joseph John Thomson discovers the electron, the first known particle that is smaller than an atom, in part because he has better vacuum pumps that were previously available. He, and independently, Emil Wiechert, determine the ratio of mass to charge of the particles by deflecting them by electric and magnetic fields.

Marie Curie begins research of "uranium rays" that will lead to the discovery of radioactivity.

America's first subway opens, in Boston.

Russian physicist Alexander Popov uses an antenna to transmit radio waves over a distance of 5 km.

Marie and Pierre Curie discovered that thorium, gives off "uranium rays", which Marie renames RADIOACTIVITY.

Kodak introduces the Folding Pocket Kodak.

British physicist Ernest Rutherford discovers the radioactivity from uranium has at least two different forms, which he calls alpha and beta rays.

Fritz Geisel, Antoine-Henri Becquerel, and Marie Curie proved the beta rays consist of high-speed electrons.

L. Cuénot (France) working with animals, and Strasburger (Germany) working with plants, advance theory that sex is controlled within the germ cell, not by environment.

Richard Altmann renames "nuclein" as NUCLEIC ACID.

The First International Congress of Genetics held in London.

William Bateson writes a paper on hybridisation and cross-breeding as a method of scientific investigation that anticipates Mendel's rediscovery.

H. de Vries, C. Correns, and E. Tschermak independently rediscover Mendel's paper. Using several plant species, de Vries and Correns had performed breeding experiments that paralleled Mendel's earlier studies and had independently arrived at similar interpretations of their results. Therefore, upon reading Mendel's publication they immediately recognized its significance. W. Bateson also stresses the importance of Mendel's contribution in an address to the Royal Society of London.

K. Landsteiner discovers the blood-agglutination phenomenon in man.

Karl Pearson develops the chi-square test.

Paul Karl Ludwig Drude shows that moving electrons conduct electricity in metals.

Paul Ulrich Villard is the first to observe a radiation that is more penetrating than X-rays, now called gamma rays.

Kodak introduces their first Brownie, a very inexpensive user-reloadable point-and-shoot box camera.

On December 14, Max Planck announces the first step toward quantum theory. He states that substances can emit light only at certain energies, which implies that some physical processes are not continuous, but occur only in specified amounts called quanta.

H. de Vries adopts the term MUTATION to describe sudden, spontaneous, drastic alterations in the hereditary material of Oenothera.

T. H. Montgomery studies spermatogenesis in various species of Hemiptera. He concludes that maternal chromosomes only pair with paternal chromosomes during meiosis.

Harry Govier Seeley publishes Dragons of the Air, the first popular book on pterosaurs, arguing that they were warm-blooded and should be classified parallel to birds, in between reptiles and mammals. This is in direct opposition to Richard Owen's classification of pterosaurs as cold-blooded and poor flyers.

Herman Hollerith patents Apperatus For Punching Record Cards

Kodak introduces the 120 film format.

The Metro subway opens in Paris.

Archibald Garrod, a British physician, reports that alkaptonuria (a human disease) seems to be inherited as a Mendelian recessive.

C. E. McClung argues that particular chromosomes determine the sex of the individual carrying them, not just in insects, but perhaps in other species (including man).

Walter Sutton concludes that (a) chromosomes have individuality, (b) that they occur in pairs, with one member of each pair contributed by each parent, and (c) that the paired chromosomes separate from each other during meiosis.

T. Boveri studies sea urchin embryos and finds that in order to develop normally, the organism must have a full set of chromosomes, and from this he concludes that the individual chromosomes must carry different essential hereditary determinants.

William Bateson coins terms that will become essential to describing findings in the new science of heredity: GENETICS, F₁, F₂, ALLELOMORPH (later shortened to ALLELE), HOMOZYGOTE, HETEROZYGOTE, and EPISTASIS.

Barnum Brown of the American Museum of Natural History discovers Tyrannosaurus rex.

Arthur Korn devises practical telephotography technology (reduction of photographic images to signals that can be transmitted by wire to other locations).Wire-Photos are in wide use in Europe by 1910, and transmitted to other continents by 1922.

Cheddar Man, a human male fossil, is discovered at Gough's Cave in Cheddar Gorge, England. Sometimes referred to as the earliest Englishman, Cheddar Man turns out to be only about 15,000 years old. it appears that he died a violent death. A large crater-like lesion just above the skull's right orbit suggests that the man may have also been suffering from a bone infection at the time. It is Britain s oldest complete human skeleton.

The concepts of PHENOTYPE, GENOTYPE, and SELECTION were introduced and clearly defined by Wilhelm Ludwig Johannsen.

L. de Vesly describes first- to third-century remains at Gallo Roman temples and wells near Rouen, France. Finds there include a cache of Neolithic axes and fossil sea urchins — evidence of association of axes and urchins over thousands of years.

Carl Neuberg first used the term BIOCHEMISTRY.

Physicist Ernest Rutherford lectures the British Association that radioactivity could power the sun and maintain its heat, meaning the sun and Earth could be much older than Lord Kelvin's estimate.

The first motor taxis appear in London

Entomologist George Willis Kirkaldy publishes species descriptions of a series of insects whose names all end in "-chisme" (pronounced "kiss me"), such as Ohchisme, Dolichisme, Elachisme, Florichisme, Isachisme, Marichisme, Nanichisme, Peggichisme, and Polychisme. Kirkaldy's proposed names preface -chisme with the names of various women from alleged romantic conquests. In 1912 a letter to the International Entomological Congress from Lord Walsingham sought to make these names invalid on the basis of their being non-classical in their derivation. Kirkaldy himself had been a firm adherent to the principle of priority and was against any form of orthographic emendation to the spelling proposed by the original authors.

The Rolls-Royce company is founded in Britain.

K. S. Merezhkovsky suggests that chloroplasts originated as a cyanobacterium swallowed by a protozoan, i.e., algal and plant cells result from two independent organisms that became symbionts. The idea will be largely forgotten until it is suggested again in the 1960s.

Lucien Claude Cuénot performs crosses between mice carrying a gene that gives them yellow fur. Since they always produce yellow furred and agouti offspring in a 2:1 ratio, he concludes they are heterozygous. (In 1910, W. E. Castle and C. C. Little will show that yellow homozygotes die in utero. This dominant allele is thus the first gene shown to behave as a homozygous lethal.)

The Swimming Reindeer — the largest ivory carving from the late Ice Age yet found — is pieced together by Abbé Henri Breuil from two reindeer carved from mammoth ivory found decades earlier by Peccadeau de l'Isle.

Albert Einstein proposes the special theory of relativity (E=mc²).

The first motorized buses operate in London.

The first neon signs appear.

William Bateson and Reginald Crundall Punnett report the discovery of two new genetic principles: LINKAGE and GENE INTERACTION.

In his presidential address to the Geological Society of America, Raphael Pumpelly claims that the end of the Pleistocene started the Neolithic Revolution.

Computer Pioneer Grace Hopper is Born

Chemist Bertram Boltwood measures the ratio of isotopes of uranium and lead in a mineral from Connecticut. He concludes the mineral formed 410 million years ago. His estimate will later be changed to 265 million, but this experiment lays the groundwork for radiometric dating techniques.

P. Raymond describes a Neolithic deposit in Saône-et-Loire in France containing an axe with three fossil sea urchins.

The Mauer jaw is discovered in Germany. On October 21, 1907, Daniel Hartmann, a worker at a sand mine in the Grafenrain open field system of the Mauer community unearthed a mandible at a depth of 24.63 m (80.81 ft), which he recognized as of human origin.[4] He was aware of the likelihood of finds, as for 20 years the Heidelberg scholar Otto Schoetensack had asked that the workers at the sand mine be encouraged to look out for fossils, after the well-preserved skull of a straight-tusked elephant had come to light there in 1887. Schoetensack had the workers taught the characteristics of human bones based on recent examples on his regular visits to the sand mine in search for "traces of mankind". The mandible will become the type specimen for Homo heidelbergensis (Archaic Homo sapiens, precursors to Neanderthals).

The Autochrome plate is introduced. It becomes the first commercially successful color photography product.

Godfrey Harold Hardy, a Cambridge mathematician, writes a letter to the editor of Science, suggesting that Mendelian mechanisms acting alone have no effect on allele frequencies. The letter begins, I am reluctant to intrude in a discussion concerning matters of which I have no expert knowledge, and I should have expected the very simple point which I wish to make to have been familiar to biologists. However,... This short (less than one page) letter constitutes Hardy's entire lifetime contribution to the field of biology, yet still forms the mathematical basis for population genetics.

Amadee and Jean Bouyssonie find a Neanderthal skeleton in a pit at La Chapelle-aux-Saints. The find spurs hypotheses of intentional Neanderthal burial of the dead, although some anthropologists will dispute this interpretation several decades later.

Charles and George Sternberg discover a dinosaur mummy, a duckbill dinosaur with skin, tendons and bits of flesh all fossilized.

Kinemacolor, a two-color process known as the first commercial "natural color" system for movies, is introduced.

General Motors Corporation is formed.

The Ford Motor Company produces the first Model T. Ultimately, more than 15 million will be produced.

T. H. Morgan, later to become the first recipient of the Nobel Prize for work in genetics, writes a paper expressing doubts about the profusion of Mendelian explanations for inherited properties.

A. E. Garrod publishes Inborn Errors of Metabolism, the earliest discussion of the biochemical genetics of man (or any other species).

George H. Shull advocates the use of self-fertilized lines in production of commercial seed corn. The hybrid corn program that resulted, created an abundance of foodstuffs worth billions of dollars.

H. Nilsson Ehle puts forward the multiple-factor hypothesis to explain the quantitative inheritance of seed-coat color in wheat.

W. Johannsen's studies of the inheritance of seed size in self-fertilized lines of beans leads him to realize the necessity of distinguishing between the appearance of an organism and its genetic constitution. He invents the terms PHENOTYOPE and GENOTYPE to serve this purpose, and he also coins the word GENE.

Abbé Breuil depicts a presumed Neanderthal burial at La Ferrassie.

Arthur Smith Woodward lectures the British Association for the Advancement of Science on "excess growth" and tooth loss in dinosaurs, citing these things as evidence of "racial senility" that doomed the dinosaurs to extinction.

Charles Doolittle Walcott starts digging fossils of soft-bodied animals in the Burgess Shale in the Canadian Rockies. He proceeds to publish several papers in which he describes these animals, which lived over 500 million years ago, as primitive ancestors of modern groups.

Kodak announces a 35 mm "safety" motion picture film on an acetate base as an alternative to the highly flammable nitrate base. The motion picture industry discontinues its use after 1911 due to technical imperfections.

The plastic age begins with the first commercial manufacture of Bakelite.

T. H. Morgan discovers white eye and consequently sex linkage in Drosophila. Drosophila genetics begins.

A few years after the find of some isolated teeth from the same species, British paleontologist Clive Forster Cooper finds better specimens of what will later be identified as Paraceratherium in an area that will later be part of Pakistan. A century later, Paraceratherium will still hold the title of the biggest land mammal yet discovered.

While digging the foundation for an imposing home, two laborers, Mercer and Crittenden, discover the remains of a cremation from the Iron Age, including a Neolithic axe and a fossil echinoid.

Three companies merge to become C-T-R

A chance discovery turns up the astonishingly well-preserved Clacton Spear. Made of yew and over 400,000 years old, it's one of the world's oldest wooden artifacts.

T. H. Morgan proposes that the genes for white eyes, yellow body, and miniature wings in Drosophila are linked together on the X chromosome.

A hand axe, possibly 200,000 years old and of Neanderthal design, is found in Norfolk, England. The axe has been fashioned to give prominence to a fossil bivalve.

Charles Dawson discovers the Piltdown skull in southern England. Excavations of faked fossils will continue for years.

Alfred Wegener proposes the theory of continental drift. His ideas will be almost completely ignored until the late 1960s.

Thomas Edison introduces a short-lived 22 mm home motion picture format using acetate "safety" film manufactured by Kodak.

Vest Pocket Kodak using 127 film.

A. H. Sturtevant, an undergraduate working with Morgan at Columbia, provides the experimental basis for the linkage concept in Drosophila and produces the first GENETIC MAP.

Geologist-physicist Arthur Holmes concludes that the breakdown of radioactive isotopes in igneous rocks can be used to determine when the rocks solidified. The ability to determine the absolute ages of rocks will enable scientists to better date fossils.

Roland Garros, a French aviator, becomes the first person to fly across the Mediterranean. Garros' original plan was to fly from St. Raphael in France to Bizerta, Tunisia, with the possibility of a fueling stop on Sardinia. En route, the trip seemed to be going well, so he skipped the refueling stop and flew directly to Bizerta, where he arrived at 1:45pm, with about five liters of fuel left in his tank.

Oskar Barnack develops a prototype camera for testing 35mm movie film. This device, now often referred to as an UR-Leica, was quickly recognized as a miniature camera for producing still images. A dozen years later, the first commercially available 35mm still camera was marketed as the Leica I.

Kodak makes 35 mm panchromatic motion picture film available on a bulk special order basis.

Hans Geiger unveils his radiation detector.

Calvin Blackman Bridges reports nondisjunction of sex chromosomes as PROOF of the chromosome theory of heredity.

Charles Doolittle Walcott identifies fossil bacteria in Cryptozoon-like structures (stromatolites).

Peyrony finds the remains of Neanderthal baby in southwestern France. Because no one knows the bones are Neanderthal, they are not examined closely and are later believed lost. They will be rediscovered and described nearly 90 years later.

Thomas J. Watson Sr. joins C-T-R

Kodak introduces the Autographic film system.

The World, the Flesh and the Devil, made in Kinemacolor, is the first dramatic feature film in color released.

Calvin Bridges identifies strains of mutant fruit flies with extra pairs of wings. Decades later, these strains will help biologists understand Hox genes that control the head-to-toe anatomy of widely varying animals.

Frederick Twort discovers a virus capable of infecting and destroying bacteria.

Thomas Hunt Morgan, Alfred Henry Sturtevant, Calvin Blackman Bridges, and Hermann Joseph Muller publish The Mechanism of Mendelian Heredity. This monograph provides the first systematic description of the actual mechanisms that control inheritance as evidenced in the Mendelian model. Here, for the first time, the gene is made real.

Two duckbill dinosaur fossils, with extremely rare skin impressions, sink to the bottom of the Atlantic when the ship carrying them to London — the SS Mount Temple — is stopped by the German military vessel, the SMS Möwe. The German ship takes the passengers prisoner and then sinks the Mount Temple.

Stone tools discovered at Bir el Ater in eastern Algeria include triangular objects that might have been arrowheads or spear points. The tools will be dubbed Aterian, but their age will be underestimated for decades.

British polymath D'Arcy Wentworth Thompson publishes On Growth and Form arguing that the forms Darwinian natural selection can produce through evolution are constrained by physical and mathematical laws, and that organic structures often emulate inorganic natural structures. His analysis led the way for the scientific explanation of morphogenesis, the process by which patterns and body structures are formed in plants and animals. Thompson's description of the mathematical beauty of nature and the mathematical basis of the forms of animals stimulated thinkers as diverse as Julian Huxley, Conrad Hal Waddington, Alan Turing, Claude Lévi-Strauss, Eduardo Paolozzi, Le Corbusier, and Mies van der Rohe.

C. B. Bridges discovers the first chromosome deficiency in Drosophila.

Felix Hubert D'Herelle, independently of Frederick Twort, discovers a virus capable of infecting and destroying bacteria, which he calls a BACTERIOPHAGE.

First reported connection between smoking and lung cancer.

Core memory inventor Jay Forrester is born

Thomas Hunt Morgan and coworkers publish The Physical Basis of Heredity, a book-length summary of the rapidly growing findings in genetics.

C. B. Bridges discovers chromosomal duplications in Drosophila.

T. H. Morgan calls attention to the equality in Drosophila melanogaster between the number of linkage groups and the haploid number of chromosomes.

Swedish geologist Johann Andersson discovers a major "dragon bone works" in northern China. Otto Zdansky also examines the works several years later, discovering that the fossils are referred to as dragons even though the workers recognize them as more pedestrian species such as horses and deer.

ENIAC Designer Presper Eckert Is Born

(no entry for this year)

Fossil mammal expert William Diller Matthew suggests dinosaurs were driven extinct by mountain building, continental uplift and replacement by mammals.

Miners at Broken Hill in the British colony of Northern Rhodesia, Africa, find leg bones and a skull that will later be classified as Homo heidelbergensis.

Lillian V. Morgan discovers attached-X chromosomes in Drosophila.

The American Museum of Natural History begins a series of excavations in central Mongolia, led by Roy Chapman Andrews. Hoping to find fossil human remains, Chapman's team instead finds dinosaurs.

Kodak makes 35 mm panchromatic motion picture film available as a regular stock.

A. E. Boycott and C. Diver describe "delayed" Mendelian inheritance controlling the direction of the coiling of the shell in the snail Limnea peregra. A. H. Sturtevant suggests that the direction of coiling of the Limnea shell is determined by the character of the ooplasm, which is in turn controlled by the mother's genotype.

C. B. Bridges discovers chromosomal translocations in Drosophila.

Jesuit priests Émile Lincent and Pierre Teilhard de Chardin discover ancient stone tools at Shuidonggou, China. Their discoveries resemble those of the Middle Paleolithic industry in Europe.

Integrated Circuit Co-Inventor Jack Kilby is Born

Harold Edgerton invents the xenon flash lamp for strobe photography.

The 16 mm amateur motion picture format is introduced by Kodak. Their Cine-Kodak camera uses reversal film and all 16 mm is on an acetate (safety) base.

Winifred Goldring publishes a description of a fossil forest discovered during excavations for the Gilboa Dam. Dating from the Devonian Period, the site will become known as the world's oldest fossil forest.

C-T-R becomes IBM

Tennessee schoolteacher John Thomas Scopes is tried for teaching evolution in the famous "Scopes Monkey Trial." Two-time presidential candidate William Jennings Bryan leads the prosecution. Labor lawyer Clarence Darrow leads the defense and goads Bryan into declaring that humans are not mammals. The conviction will be overturned on a technicality, and the anti- evolution law will remain on the books for decades.

A. H. Sturtevant analyzes the Bar-eye phenomenon in Drosophila and discovers position effect.

Francis Turville-Petre finds Galilee Man, the first fossil hominid discovered in Western Asia. The fossil will later be dated to more than 250,000 years old, and classified as neither modern Homo sapiens nor Neanderthal.

Raymond Dart publishes a description of the "Taung Child," a hominid child's skull from Africa. He classifies it as Australopithecus africanus and concludes that it's the missing link between humans and apes.

First patent for a transistor in Canada lodged

January 1925 Douglas Engelbart is Born

Supercomputer Pioneer Seymour Cray is Born

The Leica I 35mm still camera was introduced at the Leipzig Spring Fair in Germany, thereby launching the 35mm format for portable photography.

A. H. Sturtevant finds the first inversion in Drosophila.

Harvard geology professor William Morris Davis publishes a paper entitled The Value of Outrageous Geological Hypotheses warning against quick dismissal of new ideas. The paper will become famous.

Kodak introduces its 35 mm Motion Picture Duplicating Film for duplicate negatives. Previously, motion picture studios used a second camera alongside the primary camera to create a duplicate negative.

Bernard O. Dodge initiates genetic studies on Neurospora.

H. J. Muller reports the artificial induction of mutations in Drosophila by x-rays.

J. B. S. Haldane suggests that the genes known to control certain coat colors in various rodents and carnivores may be evolutionarily homologous.

Excavations in Kent's Cavern in southern England turn up a fragment of a human upper jaw, roughly 43,000 years old. Arthur Keith will provisionally identify it as anatomically modern human, and this finding will be confirmed in a 2011 study.

Johns Hopkins University biologist Raymond Pearl publishes an article entitled "Why Lazy People Live the Longest." He will expand on this rate- of-living hypothesis in a book the next year, arguing that a faster rate of biochemical reactions leads to a shorter lifespan. This hypothesis is quickly dismissed and generally considered buncombe. Later, however, Donald Trump, the 45th president of the United States will be discovered to hold similar views.

Frederick Griffith discovers type-transformation of pneumococci. This lays the foundation for the work of Avery, MacLeod, and McCarthy (1944).

L. J. Stadler reports the artificial induction of mutations in maize, and demonstrates that the dose-frequency curve is linear.

In a letter to Science, Louise Sudbury states that fossil plants, Cycadeoidea Etrusca, were collected by Etruscans over 4,000 years ago.

In trying to piece together a Burgess Shale organism over 500 million years old, Danish zoologist K. L. Henriksen glues an Anomalocaris appendage to a Tuzoia carapace to make what he thinks is a reasonable looking shrimp-like animal. This mistaken interpretation will persist for years.

John Henry Pull, a postman and amateur archaeologist, finds fossil urchins in two separate Neolithic burial sites. His efforts to publish on his findings, however, will be thwarted due to his pedestrian background.

Introduction of 80-columns card format

Davidson Black announces the find of Sinanthropus pekinensis, or Peking Man, discovered at Zhoukoudian, China. Over the next several years, five nearly-complete skulls will be recovered from the same site. Peking Man will be lost, however, during World War II.

Estonian paleobiologist Alexander Audova publishes a paper rejecting racial senility as the cause of dinosaur extinction and instead pointing to environmental change.

Herman Hollerith Died

R. A. Fisher publishes Genetical Theory of Natural Selection, a formal analysis of the mathematics of selection.

Themistocles Zammit publishes Prehistoric Malta: The Tarxien Temples about excavations showing fossil sea urchins in Bronze Age temples.

C. Stern, and independently H. B. Creighton and B. McClintock, provide the cytological proof of crossing over.

The highly influential paleobotanist Sir Albert Charles Seward rejects the biologic interpretation of Cryptozoon fossils (stromatolites). This rejection will become known among paleontologists as "Seward's folly."

A Harvard expedition to Australia collects Kronosaurus queenslandicus, a 135-million-year-old marine reptile fossil with a 9- foot skull and banana-sized teeth. Researchers excavate the fossil from a limestone quarry with the aid of explosives.

Fossil diggers discover a 25-million-year-old toothed, dwarf whale in Australia. Seven years later it will be named Mammalodon. More than 70 years later, it will be described as a "bottom-feeding mud-sucker."

"Flowers and Trees", the first full-color cartoon, is made in Technicolor by Disney.

Kodak introduces the first 8 mm amateur motion picture film, cameras, and projectors.

Robert Broom publishes The Coming of Man: Was it Accident or Design? arguing that evolution is really driven by spiritual agencies, some with conflicting priorities, and that mankind is the ultimate aim of all evolution.

T. H. Morgan receives a Nobel Prize in Medicine for his development of the theory of the gene. He is the first geneticist to receive this award.

Barbara McClintock demonstrates in maize that a single exchange within the inversion loop of a paracentric inversion heterozygote generates an acentric and a dicentric chromatid.

T. S. Painter initiates cytogenetic studies on the salivary gland chromosomes of Drosophila.

With funding from Sinclair Oil, Barnum Brown begins excavating in Wyoming's Howe Quarry. His finds will lead to the green dinosaur logo for Sinclair's gas stations. Many of them will simply be named "Dino."

IBM 405 Alphabetical Accounting Machine introduced

The 135 film cartridge is introduced, making 35 mm easy to use for still photography.

C. B. Bridges publishes the salivary gland chromosome maps for Drosophila melanogaster.

G. W. Beadle and B. Ephrussi and A. Kuhn and A. Butenandt work out the biochemical genetics of eye-pigment synthesis in Drosophila and Ephestia, respectively.

J. B. S. Haldane is the first to calculate the spontaneous mutation frequency of a human gene.

M. Baudouin describes more than 80 fossil sea urchins drilled for use as jewelry, some worked as long as 35,000 years ago.

Becky Sharp, the first feature film made in the full-color "three-strip" version of Technicolor, is released.

Introduction of Kodachrome multi-layered color reversal film (16 mm only; 8 mm and 35 mm follow in 1936, sheet film in 1938).

A. H. Sturtevant and T. Dobzhansky publish the first account of the use of inversions in constructing a chromosomal phylogenetic tree.

Robert Broom finds the first skull of an adult australopithecine near Johannesburg.

At Cambridge Alan Turing invented the principle of the modern computer

Konrad Zuse Files For Patent

Agfacolor Neu (English: New Agfacolor) color reversal film for home movies and slides.

Introduction by IHAGEE of the Ihagee Kine Exakta 1, the first 35 mm SLR (Single Lens Reflex) camera.

T. Dobzhansky publishes Genetics and the Origin of Species — a milestone in evolutionary genetics.

Alan Turing Defines the Universal Machine

ILLIAC IV Designer Slotnick is born

The Atanasoff–Berry Computer first conceived

Fishermen find a coelacanth, a fish long believed to be extinct, off the coast of South Africa. Margaret Courtney-Latimer, a curator at the East London Museum in South Africa, keeps the fish preserved long enough for its identity to be confirmed by ichthyologist J.L.B. Smith.

Zuse Z1 built by Konrad Zuse

E. L. Ellis and M. Delbrück perform studies on coliphage growth that mark the beginning of modem phage work. They devise the "one-step growth" experiment, which demonstrates that after the phage adsorbs onto the bacterium, it replicates within the bacterium during the "latent period," and finally the progeny are released in a "burst."

About 200 worked ivory fragments, roughly 32,000 years old, are found in the Hohlenstein-Stadel Cave in Germany. Three decades later, the pieces will be reassembled as statue of a lion-headed man.

Hewlett Packard Founded

Agfacolor negative and positive 35 mm color film stock for professional motion picture use (not for making paper prints).

The View-Master 3-D viewer and its "reels" of seven small stereoscopic image pairs on Kodachrome film are introduced.

Frank Morton Carpenter collects a 2.5-foot wing from a dragonfly-like giant insect that lived in Oklahoma during the Permian Period.

G. W. Beadle and E. L. Tatum publish their classic study on the biochemical genetics of Neurospora and promulgate the ONE-GENE, ONE-ENZYME theory.

K. Mather coins the term polygenes and describes polygenic traits in various organisms.

Anthropologist E. T. Hall excavates the ruins of a dwelling in New Mexico occupied between 700 and 900 AD. He finds two fossil jawbones of Eocene mammals that were deliberately carried to the dwelling by Paleo- Indians.

German paleontologist H. Kirchner suggests that dinosaur tracks in the Rhine Valley might have inspired the legend of Siegfried slaying the dragon Fafnir.

Zuse Z3 machine completed

Ernst Mayr publishes Systematics and the Origin of Species, and Julian Huxley publishes Evolution: The Modern Synthesis. Both books are significant contributions to the neo darwinian synthesis combining elements of natural selection, genetics, mutation, population biology and paleontology.

S. E. Luria and T. F. Anderson publish the first electron micrographs of bacterial viruses. T2 has a polyhedral body and a tail.

The Atanasoff-Berry Computer is completed

Kodacolor, the first color film that yields negatives for making chromogenic color prints on paper. Roll films for snapshot cameras only, 35 mm not available until 1958.

S. E. Luria and M. Delbrück initiate the field of bacterial genetics when they demonstrate unambiguously that bacteria undergo spontaneous mutation.

The Colossus Mark 1 computer is delivered to Bletchley Park

The First Computing Journal

Work begins on ENIAC

Theoretical physicist Erwin Schrödinger publishes What is Life? arguing that living organisms store and pass along information, perhaps using something like Morse code. This book will inspire James Watson, Francis Crick and Maurice Wilkins, who will share the Nobel prize for discovering the structure of DNA.

O. T. Avery, C. M. MacLeod, and M. McCarty describe the pneumococcus transforming principle. The fact that it is rich in DNA suggests that DNA and not protein is the hereditary chemical.

First Harvard Mark 1 shipped

S. E. Luria demonstrates that mutations occur in bacterial viruses.

Grace Hopper recorded the first actual computer "bug"

Patent is Filed for the Harvard Mark I

Vannevar Bush publishes his ideas for MEMEX, a proto-hypertext system and forerunner to the World Wide Web

James B. Sumner, John H. Northrop, and Wendell M. Stanley share a Nobel Prize in Chemistry for Sumner's discovery that enzymes can be crystallized and for Northrop and Stanley's preparation of enzymes and virus proteins in a pure form.

Nobel Prize in Medicine awarded to H. J. Muller for his contributions to radiation genetics

Genetic recombination in bacteriophage is demonstrated by M. Delbrück and W. T. Bailey and by A. D. Hershey.

J. Lederberg and E. L. Tatum demonstrate genetic recombination in bacteria.

Along the Kolyma River in northeastern Siberia, Gulag prisoners discover a nest with three frozen, mummified ground squirrel carcasses. They turn the carcasses over to the Gulag camp geologist, Yuriy Popov, who relays them to other Soviet scientists. Seventy years later, radiocarbon dating and DNA analysis of the ground squirrel mummies will identify their age at over 30,000 years old, and indicate that they are not direct ancestors of modern ground squirrels in the region.

Geologist Reg Sprigg discovers fossils near the Ediacara Hills in Australia. The fossils are of multicellular organisms that predated the Cambrian Period, making them the oldest complex fossils yet discovered. At least some of the fossils are generally assumed to be related to modern cnidarians like jellyfish and corals.

Alan Turing Proposal For 'ACE' Automatic Computing Engine

ENIAC Unveiled

ENIAC, short for Electronic Numerical Integrator And Computer was announced

Frederick Williams Receives Patent for RAM device

American Museum of Natural History curator Edwin Colbert finds a massive quarry of Coelophysis dinosaurs in New Mexico and concludes from their skeletons that these Triassic dinosaurs were swift runners with a bird- like posture. Later examination of two fossils will lead Colbert to conclude they were also cannibals, but the "last meals of juvenile coelophyses" will eventually prove to be crocodilian.

Rudolph Zallinger completes The Age of Reptiles mural in the Yale Peabody Museum. His image of slow-moving dinosaurs will prevail until the 1960s.

J Lyons executives report on the potential of computers to automate clerical work

The Williams tube won the race for a practical random-access memory

Dennis Gabor invents holography.

Harold Edgerton develops the Rapatronic camera for the U.S. government.

H. J. Muller coins the term dosage compensation.

J. Lederberg and N. Zinder, and, independently, B. D. Davis develop the penicillin selection technique for isolating biochemically deficient bacterial mutants.

Mary Leakey finds the skull of the ape Proconsul, about 16 million years old. Although a very significant find, it does little to bolster Louis and Mary Leakey's meager research funding.

IBM´s Selective Sequence Electronic Calculator was built

The Manchester Baby, the world's first stored program computer, ran its first program

Edwin H. Land introduces the first Polaroid instant camera.

The Hasselblad 1600F camera is introduced.

A. D. Hershey and R. Rotman demonstrate that genetic recombination occurs in bacteriophage.

J. V. Neel provides genetic evidence that the sickle-cell disease is inherited as a simple Mendelian autosomal recessive.

French prehistorian André Leroi-Gourhan discovers the Cave of the Reindeer near the village of Arcy-sur-Cure where he will conduct a 15-year excavation. Discoveries at Arcy will suggest to some researchers an artistic sense among Neanderthals, including the collection of fossil mollusk shells and fossil coral. Doubts about ages of objects, however, will leave the subject open to debate.

EDSAC performed its first calculations

EDSAC ran its first programs

EDVAC goes onlline

Jay Forrester Records "Core Memory" Idea

Professor Bill Phillips unveils Phillips Hydraulic Economic Modelling Computer at the LSE

The Contax S camera is introduced, the first 35 mm SLR camera with a pentaprism eye-level viewfinder.

At a Cold Spring Harbor Symposium, Ernst Mayr argues that all hominid specimens so far found should be categorized in the genus Homo: H. transvaalensis, H. erectus, and H. sapiens.

E. Chargaff lays the foundations for nucleic acid structural studies by his analytical work. He demonstrates for DNA that the numbers of adenine and thymine groups are always equal and so are the numbers of guanine and cytosine groups. These findings later suggest to Watson and Crick that DNA consists of two polynucleotide strands joined by hydrogen bonding between A and T and between G and C.

E. M. Lederberg discovers lambda, the first viral episome of E. coli.

The first Elliott 152 computer appeared

Zuse sold first Z4 computer

Barbara McClintock publishes a paper describing "jumping" genes that can move around within an organism's genome.

Ferranti Mark 1 delivered to Manchester University

LEO I computer became operational

The first UNIVAC was delivered

UNIVAC-1 goes online

A. D. Hershey and M. Chase demonstrate that the DNA of phage enters the host, whereas most of the protein remains behind.

F. Sanger and his colleagues work out the complete amino acid sequence for the protein hormone insulin, and show that it contains two polypeptide chains held together by disulfide bridges.

J. Lederberg and E. M. Lederberg invent the replica plating technique.

N. D. Zinder and J. Lederberg describe transduction in Salmonella.

Russian geologist Boris Sokolov establishes the term Vendian. Based on rock strata in the Soviet Union, it designates the period immediately preceding the Cambrian, coinciding with fossils found near the Ediacara Hills.

CBS News Uses UNIVAC Computer to Predict Election

Grace Hopper completes the A-0 Compiler

Heinz Nixdorf founded Nixdorf Computer

Bwana Devil, a low-budget polarized 3-D film, premieres in late November and starts a brief 3-D craze that begins in earnest in 1953 and fades away during 1954.

J. D. Watson and F. H. C. Crick propose a model for DNA comprised of two helically intertwined chains tied together by hydrogen bonds between the purines and pyrimidines.

W. Hayes discovers polarized behavior in bacterial recombinations. He isolates the Hfr H strain of E. coli and shows that certain genes are readily transferred from Hfr to F- bacteria, whereas others are not.

Piltdown Man is determined to be a hoax: the jaw of an ape and a human skull.

Fiesel Houtermans and Clair Patterson publish independent estimates inferring the age of the Earth through radiometric dating of meteorites. Both estimates are over 4.5 billion years.

IBM announces the Model 650 computer

Jay Forrester installed magnetic core memory at MIT

Elso Barghoorn and Stanley Tyler report the discovery of bacterial cells in Canadian rock formations that are nearly 2 billion years old.

Philip Abelson and his team detect amino acids in fish that are over 300 million years old.

20th September First FORTRAN Program Runs

IBM Announces Model 705 Computer

Jack Tramiel starts Commodore

Leica M Introduced

S. Benzer works out the fine structure of the rII region of phage T4 of E. coli, and coins the terms CISTRON,RECON, and MUTON.

Professional pipefitter and amateur paleontologist Francis Tully finds an enigmatic fossil near Morris, Illinois. Dating from about 300 million years ago, the fossil will be formally named Tullimonstrum gregarium and nicknamed the Tully monster. Although it will defy classification for decades, it will nevertheless be named the state fossil of Illinois.

Apple Co-Founder Steve Jobs is Born

Bill Gates, cofounder of Microsoft Corporation, was born

English Electric Deuce Computers introduced

ENIAC is retired

F. Jacob and E. L. Wollman are able experimentally to interrupt the mating process in E. coli and show that a piece of DNA is inserted from the donor bacterium into the recipient.

Fifteen-year-old English schoolgirl Tina Negus finds a specimen of the fossil species that will later be named Charnia masoni, from the geologic period that will later be named the Ediacaran. Unfortunately, Negus can't convince her geography teacher that the fossil she has found is Precambrian and gives up, leaving the fossil to be extracted by local schoolboy Roger Mason the next year.

Keith Runcorn publishes a paper describing polar wandering based on paleomagnetic studies of Europe and North America. He suggests continental drift, but his paper attracts little attention.

Paleontologist M. W. de Laubenfels publishes a paper suggesting that the dinosaurs were driven to extinction by a meteorite impact. His paper will not be taken seriously, but this hypothesis will be presented again in 1980 with more compelling evidence.

Brian Logan and fellow geologists find living stromatolites in Shark Bay, Australia. The find is somewhat surprising as stromatolites have no defenses against mouth-bearing organisms and have probably been relatively rare since the Cambrian Period.

First keyboard used to input data

IBM brings out the Magnetic Disk Memory

IBM introduces the IBM 350

Jay Forrester Receives Patent on "Core" Memory

Pegasus, produced by Ferranti Ltd., went into service in March 1956

Wang Sells Core Memory Patent to IBM

Francis Crick proposes the "central dogma" of genetic information transfer: DNA specifies RNA and RNA specifies cell proteins.

V. M. Ingram reports that normal and sickle-cell hemoglobin differ by a single amino acid substitution.

BCS - British Computer Society is Founded

CDC Introduces 1604 Computer

DEC is founded

Ferranti Mercury Introduced

FORTRAN-1 is formally published

May 1957 LEO II Installed

First Asahi Pentax SLR introduced.

First digital computer acquisition of scanned photographs, by Russell Kirsch et al. at the U.S. National Bureau of Standards (now the NIST).

The Soviet Union launches Sputnik.

Frederick Sanger receives a Nobel Prize in Chemistry for his work on the structure of proteins, especially that of insulin.

George W. Beadle, Edward L. Tatum, and Joshua Lederberg share a Nobel Prize in Medicine for Beadle and Tatum's discovery that genes act by regulating definite chemical events, and for Lederberg's discoveries concerning genetic recombination and the organization of the genetic material of bacteria.

F. H. C. Crick suggests that during protein formation the amino acid is carried to the template by an adaptor molecule containing nucleotides and that the adaptor is the part that actually fits on the RNA template. Crick thus predicts the discovery of transfer RNA.

F. Jacob and E. L. Wollman demonstrate that the single linkage group of E. coli is circular and suggest that the different linkage groups found in different Hfr strains result from the insertion at different points of a factor in the circular linkage group that determines the rupture of the circle.

M. Meselson and F. W. Stahl use the density gradient equilibrium centrifugation technique to demonstrate the semiconservative distribution of density label during DNA replication in E. coli.

Jack Kilby created the first integrated circuit

Severo Ochoa and Arthur Kornberg share a Nobel Prize in Medicine for their discovery of the mechanisms in the biological synthesis of ribonucleic acid and deoxiribonucleic acid.

J. Lejeune, M. Gautier, and R. Turpin show that Down syndrome is a chromosomal aberration involving trisomy of a small telocentric chromosome.

R. L. Sinsheimer demonstrates that bacteriophage phiX174 of E. coli contains a single-stranded DNA molecule.

Mary Leakey finds hominid skull belonging to Paranthropus boisei.

COBOL is introduced

The Xerox 914 is the first office copier for sale

AGFA introduces the first fully automatic camera, the Optima.

Nikon F introduced.

Alister Hardy promotes his Homo aquaticus or "aquatic ape" hypothesis to the British Sub Aqua Club. He will follow up this announcement with several magazine articles.

DEC released its first mini computer: PDP-1

Gene Shoemaker and E.C.T. Chao publish a paper characterizing the Ries Basin in Bavaria as the result of a meteorite impact. This will help pave the way for eventual acceptance of asteroid and comet impacts as potential causes of mass extinction.

F. Jacob and J. Monod publish "Genetic regulatory mechanisms in the synthesis of proteins," a paper in which the theory of the OPERON is developed.

Martin Glaessner determines fossils in the Ediacara Hills of South Australia (Ediacaran fauna) to be Precambrian in age (approximately 600 million years old), making them the oldest-known multicelled organisms.

Clive Sinclair founds Sinclair Radionics

Computerized spreadsheets for use in business accounting developed

LEO III completed in 1961

Minivac 601 Computer Launched

Robert Noyce Awarded Patent for "Integrated Circuit"

Human geneticist James Neel develops the "thrifty genotype" hypothesis that human ancestors endured feast-famine cycles that made the human body very effective in storing fat for lean times.

James Watson, Francis Crick, and Maurice Wilkins share a Nobel Prize in Medicine for their work in elucidating the structure of DNA.

"Music from Mathematics" LP was created using an IBM 7090 computer

The first commercial Modem manufactured

The Machester Atlas was inaugurated on 7th December 1962

Lantian Man, a 500,000-year-old Homo erectus specimen, is found in Lantian County, China, just north of Xi'an.

Fred Vine and Drum Matthews publish a paper describing magnetic stripes formed at ocean ridges. Their findings will pave the way for the acceptance of continental drift over the next decade.

Douglas Engelbart Invents the Mouse

First edition of the ASCII standard was published.

Theodore H (Ted) Nelson coins the word Hypertext

Kodak introduces the Instamatic.

Louis Leakey describes Homo habilis, meaning "handy." The new species designation is not well received by the scientific community.

Two deciduous molars, roughly 44,000 years old, are collected at Grotta del Cavallo in southeastern Italy. After an initial classification as Neanderthal, they will be assigned to modern humans in a 2011 study.

Vincent Dethier publishes "Microscopic Brains," an article on insect behavior, in Science. He calls for a more empathetic approach to animal subjects, even tiny invertebrates.

W. Brian Harland and Martin J. S. Rudwick publish a theory that the Earth experienced a great ice age in the Neoproterozoic (late Precambrian). Rudwick suggests that the climate's return to moderate conditions paved the way for the evolution of multicelluar life.

BASIC language developed

First operation of BASIC

First operation of Ferranti Atlas

Graphic tablet developed

IBM releases the System 360 range of commercial computers

Introduction of CDC 6600

Introduction of DEC PDP-7 18-bits minicomputer

First Pentax Spotmatic SLR introduced.

François Jacob, André Lwoff, and Jacques Monod share a Nobel Prize in Medicine for their discoveries concerning genetic control of enzyme and virus synthesis.

N.H. Field publishes "Fossil sea-echinoids from a Romano-British site" describing the centuries-long occupation of a Romano-British settlement in Dorset. Newer buildings have been built upon older ones, with fossil urchins in each.

Commodore Business Machines (CBM) is founded.

DEC unveils the PDP-8,

Introduction of Wang 300 electronic calculator

Moore's Law coined

Willi Hennig works on a new approach to assessing evolutionary relationships, known as cladistics. Although it will be hotly debated, this technique will eventually become standard practice in paleontology, botany and zoology.

Harry Whittington begins reexamining Burgess Shale fossils originally identified by Charles Walcott starting in 1909. Over the next two decades, Whittington (with the assistance of his graduate students Simon Conway Morris and Derek Briggs), will eventually overturn some of Walcott's theories and propose that most of the animals left no living relatives.

Introduction of DEC PDP-9

The hand-held pocket calculator was invented at Texas Instruments in 1966

Lynn Sagan (later Lynn Margulis) hypothesizes that chloroplasts originated as cyanobacteria, and that mitochondria originated as bacteria. She suggests that both were engulfed by other cells and began functioning as symbionts.

Graduate student S.B. Misra discovers a well-preserved sea floor with numerous fossils dating from the late Precambrian (later to be dubbed the Ediacaran Period) at Mistaken Point, Newfoundland.

P. S. Martin suggests that fast-moving bands of human hunters caused the extinctions of Pleistocene big-game species.

Richard Leakey finds two fossil skulls, Omo I and Omo II, in Ethiopia. Though initially dated at 130,000 years, the fossils will later be dated (using argon decay) at 195,000 years, and designated as the oldest examples so far found of Homo sapiens.

Daniel Janzen argues that, because they live under "easy" conditions, tropical plants cannot likely survive a wide range of temperature, light, or hydrologic conditions.

Surgeon General definitively links smoking to lung cancer and presents evidence that it is causing heart problems.

Barclays Bank in the UK claims to have installed the first cash dispenser

Elliott Automation merged with English Electric

Introduction of DEC PDP-10

First MOS 10 by 10 active pixel array shown by Noble

A.G. Cairns-Smith publishes a paper suggesting that the first life on Earth might have been fine-grained clay crystals. He will publish on this topic several more times before his death, but the experimental evidence will remain scant, perhaps in part because sufficient technology doesn't yet exist to test the hypothesis.

Robert W. Holley, Har Gobind Khorana, and Marshall W. Nirenberg share a Nobel Prize in Medicine for their interpretation of the genetic code and its function in protein synthesis.

Richard Fox describes a Paleocene mammal, Prothryptacodon albertensis, retrieved from a well dug in Alberta, Canada. This find eerily resembles that of another Paleocene mammal recovered from a Louisiana oil well and described in 1932 by George Gaylord Simpson.

Teenaged fossil enthusiast Tadashi Suzuki finds a plesiosaur fossil in his hometown of Iwaki City, Japan. The fossil turns out to be a new species, but it won't be identified as such for nearly 40 years.

CDC Introduces the 7600 Supercomputer

Douglas C. Engelbart publicly demonstrates the mouse

IBM tests a 8in floppy disc

Integrated Circuits First Used in Apollo Moon shot

Introduction of HP-9100 desk calculator

Robert Noyce and Gordon Moore found Intel Corporation

T J Watson and IBM granted patent for the DRAM

R. H. Whittaker proposes to divide all living things into five kingdoms: Animalia, Plantae, Fungi, Protista and Monera.

Max Delbrück, Alfred D. Hershey, and Salvador E. Luria share a Nobel Prize in Medicine for their discoveries concerning the replication mechanism and the genetic structure of viruses.

Archaeologist Joachim Hahn pieces together the fragments of the lion- headed man found 30 years earlier the Hohlenstein-Stadel Cave in Germany.

John Ostrom publishes Osteology of Deinonychus antirrhopus, an Unusual Theropod from the Lower Cretaceous of Montana — a description of Deinonychus with a frontispiece illustration by Bob Bakker, suggesting that the dinosaur is alert, agile and intelligent.

AMD Advanced Micro Devices is founded

ARPANET launch the world's first successful packet-switched wide area computer network

DEC PDP-15 Introduced

First flight to Moon of Apollo XI with Raytheon Apollo Guidance Computer

Honeywell releases the H316 "Kitchen Computer",

Intel announces a 1 kilobit RAM chip

Plessey buys out Ferranti's numerical Control Interests

Americans land the first man on the moon.

Tobacco manufacturers legally obliged to print a warning on the labels that smoking is a health hazard.

5200 computers installed in Britain

Computer terminals in homes predicted for 1980

DEC introduces the PDP-8/E

IBM 370/145 introduced

Open University to install ICL 32K 1902A computer

Univac 1110 is introduced

UNIX is developed

Xerox opens the Palo Alto Research Center (PARC)

Five pairs of adult wall lizards are moved between two islands in Croatia. Over the next few decades, the lizards on the new island will evolve larger heads, stronger bites, and a greater tolerance for an herbivorous diet than the original lizard population.

A. G. Sharov describes a pterosaur with fossil "hair" impressions as Sordes pilosus (hairy devil).

Grad student Douglas Lawson discovers the humerus of a giant pterosaur in Texas. Over the next four years, he will continue collecting and finally publish a description of Quetzalcoatlus northropi, the largest flying animal ever found, with an estimated wingspan of 39 feet.

Polish and Mongolian paleontologists discover the entwined skeletons of a Protoceratops and a juvenile Velociraptor in the Gobi Desert, most likely locked in mortal combat.

Burroughs introduces L500 Visible Record Model

DEC launches Giant Mini PDP-11/45

DEC launches PDP-11/03

Decsystem 10 introduced

First Network Email sent by Ray Tomlinson

IBM's Thomas J Watson retires

Intel Introduces the World's First EPROM

Intel Launches the First Microprocessor - The 4004

Nixdorf merge with AEG-Telefunken

Olivetti launches P602 "minicomputer"

Stephen Jay Gould and Niles Eldredge publish their theory of punctuated equilibrium, stating that evolution often occurs in short bursts, followed by long periods of stability.

Christian B. Anfinsen, Stanford Moore, and William H. Stein share a Nobel Prize in Chemistry, with Anfinsen cited for his work on ribonuclease, especially concerning the connection between the amino acid sequence and the biologically active conformation, and Moore and Stein cited for their contribution to the understanding of the connection between chemical structure and catalytic activity of the active centre of the ribonuclease molecule.

Bob Bakker publishes "Anatomical and Ecological Evidence of Endothermy in Dinosaurs" in Nature, arguing that dinosaurs were warm-blooded animals.

Harry Whittington shows a preliminary reconstruction of the Burgess Shale species Opabinia at a Palaeontological Association meeting, and the crowd roars with laughter.

£1.3m RAF order for Cossor Terminals

370/125 and OCR reader from IBM

ARPA Network - UK gets link to major US network

ASC developed by Texas Instruments

Atanasoff Official "Inventor" of Computer

Atari Introduces Pong

Burroughs Launch L8000 Range of Computers

Burroughs launches L7000 range on UK market

C programming language developed

Clive Sinclair introduces the first pocket calculator

Development of standard OS to be halted

First e-mail program developed

First Infra-red Data Link transmission in the UK

Flat screen terminal introduced by Burroughs

Foundation of Cray Research Inc by Seymour Cray

Fujitsu and Hitachi in joint deal

GE Time Sharing Service

Hewlett-Packard introduces the HP-35

Honeywell's 700 range comes to the UK

IBM's DOS/VS

NCR 399

Problems with IBM 370/155 and 370/165

Sigma 6

SITA Network

Space Craft Pioneer 10 & 11 use Custom CPU in TTL

Terminal range boosted by Burroughs TC 3500

The Future of ICL as a British-controlled going concern

The Intel 8008 was introduced

The Magnavox Odyssey, the first video game console, is released

UK launch for Burroughs L8000 range

Worlds first IBM 370/135 installed in Britain

Integrated Photomatrix (Noble) demonstrates for 64 by 64 MOS active pixel array

Half in jest, Francis Crick and Leslie Orgel suggest that ancient aliens may have seeded the early Earth with DNA, and all life on this planet arose from that.

Peter and Rosemary Grant begin a long-term study of finches on the Galápagos Islands. In succeeding years, as they watch finches adapt to alternating wet and dry conditions, the Grants will uncover evidence that evolution proceeds more rapidly than what Darwin estimated.

Taking a line from Through the Looking Glass, Leigh Van Valen establishes the "Red Queen" hypothesis of coevolution between predator and prey: "it takes all the running you can do, to keep in the same place. If you want to get somewhere else, you must run at least twice as fast as that!"

Heinz Tobien collects a primate tooth fragment from limestone rocks in southern Germany. Studies published decades later, in 2001 and 2011, will suggest that the fossil is 17 million years old, and that a hominoid migration into Eurasia occurred 3 million years earlier than previously thought.

8" floppy & first "Hard Drive introduced by IBM

Bob Metcalfe invents Ethernet

Britain exports more computing equipment than it imports

Gary Kildall writes CP/M

IBM 370/145 product range released

IBM in Nigeria

IMSAI is founded. In 1973

The Micral was the earliest commercial, non-kit personal computer

Xerox Alto personal computer was developed at Xerox PARC

Fairchild Semiconductor releases the first large image forming CCD chip: 100 rows and 100 columns of pixels.

Donald Johanson and his team discover a female fossil hominid (to be later named Australopithecus afarensis) and call her Lucy. Lucy's discovery establishes that hominids walked upright before developing large brains, overturning some long-held beliefs about hominid evolution. Her status as a direct ancestor of modern humans, however, will remain controversial.

Heavy equipment operator Porky Hansen accidentally uncovers a mammoth tusk while leveling ground for a building. The site will reveal many more mammoths, becoming a tourist attraction for Hot Springs, South Dakota.

John Ostrom publishes a paper titled "Archaeopteryx and the Origin of Flight" reviving Thomas Henry Huxley's arguments from the 1860s.

GA LSI 12/16 and LSI16

introduction of Intel 8080 2MHz microprocessor

MITS completes the first prototype Altair 8800 microcomputer

NCR 250-6000

Philips P852M

The Z-80, 8 bit processor is designed by Zilog Corp

Xerox Palo Alto Research Center designed the Alto

Mary-Claire King and Allan Wilson publish their finding that human and chimpanzee DNA sequences differ by roughly 1 percent, meaning humans have more in common with chimps than chimps do with gorillas. King and Wilson suggest that humans and chimps differ largely in the DNA that switches on and off genes.

David Baltimore, Renato Dulbecco, and Howard Temin share Nobel Prize in Medicine for their discoveries concerning the interaction between tumour viruses and the genetic material of the cell.

Armed with an old geological map, selt-taught fossil hunter Joan Wiffin finds New Zealand's first recognized dinosaur fossil, a theropod tail vertebra, in the Maungahouanga Valley.

Bill Gates and Paul Allen sign a licensing agreement with MITS

CP/M operating system finished

Cray 1A announced

First meeting of the Homebrew Club

Microsoft Founded

MITS Altair launched on the cover of Popular Electronics magazine

Bryce Bayer of Kodak develops the Bayer filter mosaic pattern for CCD color image sensors.

Overturning the classifications introduced by R. H. Whittaker seven years earlier, Carl Woese proposes to divide all living things into three categories: Bacteria, Archaea and Eukarya.

Paleontologists looking for cave bear remains explore Sima de los Huesos ("Pit of the Bones") at Atapuerca, Spain. For many years afterwards, it will remain the densest accumulation of fossil human bones ever discovered, including the remains of more than 30 Homo heidelbergensis individuals.

Apple 1 Released

Burroughs introduce the large B7700 series

Dec System 20 introduced

Intel introduce SBC-80/10 "computer on a card"

Last slide rule manufactured today

Seymour Cray demonstrates CRAY-1 - The first vector-processor supercomputer

Steve Wozniak, Steve Jobs and Ronald Wayne Found Apple Computer Inc.

The 5 1/4" flexible disk drive was introduced

Steadicam becomes available.

Submersible vehicle Alvin reveals deep sea vents on the ocean floor that give rise to an ecosystem owing nothing to photosynthesis. This finding prompts speculation that life on Earth first arose in deep-sea, not shallow-water, ecosystems.

Fred Sanger and collaborators publish the first complete DNA sequence of an organism, a bacteriophage, or virus infecting bacteria.

Commodore International shows its Commodore PET 2001

Radio Shack announces TRS-80 computer

Science of Cambridge Ltd Formed

The Apple II launched

The MK14 was introduced by Science of Cambridge

The RCA CDP1802 microprocessor was used in the Galileo spacecraft

F. Metzger-Krahé describes a ninth-century Viking settlement in southern Jutland — perhaps the first city-like settlement in Northern Europe — holding 185 fossils, most of them sea urchins.

Werner Arber, Dan Nathans, and Hamilton Smith share a Nobel Prize in Medicine for the discovery of restriction enzymes and their application to problems of molecular genetics.

J. W. Kitching discovers a clutch of prosauropod eggs in South Africa, the oldest dinosaur embryos yet found. They will show that sauropods walked on all fours as small animals, but the significance of this find will be overlooked for nearly three decades.

Mary Leakey announces the discovery of fossil footprints at Laetoli demonstrating that hominids walked upright 3.6 million years ago.

Acorn Computers Ltd formed in Cambridge, UK

Texas Instruments introduced Speak & Spell

VisiCalc Spreadsheet is born

Fresh out of law school and short on cash, Robert Heggestad buys an antique cabinet on an installment plan from a Virginia antique shop. The cabinet turns out to contain some 1,700 plant and invertebrate specimens from the personal collection of Alfred Russel Wallace.

Crystal Bennett finds a human-altered sea urchin fossil in Islamic (Fatimid) deposits dating from the 10th to 12th centuries in the Amman Citadel.

The Geological Society of America awards 96-year-old Harlen Bretz the Penrose Medal for identifying the cause of the Channeled Scablands in the northwestern United States: a massive flood from Glacial Lake Missoula after it broke through its ice dam. The recognition is somewhat late as Bretz first hypothesized a megaflood in the 1920s.

"VisiCalc" introduced

Acorn System 1 Launched

Apple II+ Launched

Microsoft moves from Albuquerque, New Mexico to Bellevue, Washington

Christiane Nüsslein-Volhard and Eric Wieschaus describe genetic mutations affecting the body plan of the fruit fly Drosophila, and identify genes controlling the basic body plans of all animals. These genes will eventually be known as Hox genes.

Paul Berg, Walter Gilbert, and Frederick Sanger share a Nobel Prize in Chemistry, with Berg cited for his fundamental studies of the biochemistry of nucleic acids, with particular regard to recombinant-DNA, and Gilbert and Sanger cited for their contributions concerning the determination of base sequences in nucleic acids. This is Sanger's second Nobel, the first having come in 1958 for his work on the structure of insulin.

Louis W. Alvarez, Walter Alvarez, Frank Asaro and Helen V. Michel publish their asteroid impact theory of dinosaur extinction. The theory will not gain widespread acceptance among scientists for several years.

Acorn Atom Launched

Apple Computer’s Initial Share Offering

Microsoft Signs Contract with IBM to Create Operating System

Sinclair ZX80 Launched

The Apple III was announced

Acorn BBC Micro Launched

HP-41 calculator Used In Space Shuttle

IBM announced that it was launching a personal computer using an Intel 8088

IBM introduces personal computer with Microsoft's 16-bit operating system, MS-DOS 1.0

Introduction of Osborne portable computer in a suitcase

Microsoft incorporates

Sinclair ZX81 Computer Launched

Space Shuttle uses Intel 8086 and RCA 1802

The first ‘portable’ computer is launched

VIC-20 Released in Europe & US

Commodore 64 Released

Dragon 32 Released

Introduction of Cray X-MP supercomputer

Introduction of Intel 80286 at 6 MHz, with 134,000 transistors

Sinclair launches the ZX Spectrum computer

Sinclair ZX Spectrum Launched

Barbara McClintock receives the Nobel Prize in Medicine for her discovery of mobile genetic elements.

German paleobiologist Adolf Seilacher suggests that most of the Ediacaran fossils discovered in the 1940s are not related to any modern forms. Calling them vendobionts, he argues that they went extinct after the emergence of large predators. Seilacher's interpretation, however, will remain in dispute.

Apple Lisa Launched

Introduction of spreadsheet program 1-2-3 by Lotus,

Microsoft Introduced 2-button Mouse

Microsoft Introduces Windows

The famicom is released in Japan

David Raup and Jack Sepkoski publish the controversial claim that mass extinctions are regularly spaced at 26 million years.

Richard Leakey and his team discover Turkana Boy, the most complete Homo erectus fossil yet discovered.

Apple launches Macintosh 128K

Creation of Dell Computer Corporation by Michael Dell

First ARM Processors Powered Up

IBM and Compaq introduce the IDE interface

IBM’s new 3480 cartridge tape system introduced

Introduction of IBM PC/AT based on Intel 80286

Macintosh 512K Launched

Novelist William Gibson coins the term cyberspace

Kenneth Oakley publishes Decorative and Symbolic Uses of Fossils describing, among other things, a hand axe crafted by Homo heidelbergensis featuring a fossil sea urchin, and a fossil urchin set within a bronze locket from a Gallo-Roman temple.

Paleoanthropologists excavate an artifact-rich portion of Cueva de los Aviones in Iberia. Fifty-thousand-year-old perforated and pigment-stained shells from the cave will prompt researchers to argue, 25 years later, that Neanderthals wore both makeup and jewelry.

Commodore 128 Released

Cray X-MP Supercomputer Begins Operation

First Commodore Amiga Released

Introduction of Intel 386

Microsoft Windows Launched

Olivetti buy 49% of Acorn Computers

Steve Jobs founds NeXT Computers Inc.

Norman H. Sleep submits a paper calculating the probability of life forms surviving an extraterrestrial impact in the Hadean Period (first 700 million years of Earth's existence). The paper is rejected on the grounds there would have been no life on Earth yet.

Acorn BBC Master Compact Launched

Acorn BBC Master Launched

Apple Macintosh Plus launched

First PC virus is released with "Brain"

Microsoft moves to corporate campus in Redmond, Washington

Microsoft stock goes public

Nintendo NES released

Kodak scientists invent the world's first megapixel sensor.

Allan Wilson and Rebecca Cann announce that all humans share a common ancestor who lived in Africa as recently as 150,000 years ago. Because the discovery is based on examination of mitochondrial DNA, the ancestral entity will be given the popular (and somewhat misleading) name of "Mitochondrial Eve." The controversial finding will be supported by another discovery in 2000.

Jenny Clack finds Acanthostega, the most complete Devonian tetrapod yet discovered. It has evidence for functional gills as well as legs, strongly suggesting that animals evolved legs while still living in the water.

Kansas rancher Charles Bonner collects a plesiosaur mother-and-fetus fossil. Nearly 25 years later, O'Keefe and Chiappe will describe this as evidence that that plesiosaurs gave live birth and might have been attentive mothers.

Commodore release the Amiga 500 and the Amiga 2000

Macintosh II released

Windows 2 was launched

Dhananjay Mohabey discovers what looks like a simple clutch of dinosaur eggs in India. Twenty-three years later, he, Jeffrey Wilson and colleagues will report that the fossil find includes not just sauropod eggs, but a predatory Cretaceous snake that apparently snacked on hapless sauropod hatchlings.

Molecular biologist John Cairns describes experiments suggesting that bacteria facing environmental stress can "direct" their mutations to produce favorable adaptations. Directed mutation will remain a controversial idea, but the possibility that organisms mutate at a greater rate (hypermutation) under environmental stress will gain more acceptance.

IBM announces 3 millionth PS/2 personal computer

RISC OS is released

The first worm experience appears

The NeXT (68030 CPU) computer is introduced after two years of research

Unisys takes over Convergent Technologies

Sidney Altman and Thomas R. Cech share a Nobel Prize in Chemistry for their discovery of catalytic properties of RNA.

Ned Colbert finally completes his definitive species description of the Coelophysis dinosaurs he found in 1947.

Philip Gingerich finds a fossil whale, Basilosaurus in Egypt. It has tiny legs, just inches long, retaining all five toes. Five years later, he will discover an even more primitive whale ancestor, Rodhocetus, with even bigger hind legs, in Pakistan. Eighteen years later, Hans Thewissen will announce the discovery of another missing link in cetacean evolution: fox- like Indohyus found in Kashmir.

Apple introduces the Macintosh SE/30

Apple Macintosh Portable Released

ICL introduces DRS model 40 and 45

Tim Berners-Lee toyed with the idea of web pages and hyperlinks

The Human Genome Project is launched with the goal of sequencing all 3 billion base pairs of human DNA by 2005.

Mongolia invites the American Museum of Natural History to reinstate excavations in the Gobi desert.

Scott Wing of the Smithsonian Institution discovers the Big Cedar Ridge fossil plant site in Wyoming. The locality will become known as the Pompeii of Cretaceous plants.

Commodore releases the Amiga 3000

Hubble Space Telescope uses 386 processor

Introduction of IBM RS/6000

Microsoft launches Windows 3.0

Chicxulub crater is discovered in the Yucatán Peninsula, supporting the asteroid impact theory first suggested in 1980.

Apple releases the PowerBook 100

First E-mail From Space Is Sent from a Mac Portable

Linus Torvalds from Finland releases Linux version 0.02

Silicon & Synapse founded

Sun Microsystems Starts Java Technology

A team led by Tim White finds the first traces of a hominid fossil that will later be named Ardipithecus ramidus. Seventeen years later, the team will publish a detailed description of a 4.4-million-year-old, 120-centimeter-tall, nearly complete adult female, along with fossils from 35 other individuals. The team will argue that "Ardi" should supplant Lucy at the base of the hominid tree.

Ian Campbell and collaborators publish a paper pointing to the Siberian Traps, an area of massive volcanic activity, as the cause of the Permo- Triassic mass extinction 251 million years ago.

Paleontologists led by Jim Kirkland discover Utahraptor, a super-sized velociraptor that conveniently supports the super-sized velociraptors that will appear in the screen version of Jurassic Park a year later.

Suburban San Diego roadwork uncovers mastodon bones and broken rocks at what becomes known as the (Richard) Cerutti Mastodon site. Roadwork halts while paleontologist Tom Deméré examines the find. Twenty-five years later, Deméré, Cerutti and nine other researchers will contend that the site is evidence of human presence in North America 130,000 years ago.

Joe Kirschvink publishes "Late Proterozoic Low-latitude Glaciation: The Snowball Earth," a short book section in a specialized monograph. This snowball Earth hypothesis will attract little attention until expanded by Paul Hoffman and his collaborators several years later.

Commodore releases the the Amiga 500+

Internet freed from Government control

Microsoft Releases Windows 3.1

Photo CD created by Kodak.

Kary Mullis and Michael Smith share a Nobel Prize in Chemistry, with Mullis cited for his contributions to the developments of methods within DNA-based chemistry and Smith for his fundamental contributions to the establishment of oligonucleiotide-based, site-directed mutagenesis and its development for protein studies.

Richard J. Roberts, and Phillip A. Sharp share a Nobel Prize in Medicine for their discoveries of split genes.

A calcite-encrusted hominid skeleton is discovered in a karst cave near Altamura, Italy. About two decades later, researchers will date the rock layers and test a scapula fragment, eventually concluding that the skeleton is probably 128,000 to 187,000 years old, and ranks among so- called "early Neanderthals."

Geology student Iwan Stossel stumbles across a nearly 400-million-year-old tetrapod fossil trackway on the island of Valentia, County Kerry, Ireland.

J. William Schopf publishes a description of microfossils of the Apex Basalt in Australia. His claims that they are 3.5-billion-year-old microbes that could photosynthesize and produce oxygen will later be challenged. One of his challengers, Martin Brasier, will coauthor a 2011 study on microfossils from a nearby outcrop, claiming that the 3.4-billion- year-old microbes fed off sulfur.

On an expedition in the Gobi desert, paleontologists from the American Museum of Natural History discover the skeleton of an Oviraptor dinosaur crouching over a nest of eggs, apparently incubating them in the same fashion as modern birds.

Roland Anderson and Jennifer Mather publish "Personalities of Octopuses" in the Journal of Comparative Psychology.

Apple Newton Message Pad announced

Commodore released the CD32 model

Compaq Introduces Presario

Foundation of Nvidia

IBM Announces a loss of $4.97m for 1992

Intel Ships "Pentium" Chip"

Introduction of Apple Newton PDA

The Jet Propulsion Laboratory begins work on image-capturing devices using CMOS or active pixel sensors.

Anthropologist Ron Clarke finds previously overlooked foot bones, showing both ape and human qualities, from Sterkfontein. Future finds will associate these bones with a skeleton nicknamed Little Foot.

In what will later be named Chauvet Cave, French cavers discover 32,000-year-old paintings showing 400 animal images.

Netscape Communications Corporation is founded

Silicon & Synapse changes its name to Blizzard Entertainment

Yahoo founded January 1994

Nikon introduces the first optical-stabilized lens.

Edward B. Lewis, Christiane Nüsslein-Volhard, and Eric F. Wieschaus share a Nobel Prize in Medicine for their discoveries concerning the genetic control of early embryonic development.

Lee Berger and Ron Clarke publish an article in the Journal of Human Evolution arguing that the Taung child, discovered in 1924, may have been killed by a bird of prey.

Microsoft launches Windows 95

Nvidia's NV1 launched

"Kodak DC40 and the Apple QuickTake 100 become the first digital cameras marketed for consumers."

Using "molecular clock" estimates of mutation rates, Greg Wray and collaborators hypothesize that metazoan phyla diverged from each other 1 billion years ago, or even earlier. In other words, they argue that metazoans existed hundreds of millions of years before the earliest metazoan fossils (about 600 million years old) yet found.

Alan Walker and Pat Shipman publish a description of advanced Vitamin A poisoning in a 1.7-million-year-old Homo erectus skeleton. They assert that it is evidence of both meat eating, caused by consuming the liver of a large carnivore, and sufficient sociability in Homo erectus to care for an ill and incapacitated individual.

Chen Pei Ji unveils Sinosauropteryx prima from Liaoning, China, the first feathered dinosaur discovered, at the Society of Vertebrate Paleontology's annual meeting. Fourteen years later, a team of Chinese and British paleontologists will argue that this animal had a striped tail, a reddish color alternating with white, based on pigment-rich microscopic spheres in the fossilized feathers.

The roughly 9,000-year-old Kennewick Man skeleton is found in the northwestern United States. Craniometric analysis initially suggests an affiliation to Ainu and Polynesian groups. Better DNA sampling methods will finally allow genetic analysis nearly 20 years later, and that will indicate a relationship closest to modern Native Americans.

Tim White's team discovers horse, antelope and other mammal bones with cut marks from stone tools — evidence of tool use 2.5 million years ago.

Apple Computer buys NeXT

eBay is founded by Jeff Skoll and Pierre Omidyar

Eastman Kodak, FujiFilm, AgfaPhoto, and Konica introduce the Advanced Photo System (APS).

A team of archaeologists finds evidence of human occupation 14,000 years ago at Monte Verde, Chile, pushing back the arrival date of humans in the Americas.

Excavations near Koblenz in northern Germany turn up a Neanderthal skullcap, estimated at 170,000 years old, that was apparently used as a bowl.

Paleontologist Karen Chin receives a 17-inch coprolite excavated in Saskatchewan. Estimated at 65 million years old and full of crunched bone, it is likely the calling card of a T. rex.

Paleontologist Paul Sereno discovers the delicate Darth Vader-like skull of a dinosaur he will later name Nigersaurus taqueti and nickname the "Mesozoic Cow."

Two 5-foot-long Humboldt squid in the Sea of Cortez "mug" a diver working on a PBS documentary, making off with the gold chain hanging around the diver's neck, and demonstrating that Humboldt squid have bad manners but good taste.

IBM's Deep Blue Beats Gary Kasparov at Chess

IBM announces RS/6000 SP Deep Blue

zon.com, an online bookseller, goes public

first known publicly shared picture via a cell phone, by Philippe Kahn.

Andrew Parker publishes a paper suggesting that some Cambrian animals (Wiwaxia, Canadia and Marella) developed flickering displays of iridescent color at about the same time that eyes evolved.

Aterian artifacts (named for stone tools discovered in Algeria in 1917) are estimated at 70,000 years old at sites in Libya. Over the next dozen years, the age of artifacts found at various sites in northern Africa will be pushed back to at least 110,000 years old.

Xiao, Zhang and Knoll describe fossilized animal embryos in Nature. Li, Chen and Hua simultaneously describe embryos in Science. The fossils all come from the Doushantuo phosphorites in southern China, and all are estimated to be about 570 million years old, making them the oldest fossil embryos so far discovered. Nine years later, however, Bailey and collaborators will challenge this interpretation, arguing the "fossil embryos" could just as easily be large bacteria. That challenge will be answered by the announcement of fossil embryos inside egg cysts.

Paul Hoffman, Alan Kaufman, Galen Halverson and Daniel Schrag publish a Neoproterozoic snowball Earth theory arguing that in the late Precambrian, the Earth underwent global glaciations followed by extreme greenhouse conditions, spurring the evolution of multicellular life forms.

Apple Release the iMac

Foundation of Google by Larry Page and Sergey Brin

Introduction of Apple iMac

Microsoft launches Windows 98

Pierre-Jean Texier and colleagues begin studying etched ostrich shells from Diepkloof Rock Shelter in Western Cape, South Africa. Eleven years later, they will argue that the artifacts, numbering roughly 280, show evidence of graphic communication dating back 60,000 years.

Chinese paleontologists discover an exceptionally well-preserved feathered dinosaur, probably a juvenile dromaeosaur. Citing the confusion caused by language barriers and jet lag, the paleontologists' American collaborators nickname the fossil "Dave the fuzzy raptor," after a character alluded to in a Cheech and Chong routine. This fossil will be assigned to the genus Sinornithosaurus. (The next fuzzy discovery will be nicknamed "Chong.")

Napster the first file sharing program introduced

Nvidia releases GeForce 256

The Millennium bug is taken seriously

Based on studies of Y chromosomes, Peter Underhill publishes his finding that all modern humans share a common ancestor, bolstering the 1987 announcement from Cann and Wilson. This suggests a "bottleneck" event (population crash) among human ancestors living in Africa roughly 150,000 years ago.

Sally McBearty and Alison Brooks publish "The Revolution that Wasn't" challenging the long-held notion of a "big bang" in human intellectual evolution approximately 40,000 years ago. Instead, they cite evidence for earlier appearances of modern behavior.

A research team led by Paul Sereno discovers Rugops primus ("first wrinkle face") in the Sahara. This dinosaur's resemblance to South American fossils suggests that Africa separated from the ancient landmass of Gondwana more recently than previously thought.

Phil Currie publishes a paper suggesting that T. rex was a social animal that hunted in packs.

Intel ES7000 server from Unisys introduced

Microsoft launches Windows 2000

J-SH04 introduced by J-Phone, the first commercially available mobile phone with a camera that can take and share still pictures.[13]

Alfred Sturtevant's A History of Genetics is republished jointly by the Electronic Scholarly Publishing Project and the Cold Spring Harbor Laboratory Press. Sturtevant provides an insider's perspective (he created the FIRST GENETIC MAP ) to this first-rate summary of the foundations of classical genetics.

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The International Human Genome Sequencing Consortium (Human Genome Project) publishes the initial sequence and analysis of the human genome in Nature Magazine. Celera Genomics simultaneously publishes a draft human genome sequence in Science Magazine.

Leland H. Hartwell, R. Timothy Hunt, and Sir Paul M. Nurse share a Nobel Prize in Medicine for their discoveries of key regulators of the cell cycle.

Chris Henshilwood and collaborators discover and describe 77,000-year-old artwork: stones carved with lines and triangles, from Blombos Cave on the Southern Cape coast of Africa. Three years later, Henshilwood and collaborators will describe more Blombos artifacts: tiny snail shells that were apparently pierced and worn as jewelry about 76,000 years ago. A few years after that, another research team will describe similar shell beads, at least 100,000 years old, in Israel and Algeria.

Joshua Smith and collaborators publish a description of a giant sauropod from Egypt, possibly the largest Cretaceous sauropod yet discovered. It is considered a possible food source for three large carnivorous dinosaur species discovered decades earlier by Ernst Stromer.

Luann Becker and collaborators publish a paper describing carbon fullerenes (buckyballs) at the Permo-Triassic boundary in China, Japan and Hungary. Because they can occur in meteorites, the fullerenes are cited as evidence of a meteorite impact at the end of the Permian. Other scientists will have difficulty reproducing their results, however, and the researchers' claim will remain controversial.

Odin and Néraudeau publish a description of a Neanderthal flint tool found in southwestern France with a fossil sea urchin on one side.

Apple Launches a New Music Device - The iPod

Microsoft Releases Windows XP

Sydney Brenner, H. Robert Horvitz, and John E. Sulston share a Nobel Prize in Medicine for their discoveries concerning genetic regulation of organ development and programmed cell death.

David Lordkipanidze and collaborators excavate a 1.77-million-year-old Homo erectus skull of a "toothless old man" in Dmanisi. New bone growth after the loss of his teeth suggests that he was cared for by others, the oldest evidence yet found of care for the sick in fossil hominids.

Michel Brunet and collaborators publish a description of Sahelanthropus tchadensis, a hominid fossil from western central Africa. Suspected to be 6 to 7 million years old, it is possibly the oldest hominid fossil yet found. Its location, in Chad, is expected to spur hominid fossil hunting west of Africa's Rift Valley.

Microsoft and partners launch Tablet PC

M.R. Sánchez-Villagra, O. Aguilera and I. Horovitz publish a description of Phoberomys, a fossil rodent from Venezuela the size of a buffalo.

Paleontologists in Germany identify the world's oldest pantry: an underground burrow system probably dug by an extinct species of ground squirrel or hamster. Estimated at 17 million years old, the food stash is stuffed with more than 1,800 fossilized nuts.

Paleontologists led by John Horner find a T. rex fossil that will later yield evidence of blood vessels and blood cells. The fossil will also prove to be an egg-laying female.

Two separate teams, digging 2,000 miles apart, find two new Antarctic dinosaurs in the same week. One appears to be a Jurassic sauropod, the other a Cretaceous theropod.

Microsoft launches Windows Server 2003

Peter Brown, Mike Morwood and collaborators announce the find of a 1-meter- tall hominid skeleton on the Indonesian island of Flores. Found near the remains of giant lizards and pygmy elephants, the new species is formally named Homo floresiensis and nicknamed the "hobbit." Though some suspect it's a kind of malformed, small-brained midget, this interpretation will be answered by braincase scans, wrist bones too primitive to be Homo sapiens, and the announcement of several more individuals of the same species. Later studies will suggest direct ancestry from Homo erectus, although another study will argue the remains really indicate Down syndrome. The species is initially given an estimated age as young as 11,000 years, but later research will indicate an age of at least 50,000 years.

A 70-million-year-old mammal jaw is found in Pui, Romania, some 100 miles from Vlad Dracula's castle. Eleven years later, the animal will be formally named Barbatodon transylvanicus by scientists who note that strengthening iron, not blood drinking, gives the teeth their bright red color.

D. Néraudeau describes deposits in western France revealing hundreds of Acheulian and Mousterian tools, 12 of them bearing fossils.

Heather Wilson and Lyall Anderson publish a paper describing the oldest land animal fossil yet discovered: Pneumodesmus newmani, a 428-million- year-old, centimeter-long millipede found by amateur fossil hunter Mike Newman.

M.-Y. Zhu and collaborators publish a description of munched trilobite parts inside another arthropod, confirming earlier suspicions that other animals snacked on the little water bugs.

Naama Goren-Inbar and her team announce the discovery of controlled fire use by hominids at a 790,000-year-old site in Israel, pushing the earliest known use of fire back 300,000 years from previous estimates.

Qingjin Meng and collaborators publish a description of an adult Psittacosaurus dinosaur associated with 34 juveniles, apparent evidence of parental care.

The British Museum begins an excavation project at Happisburgh in Norfolk. Over the next six years, researchers will uncover artifacts pushing back the earliest evidence of human activity at such a high latitude — 45 degrees — to perhaps as much as 950,000 years ago.

Using CT scans on femurs of the early hominid Orrorin tugenensis discovered in Kenya, Galik and collaborators push back the development of bipedalism in hominids to 6 million years ago (2 million years earlier than in Australopithecus anamensis).

X. Wang and Z. Zhou publish a description of the first known pterosaur egg containing an exquisitely preserved embryo. Though the egg is slightly smaller than the average chicken egg, the embryo sports a 27-centimeter wingspan. Several months later, Z. Zhou and F. Zhang publish a description of a Cretaceous bird embryo, the first found with feathers.

A team of Japanese researchers take the first photograph ever of a giant squid in the wild. Unfortunately, they rip off one of the poor creature's tentacles in the process.

The International Union of Geological Sciences adds a new period to the Earth's geologic timescale: the Ediacaran. Ranging from approximately 600 million years ago to 542 million years ago, it begins after the last Snowball Earth ice age and precedes the Cambrian. It's the first new geologic period designated in 120 years.

Firefox 1.0 Introduced

First Ubuntu Linux operating system Released

Microsoft returns $75 billion to shareholders

M.A. Whyte announces the discovery of a 330-million-year-old trackway of a 5-foot-long, six-legged water scorpion (eurypterid) that could walk on land while the first tetrapods tried to do the same thing. Two years later, Simon Braddy, Markus Poschmann and collaborators will announce the find of fossil claw from an 8-foot eurypterid.

Yaoming Hu, Jin Meng, Yuanqing Wang and Chuankui Li publish a description of two large carnivorous mammals from the Cretaceous, one of which appears to have the remains of a diminutive dinosaur in its stomach. These fossils overturn long-held notions that Mesozoic mammals were all rat-sized plebeians scurrying around dinosaur feet.

Yohannes Haile-Selassie and colleagues announce the find of a nearly 4- million-year-old hominid from Ethiopia, possibly the remains of Australopithecus anamensis.

Adrian Glover and Thomas Dahlgren announce the discovery of a new species of marine worm, discovered off the Swedish coast, that lives on whale bones on the sea floor. They name the species Osedax mucofloris.

Google now indexes over 8 billion pages

AgfaPhoto files for bankruptcy. The production of Agfa brand consumer films ends.

Jean Moliner, Gerhard Ries, Cyril Zipfel and Barbara Hohn publish their findings on stressed plants that not only mutate at a greater rate, but also pass an increased mutation tendency to their offspring.

Andrew Z. Fine and Craig C. Mello share a Nobel Prize in Medicine for their discovery of RNA interference — gene silencing by double-stranded RNA.

Roger D. Kornberg was awarded a Nobel Prize in Chemistry for his studies of the molecular basis of eukaryotic transcription.

Jin Meng and collaborators describe a Mesozoic gliding mammal that pushes back the origin of mammalian flight by 70 million years, and suggests mammals maybe dabbled in flight earlier than birds.

Qiang Li and colleagues describe Castorocauda lutrasimilis, a Jurassic mammal that looked something like a mix between a beaver, otter, and platypus. Their discovery pushes back mammalian adaptation to an aquatic lifestyle by more than 100 million years.

The Research Council of Norway announces that oil drillers have struck a piece of dinosaur bone off the country's coast. At 1.4 miles below the North Sea, the bone fragment obtains the status of the world's deepest dinosaur.

Zeresenay Alemseged and collaborators publish a description of a 3.3- million-year-old partial skeleton from a juvenile Australopithecus afarensis from Ethiopia. The remains indicate that the australopithecene toddler walked upright and climbed trees.

Paleontologist Neil Clark suggests that some Loch Ness "sightings" may have been inspired by partial glimpses of traveling circus elephants taking dips in the lake.

Microsoft announces Bill Gates transition

Dalsa produces a 111 megapixel CCD sensor, the highest resolution at that time.

Divers find a submerged cavern in the Yucatán and name it Hoyo Negro. The cavern contains the remains of a teenage female who likely died between 12,000 and 13,000 years ago.

Mario R. Capecchi, Sir Martin J. Evans, and Oliver Smithies share a Nobel Prize in Medicine for their discoveries of principles for introducing specific gene modifications in mice by the use of embryonic stem cells.

Fred Spoor, Meave Leakey and collaborators describe remains of Homo habilis and Homo erectus from the same rock layer a short distance apart. The finds suggest that the two species coexisted in the same area for up to 500,000 years, and that H. erectus probably did not descend from H. habilis as previously thought.

John Kappelman and collaborators announce the find of a 500,000-year-old hominid skull from Turkey showing signs of tuberculosis. The researchers argue that condition could be induced by a Vitamin D deficiency resulting from a dark-skinned individual migrating to an area with less sunlight.

Kate Trinajstic and collaborators announce the discovery of 380-million- year-old Australian fossil fish sporting fossilized muscle.

Xing Xu and collaborators describe Gigantoraptor erlianensis, a 25- foot-long, 3,000-pound, bird-like dinosaur from Inner Mongolia. The find runs counter to earlier assumptions that dinosaurs necessarily got smaller as they acquired more features resembling those of birds.

iPhone introduced

Microsoft launches Windows Vista and Office 2007

After studying grunting fish, Andrew Bass and colleagues report that the part of the brain controlling volcalization is extremely primitive, and propose that vertebrates evolved the ability to communicate through sound some 400 million years ago.