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Leonardo da Vinci as comparative anatomist: human leg vs. canine leg.

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Leonardo da Vinci produces his Codex on the Flight of Birds, a relatively short codex. It comprises 18 folios and measures 21 × 15 centimetres. Now held at the Royal Library of Turin, the codex begins with an examination of the flight behavior of birds and proposes mechanisms for flight by machines. Leonardo constructed a number of these machines, and attempted to launch them from a hill near Florence. However, his efforts failed. In the codex, Leonardo notes for the first time that the center of gravity of a flying bird does not coincide with its center of pressure.

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Leonhart Fuchs publishes his new herbal De historia stirpium commentarii insignes in Basel. It was illustrated by: Albrecht Meyer, who made drawings based on the actual plants; Heinrich Füllmaurer, who transferred the drawings to woodblock; and Vitus Rudolph Speckle, who cut the blocks and printed the drawings. It covers about 497 plants and has over 500 woodcut illustrations. Over 100 of the plants in the book were first descriptions. The University of Glasgow states that it is considered a landmark work in its field. Stanford University Press considers it one of the best illustrated books of all time and a masterpiece of the German Renaissance. It set a new standard for accuracy and quality, as well as being the first known publication of plants from the Americas, such as pumpkin, maize, marigold, potato, and tobacco. Plants were identified in German, Greek, and Latin, and sometimes English. The book was initially published in Latin and Greek and quickly translated into German. Just during Fuchs' lifetime the book went through 39 printings in Dutch, French, German, Latin, and Spanish and 20 years after his death was translated into English.

Andreas Vesalius (Andries van Wesel) publishes the anatomy treatise De humani corporis fabrica (On the Workings of the Human Body).

Orto botanico di Pisa botanical garden established by Cosimo I de' Medici, Grand Duke of Tuscany, under the direction of Luca Ghini, who also creates the first herbarium.

William Turner's Avium praecipuarum, quarum apud Plinium et Aristotelem mentio est, brevis et succincta historia is published in Cologne, the first printed book devoted entirely to ornithology.

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German minerologist Georgius Agricola publishes De Natura Fossilium (On the Nature of Fossils), the first published paleontological treatise.

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Cornelius Gemma publishes the first illustration of a human tapeworm.

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Guillaume Rondelet publishes a volume on Mediterranean fish — De Piscibus — and includes the assertion that glossopetrae, or tongue stones, resemble shark teeth. The hypothesis attracts little attention.

Roman naturalist Ippolito Salviani publishes History of Aquatic Animals.

Pierre Belon publishes L'Histoire de la nature des oyseaux, a pioneering work in the comparative anatomy of birds.

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Conrad Gessner publishes De Omni Rerum Fossilium ("A Book of Fossil Objects").

Antwerp doctor Samuel Quiccheberg publishes a description of the curiosity cabinet of Hans Jakob Fugger, including items from the animal, vegetable and mineral world.

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Andrea Cesalpino publishes De Plantis, ordering plants in families. In his works he classified plants according to their fruits and seeds, rather than alphabetically or by medicinal properties. In 1555, he succeeded Luca Ghini as director of the botanical garden in Pisa.

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Jacques Dal champs publishes Historia generalis plantarum in Lyon, describing 2,731 plants, a record number for this time.

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José de Acosta publishes Natural and Moral History of the Indies describing such weird creatures as iguanas.

Girolamo Porro produces a plan for a botanical garden at Padua, arguably expecting to assemble all the world's plants. Over the next century, well- traveled naturalists will abandon such goals as unrealistic.

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The tulip bulbs planted by Carolus Clusius in the Hortus Botanicus Leiden, Holland, first flower.

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Jean Bauhin, a former student of Conrad Gesner's, publishes a monograph of the medicinal waters and surrounding environment of the German fountains at Boll, the first publication of a complete set of fossils from a specific location.

After being separated from the main Second Dutch Expedition to Indonesia fleet of Admiral Wybrand Van Warwyck, three ships under Jacob Cornelisz. van Neck land on the island which they name Mauritius and sight the dodo bird (Raphus cucullatus); it will become extinct around 1681.

Lawyer Carlo Ruini's Anatomia del cavallo is published posthumously in Venice. This anatomy of the horse is the first published of any non-human animal.

Ferrante Imperato publishes Dell'Historia Naturale (Natural History) attempting to catalog all of nature's animal, vegetable and mineral forms. He illustrated the book with his own cabinet of curiosities displayed at Palazzo Gravina in Naples. The engraving became the first pictorial representation of a Renaissance humanist's displayed natural history research collection.

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Ulisse Aldrovandi publishes De Animalibus Insectis.

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Fabio Colonna publishes "Dissertation on Tongue Stones" arguing that "nobody is so stupid" that he or she will not agree that tongue stones are really shark teeth. Like Rondelet several decades earlier, he attracts little attention.

Italian philosopher Lucilio Vanini suggests that humans descended from apes. In 1618 Vanini is arrested and, after a prolonged trial, condemned to have his tongue cut out, to be strangled at the stake and to have his body burned to ashes. The sentence was executed on 9 February 1619.

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Gaspard Bauhin publishes Pinax Theatri Botanici describing some 6,000 plants.

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Aurochs go extinct.

William Harvey publishes Exercitatio Anatomica de Motu Cordis et Sanguinis in Animalibus (Latin for "An Anatomical Exercise on the Motion of the Heart and Blood in Living Beings"). The book established the circulation of the blood and was a landmark in the history of physiology. Just as important as its substance was its method. Harvey combined observations, experiments, measurements, and hypotheses in extraordinary fashion to arrive at his doctrine. His work is a model of its kind. It had an immediate and far-reaching influence on Harvey's contemporaries. In the book, Harvey investigated the effect of ligatures on blood flow. The book also argued that blood was pumped around the body in a "double circulation", where after being returned to the heart, it is recirculated in a closed system to the lungs and back to the heart, where it is returned to the main circulation.

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Francesco Stelluti publishes a summary of research on fossil wood conducted by himself and fellow Lincean Academy member Federico Cesi. Though resulting from meticulous research, the work reaches the wrong conclusion, describing the origin of fossil wood as inorganic.

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Calvinist lawyer Isaac La Peyrère seeks permission to publish his manuscript claiming that people have existed before Adam, and that Chaldeans can legitimately trace their civilization back 470,000 years. Permission is denied, but he will publish Men Before Adam anonymously 14 years later, inciting both outrage and mild amusement among religious leaders.

Dutch anatomist Nicolaas Tulp produces the first formal description of an ape (a chimp, bonobo or orangutan).

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Workers dig up a skeleton in Flanders. A court physician to the Danish king observes the excavation, measures the skeleton in "Brabantian cubits," and attributes the skeleton to a giant. It will later be identified as a fossil proboscidian.

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Franciscus Hackius publishes a lavish book on the natural history and medicines available from Brazil, Historia Naturalis Brasileae.

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William Harvey publishes Exercitationes de generatione animalium (On Animal Generation) explaining that all animal life begins as eggs, whether in birds, amphibians or mammals. According to Joseph Needham, in this work Harvey: (1) presented a doctrine of omne vivum ex ovo (all life comes from the egg), the first definite statement against the idea of spontaneous generation; (2) denied the possibility of generation from excrement and from mud, and pointed out that even worms have eggs; (3) identified the citricula as the point in the yolk from which the embryo develops and the blastoderm surrounding the embryo; (4) destroyed once and for all the Aristotelian (semen-blood) and Epicurean (semen-semen) theories of early embryogeny; and (5) settled the long controversy about which parts of the egg were nutritive and which was formative, by demonstrating the unreality of the distinction.

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Danish scholar Ole Worm publishes Musei Wormiani Historia, a successful book about his cabinet of natural curiosities.

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John Tradescant deeds his family treasures to fellow collector Elias Ashmole. Ashmole will later donate the collection to Oxford University, stipulating that a separate building is to be constructed for it.

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German physician Otto von Guericke pieces together bones from different species to make a fossil "unicorn."

In his private museum in Rome, Virgilio Romano exhibits a Hippopotamus major canine tooth found in Pleistocene gravels along the Via Nomentana.

Thomas Willis publishes The Anatomy of the Brain and Nerves.

Robert Hooke observes cork under a microscope and uses the word cells to describe the tiny chambers that he sees. He publishes drawings of these cells, of fleas, and of other small creatures, in his book Micrographia.

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Niels Stensen (Steno) describes his dissection of the head of a giant white shark and correctly identifies shark teeth, still generally thought (despite arguments to the contrary from Rondelet and Colonna in the preceding century) to be serpent tongues.

Natural historian John Somner finds woolly rhino teeth near Canterbury in Kent, and figures they might be the remains of a sea monster. As he will die before he can publish his conclusions, his brother William will print his article A Brief Relation of Some Strange Bones There Lately Digged Up In Some Grounds of Mr. John Somner.

Francesco Redi publishes Esperienze Intorno alla Generazione degli Insetti (Experiments on the Generation of Insects), which is regarded as his masterpiece and a milestone in the history of modern science. At the time, prevailing wisdom was that maggots arose spontaneously from rotting meat. Redi took six jars and divided them into two groups of three: In one experiment, in the first jar of each group, he put an unknown object; in the second, a dead fish; in the last, a raw chunk of veal. Redi covered the tops of the first group of jars with fine gauze so that only air could get into it. He left the other group open. After several days, he saw maggots appear on the objects in the open jars, on which flies had been able to land, but not in the gauze-covered jars. In the second experiment, meat was kept in three jars. One of the jars was uncovered, and two of the jars were covered, one with cork and the other one with gauze. Flies could only enter the uncovered jar, and in this, maggots appeared. In the jar that was covered with gauze, maggots appeared on the gauze but did not survive. Knowing full well the terrible fates of out-spoken thinkers such as Giordano Bruno and Galileo Galilei, Redi was careful to express his new views in a manner that would not contradict theological tradition of the Church; hence, his interpretations were always based on biblical passages, such as his famous adage: omne vivum ex vivo ("All life comes from life").

Jan Swammerdam dissects a caterpillar for Cosimo de Medici, demonstrating that the butterfly wings already exist inside the caterpillar's body. A year later, he will publish Historia Insectorum Generalis.

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Agostino Scilla publishes Vain Speculation Undeceived by Sense arguing for the organic origin of fossils.

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Apothecary and antiquary John Conyers finds an elephant tusk and a nearby handaxe about 12 feet below ground at Gray's Inn Lane, London. The Gray's Inn Lane handaxe will later be dated at 350,000 years old.

Leeuwenhoek begins corresponding with the Royal Society of London describing his discoveries under the microscope.

Antonie van Leeuwenhoek creates a simple microscope with only one lens. He developed glass-handling techniques that allowed him to create lenses with magnifying power up to 270x — by far the most powerful magnifying lenses available. Although compound microscopes had been invented in the 1590s, nearly forty years before Leeuwenhoek was born, there were technical difficulties in building them, meaning that early compound microscopes (such as used by Robert Hooke) had a maximum magnification of only 20x or 30x. Leeuwenhoek's more powerful lenses allowed him to discover protozoa and other single-celled organisms and to be the first to observe bacteria.

Jan Swammerdam publishes a treatise on the mayfly entitled A Figure of Man's Miserable Life.

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Royal Society member Neremiah Grew examines the "sea serpent teeth" found by John Somner in 1668 and recognizes that they are rhino teeth.

Amsterdam physician Gerard Blasius publishes Anatome Animalium examining animals' internal anatomy and skeletal structure.

Neremiah Grew publishes The Anatomy of Plants with microscopic observations of plant features.

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Dublin doctor Thomas Molyneux shows that a "giant's tooth" from the collection of Ole Worm really belongs to a whale, and a "giant's hand" shown in London is really the fin of a porpoise.

Filippo Buonanni publishes Ricreatione dell' occhio e della mente. — perhaps the first book devoted entirely to shells, for which he is considered a founder of conchology.

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Timothy Nourse anticaptes eugenics with the argument that a gentleman "ought at least to be as careful of his race as he is of that of his horses, where the fairest and most beautiful are made choice of for breed."

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Giovanni Ciampini describes remains of the extinct straight-tusked elephant, Elephas antiquus, found in the town of Vitorchiano in the region of Latium.

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Naturalist John Ray publishes Three Physicotheological Discourses about the Creation, the Deluge and the Conflagration, discussing conflicting theories about the nature of fossils.

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Edward Lhwyd publishes a description of a "flatfish" in the Philosophical Transactions of the Royal Society. (The flatfish is really a trilobite, an ancient marine arthropod.)

Edward Lhwyd publishes a book devoted to British fossils. In it, he describes ichthyosaur remains as those of a fish.

Based on a dissection he performed the year before, Edward Tyson publishes Orang Outan, sive Homo sylvestris pointing out similarities between chimpanzee and human anatomy. (Although he has dissected an infant chimp, Tyson uses the term "orang-outan.")

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A giant fossil tooth is found along the banks of the Hudson River. It will initially be identified (by Cotton Mather) as that of a human giant who perished in Noah's flood, then correctly identified (by Georges Cuvier) as that of a mastodon.

Maria Sibylla Merian publishes Metamorphosis Insectorum Surinamensium describing insect species and other animals she has studied in Surinam.

The Ambonese Curiosity Cabinet by G.E. Rumphius is published. It provides detailed descriptions of soft and hard shellfish, minerals, rocks and fossils from Indonesia.

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Hans Sloane publishes the first of two volumes describing the natural wonders of Jamaica. (The second volume will be published in 1725.)

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In Physico-theology, or a demonstration of the being and attributes of God from His works of creation William Derham tries to show that this is the best of all possible worlds.

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William Stukely publishes An Account of the Almost Entire Sceleton of a Large Animal in a Very Hard Stone. The fossil is a plesiosaur, but is identified as a crocodile.

Dutch pharmacist Albertus Seba inventories his wonder cabinet for the avid collector Peter the Great, including 1,000 European insects and 400 animal specimens. The czar buys the inventory, and Seba begins his second collection, which he will describe in print starting in 1734.

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Balthasar Ehrhart identifies belemnites as fossil cephalopods.

Hans Sloane publishes two papers on fossils found in Siberia and North America arguing that they are fossil elephants, not giants or monsters.

In An Attempt towards a Natural History of England, John Woodward describes three "pinecones" that, upon later examination, will prove to be coprolites.

Louis Bourget's Lettres philosophiques sur la formation des sels et de cristaux et sur la génération et la méchanique organique (Philosophical letters on the formation of salts and crystals and on generation and organic mechanisms) makes the distinction between organic and inorganic growth.

Otto Müller is among the first to see bacteria since Leeuwenhoek and the first to classify them into types.

Jethro Tull's Horse-hoeing husbandry advocates the use of manure, pulverization of the soil, growing crops in rows, and hoeing to remove weeds.

Nöel-Antoine Pluche publishes the first of eight volumes of Le spectacle de la nature (Spectacle of nature), popularizing "natural theology" in France.

Stephen Hales' Statical essays, containing haemastatics, etc., two volumes, reports his investigations on blood flow and pressure in animals and the hydrostatics of sap in plants.

René de Réamure's Mémaoires pour servir à l'histoire des insects (History of insects) is one of the foundation works in entomology.

Systema Naturae (System of Nature) by Carolus Linnaeus introduces the system of classification for organisms that is still in use today.

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Hermann Boerhaave prints Jan Swammerdam's Biblia naturae (Bible of nature), which was originally published to little notice in 1658. It contains his reports on the dissection of insects under a microscope.

Linnaeus's Genera Plantorum (Genera of Plants) explains his method of systematic botany and classifies 18,000 species of plants.

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Native Americans traveling with French soldiers find mastodon fossils along the Ohio River. The bones will be shipped back to France and become the first American fossils studied by scientists.

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Abraham Trembley makes the first permanent graft of animal tissue, using the Hydra.

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Abraham Trembley's Mémoires summarizes his research on the hydra and his discovery of regeneration in polyps.

Scholar and teacher Abraham Trembley publishes Mémoires Concerning the Natural History of a Type of Freshwater Polyp with Arms Shaped Like Horns. After watching them move and eat, he has concluded that the simple creatures (later to be classified as cnidarians) are animals, not plants.

Traité d'insectologie (Treatise on insect ecology) by Charles Bonnet describes his observations on parthenogenetic reproduction and metamorphosis of aphids.

Bologna physician Vincenzo Menghini roasts the blood of fish, birds and mammals (including humans) then sifts through the residue with a magnetic blade, noting that roasted-blood particles adhere to it. The experiment provides evidence that blood contains iron.

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Andreas Marggraf discovers sugar in beets, laying the foundation for Europe's sugar-beet industry.

L'homme Machine (Man the Machine) by Julien Offray de la Mettrie describes humans as machines, without freedom or will.

Georges-Louis Leclerc de Buffon publishes the first volume of Historie Naturelle. Thirty-six volumes came out between 1749 and 1789, followed by eight more after his death. The Histoire Naturelle was meant to address the whole of natural history, but actually covers only minerals, birds, and the quadrupeds among animals. It is accompanied by some discourses and a theory of the earth by way of introduction, and by supplements including an elegantly written account of the epochs of nature. The Histoire Naturelle had a distinctly mixed reception in the eighteenth century. Wealthy homes in both England and France purchased copies, and the first edition was sold out within six weeks. But Buffon was criticised by some priests for suggesting (in the essay Les Epoques de Nature, Volume XXXIV) that the earth was more than 6,000 years old and that mountains had arisen in geological time. The Paris faculty of theology, acting as the official censor, wrote to Buffon with a list of statements in the Histoire Naturelle that were contradictory to Roman Catholic Church teaching. In June, 2017, an antiquarian book deal offered a complete second edition of the Historie Naturelle for 14500 .

Carolus Linnaeus's Philosophia Botanica rejects any notion of evolution and continues his work in classifying plants.

John Needham publishes Nouvelles Observations Microscopiques arguing that decomposing plant and animal matter can spontaneously generate new life. Fifteen years later, Italian polymath Lazzaro Spallanzani will conduct a more careful set of experiments then publish a report rejecting Needham's conclusions.

Linnaeus's Species Plantarum completes his development of the use of binary nomenclature in botany. The work still provides the foundation for the modern classification of species.

Pierre-Louis de Maupertuis's Système de la Nature provides a theoretical speculation on heredity and the origin of species by chance.

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Henri-Louis Duhamel du Monceau discovers that when he turns a seedling upside down, its roots and shoots reorient so that the root continues to grow downward while the shoot continues to grow upward.

In Theoria Generationis (his MD dissertation), Caspar Friedrich Wolff claims the existence of a vis essentialis — an essential force — that is at the heart of all living matter. He also describes the differentiation of tissues in a developing embryo, refuting the preformation concept — the idea that development consists in the growth of a fully formed, but miniature individual. His views were not well received.

The Kew Botanical Gardens open in London.

Joseph Gottlieb Kölreuter'S Vorläufige nachricht von einigen das geschlecht der pflantzen betreffende versuche and beobachtungen describes his research in heredity in plants.

Jean-Baptiste Robinet's five-volume De la nature claims that organic species form a linear scale of progress, without gaps.

Between 1761 and 1766, Joseph Gottlieb Kölreuter (Germany) demonstrates that hybrid offspring receive traits from both parents (pollen and ovule transmit genetic information), and are intermediate in most traits. First scientific hybrid produced (tobacco). Demonstrates the identity of reciprocal crosses. Notes hybrid vigor, segregation of offspring (parental and non-parental types) from a hybrid.

Charles Bonnet's Considerations sur les corps organisées gives his theory of "preformation" — the idea that each creature is already preformed in miniature in the egg, and that the egg contains all future generations in even smaller scale, ad infinitum.

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Italian biologist Lazzaro Spallanzani suggests preserving food by sealing it in containers that do not permit air to penetrate.

Albrecht von Haller is the first to show that nerves stimulate muscles to contract and that all nerves lead to the spinal cord and the brain.

Benjamin Franklin writes a thank-you letter to a wealthy Irish trader for a box of proboscidian "tusks and grinders." Franklin believes the remains belong to elephants but makes astute observations about how their climate must have differed from the present.

Lazzaro Spallanzani's Prodromo d'un ouvrage sur les reproductions animales (Foreword to a work on animal reproduction) tells of his demonstration that spontaneous generation of animals does not take place in tightly closed bottles that have been boiled for more than 30 minutes.

Caspar Friedrich Wolff's De formatione intestinarum establishes principles of the formation of organs in embryos.

Charles Bonnet's Philosophical palingenesis, or ideas on the past and future states of living beings contains his view that the females of every species contain the germs of all future generations.

Erasmus Darwin has the allegorical motto E conchis omnia or "Everything from shells" painted on his carriage, promoting the idea of common descent. Bowing to social pressure, he removes it shortly thereafter.

In Gailenreuth Cave in Germany, Father Johann Esper finds human bones underlying those of extinct animals. He concludes that the bones got there by accident, an opinion Cuvier will share.

Italian anatomist Luigi Galvani discovers accidentally the action of electricity on the muscles of the dissected frog: it causes a twitch.

Joseph Priestly discovers that a plant can produce enough breathable air to sustain a mouse and keep a candle burning. Though he describes it in different terms, he has discovered oxygen.

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Franz Anton Mesmer suggests that "animal magnetism" causes attractions between certain persons. Mesmer's name becomes the root of the English verb "mesmerize".

Johann Christian Fabricius's Systema Entomologiae classifies insects based on the structure of mouth organs rather than wings.

Abbé Jacques-François Dicquemare describes reptilian fossils in Journal de Physique but refrains from speculating about their sources.

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Jan Ingenhousz discovers two distinct respiratory cycles in plants: at night oxygen is absorbed and carbon dioxide is exhaled; during the day carbon dioxide is absorbed and oxygen is exhaled. The exact nature of the exhaled gases becomes clear with the later discoveries by Lavoisier.

Jan Ingenhousz discovers photosynthesis: In Experiments on Vegetables Ingenhousz shows that sunlight is essential for the production of oxygen by leaves.

The peculiar inheritance of human color-blindness reported to The Royal Society of London by Michael Lort.

Lazzaro Spallanzani studies the role of semen in fertilization and learns that the sperm must make physical contact with the egg for fertilization to take place.

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Historian and naturalist Cosimo Alessandro Collini publishes a description of the first known pterosaur.

Lazzaro Spallanzani performs artificial insemination on a dog.

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Juan-Bautista Bru mounts the first relatively accurate fossil reconstruction of an extinct animal from South America. Georges Cuvier classifies it as a giant sloth.

Gilbert White's The Natural History and Antiquities of Selborne, a series of notes about animal and plant life in Selborne, England, is the first recognizable work of ecology. It goes through about 300 different editions and is still in print today.

Johann Wolfgang Goethe's Versuch, die Metamorphose der Pflanzen zu erklären (Attempt to explain the metamorphosis of plants) claims incorrectly that all plant structures are modified leaves, but clearly espouses evolution.

German poet Johann Wolfgang von Goethe writes The Morphology of Plants stating that all plant organs, flowers included, began as leaves — an assertion that will enjoy some support from 21st-century genetic research.

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Reverend James Douglas publishes Nenia Britannica; or, A Sepulchral History of Great Britain providing perhaps the first record of a fossil (sea urchin) at an archaeological site.

Erasmus Darwin (Charles' grandfather) publishes Zoonomia, or the Laws of Organic Life.

James Hutton publishes An Investigation of the Principles of Knowledge. Buried in the 2,138-page philosophical tome is a chapter about variety in nature in which Hutton anticipates Charles Darwin's theory of natural selection.

John Dalton's Extraordinary facts relating to the vision of colors gives an early account of red-green color blindness, which he refers to as Daltonism, since he is afflicted with the condition.

Zoonomia, or the Laws of Organic Life by Erasmus Darwin (grandfather of Charles Darwin) contains his ideas about evolution, which are Lamarckian in that they assume the environment has a direct influence on organisms, causing permanent changes in the germ line.

James Hutton's Theory of the Earth published, interpreting certain geological strata as former sea beds. Hutton proposes geological theory of gradualism.

Johann Friedrich Blumenbach publishes De generis humani varietate nativa liber arguing that humans comprise a single species with five varieties: Caucasian, Mongolian, Ethiopian, (American) Indian and Malayan.

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Publication of Thomas Malthus' Essay on the Principle of Population, a work that Darwin asserted helped him frame the principle of evolution by natural selection.

The first mammoth fossil fully documented by modern science is discovered near the delta of the Lena River in 1799 by Ossip Schumachov, a Siberian hunter. Schumachov allows it to thaw (a process taking several years) until he can retrieve the tusks for sale to the ivory trade in Yakutsk. He then abandons the specimen, allowing it to decay before its recovery. In 1806, Russian botanist Mikhail Adams rescues what remained of the specimen and brought it to the Zoological Museum of the Zoological Institute of the Russian Academy of Sciences in St. Petersburg. The specimen, which became known as the Adams Mammoth, is stuffed and mounted, and continues to be on display at the Zoological Institute.

Charles White publishes An Account of the Regular Gradation in Man, and in Different Animals and Vegetables, a treatise on the great chain of being, showing people of color at the bottom of the human chain.

Faujas publishes a description of the Maastricht animal, a spectacular mosasaur found in chalk quarries in the Netherlands, describing it as a crocodile.

Thomas Jefferson publishes a paper describing Megalonyx, a North American fossil ground sloth similar to the one found in South America.

George Shaw publishes a description of a platypus even though he suspects the odd animal might be a hoax.

Between 1800 and 1803, naturalist Alexander von Humboldt visits Mexico and writes influential accounts of his observations.

Karl Friedrich Burdach coins the term BIOLOGY to denote the study of human morphology, physiology and psychology.

Erasmus Darwin publishes Phytologia declaring that leaves breathe air through tiny pores, sugar and starch are the products of plant "digestion," and nitrates and phosphorus promote vegetation.

Jean-Baptiste Lamarck's Système de Animaux sans Vertèbres (System for Animals without Vertebrae) includes a classification system for invertebrates and a preliminary view of his ideas of evolution.

In Natural Theology, William Paley uses the analogy of a watch requiring a watchmaker to argue that the universe implies an intelligent designer.

Gottfried Treviranus and Jean Baptiste de Lamarck independently broaden the meaning of BIOLOGY to include the study of all living things.

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Georges Cuvier suggests that fossils found in the area around Paris are "thousands of centuries" old. This casual observation pushes the age of the Earth well beyond its commonly accepted limits. Cuvier also publishes a paper explaining that the fossil animals he has studied bear no resemblance to anything still living, an unambiguous endorsement of the theory of extinction.

James Parkinson publishes the first of a three-volume work entitled Organic Remains of a Former World. In this volume, he describes fossils as the remains of Noah's Flood. In the next several years, he will recognize fossils as the remains of a world before people, and acknowledge as much in the third volume, published in 1811.

Nicolas-Théodore de Saussure's Recherches chimiques sur la végétation "Chemical researches on vegetation" shows that plants require carbon dioxide from the air and nitrogen from the soil. Earlier researchers had assumed the plants got carbon from the soil instead of from the air.

The field of comparative anatomy begins, with the publications of Baron Georges Cuvier's Lesson in Comparative Anatomy

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12 Feb 1809

Charles Darwin is born

Jean Baptiste de Lamarck's theory of evolution presented with the publication of his Philosophie Zoologique, which emphasized the fundamental unity of life and the capacity of species to vary.

Mary Anning's brother Joseph discovers the world's first recognized fossil ichthyosaur. Mary Anning will collect the fossil the next year.

Georges Cuvier identifies the "biblical flood" victim, described by Johann Jakob Scheuchzer in 1731, as a giant salamander.

Georges Cuvier correctly identifies pterosaurs as flying reptiles. His conclusions will be largely ignored for many years.

Swiss-French botanist Augustin Pyramus de Candolle introduces the word TAXONOMY in his lifelong project of a 21-volume plant encyclopedia. Seven volumes are published during his lifetime, the remainder after his death.

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Russian biologist Heinz Christian Pander studies the chick embryo and discovers the germ layers (i.e., three distinct regions of the embryo that give rise to the specific organ systems). Because of these findings, he is considered by many to be the "founder of embryology".

Georges Cuvier's Le règne animal distribué d'après son organisation (The animal kingdom, distributed according to its organization) gives an account of the whole animal kingdom, dividing it into four distinct groups.

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A baby, who would later become Queen Victoria of England, is born carrying a new genetic mutation. Three generations later, that mutation may have changed the course of history.

Christian Friedrich Nasse formulated Nasse's law: hemophilia occurs only in males and is passed on by unaffected females.

Gideon Mantell discovers, in England, a fossil trunk of a tree resembling that of a tropical palm, evidence of a much warmer climate.

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Etienne Geoffroy publishes Anatomical Philosophy discussing similarities between skeletal structures — such as bat wings, paws and hands — that support the evolutionary claims of Lamarck. He also argues that arthropods and vertebrates have similar but inverse body plans, an assertion that will ultimately be widely accepted.

Between 1822-1824, Thomas Andrew Knight, John Goss, and Alexander Seton all independently perform crosses with the pea and observe dominance in the immediate progeny, and segregation of various hereditary characters in the next generation. However, they do not study later generations or determine the numerical ratios in which the characters are transmitted.

William Buckland publishes an account of how ancient hyenas lived and fed in Kirkdale Cave, based on their fossil remains. This is one of the first descriptions of living habits based on fossil evidence.

Thomas Andrew Knight confirms reports of dominance, recessivity, and segregation in peas, but does not detect regularities.

William Buckland finds a skeleton covered in ocher. Called the Red Lady, it will later be identified as Cro-Magnon (and male).

William Buckland publishes Notice on the Megalosaurus ("giant lizard"), the first dinosaur fossil to be described and named, although the term "dinosaur" doesn't yet exist. Buckland also announces the discovery of the first fossil mammal from the Mesozoic.

Father John MacEnery starts digging in Kent's Cave in Devon. He'll eventually find human remains in the same layer as those of extinct mammals, a finding that will be dismissed by Buckland.

Gideon Mantell publishes Notice on the Iguanodon, the second description of a dinosaur and the first description of an herbivorous fossil reptile.

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Karl Ernst von Baer first demonstrated the mammalian ovum; he regarded the sperm cells as "Entozoa," i.e., parasites, and named them spermatozoa.

A year after discovering the mammalian egg cell, Karl Ernst von Baer publishes Entwickelungsgeschichte der Thiere tracing the developmental history of animals.

Publication of Karl Ernst von Baer's The Embryology of Animals which strongly opposed preformationism.

Adolphe Brongniart publishes Prodrome d'une histoire des Végétaux Fossils, a study of fossil plants. He outlines four distinct phases in plant prehistory: (1) primitive plants from the Coal Measures, (2) the first conifers, (3) domination by cycads and conifers, and (4) flowering plants.

Mary Anning discovers Britain's first recognized pterosaur fossil. (Gideon Mantell has already found pterosaur remains, but has attributed them to a bird).

Chemist Friedrich Wöhler (1800-1882) synthesizes the organic compound urea, a feat previously thought impossible because of the vital force thought to be a part of organic substances.

Philippe-Charles Schmerling discovers a Neanderthal fossil, the partial cranium of a small child. The fossil will not be accurately identified as Neanderthal, however, for a century, though Charles Lyell will illustrate it in Antiquity of Man in 1863.

Charles Lyell's multi-volume Principles of Geology appear (between 1830 amd 1833), advancing the theory of uniformitarianism, i.e., the view that geological formations are explainable in terms of forces and conditions observable at present.

Georg Goldfuss announces that he sees "hairs" on a pterosaur fossil. This outlandish assertion will be supported by later finds.

The first edition of Birds of America, by the painter and ornithologist John James Audubon (1785-1851), appears.

Charles Darwin joins the crew of the HMS Beagle as the ship's naturalist. The Beagle plans a two-year voyage to map the coast of South America. This turns out to be a five-year trip.

Patrick Matthew publishes On Naval Timber and Arboriculture with an appendix describing what Charles Darwin will later name natural selection. After becoming aware of Matthew's hypothesis, Darwin will acknowledge it in a reprint of On the Origin of Species.

Robert Brown published his observations reporting the discovery and widespread occurrence of nuclei in cells.

Gideon Mantell finds the first fossil Hylaeosaurus, an ankylosaur. He will formally name it the following year, making it the third identified dinosaur species.

The first volume of the five-volume Recherches sur les poissons fossiles (Researches on Fossil Fishes) by Jean-Louis-Rodolphe Agassiz is published.

Based on a vertebrae and other fragments from Alabama, anatomist Richard Harlan identifies Basilosaurus as a fossil reptile. It will later be identified as a fossil whale.

While serving as scientific officer on the HMS Beagle, Charles Darwin visits the Galapagos Islands. He observes that the many varieties of finches on the islands seem to have developed from a common ancestor found on the mainland of South America.

Henry Riley and Samuel Stutchbury name Thecodontosaurus, the fourth named dinosaur species.

Elements of Botany, by the naturalist Asa Gray (1810-1888), is published. It is the first botanical textbook.

German biologist Theodor Schwann discovers the enzyme pepsin — the first known animal enzyme. He reports the discovery in Über das Wesen der Verdauungsprozesses (On the essence of digestion).

Charles Darwin formulates the theory of natural selection to explain evolution. Fearful of the reaction his theory will cause, he delays publishing.

Hermann von Meyer names Plateosaurus, the fifth named dinosaur species.

M. J. Schleiden and T. Schwann develop the cell theory. Schleiden notes nucleoli within nuclei.

Chemist Jöns Jakob Berzelius (1779-1848) shows that the presence of iron is what enables blood to absorb as much oxygen as it does.

The word PROTEIN first appears in the chemical literature in a paper by G. J. Mulder. The term, however, was invented by J. J. Berzelius.

Czech scientist Jan Evangelista Purkyně (also written Johannes Evangelist Purkinje) coins the word PROTOPLASM to describe the contents of a cell.

Charles Darwin's Zoology of the Voyage of the Beagle appears.

Martin Barry expressed the belief that the spermatozoon enters the egg.

(no entry for this year)

Charles Darwin's book The Structure and Distribution of Coral Reefs being the first part of the geology of the voyage of the Beagle, is published. During the year Darwin composes an abstract of his theory of species evolution.

Carl Wilhelm von Nägeli (1817-1891) publishes Zur Entwicklungsgeschichte des Pollens. His paper describes cell division in plants with remarkable accuracy, and discusses seed formation in flowering plants.

Richard Owen names Cetiosaurus, the sixth named dinosaur species.

Die Thierchemie, by chemist Baron Justus von Liebig (1803-1873), is published, and the science of biochemistry begins.

The term DINOSAUR is coined by Richard Owen (1804-1892) to describe a class of animals that we now believe were dominant on the Earth for approximately 175 million years.

Louis Agassiz completes Les Poissons Fossiles describing fossil fish of the world. This single monograph increases tenfold the formally described vertebrates known to science.

That the nervous system uses electricity in communicating between different parts of the body is demonstrated by Emil Heinrich du Bois-Reymond (1818-1896). He founds the field of electrophysiology.

Charles Darwin first outlines his thoughts on natural selection in an unpublished essay.

Robert Chambers, a Scottish journalist, publishes (anonymously) his Vestiges of the Natural History of Creation, an early book outlining an evolutionary view of the natural world.

The second part of the Geology of the Beagle, Charles Darwin's Geological Observations on Volcanic Islands Visited During the Voyage of H.M.S. Beagle, is published. Darwin's book claims to supply evidence for the geological theories of Charles Lyell (1797-1875), from areas that Lyell himself had never seen.

That all the cells in an organism are generated from successive divisions of the egg cell is described by Rudolf Albert von Kölliker (1817-1905). Kölliker shows that the egg is itself a cell.

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Karl Wilhelm Von Nägeli shows that plant cells are not formed as buds from the surfaces of existing cells, as was proposed by Theodore Schwann.

Joseph Leidy identifies in pork the parasite that causes trichinosis, a potentially fatal human disease.

Jakob Mathias Schleiden and Theodor Schwann announce that cells are the basic units of all living structures.

On the archetype and homologies of the vertebrate skeleton, by Richard Owen (1804-1892), is published. In the book Owen argues that the skull, and other parts of the body, are formed by the modification of the vertebra of different animals.

Richard Owen describes "homologies" — similarities of design in bird wings, fish fins and human hands.

A Neanderthal skull is excavated from Forbes Quarry on the northern side of the Rock of Gibraltar. Over the next few decades, the skull will be stashed in a library cabinet in Gibraltar, dusted off and sent to London, accurately likened to the ancient skullcap from Neander Valley in Germany, nearly named Homo calpicus, and finally stored and largely forgotten in the Royal College of Surgeons.

Botanist Carl Friedrich von Gärtner (1772-1850) publishes Versuche und Beobachtungen über die Bastarderzeugung im Pflanzenreiche. The book describes thousands of experiments, many involving the production of hybrids, on more than 500 species of plants. Mendel will study this book in detail when he attends the University of Vienna in the early 1850s, and will cite the book in the opening of his paper of 1865.

Based on a humerus 58 inches in circumference, Mantell names a new dinosaur species: Pelorosaurus, the first recognized sauropod.

German physicist Gustav Theodor Fechner discovers that an increase in the intensity of a stimulus does not produce a one-to-one increase in the intensity of sensation. Instead, the sensation seems to increase as the logarithm of the excitation.

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Albrecht von Kölliker publishes the first textbook of histology, Handbuch der Gewebelehre.

Hermann Ludwig von Helmholtz becomes the first to discover how fast a message travels along a nerve, measuring the speed of transmission in a frog nerve cell.

Rudolph Albert von Kölliker discovers the cellular origin of spermatozoa, which were believed by some to originate from a fermentation process.

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Alfred Russel Wallace publishes "On the Law which has Regulated the Introduction of New Species," anticipating Darwin's theory of evolution by natural selection.

Rudolf Virchow states the principle that new cells come into being only by division of previously existing cells: Omnis cellula e cellula.

Recherches sur la putréfaction, by Louis Pasteur, is published. The book describes how fermentation is caused by microorganisms.

The remains of the first known example of what come to be known as the "Neanderthals" is found in a cave near Düsseldorf, in the Neander Valley. The discovery was made by limestone quarry miners and consists of a skullcap, two femora, the three right arm bones, two of the left arm bones, ilium, and fragments of a scapula and ribs. The fossils were given to Johann Carl Fuhlrott, a local teacher and amateur naturalist. The first description of the remains was made by anatomist Hermann Schaaffhausen and the find was announced jointly in 1857.In 1997, the specimen was the first to yield Neanderthal mitochondrial DNA fragments. The description of this discovery represents the beginning of paleoanthropology as a scientific discipline.

Louis Agassiz publishes Essay on Classification advocating a theory of multiple creations and contradicting both evolution and Noah's ark.

Gregor Mendel, a monk at the Augustinian monastery of St. Thomas in Brünn, Austria (now Brno, Czechoslovakia), begins breeding experiments with the garden pea, Pisum sativum.

Heinz Christian Pander describes conodonts — toothy microfossils that will puzzle paleontologists for many years.

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Rudolf Virchow finalizes the cell theory originally announced by Schleiden and Schwann 11 years earlier by declaring that cells are the basic units of all living things, and all cells are formed by the division of existing cells.

Alfred Russel Wallace sends to Darwin a manuscript — "On the Tendency of Varieties to Depart Indefinitely from the Original Type" — that shows clearly that Wallace has independently formulated a model of evolution by natural selection.

Darwin's and Wallace's ideas are jointly presented to the Linnaean Society of London.

The first relatively complete dinosaur skeleton, of Hadrosaurus foulkii, is found in New Jersey.

Physician Henry Gray publishes Anatomy of the Human Body, Descriptive and Surgical. Gray's Anatomy will be a standard textbook of anatomy for more than a century.

Charles Darwin publishes On the Origin of Species.

An exceptionally well-preserved skeleton is discovered in Bavaria. Two years later, this bird-like, bipedal dinosaur will be named Compsognathus, meaning "dainty jaw."

Catholic priest Jean-Jacques Pouech describes fossil eggshell fragments. They will eventually prove to be the first described dinosaur eggs.

Louis Agassiz attacks Darwin's the origin of species, rejecting the idea of evolution of the species and arguing that each species was created separately.

Thomas Henry Huxley (sometimes known as Darwin's bulldog) clashes with Bishop "Soapy Sam" Wilberforce about evolution at the annual meeting of The British Association for the Advancement of Science, in what has come to be known as the Huxley-Wilberforce debate.

Bishop Wilberforce is supposed to have asked Huxley sarcastically whether "it was through his grandfather or his grandmother that he claimed descent from a monkey." Huxley responded, "If then the question is put to me whether I would rather have a miserable ape for a grandfather or a man highly endowed by nature and possessed of great means of influence and yet employs these faculties and that influence for the mere purpose of introducing ridicule into a grave scientific discussion, I unhesitatingly affirm my preference for the ape." Or words to that effect.

John Phillips diagrams the progressive but fluctuating diversity of life on Earth based on the fossil record. His work evidences massive extinctions at the end of the Paleozoic and Mesozoic, and increased diversity in each subsequent age.

Louis Pasteur becomes significantly involved in biological research with the publication of "Mémoir sur la fermentation alcoolique" in which he showed that alcoholic fermentation seemed to be carried out by yeast, which were themselves living organisms.

Between 1861 and 1862, Max Johann Sigismund Schultze (Germany) and Heinrich Anton de Bary (Germany) establish the essential unity of protoplasm in all living cells.

First recognized fossil Archaeopteryx lithographica skeleton is found in the stone quarries of Solnhofen.

In "Mémoires sur les corpuscles organisés qui existent dans l'atmosphère," Pasteur applies heat to bent-neck flasks to show unequivocally that the "organized bodies" (microbes) which drive fermentation originate from "organized bodies" that exist in the atmosphere. In this elegant series of experiments, Pasteur laid to rest the long-held belief in spontaneous generation."

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Anti-evolutionist James Hunt, founder of the Anthropological Society of London, gives a presidential address to the society stating that human races were created separately. He further argues that the African species is closer in ability to apes than to Europeans.

Alfred Russel Wallace describes the "Wallace line," the dividing line between Indo-Malayan and Austro-Malayan fauna, in Proceedings of the Royal Geographical Society of London.

Dominique Alexandre Godron and Charles Victor Naudin (France) independently report experiments in plant hybridization. Naudin confirmed Sageret's work, in general discussed work of the early hybridizers, and reported dominance and segregation in Datura (jimsonweed) hybrids. He did not deal with single characters and reported no statistical observations on the second generation. His theoretical explanation of his facts was a forerunner of Mendel's ideas, but inferred rather than deduced.

T. H. Huxley publishes Man's Place in Nature discussing human and primate paleontology, and showing similarities between humans and other animals.

Father-and-son glassworkers Leopold and Rudolf Blaschka begin making glass models of marine invertebrates. Marine biologists will refer to their exquisitely detailed, accurate models 150 years later while trying to see how many of the depicted species can still be found in the wild.

Ernst Haeckel (Häckel) outlines the essential elements of modern zoological classification.

John Lubbock publishes Prehistoric Times dividing what has previously been understood to be the Stone Age into two parts: the older Paleolithic and the newer Neolithic. In the same book, he also argues that modern Tasmanians and Fuegians are throwbacks to archaic humans.

Franz Schweigger-Seidel and A. von la Valette St. George (Germany) independently prove that a spermatozoon is a single cell and contains nucleus and cytoplasm

Gregor Mendel presents his work on inheritance in peas to the Brünn Natural History Society. The results are published the following year.

Sir John William Dawson of McGill University identifies "shells" of huge foraminiferal protozoans. Known as Eozoön or "dawn animal," this find is used as an argument against evolution because it shows a relatively "modern" animal early in the fossil record. It will prove, however, to be a geologically young pseudofossil formed by heat and pressure on limestone.

Paolo Mantegazza publishes Degli Innesti Animali e della Produzione Artificiale delle Cellule (On Animal Grafts and Artificial Cell Production) describing the results of a series of interspecies animal grafts, such as the transplant of a cockspur onto a cow ear. Grafts described include transplants between dogs, frogs and rodents. Mantegazza reports that some grafts decomposed while others became "pathological tumours."

German zoologist Ernst Haeckel publishes General Morphology of Organisms, the first detailed genealogical tree relating all known organisms, incorporating the principles of Darwinian evolution.

Ernst Heinrich Haeckel (Häckel) hypothesizes that the nucleus of a cell transmits its hereditary information.

Mendel publishes his work on heredity, Versuche über Pflanzen Hybriden.

Ernst Heinrich Haeckel (Häckel) first used the term ECOLOGY to describe the study of living organisms and their interactions with other organisms and with their environment.

H. S. Bidwell (United States) reports controlled pollination in maize.

Charles Darwin publishes The Variation of Animals and Plants under Domestication, in which he offers his own theory of heredity, which he called the "Provisional Hypothesis of Pangenesis."

Ernst Haeckel publishes Natürliche Schöpfungsgeschichte, subdividing humanity into 12 separate species. He also asserts that evolution consists of 22 phases, the 21st being the "missing link" between apes and humans.

Thomas Henry Huxley publishes "On the Animals which are Most Nearly Intermediate between Birds and Reptiles," arguing that birds are descendants of dinosaurs. This suggestion will not be taken very seriously for another century.

Three human skulls and other skeletal remains, roughly 30,000 years old, are discovered at a rock shelter called Cro-Magnon (old French for "big hole").

Francis Galton publishes Hereditary Genius. In it he describes a scientific study of human pedigrees from which he concludes that intelligence has a genetic basis.

O. C. Marsh discovers the first North American pterosaur, from chalk deposits in Kansas. He calculates the wingspan at 20 feet. The following year, he will collect more fossils that confirm this calculation.

Quarry workers in the Valley Forge area discover the Port Kennedy Bone Cave, under roughly the same site where the Continental Army wintered over a century earlier. The site proves rich in Pleistocene plant and animal fossils, but will be accidentally flooded decades later. The site will be lost to science until its rediscovery after the turn of the 21st century.

The rivalry between fossil collectors O. C. Marsh and E. D. Cope turns ugly when Marsh publicly points out Cope's error in reconstructing a fossil marine reptile (putting its head on the tip of its tail). Their rivalry is the public's gain as they try to outdo each other in identifying new dinosaur species — over 130.

Publication of Charles Darwin's Descent of Man, in which the role of sexual selection in evolution is described for the first time.

Lord Kelvin suggests that "the germs of life might have been brought to the Earth by some meteorite," an idea that will enjoy support a century later.

Johann Friedrich Miescher isolates a substance which he calls NUCLEIN from the nuclei of white blood cells. The substance was soluble in alkalis but not in acids and came to be known as nucleic acid.

Lambert Adolphe Jacques Quetelet showed the importance of statistical analysis for biologists and laid the foundation of biometry.

Ferdinand Julius Cohn coined the term BACTERIUM and founded the study of bacteriology.

Anton Schneider observed and described the behavior of nuclear filaments (chromosomes) during cell division in his study of the platyhelminth Mesostoma. His account was the first accurate description of the process of mitosis in animal cells.

Francis Galton publishes a paper entitled "Hereditary Improvement" arguing that people "of really good breed" should be encouraged to reproduce while their inferiors should be discouraged from doing so. This, he argues, will improve humanity the way selective breeding improves livestock.

The Hamburg Tierpark features an "anthropological-zoological" display of Lapps acting out "daily life" with reindeer. The show draws enthusiastic crowds.

Eduard Strasburger accurately described the processes of mitotic cell division in plants.

Francis Galton demonstrates the usefulness of twin studies for elucidating the relative influence of nature (heredity) and nurture (environment) upon behavioral traits.

Oscar Hertwig concludes from a study on sea urchins that fertilization in both animals and plants consists of the physical union of the two nuclei contributed by the male and female parents.

Paleontologist Roberto Lawley collects a badly eroded Pliocene whale bone near Pisa, Italy, and donates it to the paleontology museum of Florence. In the 21st century, close examination will indicate boreholes of Osedax, mouthless, gutless marine worms (nicknamed zombie worms) that extract nutrients by drilling into bones.

Charles Doolittle Walcott becomes the first to successfully find and describe elusive trilobite legs, ending speculation about how the animals moved.

Hermann Fol reports watching the spermatozoan of a starfish penetrate the egg. He was able to see the transfer of the intact nucleus of the sperm into the egg, where it became the male pronucleus.

A new Archaeopteryx fossil is discovered in Solnhofen, complete with a toothy jaw. This well-preserved fossil, which will become known as the Berlin Archaeopteryx, supports Huxley's previous observations about its reptilian affinities.

Comparative anatomy professor François Louis Paul Gervais undertakes thin-section microscopy studies of fossil eggs. His work will be largely forgotten until Roy Chapman Andrews discovers dinosaur eggs in Mongolia in the 1920s.

Germ Theory of Disease: Louis Pasteur presented his Germ Theory of disease. Joseph Lister went on to initiate the practice of insuring that surgeons were clean before they conducted surgery.

Wilhelm Friedrich Kühne proposed the term ENZYME (meaning "in yeast") and distinguished enzymes from the micro-organisms that produce them.

Charlotte Hill collects a well-preserved fossil butterfly, later named Prodryas persephone, from the Florissant Formation in Colorado. The fossil is about 35 million years old.

Entire skeletons of Iguanodon are discovered in Belgium, enabling a more accurate reconstruction of this dinosaur than those of Owen and Waterhouse Hawkins in the 1850s. Engineer-turned-paleontologist Louis Dollo will publish the first of several papers on these fossils in 1882.

From 1879 through 1882, Walther Flemming describes and names CHROMATIN, MITOSIS, and the SPIREME. He makes the first accurate counts of chromosome numbers and accurately drew the "longitudinal splitting" of chromosomes.

Eight-year-old Maria de Sautuola finds a Paleolithic cave drawing of bison on her father's property in Spain. It is the oldest artwork yet discovered, but it will be dismissed as a forgery for years, considered too beautiful to be the work of prehistoric savages.

Throughout the decade of 1880-1890, Walther Flemming, Eduard Strasburger, Edouard van Beneden, and others elucidate the essential facts of cell division and stressed the importance of the qualitative and quantitative equality of chromosome distribution to daughter cells.

Charles Darwin and his son Francis publish the results of their studies on plant responses to light, explaining that phototropism (bending toward the light) results from light reaching the top of a plant's shoot.

(no entry for this year)

Walther Flemming publishes accurate depictions of cell division (mitosis) in Zellsubstanz, Kern und Zelltheilung.

Eduard Strasburger coins the terms CYTOPLASM and NUCLEOPLASM.

W. Flemming discovers lampbrush chromosomes and coins the term MITOSIS.

Karl Alfred von Zittel describes an exceptionally well-preserved pterosaur wing showing flight membranes in detail.

Charles Darwin publishes his final letter to Nature, on the dispersal of freshwater bivalves. His obituary appears the same month. In this paper, Darwin acknowledges the assistance of W. D. Crick or Northampton. Later, Crick's grandson — Francis Crick — will be one of the co- discoverers of the structure of DNA.

August Weismann points out the distinction in animals between the somatic cell line and the germ cells, stressing that only changes in germ cells are transmitted to further generations.

Edouard van Beneden announced the principles of genetic continuity of chromosomes and reported the occurrence of chromosome reduction at germ cell formation. The sperm and egg are haploid and fertilization restores the diploid chromosome number.

Wilhelm Roux offers a possible explanation for the function of mitosis.

William Keith Brooks, a professor at The Johns Hopkins University, publishes The Law of Heredity: A Study of the Cause of Variation and the Origin of Living Organisms. Although this speculative work did not significantly advance the understanding of heredity, brooks' thinking is important because during his career he provided instruction to and supervised the early research of Thomas H. Morgan, Edmund Beecher Wilson, and William Bateson — ultimately some of the most important contributors to the new science of genetics.

Pierre Émile Duclaux introduces the custom of designating an enzyme by the by the name of the substrate on which its action was first reported and adding the suffix -ase.

During 1884-88, identification of the cell nucleus as the basis for inheritance was independently reported by Oscar Hertwig, Eduard Strasburger, Albrecht von Kölliker, and August Weismann.

Gregor Mendel dies on January 6th, without ever knowing that his work on peas would lead to the transformation of biological research.

Walther Flemming, Eduard Strasburger and Edouard van Beneden demonstrate that chromosome doubling occurs by a process of longitudinal splitting. Strasburger describes and names the PROPHASE, METAPHASE, and ANAPHASEstages of chromosomal division.

August Weismann formulates the germ-plasm theory which held that the germ plasm was separate from the somatoplasm and was continuous from generation to generation.

Carl Rabl theorized the individuality of chromosomes in all stages of the cell cycle.

Walther Flemming observed sister chromatids passing to opposite poles of the cell during mitosis.

Francis Galton devised a new useful statistical tool, the correlation table.

Hugo de Vries (Holland) discovers aberrant evening primrose plants at Hilversum, Holland. Experiments with these extending over 15 years formed the basis for his mutation theory of evolution.

A. Ficatier publishes an account of the discovery of a trilobite perforated with two holes (perhaps to hang on a thread) at a Magdalenian- age site in France. The fossil lends the site its name of La Grotte du Trilobite.

John Bell Hatcher develops the "ant hill method of collecting minute fossils," collecting hundreds of tiny fossil teeth and jaws pushed to the surface by ants. He even carries shovelfuls of ants and sediment to other fossil localities in need of excavation by the arthropods.

August Weismann elaborated an all-encompassing theory of chromosome behavior during cell division and fertilization and predicted the occurrence of a reduction division (meiosis) in all sexual organisms.

Edouard van Beneden demonstrated chromosome reduction in gamete maturation, thereby confirming August Weismann's predictions.

Wilhelm Roux put forth the suggestion that the linearly arranged qualities of the chromosomes were equally transmitted to both daughter cells at meiosis.

Harry Govier Seeley determines that dinosaurs consist of "lizard- hipped" (saurischian) and "bird-hipped" (ornithischian) branches.

German anatomist W. von Waldeyer names chromosomes.

Heinrich Wilhelm Gottfried von Waldeyer names the CHROMOSOME.

Theodor Boveri verifies August Weismann's predictions of chromosome reduction by direct observation in Ascaris.

Francis Galton publishes Natural Inheritance. In it he describes the quantitative measurement of metric traits in populations. He thus founds biometry and the statistical study of variation. Ultimately, he formulates the Law of Ancestral Inheritance, a statistical description of the relative contributions to heredity made by one's ancestors.

The numerical equality of paternal and maternal chromosomes at fertilization was established by Theodor Boveri and Jean-Louis-Léon Guignard.

(no entry for this year)

Publication of August Weismann's book Das Keimplasma (The Germ Plasm) emphasized meiosis as an exact mechanism of chromosome distribution.

Joseph Whiteaves describes Anomalocaris, meaning "anomalous shrimp," from the Cambrian. The fossil that Whiteaves identifies as a shrimp will later prove to be part of a much larger animal.

Entomologist E.B. Poulton studies caterpillars from the species Gastropacha quercifolia, noting how siblings look different depending on where they live and what they eat. His discovery will become known as phenotypic plasticity.

Hans Driesch expounded the view that all nuclei of an organism were equipotential but varied in their activity in accordance with the differentiation of tissues.

Karl Pearson published the first in a long series of contributions to the mathematical theory of evolution. Methods for analyzing statistical frequency distributions were developed in detail.

William Bateson's Materials for the Study of Variation emphasized the importance of discontinuous variations, foreshadowing the rediscovery of Mendel's work.

Eugène Dubois publishes his monograph of Pithecanthropus erectus, or Java Man, a missing link between humans and apes.

French paleontologist Charles Brongniart describes a fossil dragonfly from the Carboniferous with a 2-foot (63-centimeter) wingspan. The find implies a higher oxygen content in the Earth's ancient atmosphere.

The intricately carved mammoth ivory figurine known as the Lady (or Venus) of Brassempouy is discovered in France. At roughly 25,000 years old, it ranks among the earliest known depictions of a human face.

A team of paleontologists, including Samuel Williston, Elmer Riggs and Barnum Brown, successfully excavates a Triceratops fossil in Wyoming.

E. B. Wilson publishes The Cell in Development and Heredity. This influential treatise (ultimately reprinted in several editions) distills the information compiled concerning cytology in the half-century since Schleiden and Schwann put forth the cell theory.

Dublin anatomist Daniel Cunningham concludes that Neanderthals represent an intermediate step between Pithecanthropus erectus and modern humans.

J. de Morgan describes nine pierced fossil urchins found in a Chalcolithic tomb at Toukh.

Gabriel Bertrand coined the term COENZYME to designate inorganic substances which were necessary to activate certain enzymes.

(no entry for this year)

L. Cuénot (France) working with animals, and Strasburger (Germany) working with plants, advance theory that sex is controlled within the germ cell, not by environment.

Richard Altmann renames "nuclein" as NUCLEIC ACID.

The First International Congress of Genetics held in London.

William Bateson writes a paper on hybridisation and cross-breeding as a method of scientific investigation that anticipates Mendel's rediscovery.

H. de Vries, C. Correns, and E. Tschermak independently rediscover Mendel's paper. Using several plant species, de Vries and Correns had performed breeding experiments that paralleled Mendel's earlier studies and had independently arrived at similar interpretations of their results. Therefore, upon reading Mendel's publication they immediately recognized its significance. W. Bateson also stresses the importance of Mendel's contribution in an address to the Royal Society of London.

K. Landsteiner discovers the blood-agglutination phenomenon in man.

Karl Pearson develops the chi-square test.

H. de Vries adopts the term MUTATION to describe sudden, spontaneous, drastic alterations in the hereditary material of Oenothera.

T. H. Montgomery studies spermatogenesis in various species of Hemiptera. He concludes that maternal chromosomes only pair with paternal chromosomes during meiosis.

Harry Govier Seeley publishes Dragons of the Air, the first popular book on pterosaurs, arguing that they were warm-blooded and should be classified parallel to birds, in between reptiles and mammals. This is in direct opposition to Richard Owen's classification of pterosaurs as cold-blooded and poor flyers.

Archibald Garrod, a British physician, reports that alkaptonuria (a human disease) seems to be inherited as a Mendelian recessive.

C. E. McClung argues that particular chromosomes determine the sex of the individual carrying them, not just in insects, but perhaps in other species (including man).

Walter Sutton concludes that (a) chromosomes have individuality, (b) that they occur in pairs, with one member of each pair contributed by each parent, and (c) that the paired chromosomes separate from each other during meiosis.

T. Boveri studies sea urchin embryos and finds that in order to develop normally, the organism must have a full set of chromosomes, and from this he concludes that the individual chromosomes must carry different essential hereditary determinants.

William Bateson coins terms that will become essential to describing findings in the new science of heredity: GENETICS, F₁, F₂, ALLELOMORPH (later shortened to ALLELE), HOMOZYGOTE, HETEROZYGOTE, and EPISTASIS.

Barnum Brown of the American Museum of Natural History discovers Tyrannosaurus rex.

The concepts of PHENOTYPE, GENOTYPE, and SELECTION were introduced and clearly defined by Wilhelm Ludwig Johannsen.

L. de Vesly describes first- to third-century remains at Gallo Roman temples and wells near Rouen, France. Finds there include a cache of Neolithic axes and fossil sea urchins — evidence of association of axes and urchins over thousands of years.

Carl Neuberg first used the term BIOCHEMISTRY.

Entomologist George Willis Kirkaldy publishes species descriptions of a series of insects whose names all end in "-chisme" (pronounced "kiss me"), such as Ohchisme, Dolichisme, Elachisme, Florichisme, Isachisme, Marichisme, Nanichisme, Peggichisme, and Polychisme. Kirkaldy's proposed names preface -chisme with the names of various women from alleged romantic conquests. In 1912 a letter to the International Entomological Congress from Lord Walsingham sought to make these names invalid on the basis of their being non-classical in their derivation. Kirkaldy himself had been a firm adherent to the principle of priority and was against any form of orthographic emendation to the spelling proposed by the original authors.

K. S. Merezhkovsky suggests that chloroplasts originated as a cyanobacterium swallowed by a protozoan, i.e., algal and plant cells result from two independent organisms that became symbionts. The idea will be largely forgotten until it is suggested again in the 1960s.

Lucien Claude Cuénot performs crosses between mice carrying a gene that gives them yellow fur. Since they always produce yellow furred and agouti offspring in a 2:1 ratio, he concludes they are heterozygous. (In 1910, W. E. Castle and C. C. Little will show that yellow homozygotes die in utero. This dominant allele is thus the first gene shown to behave as a homozygous lethal.)

The Swimming Reindeer — the largest ivory carving from the late Ice Age yet found — is pieced together by Abbé Henri Breuil from two reindeer carved from mammoth ivory found decades earlier by Peccadeau de l'Isle.

William Bateson and Reginald Crundall Punnett report the discovery of two new genetic principles: LINKAGE and GENE INTERACTION.

In his presidential address to the Geological Society of America, Raphael Pumpelly claims that the end of the Pleistocene started the Neolithic Revolution.

Chemist Bertram Boltwood measures the ratio of isotopes of uranium and lead in a mineral from Connecticut. He concludes the mineral formed 410 million years ago. His estimate will later be changed to 265 million, but this experiment lays the groundwork for radiometric dating techniques.

P. Raymond describes a Neolithic deposit in Saône-et-Loire in France containing an axe with three fossil sea urchins.

The Mauer jaw is discovered in Germany. On October 21, 1907, Daniel Hartmann, a worker at a sand mine in the Grafenrain open field system of the Mauer community unearthed a mandible at a depth of 24.63 m (80.81 ft), which he recognized as of human origin.[4] He was aware of the likelihood of finds, as for 20 years the Heidelberg scholar Otto Schoetensack had asked that the workers at the sand mine be encouraged to look out for fossils, after the well-preserved skull of a straight-tusked elephant had come to light there in 1887. Schoetensack had the workers taught the characteristics of human bones based on recent examples on his regular visits to the sand mine in search for "traces of mankind". The mandible will become the type specimen for Homo heidelbergensis (Archaic Homo sapiens, precursors to Neanderthals).

Godfrey Harold Hardy, a Cambridge mathematician, writes a letter to the editor of Science, suggesting that Mendelian mechanisms acting alone have no effect on allele frequencies. The letter begins, I am reluctant to intrude in a discussion concerning matters of which I have no expert knowledge, and I should have expected the very simple point which I wish to make to have been familiar to biologists. However,... This short (less than one page) letter constitutes Hardy's entire lifetime contribution to the field of biology, yet still forms the mathematical basis for population genetics.

Amadee and Jean Bouyssonie find a Neanderthal skeleton in a pit at La Chapelle-aux-Saints. The find spurs hypotheses of intentional Neanderthal burial of the dead, although some anthropologists will dispute this interpretation several decades later.

Charles and George Sternberg discover a dinosaur mummy, a duckbill dinosaur with skin, tendons and bits of flesh all fossilized.

T. H. Morgan, later to become the first recipient of the Nobel Prize for work in genetics, writes a paper expressing doubts about the profusion of Mendelian explanations for inherited properties.

A. E. Garrod publishes Inborn Errors of Metabolism, the earliest discussion of the biochemical genetics of man (or any other species).

George H. Shull advocates the use of self-fertilized lines in production of commercial seed corn. The hybrid corn program that resulted, created an abundance of foodstuffs worth billions of dollars.

H. Nilsson Ehle puts forward the multiple-factor hypothesis to explain the quantitative inheritance of seed-coat color in wheat.

W. Johannsen's studies of the inheritance of seed size in self-fertilized lines of beans leads him to realize the necessity of distinguishing between the appearance of an organism and its genetic constitution. He invents the terms PHENOTYOPE and GENOTYPE to serve this purpose, and he also coins the word GENE.

Abbé Breuil depicts a presumed Neanderthal burial at La Ferrassie.

Arthur Smith Woodward lectures the British Association for the Advancement of Science on "excess growth" and tooth loss in dinosaurs, citing these things as evidence of "racial senility" that doomed the dinosaurs to extinction.

Charles Doolittle Walcott starts digging fossils of soft-bodied animals in the Burgess Shale in the Canadian Rockies. He proceeds to publish several papers in which he describes these animals, which lived over 500 million years ago, as primitive ancestors of modern groups.

T. H. Morgan discovers white eye and consequently sex linkage in Drosophila. Drosophila genetics begins.

A few years after the find of some isolated teeth from the same species, British paleontologist Clive Forster Cooper finds better specimens of what will later be identified as Paraceratherium in an area that will later be part of Pakistan. A century later, Paraceratherium will still hold the title of the biggest land mammal yet discovered.

While digging the foundation for an imposing home, two laborers, Mercer and Crittenden, discover the remains of a cremation from the Iron Age, including a Neolithic axe and a fossil echinoid.

T. H. Morgan proposes that the genes for white eyes, yellow body, and miniature wings in Drosophila are linked together on the X chromosome.

A hand axe, possibly 200,000 years old and of Neanderthal design, is found in Norfolk, England. The axe has been fashioned to give prominence to a fossil bivalve.

Charles Dawson discovers the Piltdown skull in southern England. Excavations of faked fossils will continue for years.

(no entry for this year)

A. H. Sturtevant, an undergraduate working with Morgan at Columbia, provides the experimental basis for the linkage concept in Drosophila and produces the first GENETIC MAP.

Calvin Blackman Bridges reports nondisjunction of sex chromosomes as PROOF of the chromosome theory of heredity.

Charles Doolittle Walcott identifies fossil bacteria in Cryptozoon-like structures (stromatolites).

Peyrony finds the remains of Neanderthal baby in southwestern France. Because no one knows the bones are Neanderthal, they are not examined closely and are later believed lost. They will be rediscovered and described nearly 90 years later.

Calvin Bridges identifies strains of mutant fruit flies with extra pairs of wings. Decades later, these strains will help biologists understand Hox genes that control the head-to-toe anatomy of widely varying animals.

Frederick Twort discovers a virus capable of infecting and destroying bacteria.

Thomas Hunt Morgan, Alfred Henry Sturtevant, Calvin Blackman Bridges, and Hermann Joseph Muller publish The Mechanism of Mendelian Heredity. This monograph provides the first systematic description of the actual mechanisms that control inheritance as evidenced in the Mendelian model. Here, for the first time, the gene is made real.

Two duckbill dinosaur fossils, with extremely rare skin impressions, sink to the bottom of the Atlantic when the ship carrying them to London — the SS Mount Temple — is stopped by the German military vessel, the SMS Möwe. The German ship takes the passengers prisoner and then sinks the Mount Temple.

British polymath D'Arcy Wentworth Thompson publishes On Growth and Form arguing that the forms Darwinian natural selection can produce through evolution are constrained by physical and mathematical laws, and that organic structures often emulate inorganic natural structures. His analysis led the way for the scientific explanation of morphogenesis, the process by which patterns and body structures are formed in plants and animals. Thompson's description of the mathematical beauty of nature and the mathematical basis of the forms of animals stimulated thinkers as diverse as Julian Huxley, Conrad Hal Waddington, Alan Turing, Claude Lévi-Strauss, Eduardo Paolozzi, Le Corbusier, and Mies van der Rohe.

C. B. Bridges discovers the first chromosome deficiency in Drosophila.

Felix Hubert D'Herelle, independently of Frederick Twort, discovers a virus capable of infecting and destroying bacteria, which he calls a BACTERIOPHAGE.

(no entry for this year)

Thomas Hunt Morgan and coworkers publish The Physical Basis of Heredity, a book-length summary of the rapidly growing findings in genetics.

C. B. Bridges discovers chromosomal duplications in Drosophila.

T. H. Morgan calls attention to the equality in Drosophila melanogaster between the number of linkage groups and the haploid number of chromosomes.

Swedish geologist Johann Andersson discovers a major "dragon bone works" in northern China. Otto Zdansky also examines the works several years later, discovering that the fossils are referred to as dragons even though the workers recognize them as more pedestrian species such as horses and deer.

(no entry for this year)

Fossil mammal expert William Diller Matthew suggests dinosaurs were driven extinct by mountain building, continental uplift and replacement by mammals.

Miners at Broken Hill in the British colony of Northern Rhodesia, Africa, find leg bones and a skull that will later be classified as Homo heidelbergensis.

Lillian V. Morgan discovers attached-X chromosomes in Drosophila.

The American Museum of Natural History begins a series of excavations in central Mongolia, led by Roy Chapman Andrews. Hoping to find fossil human remains, Chapman's team instead finds dinosaurs.

A. E. Boycott and C. Diver describe "delayed" Mendelian inheritance controlling the direction of the coiling of the shell in the snail Limnea peregra. A. H. Sturtevant suggests that the direction of coiling of the Limnea shell is determined by the character of the ooplasm, which is in turn controlled by the mother's genotype.

C. B. Bridges discovers chromosomal translocations in Drosophila.

Jesuit priests Émile Lincent and Pierre Teilhard de Chardin discover ancient stone tools at Shuidonggou, China. Their discoveries resemble those of the Middle Paleolithic industry in Europe.

Winifred Goldring publishes a description of a fossil forest discovered during excavations for the Gilboa Dam. Dating from the Devonian Period, the site will become known as the world's oldest fossil forest.

Tennessee schoolteacher John Thomas Scopes is tried for teaching evolution in the famous "Scopes Monkey Trial." Two-time presidential candidate William Jennings Bryan leads the prosecution. Labor lawyer Clarence Darrow leads the defense and goads Bryan into declaring that humans are not mammals. The conviction will be overturned on a technicality, and the anti- evolution law will remain on the books for decades.

A. H. Sturtevant analyzes the Bar-eye phenomenon in Drosophila and discovers position effect.

Francis Turville-Petre finds Galilee Man, the first fossil hominid discovered in Western Asia. The fossil will later be dated to more than 250,000 years old, and classified as neither modern Homo sapiens nor Neanderthal.

Raymond Dart publishes a description of the "Taung Child," a hominid child's skull from Africa. He classifies it as Australopithecus africanus and concludes that it's the missing link between humans and apes.

A. H. Sturtevant finds the first inversion in Drosophila.

Bernard O. Dodge initiates genetic studies on Neurospora.

H. J. Muller reports the artificial induction of mutations in Drosophila by x-rays.

J. B. S. Haldane suggests that the genes known to control certain coat colors in various rodents and carnivores may be evolutionarily homologous.

Excavations in Kent's Cavern in southern England turn up a fragment of a human upper jaw, roughly 43,000 years old. Arthur Keith will provisionally identify it as anatomically modern human, and this finding will be confirmed in a 2011 study.

Johns Hopkins University biologist Raymond Pearl publishes an article entitled "Why Lazy People Live the Longest." He will expand on this rate- of-living hypothesis in a book the next year, arguing that a faster rate of biochemical reactions leads to a shorter lifespan. This hypothesis is quickly dismissed and generally considered buncombe. Later, however, Donald Trump, the 45th president of the United States will be discovered to hold similar views.

Frederick Griffith discovers type-transformation of pneumococci. This lays the foundation for the work of Avery, MacLeod, and McCarthy (1944).

L. J. Stadler reports the artificial induction of mutations in maize, and demonstrates that the dose-frequency curve is linear.

In a letter to Science, Louise Sudbury states that fossil plants, Cycadeoidea Etrusca, were collected by Etruscans over 4,000 years ago.

In trying to piece together a Burgess Shale organism over 500 million years old, Danish zoologist K. L. Henriksen glues an Anomalocaris appendage to a Tuzoia carapace to make what he thinks is a reasonable looking shrimp-like animal. This mistaken interpretation will persist for years.

John Henry Pull, a postman and amateur archaeologist, finds fossil urchins in two separate Neolithic burial sites. His efforts to publish on his findings, however, will be thwarted due to his pedestrian background.

Davidson Black announces the find of Sinanthropus pekinensis, or Peking Man, discovered at Zhoukoudian, China. Over the next several years, five nearly-complete skulls will be recovered from the same site. Peking Man will be lost, however, during World War II.

Estonian paleobiologist Alexander Audova publishes a paper rejecting racial senility as the cause of dinosaur extinction and instead pointing to environmental change.

R. A. Fisher publishes Genetical Theory of Natural Selection, a formal analysis of the mathematics of selection.

Themistocles Zammit publishes Prehistoric Malta: The Tarxien Temples about excavations showing fossil sea urchins in Bronze Age temples.

C. Stern, and independently H. B. Creighton and B. McClintock, provide the cytological proof of crossing over.

The highly influential paleobotanist Sir Albert Charles Seward rejects the biologic interpretation of Cryptozoon fossils (stromatolites). This rejection will become known among paleontologists as "Seward's folly."

A Harvard expedition to Australia collects Kronosaurus queenslandicus, a 135-million-year-old marine reptile fossil with a 9- foot skull and banana-sized teeth. Researchers excavate the fossil from a limestone quarry with the aid of explosives.

Fossil diggers discover a 25-million-year-old toothed, dwarf whale in Australia. Seven years later it will be named Mammalodon. More than 70 years later, it will be described as a "bottom-feeding mud-sucker."

Robert Broom publishes The Coming of Man: Was it Accident or Design? arguing that evolution is really driven by spiritual agencies, some with conflicting priorities, and that mankind is the ultimate aim of all evolution.

T. H. Morgan receives a Nobel Prize in Medicine for his development of the theory of the gene. He is the first geneticist to receive this award.

Barbara McClintock demonstrates in maize that a single exchange within the inversion loop of a paracentric inversion heterozygote generates an acentric and a dicentric chromatid.

T. S. Painter initiates cytogenetic studies on the salivary gland chromosomes of Drosophila.

With funding from Sinclair Oil, Barnum Brown begins excavating in Wyoming's Howe Quarry. His finds will lead to the green dinosaur logo for Sinclair's gas stations. Many of them will simply be named "Dino."

C. B. Bridges publishes the salivary gland chromosome maps for Drosophila melanogaster.

G. W. Beadle and B. Ephrussi and A. Kuhn and A. Butenandt work out the biochemical genetics of eye-pigment synthesis in Drosophila and Ephestia, respectively.

J. B. S. Haldane is the first to calculate the spontaneous mutation frequency of a human gene.

M. Baudouin describes more than 80 fossil sea urchins drilled for use as jewelry, some worked as long as 35,000 years ago.

A. H. Sturtevant and T. Dobzhansky publish the first account of the use of inversions in constructing a chromosomal phylogenetic tree.

Robert Broom finds the first skull of an adult australopithecine near Johannesburg.

T. Dobzhansky publishes Genetics and the Origin of Species — a milestone in evolutionary genetics.

Fishermen find a coelacanth, a fish long believed to be extinct, off the coast of South Africa. Margaret Courtney-Latimer, a curator at the East London Museum in South Africa, keeps the fish preserved long enough for its identity to be confirmed by ichthyologist J.L.B. Smith.

E. L. Ellis and M. Delbrück perform studies on coliphage growth that mark the beginning of modem phage work. They devise the "one-step growth" experiment, which demonstrates that after the phage adsorbs onto the bacterium, it replicates within the bacterium during the "latent period," and finally the progeny are released in a "burst."

About 200 worked ivory fragments, roughly 32,000 years old, are found in the Hohlenstein-Stadel Cave in Germany. Three decades later, the pieces will be reassembled as statue of a lion-headed man.

Frank Morton Carpenter collects a 2.5-foot wing from a dragonfly-like giant insect that lived in Oklahoma during the Permian Period.

G. W. Beadle and E. L. Tatum publish their classic study on the biochemical genetics of Neurospora and promulgate the ONE-GENE, ONE-ENZYME theory.

K. Mather coins the term polygenes and describes polygenic traits in various organisms.

Anthropologist E. T. Hall excavates the ruins of a dwelling in New Mexico occupied between 700 and 900 AD. He finds two fossil jawbones of Eocene mammals that were deliberately carried to the dwelling by Paleo- Indians.

German paleontologist H. Kirchner suggests that dinosaur tracks in the Rhine Valley might have inspired the legend of Siegfried slaying the dragon Fafnir.

Ernst Mayr publishes Systematics and the Origin of Species, and Julian Huxley publishes Evolution: The Modern Synthesis. Both books are significant contributions to the neo darwinian synthesis combining elements of natural selection, genetics, mutation, population biology and paleontology.

S. E. Luria and T. F. Anderson publish the first electron micrographs of bacterial viruses. T2 has a polyhedral body and a tail.

S. E. Luria and M. Delbrück initiate the field of bacterial genetics when they demonstrate unambiguously that bacteria undergo spontaneous mutation.

Theoretical physicist Erwin Schrödinger publishes What is Life? arguing that living organisms store and pass along information, perhaps using something like Morse code. This book will inspire James Watson, Francis Crick and Maurice Wilkins, who will share the Nobel prize for discovering the structure of DNA.

O. T. Avery, C. M. MacLeod, and M. McCarty describe the pneumococcus transforming principle. The fact that it is rich in DNA suggests that DNA and not protein is the hereditary chemical.

S. E. Luria demonstrates that mutations occur in bacterial viruses.

James B. Sumner, John H. Northrop, and Wendell M. Stanley share a Nobel Prize in Chemistry for Sumner's discovery that enzymes can be crystallized and for Northrop and Stanley's preparation of enzymes and virus proteins in a pure form.

Nobel Prize in Medicine awarded to H. J. Muller for his contributions to radiation genetics

Genetic recombination in bacteriophage is demonstrated by M. Delbrück and W. T. Bailey and by A. D. Hershey.

J. Lederberg and E. L. Tatum demonstrate genetic recombination in bacteria.

Along the Kolyma River in northeastern Siberia, Gulag prisoners discover a nest with three frozen, mummified ground squirrel carcasses. They turn the carcasses over to the Gulag camp geologist, Yuriy Popov, who relays them to other Soviet scientists. Seventy years later, radiocarbon dating and DNA analysis of the ground squirrel mummies will identify their age at over 30,000 years old, and indicate that they are not direct ancestors of modern ground squirrels in the region.

Geologist Reg Sprigg discovers fossils near the Ediacara Hills in Australia. The fossils are of multicellular organisms that predated the Cambrian Period, making them the oldest complex fossils yet discovered. At least some of the fossils are generally assumed to be related to modern cnidarians like jellyfish and corals.

American Museum of Natural History curator Edwin Colbert finds a massive quarry of Coelophysis dinosaurs in New Mexico and concludes from their skeletons that these Triassic dinosaurs were swift runners with a bird- like posture. Later examination of two fossils will lead Colbert to conclude they were also cannibals, but the "last meals of juvenile coelophyses" will eventually prove to be crocodilian.

Rudolph Zallinger completes The Age of Reptiles mural in the Yale Peabody Museum. His image of slow-moving dinosaurs will prevail until the 1960s.

H. J. Muller coins the term dosage compensation.

J. Lederberg and N. Zinder, and, independently, B. D. Davis develop the penicillin selection technique for isolating biochemically deficient bacterial mutants.

Mary Leakey finds the skull of the ape Proconsul, about 16 million years old. Although a very significant find, it does little to bolster Louis and Mary Leakey's meager research funding.

A. D. Hershey and R. Rotman demonstrate that genetic recombination occurs in bacteriophage.

J. V. Neel provides genetic evidence that the sickle-cell disease is inherited as a simple Mendelian autosomal recessive.

French prehistorian André Leroi-Gourhan discovers the Cave of the Reindeer near the village of Arcy-sur-Cure where he will conduct a 15-year excavation. Discoveries at Arcy will suggest to some researchers an artistic sense among Neanderthals, including the collection of fossil mollusk shells and fossil coral. Doubts about ages of objects, however, will leave the subject open to debate.

At a Cold Spring Harbor Symposium, Ernst Mayr argues that all hominid specimens so far found should be categorized in the genus Homo: H. transvaalensis, H. erectus, and H. sapiens.

E. Chargaff lays the foundations for nucleic acid structural studies by his analytical work. He demonstrates for DNA that the numbers of adenine and thymine groups are always equal and so are the numbers of guanine and cytosine groups. These findings later suggest to Watson and Crick that DNA consists of two polynucleotide strands joined by hydrogen bonding between A and T and between G and C.

E. M. Lederberg discovers lambda, the first viral episome of E. coli.

Barbara McClintock publishes a paper describing "jumping" genes that can move around within an organism's genome.

A. D. Hershey and M. Chase demonstrate that the DNA of phage enters the host, whereas most of the protein remains behind.

F. Sanger and his colleagues work out the complete amino acid sequence for the protein hormone insulin, and show that it contains two polypeptide chains held together by disulfide bridges.

J. Lederberg and E. M. Lederberg invent the replica plating technique.

N. D. Zinder and J. Lederberg describe transduction in Salmonella.

J. D. Watson and F. H. C. Crick propose a model for DNA comprised of two helically intertwined chains tied together by hydrogen bonds between the purines and pyrimidines.

W. Hayes discovers polarized behavior in bacterial recombinations. He isolates the Hfr H strain of E. coli and shows that certain genes are readily transferred from Hfr to F- bacteria, whereas others are not.

Piltdown Man is determined to be a hoax: the jaw of an ape and a human skull.

Elso Barghoorn and Stanley Tyler report the discovery of bacterial cells in Canadian rock formations that are nearly 2 billion years old.

Philip Abelson and his team detect amino acids in fish that are over 300 million years old.

S. Benzer works out the fine structure of the rII region of phage T4 of E. coli, and coins the terms CISTRON,RECON, and MUTON.

Professional pipefitter and amateur paleontologist Francis Tully finds an enigmatic fossil near Morris, Illinois. Dating from about 300 million years ago, the fossil will be formally named Tullimonstrum gregarium and nicknamed the Tully monster. Although it will defy classification for decades, it will nevertheless be named the state fossil of Illinois.

F. Jacob and E. L. Wollman are able experimentally to interrupt the mating process in E. coli and show that a piece of DNA is inserted from the donor bacterium into the recipient.

Fifteen-year-old English schoolgirl Tina Negus finds a specimen of the fossil species that will later be named Charnia masoni, from the geologic period that will later be named the Ediacaran. Unfortunately, Negus can't convince her geography teacher that the fossil she has found is Precambrian and gives up, leaving the fossil to be extracted by local schoolboy Roger Mason the next year.

Keith Runcorn publishes a paper describing polar wandering based on paleomagnetic studies of Europe and North America. He suggests continental drift, but his paper attracts little attention.

Paleontologist M. W. de Laubenfels publishes a paper suggesting that the dinosaurs were driven to extinction by a meteorite impact. His paper will not be taken seriously, but this hypothesis will be presented again in 1980 with more compelling evidence.

Brian Logan and fellow geologists find living stromatolites in Shark Bay, Australia. The find is somewhat surprising as stromatolites have no defenses against mouth-bearing organisms and have probably been relatively rare since the Cambrian Period.

Francis Crick proposes the "central dogma" of genetic information transfer: DNA specifies RNA and RNA specifies cell proteins.

V. M. Ingram reports that normal and sickle-cell hemoglobin differ by a single amino acid substitution.

Frederick Sanger receives a Nobel Prize in Chemistry for his work on the structure of proteins, especially that of insulin.

George W. Beadle, Edward L. Tatum, and Joshua Lederberg share a Nobel Prize in Medicine for Beadle and Tatum's discovery that genes act by regulating definite chemical events, and for Lederberg's discoveries concerning genetic recombination and the organization of the genetic material of bacteria.

F. H. C. Crick suggests that during protein formation the amino acid is carried to the template by an adaptor molecule containing nucleotides and that the adaptor is the part that actually fits on the RNA template. Crick thus predicts the discovery of transfer RNA.

F. Jacob and E. L. Wollman demonstrate that the single linkage group of E. coli is circular and suggest that the different linkage groups found in different Hfr strains result from the insertion at different points of a factor in the circular linkage group that determines the rupture of the circle.

M. Meselson and F. W. Stahl use the density gradient equilibrium centrifugation technique to demonstrate the semiconservative distribution of density label during DNA replication in E. coli.

Severo Ochoa and Arthur Kornberg share a Nobel Prize in Medicine for their discovery of the mechanisms in the biological synthesis of ribonucleic acid and deoxiribonucleic acid.

J. Lejeune, M. Gautier, and R. Turpin show that Down syndrome is a chromosomal aberration involving trisomy of a small telocentric chromosome.

R. L. Sinsheimer demonstrates that bacteriophage phiX174 of E. coli contains a single-stranded DNA molecule.

Mary Leakey finds hominid skull belonging to Paranthropus boisei.

Alister Hardy promotes his Homo aquaticus or "aquatic ape" hypothesis to the British Sub Aqua Club. He will follow up this announcement with several magazine articles.

F. Jacob and J. Monod publish "Genetic regulatory mechanisms in the synthesis of proteins," a paper in which the theory of the OPERON is developed.

Martin Glaessner determines fossils in the Ediacara Hills of South Australia (Ediacaran fauna) to be Precambrian in age (approximately 600 million years old), making them the oldest-known multicelled organisms.

Human geneticist James Neel develops the "thrifty genotype" hypothesis that human ancestors endured feast-famine cycles that made the human body very effective in storing fat for lean times.

James Watson, Francis Crick, and Maurice Wilkins share a Nobel Prize in Medicine for their work in elucidating the structure of DNA.

Lantian Man, a 500,000-year-old Homo erectus specimen, is found in Lantian County, China, just north of Xi'an.

Louis Leakey describes Homo habilis, meaning "handy." The new species designation is not well received by the scientific community.

Two deciduous molars, roughly 44,000 years old, are collected at Grotta del Cavallo in southeastern Italy. After an initial classification as Neanderthal, they will be assigned to modern humans in a 2011 study.

Vincent Dethier publishes "Microscopic Brains," an article on insect behavior, in Science. He calls for a more empathetic approach to animal subjects, even tiny invertebrates.

François Jacob, André Lwoff, and Jacques Monod share a Nobel Prize in Medicine for their discoveries concerning genetic control of enzyme and virus synthesis.

N.H. Field publishes "Fossil sea-echinoids from a Romano-British site" describing the centuries-long occupation of a Romano-British settlement in Dorset. Newer buildings have been built upon older ones, with fossil urchins in each.

Willi Hennig works on a new approach to assessing evolutionary relationships, known as cladistics. Although it will be hotly debated, this technique will eventually become standard practice in paleontology, botany and zoology.

Harry Whittington begins reexamining Burgess Shale fossils originally identified by Charles Walcott starting in 1909. Over the next two decades, Whittington (with the assistance of his graduate students Simon Conway Morris and Derek Briggs), will eventually overturn some of Walcott's theories and propose that most of the animals left no living relatives.

Lynn Sagan (later Lynn Margulis) hypothesizes that chloroplasts originated as cyanobacteria, and that mitochondria originated as bacteria. She suggests that both were engulfed by other cells and began functioning as symbionts.

Graduate student S.B. Misra discovers a well-preserved sea floor with numerous fossils dating from the late Precambrian (later to be dubbed the Ediacaran Period) at Mistaken Point, Newfoundland.

P. S. Martin suggests that fast-moving bands of human hunters caused the extinctions of Pleistocene big-game species.

Richard Leakey finds two fossil skulls, Omo I and Omo II, in Ethiopia. Though initially dated at 130,000 years, the fossils will later be dated (using argon decay) at 195,000 years, and designated as the oldest examples so far found of Homo sapiens.

Daniel Janzen argues that, because they live under "easy" conditions, tropical plants cannot likely survive a wide range of temperature, light, or hydrologic conditions.

A.G. Cairns-Smith publishes a paper suggesting that the first life on Earth might have been fine-grained clay crystals. He will publish on this topic several more times before his death, but the experimental evidence will remain scant, perhaps in part because sufficient technology doesn't yet exist to test the hypothesis.

Robert W. Holley, Har Gobind Khorana, and Marshall W. Nirenberg share a Nobel Prize in Medicine for their interpretation of the genetic code and its function in protein synthesis.

Richard Fox describes a Paleocene mammal, Prothryptacodon albertensis, retrieved from a well dug in Alberta, Canada. This find eerily resembles that of another Paleocene mammal recovered from a Louisiana oil well and described in 1932 by George Gaylord Simpson.

Teenaged fossil enthusiast Tadashi Suzuki finds a plesiosaur fossil in his hometown of Iwaki City, Japan. The fossil turns out to be a new species, but it won't be identified as such for nearly 40 years.

R. H. Whittaker proposes to divide all living things into five kingdoms: Animalia, Plantae, Fungi, Protista and Monera.

Max Delbrück, Alfred D. Hershey, and Salvador E. Luria share a Nobel Prize in Medicine for their discoveries concerning the replication mechanism and the genetic structure of viruses.

Archaeologist Joachim Hahn pieces together the fragments of the lion- headed man found 30 years earlier the Hohlenstein-Stadel Cave in Germany.

John Ostrom publishes Osteology of Deinonychus antirrhopus, an Unusual Theropod from the Lower Cretaceous of Montana — a description of Deinonychus with a frontispiece illustration by Bob Bakker, suggesting that the dinosaur is alert, agile and intelligent.

(no entry for this year)

Five pairs of adult wall lizards are moved between two islands in Croatia. Over the next few decades, the lizards on the new island will evolve larger heads, stronger bites, and a greater tolerance for an herbivorous diet than the original lizard population.

A. G. Sharov describes a pterosaur with fossil "hair" impressions as Sordes pilosus (hairy devil).

Grad student Douglas Lawson discovers the humerus of a giant pterosaur in Texas. Over the next four years, he will continue collecting and finally publish a description of Quetzalcoatlus northropi, the largest flying animal ever found, with an estimated wingspan of 39 feet.

Polish and Mongolian paleontologists discover the entwined skeletons of a Protoceratops and a juvenile Velociraptor in the Gobi Desert, most likely locked in mortal combat.

Stephen Jay Gould and Niles Eldredge publish their theory of punctuated equilibrium, stating that evolution often occurs in short bursts, followed by long periods of stability.

Christian B. Anfinsen, Stanford Moore, and William H. Stein share a Nobel Prize in Chemistry, with Anfinsen cited for his work on ribonuclease, especially concerning the connection between the amino acid sequence and the biologically active conformation, and Moore and Stein cited for their contribution to the understanding of the connection between chemical structure and catalytic activity of the active centre of the ribonuclease molecule.

Bob Bakker publishes "Anatomical and Ecological Evidence of Endothermy in Dinosaurs" in Nature, arguing that dinosaurs were warm-blooded animals.

Harry Whittington shows a preliminary reconstruction of the Burgess Shale species Opabinia at a Palaeontological Association meeting, and the crowd roars with laughter.

Half in jest, Francis Crick and Leslie Orgel suggest that ancient aliens may have seeded the early Earth with DNA, and all life on this planet arose from that.

Peter and Rosemary Grant begin a long-term study of finches on the Galápagos Islands. In succeeding years, as they watch finches adapt to alternating wet and dry conditions, the Grants will uncover evidence that evolution proceeds more rapidly than what Darwin estimated.

Taking a line from Through the Looking Glass, Leigh Van Valen establishes the "Red Queen" hypothesis of coevolution between predator and prey: "it takes all the running you can do, to keep in the same place. If you want to get somewhere else, you must run at least twice as fast as that!"

Heinz Tobien collects a primate tooth fragment from limestone rocks in southern Germany. Studies published decades later, in 2001 and 2011, will suggest that the fossil is 17 million years old, and that a hominoid migration into Eurasia occurred 3 million years earlier than previously thought.

Donald Johanson and his team discover a female fossil hominid (to be later named Australopithecus afarensis) and call her Lucy. Lucy's discovery establishes that hominids walked upright before developing large brains, overturning some long-held beliefs about hominid evolution. Her status as a direct ancestor of modern humans, however, will remain controversial.

Heavy equipment operator Porky Hansen accidentally uncovers a mammoth tusk while leveling ground for a building. The site will reveal many more mammoths, becoming a tourist attraction for Hot Springs, South Dakota.

John Ostrom publishes a paper titled "Archaeopteryx and the Origin of Flight" reviving Thomas Henry Huxley's arguments from the 1860s.

Mary-Claire King and Allan Wilson publish their finding that human and chimpanzee DNA sequences differ by roughly 1 percent, meaning humans have more in common with chimps than chimps do with gorillas. King and Wilson suggest that humans and chimps differ largely in the DNA that switches on and off genes.

David Baltimore, Renato Dulbecco, and Howard Temin share Nobel Prize in Medicine for their discoveries concerning the interaction between tumour viruses and the genetic material of the cell.

Armed with an old geological map, selt-taught fossil hunter Joan Wiffin finds New Zealand's first recognized dinosaur fossil, a theropod tail vertebra, in the Maungahouanga Valley.

Overturning the classifications introduced by R. H. Whittaker seven years earlier, Carl Woese proposes to divide all living things into three categories: Bacteria, Archaea and Eukarya.

Paleontologists looking for cave bear remains explore Sima de los Huesos ("Pit of the Bones") at Atapuerca, Spain. For many years afterwards, it will remain the densest accumulation of fossil human bones ever discovered, including the remains of more than 30 Homo heidelbergensis individuals.

Submersible vehicle Alvin reveals deep sea vents on the ocean floor that give rise to an ecosystem owing nothing to photosynthesis. This finding prompts speculation that life on Earth first arose in deep-sea, not shallow-water, ecosystems.

Fred Sanger and collaborators publish the first complete DNA sequence of an organism, a bacteriophage, or virus infecting bacteria.

Werner Arber, Dan Nathans, and Hamilton Smith share a Nobel Prize in Medicine for the discovery of restriction enzymes and their application to problems of molecular genetics.

J. W. Kitching discovers a clutch of prosauropod eggs in South Africa, the oldest dinosaur embryos yet found. They will show that sauropods walked on all fours as small animals, but the significance of this find will be overlooked for nearly three decades.

Mary Leakey announces the discovery of fossil footprints at Laetoli demonstrating that hominids walked upright 3.6 million years ago.

Fresh out of law school and short on cash, Robert Heggestad buys an antique cabinet on an installment plan from a Virginia antique shop. The cabinet turns out to contain some 1,700 plant and invertebrate specimens from the personal collection of Alfred Russel Wallace.

Crystal Bennett finds a human-altered sea urchin fossil in Islamic (Fatimid) deposits dating from the 10th to 12th centuries in the Amman Citadel.

Christiane Nüsslein-Volhard and Eric Wieschaus describe genetic mutations affecting the body plan of the fruit fly Drosophila, and identify genes controlling the basic body plans of all animals. These genes will eventually be known as Hox genes.

Paul Berg, Walter Gilbert, and Frederick Sanger share a Nobel Prize in Chemistry, with Berg cited for his fundamental studies of the biochemistry of nucleic acids, with particular regard to recombinant-DNA, and Gilbert and Sanger cited for their contributions concerning the determination of base sequences in nucleic acids. This is Sanger's second Nobel, the first having come in 1958 for his work on the structure of insulin.

(no entry for this year)

(no entry for this year)

Barbara McClintock receives the Nobel Prize in Medicine for her discovery of mobile genetic elements.

German paleobiologist Adolf Seilacher suggests that most of the Ediacaran fossils discovered in the 1940s are not related to any modern forms. Calling them vendobionts, he argues that they went extinct after the emergence of large predators. Seilacher's interpretation, however, will remain in dispute.

David Raup and Jack Sepkoski publish the controversial claim that mass extinctions are regularly spaced at 26 million years.

Richard Leakey and his team discover Turkana Boy, the most complete Homo erectus fossil yet discovered.

Kenneth Oakley publishes Decorative and Symbolic Uses of Fossils describing, among other things, a hand axe crafted by Homo heidelbergensis featuring a fossil sea urchin, and a fossil urchin set within a bronze locket from a Gallo-Roman temple.

Paleoanthropologists excavate an artifact-rich portion of Cueva de los Aviones in Iberia. Fifty-thousand-year-old perforated and pigment-stained shells from the cave will prompt researchers to argue, 25 years later, that Neanderthals wore both makeup and jewelry.

(no entry for this year)

Allan Wilson and Rebecca Cann announce that all humans share a common ancestor who lived in Africa as recently as 150,000 years ago. Because the discovery is based on examination of mitochondrial DNA, the ancestral entity will be given the popular (and somewhat misleading) name of "Mitochondrial Eve." The controversial finding will be supported by another discovery in 2000.

Jenny Clack finds Acanthostega, the most complete Devonian tetrapod yet discovered. It has evidence for functional gills as well as legs, strongly suggesting that animals evolved legs while still living in the water.

Kansas rancher Charles Bonner collects a plesiosaur mother-and-fetus fossil. Nearly 25 years later, O'Keefe and Chiappe will describe this as evidence that that plesiosaurs gave live birth and might have been attentive mothers.

Molecular biologist John Cairns describes experiments suggesting that bacteria facing environmental stress can "direct" their mutations to produce favorable adaptations. Directed mutation will remain a controversial idea, but the possibility that organisms mutate at a greater rate (hypermutation) under environmental stress will gain more acceptance.

Sidney Altman and Thomas R. Cech share a Nobel Prize in Chemistry for their discovery of catalytic properties of RNA.

Ned Colbert finally completes his definitive species description of the Coelophysis dinosaurs he found in 1947.

Philip Gingerich finds a fossil whale, Basilosaurus in Egypt. It has tiny legs, just inches long, retaining all five toes. Five years later, he will discover an even more primitive whale ancestor, Rodhocetus, with even bigger hind legs, in Pakistan. Eighteen years later, Hans Thewissen will announce the discovery of another missing link in cetacean evolution: fox- like Indohyus found in Kashmir.

The Human Genome Project is launched with the goal of sequencing all 3 billion base pairs of human DNA by 2005.

Mongolia invites the American Museum of Natural History to reinstate excavations in the Gobi desert.

Scott Wing of the Smithsonian Institution discovers the Big Cedar Ridge fossil plant site in Wyoming. The locality will become known as the Pompeii of Cretaceous plants.

Chicxulub crater is discovered in the Yucatán Peninsula, supporting the asteroid impact theory first suggested in 1980.

A team led by Tim White finds the first traces of a hominid fossil that will later be named Ardipithecus ramidus. Seventeen years later, the team will publish a detailed description of a 4.4-million-year-old, 120-centimeter-tall, nearly complete adult female, along with fossils from 35 other individuals. The team will argue that "Ardi" should supplant Lucy at the base of the hominid tree.

Ian Campbell and collaborators publish a paper pointing to the Siberian Traps, an area of massive volcanic activity, as the cause of the Permo- Triassic mass extinction 251 million years ago.

Paleontologists led by Jim Kirkland discover Utahraptor, a super-sized velociraptor that conveniently supports the super-sized velociraptors that will appear in the screen version of Jurassic Park a year later.

Suburban San Diego roadwork uncovers mastodon bones and broken rocks at what becomes known as the (Richard) Cerutti Mastodon site. Roadwork halts while paleontologist Tom Deméré examines the find. Twenty-five years later, Deméré, Cerutti and nine other researchers will contend that the site is evidence of human presence in North America 130,000 years ago.

Kary Mullis and Michael Smith share a Nobel Prize in Chemistry, with Mullis cited for his contributions to the developments of methods within DNA-based chemistry and Smith for his fundamental contributions to the establishment of oligonucleiotide-based, site-directed mutagenesis and its development for protein studies.

Richard J. Roberts, and Phillip A. Sharp share a Nobel Prize in Medicine for their discoveries of split genes.

A calcite-encrusted hominid skeleton is discovered in a karst cave near Altamura, Italy. About two decades later, researchers will date the rock layers and test a scapula fragment, eventually concluding that the skeleton is probably 128,000 to 187,000 years old, and ranks among so- called "early Neanderthals."

Geology student Iwan Stossel stumbles across a nearly 400-million-year-old tetrapod fossil trackway on the island of Valentia, County Kerry, Ireland.

J. William Schopf publishes a description of microfossils of the Apex Basalt in Australia. His claims that they are 3.5-billion-year-old microbes that could photosynthesize and produce oxygen will later be challenged. One of his challengers, Martin Brasier, will coauthor a 2011 study on microfossils from a nearby outcrop, claiming that the 3.4-billion- year-old microbes fed off sulfur.

On an expedition in the Gobi desert, paleontologists from the American Museum of Natural History discover the skeleton of an Oviraptor dinosaur crouching over a nest of eggs, apparently incubating them in the same fashion as modern birds.

Roland Anderson and Jennifer Mather publish "Personalities of Octopuses" in the Journal of Comparative Psychology.

Anthropologist Ron Clarke finds previously overlooked foot bones, showing both ape and human qualities, from Sterkfontein. Future finds will associate these bones with a skeleton nicknamed Little Foot.

In what will later be named Chauvet Cave, French cavers discover 32,000-year-old paintings showing 400 animal images.

Edward B. Lewis, Christiane Nüsslein-Volhard, and Eric F. Wieschaus share a Nobel Prize in Medicine for their discoveries concerning the genetic control of early embryonic development.

Lee Berger and Ron Clarke publish an article in the Journal of Human Evolution arguing that the Taung child, discovered in 1924, may have been killed by a bird of prey.

Using "molecular clock" estimates of mutation rates, Greg Wray and collaborators hypothesize that metazoan phyla diverged from each other 1 billion years ago, or even earlier. In other words, they argue that metazoans existed hundreds of millions of years before the earliest metazoan fossils (about 600 million years old) yet found.

Alan Walker and Pat Shipman publish a description of advanced Vitamin A poisoning in a 1.7-million-year-old Homo erectus skeleton. They assert that it is evidence of both meat eating, caused by consuming the liver of a large carnivore, and sufficient sociability in Homo erectus to care for an ill and incapacitated individual.

Chen Pei Ji unveils Sinosauropteryx prima from Liaoning, China, the first feathered dinosaur discovered, at the Society of Vertebrate Paleontology's annual meeting. Fourteen years later, a team of Chinese and British paleontologists will argue that this animal had a striped tail, a reddish color alternating with white, based on pigment-rich microscopic spheres in the fossilized feathers.

The roughly 9,000-year-old Kennewick Man skeleton is found in the northwestern United States. Craniometric analysis initially suggests an affiliation to Ainu and Polynesian groups. Better DNA sampling methods will finally allow genetic analysis nearly 20 years later, and that will indicate a relationship closest to modern Native Americans.

Tim White's team discovers horse, antelope and other mammal bones with cut marks from stone tools — evidence of tool use 2.5 million years ago.

A team of archaeologists finds evidence of human occupation 14,000 years ago at Monte Verde, Chile, pushing back the arrival date of humans in the Americas.

Excavations near Koblenz in northern Germany turn up a Neanderthal skullcap, estimated at 170,000 years old, that was apparently used as a bowl.

Paleontologist Karen Chin receives a 17-inch coprolite excavated in Saskatchewan. Estimated at 65 million years old and full of crunched bone, it is likely the calling card of a T. rex.

Paleontologist Paul Sereno discovers the delicate Darth Vader-like skull of a dinosaur he will later name Nigersaurus taqueti and nickname the "Mesozoic Cow."

Two 5-foot-long Humboldt squid in the Sea of Cortez "mug" a diver working on a PBS documentary, making off with the gold chain hanging around the diver's neck, and demonstrating that Humboldt squid have bad manners but good taste.

Andrew Parker publishes a paper suggesting that some Cambrian animals (Wiwaxia, Canadia and Marella) developed flickering displays of iridescent color at about the same time that eyes evolved.

Aterian artifacts (named for stone tools discovered in Algeria in 1917) are estimated at 70,000 years old at sites in Libya. Over the next dozen years, the age of artifacts found at various sites in northern Africa will be pushed back to at least 110,000 years old.

Xiao, Zhang and Knoll describe fossilized animal embryos in Nature. Li, Chen and Hua simultaneously describe embryos in Science. The fossils all come from the Doushantuo phosphorites in southern China, and all are estimated to be about 570 million years old, making them the oldest fossil embryos so far discovered. Nine years later, however, Bailey and collaborators will challenge this interpretation, arguing the "fossil embryos" could just as easily be large bacteria. That challenge will be answered by the announcement of fossil embryos inside egg cysts.

Chinese paleontologists discover an exceptionally well-preserved feathered dinosaur, probably a juvenile dromaeosaur. Citing the confusion caused by language barriers and jet lag, the paleontologists' American collaborators nickname the fossil "Dave the fuzzy raptor," after a character alluded to in a Cheech and Chong routine. This fossil will be assigned to the genus Sinornithosaurus. (The next fuzzy discovery will be nicknamed "Chong.")

Based on studies of Y chromosomes, Peter Underhill publishes his finding that all modern humans share a common ancestor, bolstering the 1987 announcement from Cann and Wilson. This suggests a "bottleneck" event (population crash) among human ancestors living in Africa roughly 150,000 years ago.

Sally McBearty and Alison Brooks publish "The Revolution that Wasn't" challenging the long-held notion of a "big bang" in human intellectual evolution approximately 40,000 years ago. Instead, they cite evidence for earlier appearances of modern behavior.

A research team led by Paul Sereno discovers Rugops primus ("first wrinkle face") in the Sahara. This dinosaur's resemblance to South American fossils suggests that Africa separated from the ancient landmass of Gondwana more recently than previously thought.

Phil Currie publishes a paper suggesting that T. rex was a social animal that hunted in packs.

Alfred Sturtevant's A History of Genetics is republished jointly by the Electronic Scholarly Publishing Project and the Cold Spring Harbor Laboratory Press. Sturtevant provides an insider's perspective (he created the FIRST GENETIC MAP ) to this first-rate summary of the foundations of classical genetics.

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The International Human Genome Sequencing Consortium (Human Genome Project) publishes the initial sequence and analysis of the human genome in Nature Magazine. Celera Genomics simultaneously publishes a draft human genome sequence in Science Magazine.

Leland H. Hartwell, R. Timothy Hunt, and Sir Paul M. Nurse share a Nobel Prize in Medicine for their discoveries of key regulators of the cell cycle.

Chris Henshilwood and collaborators discover and describe 77,000-year-old artwork: stones carved with lines and triangles, from Blombos Cave on the Southern Cape coast of Africa. Three years later, Henshilwood and collaborators will describe more Blombos artifacts: tiny snail shells that were apparently pierced and worn as jewelry about 76,000 years ago. A few years after that, another research team will describe similar shell beads, at least 100,000 years old, in Israel and Algeria.

Joshua Smith and collaborators publish a description of a giant sauropod from Egypt, possibly the largest Cretaceous sauropod yet discovered. It is considered a possible food source for three large carnivorous dinosaur species discovered decades earlier by Ernst Stromer.

Luann Becker and collaborators publish a paper describing carbon fullerenes (buckyballs) at the Permo-Triassic boundary in China, Japan and Hungary. Because they can occur in meteorites, the fullerenes are cited as evidence of a meteorite impact at the end of the Permian. Other scientists will have difficulty reproducing their results, however, and the researchers' claim will remain controversial.

Odin and Néraudeau publish a description of a Neanderthal flint tool found in southwestern France with a fossil sea urchin on one side.

Sydney Brenner, H. Robert Horvitz, and John E. Sulston share a Nobel Prize in Medicine for their discoveries concerning genetic regulation of organ development and programmed cell death.

David Lordkipanidze and collaborators excavate a 1.77-million-year-old Homo erectus skull of a "toothless old man" in Dmanisi. New bone growth after the loss of his teeth suggests that he was cared for by others, the oldest evidence yet found of care for the sick in fossil hominids.

Michel Brunet and collaborators publish a description of Sahelanthropus tchadensis, a hominid fossil from western central Africa. Suspected to be 6 to 7 million years old, it is possibly the oldest hominid fossil yet found. Its location, in Chad, is expected to spur hominid fossil hunting west of Africa's Rift Valley.

M.R. Sánchez-Villagra, O. Aguilera and I. Horovitz publish a description of Phoberomys, a fossil rodent from Venezuela the size of a buffalo.

Paleontologists in Germany identify the world's oldest pantry: an underground burrow system probably dug by an extinct species of ground squirrel or hamster. Estimated at 17 million years old, the food stash is stuffed with more than 1,800 fossilized nuts.

Paleontologists led by John Horner find a T. rex fossil that will later yield evidence of blood vessels and blood cells. The fossil will also prove to be an egg-laying female.

Two separate teams, digging 2,000 miles apart, find two new Antarctic dinosaurs in the same week. One appears to be a Jurassic sauropod, the other a Cretaceous theropod.

Peter Brown, Mike Morwood and collaborators announce the find of a 1-meter- tall hominid skeleton on the Indonesian island of Flores. Found near the remains of giant lizards and pygmy elephants, the new species is formally named Homo floresiensis and nicknamed the "hobbit." Though some suspect it's a kind of malformed, small-brained midget, this interpretation will be answered by braincase scans, wrist bones too primitive to be Homo sapiens, and the announcement of several more individuals of the same species. Later studies will suggest direct ancestry from Homo erectus, although another study will argue the remains really indicate Down syndrome. The species is initially given an estimated age as young as 11,000 years, but later research will indicate an age of at least 50,000 years.

A 70-million-year-old mammal jaw is found in Pui, Romania, some 100 miles from Vlad Dracula's castle. Eleven years later, the animal will be formally named Barbatodon transylvanicus by scientists who note that strengthening iron, not blood drinking, gives the teeth their bright red color.

D. Néraudeau describes deposits in western France revealing hundreds of Acheulian and Mousterian tools, 12 of them bearing fossils.

Heather Wilson and Lyall Anderson publish a paper describing the oldest land animal fossil yet discovered: Pneumodesmus newmani, a 428-million- year-old, centimeter-long millipede found by amateur fossil hunter Mike Newman.

M.-Y. Zhu and collaborators publish a description of munched trilobite parts inside another arthropod, confirming earlier suspicions that other animals snacked on the little water bugs.

Naama Goren-Inbar and her team announce the discovery of controlled fire use by hominids at a 790,000-year-old site in Israel, pushing the earliest known use of fire back 300,000 years from previous estimates.

Qingjin Meng and collaborators publish a description of an adult Psittacosaurus dinosaur associated with 34 juveniles, apparent evidence of parental care.

The British Museum begins an excavation project at Happisburgh in Norfolk. Over the next six years, researchers will uncover artifacts pushing back the earliest evidence of human activity at such a high latitude — 45 degrees — to perhaps as much as 950,000 years ago.

Using CT scans on femurs of the early hominid Orrorin tugenensis discovered in Kenya, Galik and collaborators push back the development of bipedalism in hominids to 6 million years ago (2 million years earlier than in Australopithecus anamensis).

X. Wang and Z. Zhou publish a description of the first known pterosaur egg containing an exquisitely preserved embryo. Though the egg is slightly smaller than the average chicken egg, the embryo sports a 27-centimeter wingspan. Several months later, Z. Zhou and F. Zhang publish a description of a Cretaceous bird embryo, the first found with feathers.

A team of Japanese researchers take the first photograph ever of a giant squid in the wild. Unfortunately, they rip off one of the poor creature's tentacles in the process.

M.A. Whyte announces the discovery of a 330-million-year-old trackway of a 5-foot-long, six-legged water scorpion (eurypterid) that could walk on land while the first tetrapods tried to do the same thing. Two years later, Simon Braddy, Markus Poschmann and collaborators will announce the find of fossil claw from an 8-foot eurypterid.

Yaoming Hu, Jin Meng, Yuanqing Wang and Chuankui Li publish a description of two large carnivorous mammals from the Cretaceous, one of which appears to have the remains of a diminutive dinosaur in its stomach. These fossils overturn long-held notions that Mesozoic mammals were all rat-sized plebeians scurrying around dinosaur feet.

Yohannes Haile-Selassie and colleagues announce the find of a nearly 4- million-year-old hominid from Ethiopia, possibly the remains of Australopithecus anamensis.

Adrian Glover and Thomas Dahlgren announce the discovery of a new species of marine worm, discovered off the Swedish coast, that lives on whale bones on the sea floor. They name the species Osedax mucofloris.

Jean Moliner, Gerhard Ries, Cyril Zipfel and Barbara Hohn publish their findings on stressed plants that not only mutate at a greater rate, but also pass an increased mutation tendency to their offspring.

Andrew Z. Fine and Craig C. Mello share a Nobel Prize in Medicine for their discovery of RNA interference — gene silencing by double-stranded RNA.

Roger D. Kornberg was awarded a Nobel Prize in Chemistry for his studies of the molecular basis of eukaryotic transcription.

Jin Meng and collaborators describe a Mesozoic gliding mammal that pushes back the origin of mammalian flight by 70 million years, and suggests mammals maybe dabbled in flight earlier than birds.

Qiang Li and colleagues describe Castorocauda lutrasimilis, a Jurassic mammal that looked something like a mix between a beaver, otter, and platypus. Their discovery pushes back mammalian adaptation to an aquatic lifestyle by more than 100 million years.

The Research Council of Norway announces that oil drillers have struck a piece of dinosaur bone off the country's coast. At 1.4 miles below the North Sea, the bone fragment obtains the status of the world's deepest dinosaur.

Zeresenay Alemseged and collaborators publish a description of a 3.3- million-year-old partial skeleton from a juvenile Australopithecus afarensis from Ethiopia. The remains indicate that the australopithecene toddler walked upright and climbed trees.

Paleontologist Neil Clark suggests that some Loch Ness "sightings" may have been inspired by partial glimpses of traveling circus elephants taking dips in the lake.

Mario R. Capecchi, Sir Martin J. Evans, and Oliver Smithies share a Nobel Prize in Medicine for their discoveries of principles for introducing specific gene modifications in mice by the use of embryonic stem cells.

Fred Spoor, Meave Leakey and collaborators describe remains of Homo habilis and Homo erectus from the same rock layer a short distance apart. The finds suggest that the two species coexisted in the same area for up to 500,000 years, and that H. erectus probably did not descend from H. habilis as previously thought.

John Kappelman and collaborators announce the find of a 500,000-year-old hominid skull from Turkey showing signs of tuberculosis. The researchers argue that condition could be induced by a Vitamin D deficiency resulting from a dark-skinned individual migrating to an area with less sunlight.

Kate Trinajstic and collaborators announce the discovery of 380-million- year-old Australian fossil fish sporting fossilized muscle.

Xing Xu and collaborators describe Gigantoraptor erlianensis, a 25- foot-long, 3,000-pound, bird-like dinosaur from Inner Mongolia. The find runs counter to earlier assumptions that dinosaurs necessarily got smaller as they acquired more features resembling those of birds.

After studying grunting fish, Andrew Bass and colleagues report that the part of the brain controlling volcalization is extremely primitive, and propose that vertebrates evolved the ability to communicate through sound some 400 million years ago.

Based on studies of fossils and extant carnivores, Chris Carbone and collaborators suggest that sabertooth cats were sociable animals that hunted in packs.

Chinese and Brazilian researchers describe a sparrow-sized pterosaur from northeastern China. Although a juvenile, the pterosaur is no hatchling, and it's more mature than any of the smaller pterosaurs so far found. The researchers name the species Nemicolopterus crypticus meaning "hidden flying forest dweller."

Susan Evans, Marc Jones and David Krause describe a bowling-ball-sized fossil frog from Madagascar. Because the Cretaceous creature's closest living relative is in South America, the scientists posit a land link connecting South America, Antarctica and Madagascar. The frog is named Beelzebufo ampinga, translated loosely as "armored devil toad" or more loosely as "fossil frog from hell."

Gabriele Gentile and colleagues describe a previously overlooked pink iguana, referred to as "rosada," on the Galápagos Islands. The pink lizard species may represent the earliest divergence of land animals on the island chain that Charles Darwin made famous.

Elizabeth H. Blackburn, Carol W. Greider, and Jack W. Szostak share a Nobel Prize in Medicine for their discovery of how chromosomes are protected by telomeres and the enzyme telomerase.

Venkatraman Ramakrishnan, Thomas A. Steitz, and Ada E. Yonath share a Nobel Prize in Chemistry for their studies of the structure and function of the ribosome.

Anthony Martin and colleagues announce the discovery of three 106-million- year-old burrows in Australia that they identify as dinosaur burrows, perhaps used by the ancient reptiles to keep warm during the winter when Australia was closer to the South Pole.

Australian paleontologists announce the find of Zac, a plant-munching sauropod, on a sheep farm — the same sheep farm where paleontologists discovered Cooper, an armor-plated titanosaur, in 2004.

Chris Henshilwood and collaborators describe 13 engraved ochre artifacts from South Africa's Blombos Cave, some dating back 100,000 years. This discovery supplements earlier finds pushing back the advent of human artwork.

Erik Seiffert and coauthors argue that "missing link" Darwinius masillae described earlier in the year is not an ancestor of modern apes and monkeys but instead of modern lemurs and lorises.

Nicholas Conard and collaborators describe 35,000-year-old flutes, one nearly complete flute carved from bird bone, and flute fragments carved from ivory, discovered in Hohle Fels Cave in Ulm, Germany.

Ryan Kerney announces the discovery of algae (Oophila amblystomatis) living inside spotted salamander (Ambystoma maculatum) embryo cells — the first discovery of a photosynthetic symbiont living inside vertebrate cells.

Candy makers Hershey and Mars finance competing genomic sequences for cacao (the primary ingredient of chocolate).

Robert G. Edwards receives the Nobel prize in Medicine "for the development of in vitro fertilization"

Abderrazak El Albani and colleagues describe 2.1-billion-year-old macroscopic fossils from Gabon. The authors argue that the fossils are multicellular, pushing back the record of macroscopic life by more than 200 million years. The team also contends that the complex shapes of the fossils suggest cell signaling and coordinated growth.

Adam Brumm, Mike Morwood and colleagues publish a paper arguing that more than 40 stone artifacts found in situ and dated to approximately 1 million years ago indicate that the ancestors of Homo floresiensis (the "hobbits") arrived on Flores some 120,000 years earlier than previously thought.

Bulldozer operator Jesse Steele uncovers bones while digging a reservoir in Snowmass, Colorado. Excavations at the site will turn up more than 40 kinds of Ice Age animals.

Grzegorz Niedzwiedzki and colleagues publish a description of 395-million- year-old tetrapod tracks from Poland — 18 million years before tetrapods were thought to exist. The tracks' early date, large size and marine environment cause some skepticism about the find.

In the same week, separate research teams announce the finds of a 100- million-year-old mammal hair preserved in amber, and a 30-million-year- old pelican fossil with a 30-centimeter-long beak.

Meijer and Due announce the discovery of a 1.8-meter-tall, 16-kilogram, likely landlubbing, carnivorous stork (Leptoptilos robustus) on the island of Flores. Whether the storks ate Homo floresiensis juveniles, the hobbits hunted the storks, or everybody left each other alone is unresolved.

Nicholas Longrich describes a new dinosaur species from previously misidentified fossils at the American Museum of Natural History. Perhaps nudged by drinking buddies, he names the ceratopsian — with pretty heart shapes in its crest — Mojoceratops.

Scott Sampson and colleagues describe two species of exuberantly horned ceratopsian dinosaurs from late Cretaceous sediments in Utah: Utahceratops gettyi and Kosmoceratops richardsoni.

The Smithsonian opens its new human origins hall. A week later, Johannes Krause and colleagues announce the find of a fossil finger fragment from an unknown hominid from Siberia coincident with Neanderthals and modern humans (later dubbed Denisovans, and found distantly related to modern New Guineans). A few weeks after that, Lee Berger and colleagues announce the find of a new hominid from South Africa, Australopithecus sediba. Several weeks later, an international team announces a small DNA overlap between modern humans and Neanderthals that suggests interbreeding.

Two studies released in the same week indicate that modern Melanesians and Aboriginal Australians descended from an earlier migration out of Africa than did other populations. Further, the studies suggest that participants in the earlier migration interbred with Denisovans.

Bruce A. Beutler and Jules A. Hoffmann share the Nobel Prize in Medicine "for their discoveries concerning the activation of innate immunity"

Bruce Archibald and coauthors describe a hummingbird-sized flying ant species that hopped continents during the early Eocene.

Darren Naish and coauthors describe a 27.5-centimeter bird jaw from the Late Cretaceous found in Kazakhstan. With only the jaw, the paleontologists can't be sure whether it loped like an ostrich, or pelted unfortunate land lubbers with effluvia missiles from above.

Jianni Liu and colleagues describe Diania cactiformis, or "walking cactus." It's a kind of leggy worm known as a lobopodian that lived in the Cambrian Period some 520 million years ago. The authors indicate that it might be close to the ancestral line for arthropods — jointed animals ranging from lobsters to ladybugs.

John Paterson and coauthors report their findings on Anomalocaris, a meter- long Cambrian predator so weird its remains were once mistaken for a shrimp and a jellyfish. They find that its eyes, mounted on the ends of stalks, were compound eyes, each with 16,000 separate lenses. Like dragonfly eyes but supersized.

Junchang Lü and colleagues announce the find of a Jurassic fossil from China, a probable female pterosaur who died while laying an egg. The egg is tiny compared to the mother, and has a parchment-like eggshell. The find suggests that pterosaurs buried their eggs, and that females lacked head crests.

Lee Berger and coauthors publish several papers on Australopithecus sediba arguing that the species is a direct ancestor of modern humans and the family tree will need to be redrawn. Other paleoanthropologists aren't so sure. They do agree that the Sediba's weird mix of primitive and advanced features demonstrates remarkable hominid diversity.

Longrich and Olson describe a newly discovered wing feature on an extinct, flightless Jamaican bird named Xenicibis: built-in nunchucks.

Michael Waters and coauthors describe a stone tool assemblage at the Buttermilk Creek Complex in Texas documenting the presence of humans in the New World about 15,500 years ago — more than 2,000 years before the earliest Clovis sites.

On the sesquicentennial of its discovery, a new study challenges the status of Archaeopteryx as the earliest known bird. Xing Xu and coauthors argue that Archaeopteryx and newly discovered Xiaotingia are closer to nonavian dinosaurs. Reactions to the paper are mixed.

Relying on molecular dating and some (literally) lousy fossils, Vincent Smith and colleagues assert that lice have been rapidly evolving since well before the end of the Cretaceous, and may have hung out on feathered dinosaurs before annoying other species.

Esther Ullrich-Lüter and colleagues describe photoreceptors in sea urchin tube feet, meaning the animals may have functioned as big, compound eyes.

Sir John B. Gurdon and Shinya Yamanaka share the Novbel Prize in Medicine "for the discovery that mature cells can be reprogrammed to become pluripotent"

A boy named Evgeniy Solinder discovers a well-preserved mammoth in the Siberian Arctic. Later examination will show evidence that the mammoth was killed by spear-wielding humans, and radiocarbon dating will indicate that the animal is 45,000 years old, pushing back the earliest known human occupation of the region by 10,000 years.

After examining fossil feathers with an electron microscope and comparing them to modern feathers, a team of American and Chinese scientists announces that Microraptor, a four-winged dinosaur from China probably had an iridescent sheen to its feathers.

Chinese and Canadian researchers announce the discovery of Yutyrannus huali, a distant T. rex relative in which the 1.5-ton adult still sported long filamentous feathers.

Clive Finlayson and coauthors argue that Neanderthals collected bird feathers for use in personal adornment.

Extrapolating from contemporary cows, a team of British scientists contends that sauropod flatulence, releasing the potent greenhouse gas methane, played a significant role in the Mesozoic's warm, moist climate.

Gregory Retallack publishes a paper arguing that Ediacaran fossils long thought to be marine animals were actually land-based lichens. His argument pushes back the beginning of land-based life by 65 million years. Anticipating "sharp intakes of breath in the paleontological community," Nature sets up a comment forum at the same time it publishes Retallack's paper.

Two studies, released the same week in Science and Nature and done partly by the same researchers, describe two groups of ancient tools from South Africa. The studies say that one group, estimated to be about 71,000 years old, has small bladelets likely made from heat-treated stone, and the other group, estimated to be about 500,000 years old, has spear tips.

Walter Joyce and coauthors announce a new discovery in Germany's Messel Pit, a famous Eocene fossil site. The discovery includes multiple pairs of fossil turtles petrified in a state of indelicacy.

A team of British and U.S. scientists describe the color mechanism of a brilliant iridescent blue African fruit, Pollia condensata. Like some beetle shells, butterfly wings, and bird feathers, the fruit gets its color from microscopic structures rather than pigments, but the fruit's coiled strands of cellulose are like nothing before discovered in nature.

An international team of researchers publishes a study indicating that aphids might be able to engage in a photosynthesis-like process, using carotenoids for the "capture of light energy."

Eric Rittmeyer and coauthors describe Paedophryne amauensis, a 7.7- millimeter-long frog from New Guinea, "the smallest known vertebrate species."

Frank Glaw and coauthors describe several new species of miniature chameleons from Madagascar. Among the tiniest is Brookensia micra, with juveniles little enough to stand on the head of a match.

While sorting and relocating the Cambridge Herbarium, a university librarian finds fungi and seaweed collected by Charles Darwin on his Beagle voyage, still wrapped in newspaper from 1828.

Based on new genetic research, David Reich, Svante Pääbo and collaborators announce at a Royal Society of London meeting that Denisovans bred with Neanderthals, ancestors of people now living in East Asia and Oceania, and another group of extinct archaic humans who were genetically dissimilar to both Neanderthals and modern humans. A few weeks later, Matthias Meyer, Svante Pääbo and coauthors describe the oldest hominin DNA sequence to date, from a 400,000-year-old femur from Spain's Sima de los Huesos. The mitochondrial DNA indicate an unexpected link to Denisovans.

Using genetic material from more than 300 individuals, including aboriginal Australians from the Northern Territory, a team of geneticists argues that Australians — long believed isolated from other populations for some 45,000 years — received substantial gene flow from India about 4,230 years ago.

James E. Rothman, Randy W. Schekman and Thomas C. Südhof share the Nobel Prize in Medicine "for their discoveries of machinery regulating vesicle traffic, a major transport system in our cells"

Dale Greenwalt and coauthors describe a 46-million-year-old fossil female mosquito from Montana with traces of her last bloody meal (iron and porphyrin) in her bloated abdomen — strong evidence that these bugs have been irritating nicer animals for tens of millions of years.

David Legg describes a Cambrian arthropod with scissor-like front appendages. He names the species Kootenichela deppi after Johnny Depp.

David Lordkipanidze and coauthors publish a new paper on the hominid fossils from Dmanisi, Georgia. They argue that all the fossils from the site are Homo erectus, and make the controversial claim that hominid species found worldwide from that period — Homo erectus, Homo habilis, and Homo rudolfensis — might all belong to one species with a lot of variability.

Marie Soressi and coauthors contend that Neanderthals made leather-working tools similar to modern-day lissoirs used on pricey handbags.

Reporting on some 12 years of research at La Chapelle-aux-Saints, William Rendu and coauthors support the original interpretation of intentional Neanderthal burials. They conclude that the burial pits are not explained by natural processes and, unlike the site's scavenged animal bones, the relatively undamaged human remains at the site must have been buried quickly.

Robert DePalma and coauthors describe a likely T. rex tooth lodged between hadrosaur vertebrae. The authors also describe regenerated bone that "massively overgrew" after the hadrosaur was bitten. They cite the find as evidence that T. rex hunted, at least some of the time, and that this lucky hadrosaur lived to munch leaves another day.

Robert Reisz and collaborators announce the "discovery of an embryonic dinosaur bone bed from the Lower Jurassic of China, the oldest such occurrence in the fossil record." The find includes the remains of many individual dinosaurs at different stages of development.

John O Keefe, May-Britt Moser and Edvard I. Moser share the Nobel Prize in Medicine "for their discoveries of cells that constitute a positioning system in the brain"

After reexamining mussel shells collected by Eugène Dubois in Indonesia in the 1890s, a team of researchers announces that one of the shells bears the oldest-yet-known geometric engraving. They date the shell at around 500,000 years and attribute the handiwork to Homo erectus.

Ainara Sistiaga and colleagues describe what they contend is the oldest human coprolite yet positively identified: a roughly 50,000-year-old Neanderthal calling card from El Salt, Spain. Their analysis indicates that Neanderthals balanced their meaty diets with nuts, berries and vegetables. Other researchers find the study intriguing but hope for confirmation that the fossil turd is from a human and not, say, a bear.

An international research team announces the age of Indonesian cave art, originally discovered in the 1950s. The authors state that radiometric dating indicates the artwork is about 40,000 years old, making it comparable in age to the oldest reliably dated art found in Europe. The authors describe one hand stencil from Sulawesi's Maros karsts as "the oldest known hand stencil in the world."

Matt Lamanna and coauthors describe Anzu wyliei, an bipedal, bird- like feathered dinosaur found in North and South Dakota. Measuring 11 feet and 500 pounds, the oviraptorosaur is nicknamed the "chicken from hell."

Nick Ashton and coauthors describe human footprints discovered along England's east coast in May 2013 — exposed and eroded by ocean water in a matter of weeks. Based on the geologic setting, the researchers estimate the tracks at about 800,000 years old (making them the oldest hominid footprints yet found outside Africa), and suggest the footprints might have been left by Homo antecessor.

Nizar Ibrahim, Paul Sereno and collaborators describe the aquatic adaptations of Spinosaurus, a massive carnivorous dinosaur species first studied by Ernst Stromer around 1912. Citing the animal's tiny nostril high on the head, dense limb bones, long forelimbs and flat feet, the authors argue that the dinosaur lived a semiaquatic life.

Researchers affiliated with the Museum of Paleontlogy Egidio Feruglio announce the discovery of the biggest dinosaur yet discovered: a seven- storey-tall titanosaur from Patagonia. A few months later, an international research team names the species Dreadnoughtus schrani, and states that multiple aspects of the skeleton indicate the animal was still growing when it died.

Xiaoya Ma and coauthors describe a well preserved 520-million-year-old fossil arthropod of the species Fuxianhuia protensa. The team identifies the animal's circulatory system from dark carbon lines in the fossil. The researchers argue that this fossil preserves the oldest cardiovascular system yet known, and that complex cardiovascular systems evolved early in the Cambrian Period.

Bryan Sykes and colleagues publish their DNA analysis of 37 hair samples purported to be remains of Bigfoot or Yeti, collected from Russia, the Himalaya and the United States. They announce that two samples match the DNA of fossil polar bears, and the rest match animals such as dogs, cows, horses, raccoons, and goat-like serows.

Bhart-Anjan Bhullar, Arhat Abzhanov and colleagues announce that they have reverse engineered dinosaur snouts in chicken embryos by altering beak- building gene expressions.

Stephen Hackley publishes a review article arguing that human brains retain vestigial neural circuitry, the same circuitry that currently allows other mammals (and once allowed our ancient ancestors) to orient their ears toward novel stimuli.

William C. Campbell and Satoshi Omura share the Nobel prize in Medicine "for their discoveries concerning a novel therapy against infections caused by roundworm parasites" and Tu Youyou receives a Nobel {rize in Medicine "for her discoveries concerning a novel therapy against Malaria"

A team led by Sonia Harmand announces the discovery of stone tools at Lomekwi, Kenya, estimated to be 3.3 million years old, meaning older than the genus Homo. The heaviest of the tools prompt archaeologist David Braun to ask about their makers, "What the hell do these things look like if they can use 15-kilogram tools?"

After recruiting skinny spelunkers to excavate a cave he can't reach, and recruiting "early career scientists" to interpret the fossils, Lee Berger, with his coauthors, announces Homo naledi from South Africa. Berger and coauthors suggest that the hominid might be more than 2 million years old and that it might have intentionally disposed of its dead. In an accompanying commentary, Chris Stringer expresses surprise at "the apparent lack of attempts" to date the fossils.

After studying Chinle Formation rocks at Ghost Ranch, New Mexico, Jessica Whiteside and coauthors argue that weather extremes, drought and fires kept dinosaurs from dominating Earth's tropics for the first 30 million years of the Mesozoic Era.

An international research team announces that Sterkfontein Cave's "Little Foot," classified as Australopithecus prometheus, is 3.67 million years old, making the fossil older than the iconic Lucy.

An international research team describes Aegirocassis benmoulae, a 480- million-year-old arthropod similar to Anomalocaris that might have measured as much as 2 meters (6 feet) long. Found in Morocco, the fossils have been preserved in three dimensions, and indicate that the giant arthropod was a filter feeder.

Based on new specimens from Burgess Shale, Martin Smith and Jean-Bernard Caron describe the elusive head of the Cambrian animal Hallucigenia, noting that it is shaped like a spoon with "a really cheeky semicircular smile" next to multiple appendages. They also note that what had previously been mistaken for the head was at the other end of the body — "decay fluids" squeezed out of the gut during fossilization.

Caleb Brown and Donald Henderson describe Regaliceratops peterhewsi, a new species of ceratopsid dinosaur that they have nicknamed "Hellboy."

Emily Mitchell and coauthors hypothesize that Fractofusus, an Ediacaran Period rangeomorph (unlike a modern plant or animal, but big enough to leave a distinctive fossil), reproduced in two ways: by sprouting clones from its body, and by releasing propagules (akin to seeds) into the ocean water.

Fernando Novas and coauthors describe Chilesaurus diegosuarezi, a "bizarre herbivorous" theropod, i.e., a member of a group of typically carnivorous dinosaurs, from Jurassic-aged rocks in Chile. The dinosaur species is named for Diego Suárez, who found the first fossil bones in the rock formation when he was seven years old.

James Lamsdell and coauthors describe the oldest-yet-known sea scorpion (eurypterid), from 467-million-year-old rocks in Iowa. The researchers state that Pentecopterus decorahensis grew to over 5 feet long and, unlike any other arthropod known (living or extinct), radically changed limb shape during the growth process. The authors suggest that eurypterids either diversified very quickly, or originated much earlier than previously thought.

Nohemi Sala and coauthors describe a 430,000-year-old skull from Spain's Sima de los Huesos Cave bearing two fractures indicative of deadly blunt- force trauma. The authors describe the find as "the earliest evidence of lethal interpersonal violence in the hominin fossil record."

Silvia Danise and Nicholas Higgs describe trace fossils suggesting that the marine worm genus Osedax fed on the bones of Cretaceous plesiosaurs that fell to the ocean floor 100 million years ago. They hypothesize that the genus of the species Osedax mucofloris ("bone-eating snot flower" first described in 2005) ate the bones of Mesozoic marine reptiles and sea turtles before whales evolved into the worms' favorite food.

Xiaoya Ma and coauthors argue that brain tissue has been fossilized in seven specimens of the Cambrian arthropod Fuxianhuia protensa from the Chenjiang fossil beds in southwest China.

Xing Xu and colleagues describe Yi qi, a small Jurassic dinosaur with weird rod-like bones projecting from its wrists, and traces of membranes. The researchers assert that the rod-like bones might have supported membranes that might have been used in flight, but probably just gliding. They also note that the dinosaur had a relatively heavy behind and would have occasionally stalled.

A team of scientists describes Acmella nana collected from the forests of Borneo. The shells range in size from 0.60 to 0.79 millimeters, roughly 0.30 millimeters smaller than the previous tiniest-snail-species record holder identified just a month before.

Jérémie Teyssier and coauthors attribute panther chameleons' ability to quickly change color to their ability to rapidly tune a network of photonic crystals under their skin. The authors also argue that a deeper layer of larger crystals in the chameleons' skin reflects sunlight, especially in the near-infrared. In short, the crystals keep the chameleons both cool and colorful.

Nature publishes "Here Be Dragons" explaining that medieval dragons, who engaged in a centuries-long slumber encouraged by the Little Ice Age and "a bewildering lack of knights," might undergo a resurgence due to global warming since higher temperatures benefit "buccal and nasal furnaces." The article is published online on April 1 with the editorial note that "some of its content may merit a degree of scepticism."

Yoshinori Ohsumi receives the Nobel prize in Medicine "for his discoveries of mechanisms for autophagy"

A team led by Victoria McCoy publishes an analysis of Tullimonstrum gregarium (the Tully monster, originally found in 1955) concluding that the animal was a vertebrate related to lampreys. One of the paper authors, Carmen Soriano, remarks, "If you put in a box a worm, a mollusk, an arthropod and a fish, and you shake, then what you have at the end is a Tully monster."

Allen Nutman and colleagues argue that a group of metamorphic rocks from the Isua Supracrustal Belt in southwest Greenland preserve 3.7-billion- year-old stromatolites. If the claim is correct, the fossils are the oldest so far discovered, but other researchers express doubts.

Błażej Błażejowski and coauthors argue that Trimerocephalus chopini, 365-million-year-old eyeless Devonian trilobites, migrated by forming single-file lines, keeping their queues together through touch and/or chemical signals such as pungent urine.

David Norman and colleagues announce that a mineral lump found on a Sussex beach in 2004 is fossilized brain tissue from a 133-million-year-old dinosaur, perhaps an Iguanodon or related species.

Elizabeth Martin-Silverstone and coauthors describe fossil pterosaur fragments (an upper arm bone and some vertebrae) from Hornby Island, British Columbia. The researchers state that the internal structure of the humerus and the partially fused condition of the vertebrae suggest the individual was nearly full grown when it died, and had a wingspan of just 1.5 meters (5 feet). If the pterosaur was as little as the researchers suspect, then when it was perched, it would be about as short as a house cat.

Frido Welker and coauthors argue that 40,000-year-old jewelry, collected decades earlier from Arcy-sur-Cure, was made by Neanderthals. The researchers base their claim on the amino acids found in the collagen of bone fragments associated with the ancient bits of bling — amino acids indicative of Neanderthals as opposed to archaic humans.

Gerrit van den Bergh and coauthors announce the find of Homo floresiensis- like fossils from a new site on the island of Flores, about 50 miles east of the 2004 "hobbit" discovery site. The new find, including a partial mandible and some teeth, is estimated at 700,000 years old, more than half a million years older than the fossils found in 2004.

John Kappelman and colleagues claim that the Australopithecus africanus specimen Lucy fell from a tree more than 30 feet high, dying in the fall that left observable fractures in her fossil bones. The claim attracts skepticism from Donald Johanson and Tim White, members of the original Lucy discovery team.

Lida Xing and coauthors describe the feathered tail of a theropod dinosaur, perhaps a young coelurosaur. The fossil is preserved in Cretaceous amber from Myanmar (Burma).

Mary Higby Schweitzer and coauthors publish a study of medullary bone (known as a ready-to-use source of calcium for making eggshells in modern birds) in a Tyrannosaurus rex fossil. The researchers argue that the medullary tissue shows that this T. rex was not only female but also pregnant.

Mikkel Pedersen and coauthors argue that Beringia did not shed glaciers and gain vegetation early enough to support the ancestors of Clovis people, though later migrants to the Americas might have traveled that route.

Nichole Gunter and coauthors hypothesize that dung beetles probably evolved during the Cretaceous Period to eat dinosaur poo, and that "the switch in dinosaur diet to incorporate more nutritious and less fibrous angiosperm foliage provided a palatable dung source that ultimately created a new niche for diversification."

Julius Nielsen and coauthors publish an account of the longest-lived vertebrate so far discovered: a Greenland shark (Somniosus microcephalus) that ranges in age from 272 to 512 years old.

Jeffrey C. Hall, Michael Rosbash and Michael W. Young share the Nobel Prize in Medicine "for their discoveries of molecular mechanisms controlling the circadian rhythm"

A Chinese-U.S. team announces the discovery of two hominid skullcaps, 105,000 to 125,000 years old, from eastern China. Although the researchers don't assign the crania to any species, some of their peers speculate that the fossils might be Denisovan.

After studying von Ebner lines (microscopic daily growth lines in teeth) from Protoceratops andrewsi and Hypacrosaurus stebingeri embryos, Gregory Erickson and coauthors argue that the dinosaurs had months-long gestation periods, developing more like slow-growing reptiles than fast-growing birds.

An international research team describes a well-preserved baby bird specimen in a 99-million-year-old piece of amber collected from Burma. The scientists classify the hatchling as a member of the enantiornithes, extinct relatives of modern birds that still had clawed wings and teeth.

An international team describes California's Cerutti Mastodon site, found in 1992. The researchers argue that the assemblage of broken mastodon bones and rocks comprises evidence of human activity. Based on measures of radioactive uranium and thorium in the bones, they argue that the site is 130,000 years old. Because this date is generally understood to precede modern Homo sapiens spreading beyond Africa, the paper suggests that Neanderthals, Denisovans or even late Homo erectus might have reached North America via the Bering Land Bridge and Pacific Coast. Nature, the paper's publisher, calls the study a "jaw-dropping claim." Parties to the announcement anticipate skepticism.

Darren Naish and Mark Witton describe a robust cervical verterbra from the Transylvanian azhdarchid pterosaur Hatzegopteryx. The researchers argue that the animal had a short, thick neck that could withstand torsion and compression, and could bear heavy loads. Considering the fossil locality (the Romanian town of Haţeg) was an island during the Cretaceous, and therefore lacked typical terrestrial predators, the authors contend that Hatzegopteryx might have occupied the top of the food chain. Witton describes these pterosaurs as "giraffe-sized, quadrupedal Panzer- storks."

Gerald Mayr and colleagues describe a 150-centimeter- (60-inch-) long, 61- million-year-old fossil penguin, almost the biggest fossil penguin ever found, and the oldest of that size. The researchers state that this fossil's differences from more primitive penguins implies that penguins arose earlier than previously thought, probably during the Mesozoic.

Thomas Hegna and coauthors describe possible eggs from a roughly 450- million-year-old pyritized trilobite, Triarthrus eatoni. The tiny eggs are clustered near the animal's head, indicating that the head was the gamete-ejection point.

James P. Allison and Tasuku Honjo share the Nobel Prize in Medicine "for their discovery of cancer therapy by inhibition of negative immune regulation"

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