Foundation of the Royal Society, London, for the promotion of mathematical and physical science.

Robert Boyle publishes The Sceptical Chymist helping to transform alchemy into chemistry. Though an alchemist himself with his own cache of secret notebooks, Boyle begins writing up experiments for use by others.

(no entry for this year)

German physician Otto von Guericke pieces together bones from different species to make a fossil "unicorn."

In his private museum in Rome, Virgilio Romano exhibits a Hippopotamus major canine tooth found in Pleistocene gravels along the Via Nomentana.

Thomas Willis publishes The Anatomy of the Brain and Nerves.

Isaac Newton discovers that white light is composed of different colors.

Robert Hooke observes cork under a microscope and uses the word cells to describe the tiny chambers that he sees. He publishes drawings of these cells, of fleas, and of other small creatures, in his book Micrographia.

Le Journal des Savants is first published in France, and Philosophical Transactions of the Royal Society is first published in England.

Samuel Morland builds a mechanical calculator that will add and subtract

Gravity is discovered.

Niels Stensen (Steno) describes his dissection of the head of a giant white shark and correctly identifies shark teeth, still generally thought (despite arguments to the contrary from Rondelet and Colonna in the preceding century) to be serpent tongues.

Natural historian John Somner finds woolly rhino teeth near Canterbury in Kent, and figures they might be the remains of a sea monster. As he will die before he can publish his conclusions, his brother William will print his article A Brief Relation of Some Strange Bones There Lately Digged Up In Some Grounds of Mr. John Somner.

Francesco Redi publishes Esperienze Intorno alla Generazione degli Insetti (Experiments on the Generation of Insects), which is regarded as his masterpiece and a milestone in the history of modern science. At the time, prevailing wisdom was that maggots arose spontaneously from rotting meat. Redi took six jars and divided them into two groups of three: In one experiment, in the first jar of each group, he put an unknown object; in the second, a dead fish; in the last, a raw chunk of veal. Redi covered the tops of the first group of jars with fine gauze so that only air could get into it. He left the other group open. After several days, he saw maggots appear on the objects in the open jars, on which flies had been able to land, but not in the gauze-covered jars. In the second experiment, meat was kept in three jars. One of the jars was uncovered, and two of the jars were covered, one with cork and the other one with gauze. Flies could only enter the uncovered jar, and in this, maggots appeared. In the jar that was covered with gauze, maggots appeared on the gauze but did not survive. Knowing full well the terrible fates of out-spoken thinkers such as Giordano Bruno and Galileo Galilei, Redi was careful to express his new views in a manner that would not contradict theological tradition of the Church; hence, his interpretations were always based on biblical passages, such as his famous adage: omne vivum ex vivo ("All life comes from life").

Jan Swammerdam dissects a caterpillar for Cosimo de Medici, demonstrating that the butterfly wings already exist inside the caterpillar's body. A year later, he will publish Historia Insectorum Generalis.

Robert Hooke presents a lecture to the Royal Society claiming that earthquakes, not the biblical flood, have caused fossils to be found on mountaintops and buried in stone.

Niels Stensen (Steno) publishes Forerunner, showing diagrammatic sections of the Tuscany area geology, making the important point that sediments are deposited in horizontal layers.

Brandt discovers phosphorus.