Chinese legendary adventurer Wan Hu attempts to leave the Earth by sitting on a chair with 47 rockets tied to it, holding a kite in each of his hands, and flying into the sky after his servants were ordered to light the fuses to the rockets. But the rockets exploded and Wan Hu was gone when the air cleared. While most authorities consider the story apocryphal, some Chinese scholars believe that foreigners from several different countries in the west were unlikely to fabricate such a story out of thin air. The tale may be based on the stories told by European missionaries who arrived in China since the late Ming dynasty, and then passed on by word of mouth. Alternatively, these European and American scholars may have indirectly relied on records in an ancient Chinese document that has been subsequently lost.

African Slaves in the New World Spanish settlers bring slaves from Africa to Santo Domingo (now the capital of the Dominican Republic).

Ismail I, the founder and first shah of Safavid Iran, ruled from 1501 until his death in 1524. His reign is often considered the beginning of modern Iranian history, as well as one of the gunpowder empires. The rule of Ismail I is one of the most vital in the history of Iran. Before his accession in 1501, Iran, since its Islamic conquest eight-and-a-half centuries earlier, had not existed as a unified country under native Iranian rule. The dynasty founded by Ismail I would rule for over two centuries, being one of the greatest Iranian empires and at its height being amongst the most powerful empires of its time, ruling all of present-day Iran, the Republic of Azerbaijan, Armenia, most of Georgia, the North Caucasus, and Iraq, as well as parts of modern-day Turkey, Syria, Pakistan, Afghanistan, Uzbekistan, and Turkmenistan.

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At the Battle of Cerignola Spanish forces defeat the French, considered the first battle in history won by gunpowder small arms.

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Martin Luther ordained to the priesthood. Luther was the seminal figure of the Protestant Reformation. He is widely regarded as one of the most influential figures in Western and Christian history. He came to reject several teachings and practices of the Roman Catholic Church; in particular, he disputed the view on indulgences. Luther attempted to resolve these differences amicably, first proposing an academic discussion of the practice and efficacy of indulgences in Ninety-five Theses, which he authored in 1517. In 1520, Pope Leo X demanded that Luther renounce all of his writings, and when Luther refused to do so, excommunicated him in January 1521. Later that year, Holy Roman Emperor Charles V condemned Luther as an outlaw at the Diet of Worms. When Luther died in 1546, Pope Leo X's excommunication was still in effect. Luther taught that salvation and, consequently, eternal life are not earned by good deeds; rather, they are received only as the free gift of God's grace through the believer's faith in Jesus Christ, who is the sole redeemer from sin. Luther's theology challenged the authority and office of the pope by teaching that the Bible is the only source of divinely revealed knowledge, and opposed sacerdotalism by considering all baptized Christians to be a holy priesthood. Attempts by the Catholic Church to suppress the new protestant movement led to more than 200 years of wars — the European wars of religion.

Maximilian I becomes Holy Roman Emperor, a role he held until his death in 1519. He was never crowned by the Pope, as the journey to Rome was blocked by the Venetians. He proclaimed himself elected emperor in 1508 (Pope Julius II later recognized this) at Trent, thus breaking the long tradition of requiring a papal coronation for the adoption of the Imperial title. Maximilian was the only surviving son of Frederick III, Holy Roman Emperor, and Eleanor of Portugal. Since his coronation as King of the Romans in 1486, he ran a double government, or Doppelregierung (with a separate court), with his father until Frederick's death in 1493. Maximilian expanded the influence of the House of Habsburg through war and his marriage in 1477 to Mary of Burgundy, the ruler of the Burgundian State, heiress of Charles the Bold, though he also lost his family's original lands in today's Switzerland to the Swiss Confederacy. Through the marriage of his son Philip the Handsome to eventual queen Joanna of Castile in 1496, Maximilian helped to establish the Habsburg dynasty in Spain, which allowed his grandson Charles to hold the thrones of both Castile and Aragon.

Henry VIII becomes King of England. Henry is known for his six marriages and his efforts to have his first marriage (to Catherine of Aragon) annulled. His disagreement with Pope Clement VII about such an annulment led Henry to initiate the English Reformation, separating the Church of England from papal authority. He appointed himself Supreme Head of the Church of England and dissolved convents and monasteries, for which he was excommunicated by the pope. Henry brought radical changes to the Constitution of England, expanding royal power and ushering in the theory of the divine right of kings in opposition to papal supremacy. He frequently used charges of treason and heresy to quell dissent, and those accused were often executed without a formal trial using bills of attainder. He achieved many of his political aims through his chief ministers, some of whom were banished or executed when they fell out of his favor. Thomas Wolsey, Thomas More, Thomas Cromwell, and Thomas Cranmer all figured prominently in his administration.