Painting by Pieter Bruegel the Elder: Children's Games The children, who range in age from toddlers to adolescents, roll hoops, walk on stilts, spin hoops, ride hobby-horses, stage mock tournaments, play leap-frog and blind man's bluff, perform handstands, inflate pigs' bladders and play with dolls and other toys. They have also taken over the large building that dominates the square: it may be a town hall or some other important civic building, in this way emphasizing the moral that the adults who direct civic affairs are as children in the sight of God. This crowded scene is to some extent relieved by the landscape in the top left-hand corner; but even here children are bathing in the river and playing on its banks. The artist's intention for this work is more serious than simply to compile an illustrated encyclopaedia of children's games, though some eighty particular games have been identified. Bruegel shows the children absorbed in their games with the seriousness displayed by adults in their apparently more important pursuits. His moral is that in the mind of God children's games possess as much significance as the activities of their parents.

By winning the Battle of Okehazama, Oda Nobunaga becomes one of the pre-eminent warlords of Japan.

A total solar eclipse visible in Europe occurred on August 21. The prediction of this solar eclipse helped to inspire Tycho Brahe's (1546–1601) interest in astronomy at the age of 13. The announcement of this forthcoming eclipse in France caused many Frenchmen to panic, fighting one another to be next in line at the confessional. One beleaguered parish priest tried to calm the populace by announcing that since there were so many waiting to confess, a decision had been made to postpone the eclipse for two weeks.

(no entry for this year)

Painting by Pieter Bruegel the Elder: The Fall of the Rebel Angels The depiction of this subject is taken from a passage from the Book of Revelation (12, 2-9) and reveals the artist's profound debt to Hieronymous Bosch, especially in the grotesque figures of the fallen angels, shown as half-human, half-animal monsters. Together with Dulle Griet and The Triumph of Death, which have similar dimensions, it was probably painted for the same collector and destined to become part of a series.

Painting by Pieter Bruegel the Elder: The Triumph of Death The painting shows a panorama of an army of skeletons wreaking havoc across a blackened, desolate landscape. Fires burn in the distance, and the sea is littered with shipwrecks. A few leafless trees stud hills otherwise bare of vegetation; fish lie rotting on the shores of a corpse-choked pond.

Britain Joins Slave Trade. John Hawkins, the first Briton to take part in the slave trade, makes a huge profit hauling human cargo from Africa to Hispaniola.

Diego Gutiérrez and Hieronymus Cock published the map Americae Sive Quartae Orbis Partis Nova Et Exactissima Descriptio (A New and Most Exact Description of America or The Fourth Part of the World). The map (an ornate geographical map of the Americas) encompasses the eastern coast of North America, the entire Central and South America and parts of the western coasts of Europe and Africa. Americae Sive Quartae Orbis Partis Nova Et Exactissima Descriptio is the earliest scale wall map of the New World and the first to use the name "California".

Outbreak of bubonic plague — The Black Death — in London kills over 20,000. Plague epidemics ravaged London in 1563, 1593, 1603, 1625, 1636, and 1665, reducing its population by 10 to 30% during those years.

Galileo Galilei is born born in Pisa (then part of the Duchy of Florence), Italy, on 15 February 1564.

Painting by Pieter Bruegel the Elder: The Hunters in the Snow (Dutch: Jagers in de Sneeuw), also known as The Return of the Hunters, is a 1565 oil-on-wood painting by Flemish artist Pieter Bruegel the Elder. The Northern Renaissance work is one of a series of works, five of which still survive, that depict different times of the year. The Hunters in the Snow, and the series to which it belongs, are in the medieval and early Renaissance tradition of the Labours of the Months: depictions of various rural activities and work understood by a spectator in Breugel's time as representing the different months or times of the year.

College of Physicians of London empowered to carry out human dissections.

Roger Taverner writes his Arte of Surveyinge.

Painting by Giuseppe Arcimboldo: The Four Elements a series of paintings that were commissioned by Maximilian II, Holy Roman Emperor. The portraits display figures in profile formed by different animals or objects. Earth is represented by land animals, Air by birds, Water by marine creatures and Fire by burning wood and cannons. This series attempts to express harmony out of chaos with wild animals forming distinct faces. It also praises Maximilian, suggesting that he is a ruler who controls even the four primal elements.

Painting by Pieter Bruegel the Elder: The Wedding Dance The painting depicts 125 wedding guests. As was customary in the Renaissance period, the brides wore black and men wore codpieces. Voyeurism is depicted throughout the entire art work; dancing was disapproved of by the authorities and the church, and the painting can be seen as both a critique and comic depiction of a stereotypical oversexed, overindulgent, peasant class of the times.

Danish astronomer Tycho Brahe, while studying at the University of Rostock in Mecklenburg, loses part of his nose in a duel with fellow nobleman and relation Manderup Parsberg over a mathematical formula.

Mary, Queen of Scots, is imprisoned by Elizabeth I. Mary, the only surviving legitimate child of James V of Scotland, was six days old when her father died and she acceded to the throne. Mary had previously claimed Elizabeth's throne as her own and was considered the legitimate sovereign of England by many English Catholics, including participants in a rebellion known as the Rising of the North. Perceiving her as a threat, Elizabeth had her confined in various castles and manor houses in the interior of England. After eighteen and a half years in custody, Mary was found guilty of plotting to assassinate Elizabeth in 1586. She was beheaded the following year.

Paracelsus (Philippus Aureolus Theophrastus Bombastus von Hohenheim) publishes On the Miners' Sickness and Other Diseases of Miners, a pioneering example of occupational medicine.

Fabrizio Mordente publishes a single sheet treatise in Venice showing illustrations of his "proportional eight-pointed compass" which has two arms with cursors that allow the solution of problems in measuring the circumference, area and angles of a circle.

The Transylvanian Diet, under the patronage of the prince John Sigismund Zápolya, the former King of Hungary, inspired by the teachings of Ferenc Dávid, the founder of the Unitarian Church of Transylvania, promulgates the Edict of Torda, the first law of Freedom of religion and of conscience in the World.

The Mercator projection is first used in Gerardus Mercator's world map Nova et Aucta Orbis Terrae Descriptio ad Usum Navigantium Emendata.