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Publication of Erasmus Reinhold's ephemeris (collection of astronomical tables), the Tabulae Prutenicae, helping to disseminate Copernican methods of astronomical calculation.

Cornelius Gemma publishes the first illustration of a human tapeworm.

Thierry de Hery publishes La Méthode Curatoire de la Maladie Vénérienne, Vulgairement Appellée Grosse Vairolle, & de la Diuersité de Ses Symptomes, the first work in French on syphilis.

Mary Tudor becomes the first queen regnant of England and restores the Church of England under Papal authority.

Publication in Spain of Libro del Exercicio, considered the first book on the benefits of physical exercise for health.

Completion of the Church of Sant'Andrea in Via Flaminia, Rome, designed by Giacomo Barozzi da Vignola, the first church of the Italian Renaissance to have an elliptical dome.

Guillaume Rondelet publishes a volume on Mediterranean fish — De Piscibus — and includes the assertion that glossopetrae, or tongue stones, resemble shark teeth. The hypothesis attracts little attention.

Roman naturalist Ippolito Salviani publishes History of Aquatic Animals.

Venetian mathematician Giambattista Benedetti publishes two editions of Demonstratio proportionum motuum localium, developing his new doctrine of the speed of bodies in free fall.

Pierre Belon publishes L'Histoire de la nature des oyseaux, a pioneering work in the comparative anatomy of birds.

The first edition of Alessio Piemontese's Secreti is published, listing about 350 medical recipes along with observations of nature. The publisher, Girolamo Ruscelli, will later claim authorship. Enormously popular, the book will total 104 editions through 1699.

Pomponio Algerio, 25-year-old radical theologian, is executed by boiling in oil as part of the Roman inquisition. After refusing to conform to Church doctrine, he was sentenced to prison and asked to reconsider his Lutheran beliefs. After a year behind bars, he still refused to reconsider. Because Venetian authorities would not consent to an execution, Pope Paul IV sent officials to extradite Pomponio to Rome. In Rome, on 21 August 1555, a monk from the brotherhood of St John the Beheaded visited Pomponio in his cell urging him to repent. If he repented, he would be strangled before burning. The 24-year-old student refused. One year later, on 22 August 1556, he was executed by civil authorities in the Piazza Navona, Rome. Maintaining his composure while he was boiled in oil, he stayed alive for 15 minutes before dying.

The Shaanxi earthquake in China, during the Ming Dynasty, is history's deadliest known earthquake, killing approximately 830,000 people.

Great Comet of 1556 becomes visible in Europe. The comet, known as C/1556 D1 in modern nomenclature, appears to have been seen in some places before the end of February; but it was not generally observed until the middle of the first week in March. Its apparent diameter was equal to half that of the Moon, and the tail resembled " the flame of a torch agitated by the wind," — an expression doubtless referring to the coruscations which are sometimes visible in the tails of comets

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Elizabeth Tudor becomes Queen Elizabeth I at age 25. Sometimes called The Virgin Queen, Gloriana or Good Queen Bess, the childless Elizabeth was the last monarch of the Tudor dynasty. Elizabeth was the daughter of Henry VIII and Anne Boleyn, his second wife, who was executed two-and-a-half years after Elizabeth's birth. Anne's marriage to Henry VIII was annulled, and Elizabeth was declared illegitimate. Elizabeth's reign is known as the Elizabethan era. The period is famous for the flourishing of English drama, led by playwrights such as William Shakespeare and Christopher Marlowe, and for the seafaring prowess of English adventurers such as Francis Drake.

Led by Don Tristán de Luna y Arellano, a Spanish missionary colony of 1500 men on thirteen ships arrives from Vera Cruz at Pensacola Bay, founding the first European settlement on the mainland United States. On September 19, the colony is decimated by a hurricane.

Jean Nicot, French ambassador to Portugal 1559–61, describes the medicinal properties of tobacco which he introduces in the form of snuff to the French court. The plant was also an instant success and soon many of the fashionable people of Paris began to use the plant, making Nicot a celebrity. The tobacco plant, Nicotiana, also a flowering garden plant, was named after him by Carl Linnaeus, as was nicotine.