Painting by Hieronymous Bosch: The Garden of Earthly Delights the modern title given to a triptych oil painting on oak panel painted by the Early Netherlandish master Hieronymus Bosch, between 1490 and 1510, when Bosch was between 40 and 60 years old. Bosch's religious beliefs are unknown, but interpretations of the work typically assume it is a warning against the perils of temptation. The outer panels place the work on the Third Day of Creation. The intricacy of its symbolism, particularly that of the central panel, has led to a wide range of scholarly interpretations over the centuries. Twentieth-century art historians are divided as to whether the triptych's central panel is a moral warning or a panorama of the paradise lost. He painted three large triptychs (the others are The Last Judgment of c. 1482 and The Haywain Triptych of c. 1516) that can be read from left to right and in which each panel was essential to the meaning of the whole. Each of these three works presents distinct yet linked themes addressing history and faith. Triptychs from this period were generally intended to be read sequentially, the left and right panels often portraying Eden and the Last Judgment respectively, while the main subject was contained in the centerpiece. It is not known whether The Garden was intended as an altarpiece, but the general view is that the extreme subject matter of the inner center and right panels make it unlikely that it was planned for a church or monastery. It has been housed in the Museo del Prado in Madrid, Spain since 1939.

Painting by Albrecht Dürer:: Lamentation of Christ Lamentation of Christ (also known as Glimm Lamentation) is an oil-on-panel painting of the common subject of the Lamentation of Christ by the German Renaissance artist Albrecht Dürer, executed around 1500 and now in the Alte Pinakothek of Munich, Germany. The work was commissioned by goldsmith Jakob Glimm as a memorial of his first wife, Margaret Holzmann, who a died in 1500. The removal of later re-painting in 1924 showed the original figures of the donors (Glimm and his three sons) and of the dead woman, depicted in far smaller proportions than the religious characters.

Painting by Albrecht Dürer: Paumgartner altarpiece,an early triptych painting by Albrecht Dürer, commissioned by the Paumgartner family of Nuremberg. The central panel depicts a nativity scene, while the wings depict Saint George (left) and Saint Eustace (right). The saint's faces are donor portraits of the brothers Stephan and Lukas Paumgartner, respectively. Other members of the Paumgartner family are depicted as small figures in the center panel. In 1616 the painting was bought by Maximilian I, Elector of Bavaria and taken to Munich. There it was altered to suit 17th century tastes. This entailed adding helmets, horses, and landscape backgrounds to the portraits of the saints and painting over the small donor figures in the center panel. These embellishments were removed by restorators in 1903. On 20 April 1988, the Paumgartner altarpiece was one of three paintings at the Alte Pinakothek that were attacked with concentrated sulfuric acid by the serial art vandal Hans-Joachim Bohlmann. It alone suffered at least $12 million worth of damage. After 21 years of restoration, it was returned to display in 2010.

Chinese legendary adventurer Wan Hu attempts to leave the Earth by sitting on a chair with 47 rockets tied to it, holding a kite in each of his hands, and flying into the sky after his servants were ordered to light the fuses to the rockets. But the rockets exploded and Wan Hu was gone when the air cleared. While most authorities consider the story apocryphal, some Chinese scholars believe that foreigners from several different countries in the west were unlikely to fabricate such a story out of thin air. The tale may be based on the stories told by European missionaries who arrived in China since the late Ming dynasty, and then passed on by word of mouth. Alternatively, these European and American scholars may have indirectly relied on records in an ancient Chinese document that has been subsequently lost.

Pedro Álvares Cabral, a Portuguese nobleman, military commander, navigator and explorer, sailed far into the western Atlantic Ocean, perhaps intentionally, and made landfall (April 1500) on what he initially assumed to be a large island. As the new land was within the Portuguese sphere according to the 1494 Treaty of Tordesillas, Cabral claimed it for the Portuguese Crown. He explored the coast, realizing that the large land mass was probably a continent, and dispatched a ship to notify King Manuel I of the new territory. The continent was South America, and the land he had claimed for Portugal later came to be known as Brazil. The fleet reprovisioned and then turned eastward to resume the journey to India.

The Castilian navigator and cartographer, Juan de la Cosa, creates a world map that includes the earliest known representation of the New World and the first depiction of the equator and the Tropic of Cancer on a nautical chart. Juan de la Cosa's map is a manuscript nautical chart of the world drawn on two joined sheets of parchment sewn onto a canvas backing. It measures 96 cm high by 183 cm wide. A legend written in Spanish at the western edge of the map translates as "Juan de la Cosa made this (map) in the port of Santa Maria in the year 1500". The overall style is similar to other contemporary charts of the Mediterranean, especially maps produced in Majorca, an important center of map making at the time.

Leonardo da Vinci, finding many fossils in canal building sites, proposes that fossil shells of marine animals are found on mountains because Earth undergoes transformations that cause areas once submerged to become exposed.

Painting by Albrecht Dürer: Self Portrait, a panel painting. Painted early in 1500, just before his 29th birthday, it is the last of his three painted self-portraits. Art historians consider it the most personal, iconic and complex of his self-portraits. The self-portrait is most remarkable because of its resemblance to many earlier representations of Christ. Art historians note the similarities with the conventions of religious painting, including its symmetry, dark tones and the manner in which the artist directly confronts the viewer and raises his hands to the middle of his chest as if in the act of blessing. Dürer's face has the inflexibility and impersonal dignity of a mask, hiding the restless turmoil of anguish and passion within. In its directness and apparent confrontation with the viewer, the self-portrait is unlike any that came before. It is half-length, frontal and highly symmetrical; its lack of a conventional background seemingly presents Dürer without regard to time or place. The placement of the inscriptions in the dark fields on either side of Dürer are presented as if floating in space, emphasizing that the portrait has a highly symbolic meaning. Its somber mood is achieved through the use of brown tones set against the plain black background. The lightness of touch and tone seen in his earlier two self-portraits has been replaced by a far more introverted and complex representation. In 1500, a frontal pose was exceptional for a secular portrait.

Painting by Giovanni Bellini: The Doge Leonardo Loredan portrays Leonardo Loredan, the Doge of Venice from 1501 to 1521, in his ceremonial garments with the corno ducale worn over a linen cap, and is signed IOANNES BELLINVS on a cartellino ("small paper"). It is on display in the National Gallery in London. The painting would initially have been in Venice and was probably looted when Napoleon conquered the city. It was bought in 1807 for thirteen guineas by William Thomas Beckford, who in 1844 sold it to the National Gallery for £630 (equivalent to £79,585 in 2023).

Painting by Leonardo da Vinci: The (London) Virgin of the Rocks, sometimes the Madonna of the Rocks, is the name of two paintings by the Italian Renaissance artist Leonardo da Vinci, of the same subject, with a composition which is identical except for several significant details. The version generally considered the prime version, the earlier of the two, is unrestored and hangs in the Louvre in Paris. The other, which was restored between 2008 and 2010, hangs in the National Gallery, London. The works are often known as the Louvre Virgin of the Rocks and London Virgin of the Rocks respectively. The paintings are both nearly 2 meters (over 6 feet) high and are painted in oils. Both were originally painted on wooden panels, but the Louvre version has been transferred to canvas. Both paintings show the Virgin Mary and child Jesus with the infant John the Baptist and an angel Uriel, in a rocky setting which gives the paintings their usual name. The significant compositional differences are in the gaze and right hand of the angel. There are many minor ways in which the works differ, including the colors, the lighting, the flora, and the way in which sfumato has been used. Although the date of an associated commission is documented, the complete histories of the two paintings are unknown, leading to speculation about which of the two is earlier. The London version is also ascribed to Leonardo da Vinci, and ascribed a date before 1508. Originally thought to have been partially painted by Leonardo's assistants, a close inspection of the painting during the recent restoration between 2008 and 2010 has led the conservators from the National Gallery to conclude that the greater part of the work is by the hand of Leonardo, but debate continues. Parts of the painting, the flowers in particular, indicate the collaboration and have led to speculation that the work is entirely by other hands, possibly Leonardo's assistant Giovanni Ambrogio de Predis and perhaps Evangelista.

African Slaves in the New World Spanish settlers bring slaves from Africa to Santo Domingo (now the capital of the Dominican Republic).

Ismail I, the founder and first shah of Safavid Iran, ruled from 1501 until his death in 1524. His reign is often considered the beginning of modern Iranian history, as well as one of the gunpowder empires. The rule of Ismail I is one of the most vital in the history of Iran. Before his accession in 1501, Iran, since its Islamic conquest eight-and-a-half centuries earlier, had not existed as a unified country under native Iranian rule. The dynasty founded by Ismail I would rule for over two centuries, being one of the greatest Iranian empires and at its height being amongst the most powerful empires of its time, ruling all of present-day Iran, the Republic of Azerbaijan, Armenia, most of Georgia, the North Caucasus, and Iraq, as well as parts of modern-day Turkey, Syria, Pakistan, Afghanistan, Uzbekistan, and Turkmenistan.

Leonardo da Vinci as comparative anatomist: human leg vs. canine leg.

Amerigo Vespucci maps the two stars Alpha Centauri and Beta Centauri, as well as the stars of the constellation Crux, which are below the horizon in Europe.

Painting by Albrecht Dürer: Young Hare (German: Feldhase), a 1502 watercolor and bodycolor painting. Painted in 1502 in his workshop, it is acknowledged as a masterpiece of observational art alongside his Great Piece of Turf from the following year. The subject is rendered with almost photographic accuracy, and although the piece is normally given the title Young Hare, the portrait is sufficiently detailed for the hare to be identified as a mature specimen — the German title translates as "Field Hare" and the work is often referred to in English as the Hare or Wild Hare. The subject was particularly challenging: the hare's fur lay in different directions and the animal was mottled with lighter and darker patches all over, Dürer had to adapt the standard conventions of shading to indicate the outline of the subject by the fall of light across the figure. Despite the technical challenges presented in rendering the appearance of light with a multi-colored, multi-textured subject, Dürer not only managed to create a detailed, almost scientific, study of the animal but also infuses the picture with a warm golden light that hits the hare from the left, highlighting the ears and the run of hair along the body, giving a spark of life to the eye, and casting a strange shadow to the right.

Painting by Leonardo da Vinci: Salvator Mundi, a painting attributed in whole or in part to the Italian High Renaissance artist Leonardo da Vinci, dated to c. 1499–1510. Long thought to be a copy of a lost original veiled with overpainting, it was rediscovered, restored, and included in an exhibition of Leonardo's work at the National Gallery, London, in 2011–2012. Christie's, which sold the work in 2017, stated that most leading scholars consider it an original work by Leonardo, but this attribution has been disputed by other leading specialists, some of whom propose that he only contributed certain elements; others believe that the extensive restoration prevents a definitive attribution. The painting depicts Jesus Christ in anachronistic blue Renaissance attire, making the sign of the cross with his right hand, while holding a transparent, non-refracting crystal orb in his left, signalling his role as Salvator Mundi and representing the 'celestial sphere' of the heavens. The painting was sold at auction for US$450.3 million on 15 November 2017 by Christie's in New York to Prince Badr bin Abdullah Al Saud, setting a new record for the most expensive painting ever sold at public auction.

Christopher Columbus leaves Cadiz, Spain for his fourth and final voyage to the New World.

Portuguese explorers, led by Pedro Álvares Cabral, sail into Guanabara Bay, Brazil, mistaking it for the mouth of a river, which they name Rio de Janeiro.

Painting by Albrecht Dürer: The Great Piece of Turf (German: Das grosse Rasenstück), a watercolor painting created at his Nuremberg workshop. It is a study of a seemingly unordered group of wild plants, including dandelion and greater plantain. The work is considered one of the masterpieces of Dürer's realistic nature studies. In 1495 Dürer returned from his Wanderjahre in Italy and settled in Nuremberg, where he opened a workshop. He was only twenty-four years old at the time, but the workshop soon gained a great reputation for the high quality of his work. In 1500 he produced what is perhaps his most famous work, his Christ-like Self-Portrait. At the same time he was also creating smaller-scale works that were more focused on the study of nature, such as the Great Piece of Turf, which he painted in 1503, and the Young Hare from the year before. Description The watercolor shows a large piece of turf and little else. The various plants can be identified as cock's-foot, creeping bent, smooth meadow-grass, daisy, dandelion, germander speedwell, greater plantain, hound's-tongue and yarrow. The painting shows a great level of realism in its portrayal of natural objects. Some of the roots have been stripped of earth to be displayed clearly to the spectator.

Painting by Leonardo a Vinci: The Mona Lisa. Considered an archetypal masterpiece of the Italian Renaissance, it has been described as "the best known, the most visited, the most written about, the most sung about, [and] the most parodied work of art in the world." The painting's novel qualities include the subject's enigmatic expression, monumentality of the composition, the subtle modelling of forms, and the atmospheric illusionism. The painting has been traditionally considered to depict the Italian noblewoman Lisa del Giocondo. It is painted in oil on a white poplar panel. Leonardo never gave the painting to the Giocondo family. It was believed to have been painted between 1503 and 1506; however, Leonardo may have continued working on it as late as 1517. King Francis I of France acquired the Mona Lisa after Leonardo's death in 1519, and it is now the property of the French Republic. It has normally been on display at the Louvre in Paris since 1797.

At the Battle of Cerignola Spanish forces defeat the French, considered the first battle in history won by gunpowder small arms.

Painting by Albrecht Dürer: The Adoration of the Magi,a panel painting produced under commission by Frederick the Wise for the altar of the Schlosskirche in Wittenberg. It is considered one of Dürer's best and most important works from the period between his first and second trips to Italy (1494–1495 and 1505). The work is modest in size, just over a meter wide, however it is of great importance in Dürer's oeuvre and in the history of art. Before the production of this work, Dürer's achievements lay largely in his printmaking career, or with his self-portraiture. This work is especially crucial in its distinction of Dürer's difference as he combines a fine balance of northern and Italianate conventions in the work. Heinrich Wölfflin referred to the work as "the first completely lucid painting in the history of German art".

Christopher Columbus uses his knowledge of a lunar eclipse this night (February 29) to convince Jamaican tribesmen to provide him with supplies. Three days before the eclipse, Columbus requested a meeting with the Arawak chief and informed him that his Christian god was very angry with his people for no longer supplying him and his men with food. Therefore, he was about to provide a clear sign of his displeasure: Three nights hence, he would all but obliterate the rising full moon, making it appear "inflamed with wrath," which would signify the evils that would soon be inflicted upon all of them. On the appointed evening, as the sun set in the west and the moon started emerging from beyond the eastern horizon, it was plainly obvious to all that something was terribly wrong. By the time the moon appeared in full view, a small but noticeable dark scallop had been removed from its lower edge. And, just over an hour later, as evening twilight ended and full darkness descended, the moon indeed exhibited an eerily inflamed and "bloody" appearance: In place of the normally brilliant late winter full moon there now hung a dim red ball in the eastern sky. According to Columbus' son, Ferdinand, the Arawaks were terrified at this sight and "with great howling and lamentation came running from every direction to the ships laden with provisions and beseeching the admiral to intercede with his god on their behalf." They promised that they would happily cooperate with Columbus and his men if only he would restore the moon back to its normal self.

Painting by Raphael: Madonna del Granduca was probably painted in 1505, shortly after Raphael had arrived in Florence. The influence of Leonardo da Vinci, whose works he got to know there, can be seen in the use of sfumato. The painting belonged to Ferdinand III, Grand Duke of Tuscany, from whom it got its name.

Leonardo da Vinci produces his Codex on the Flight of Birds, a relatively short codex. It comprises 18 folios and measures 21 × 15 centimetres. Now held at the Royal Library of Turin, the codex begins with an examination of the flight behavior of birds and proposes mechanisms for flight by machines. Leonardo constructed a number of these machines, and attempted to launch them from a hill near Florence. However, his efforts failed. In the codex, Leonardo notes for the first time that the center of gravity of a flying bird does not coincide with its center of pressure.

Bermuda is discovered by Spanish explorer Juan de Bermúdez. Bermúdez made 11 registered trips to the New World from 1495 to 1519.

Painting by Albrecht Dürer: Feast of the Rosary, an oil painting by Albrecht Dürer, now in the National Gallery, Prague, Czech Republic. According to Czechoslovakian art historian Jaroslav Pesina, it is "probably the most superb painting that a German master has ever created." The work also relates to a series of artworks commissioned by Maximilian I, his Burgundian subjects or figures close to his family to commemorate the Duchess Mary of Burgundy, Maximilian's first wife and to provide the focus for a cult-like phenomenon that associated her with her name-saint, the Virgin Mary. The work was initially commissioned by Jakob Fugger, an intermediary between emperor Maximilian I and Pope Julius II, during the painter's stay as the banker's guest in Augsburg, though it was produced whilst the painter was in Venice.

Ancient Sculpture: The Laocoön Group,a spectacular masterpiece of ancient art was discovered in a vineyard in Rome. This dramatic ancient marble shows the Trojan priest Laocoön and his sons being crushed to death by sea serpents. This work has been one of the most famous ancient sculptures since it was excavated in Rome in 1506 and put on public display in the Vatican Museums, where it remains today. The statue is very likely the same one that was praised in the highest terms by Pliny the Elder, the main Roman writer on art, who attributed it to Greek sculptors but did not say when it was created. The figures in the statue are nearly life-sized, with the entire group measuring just over 2 m (6 ft 7 in) in height. The sculpture depicts the Trojan priest Laocoön and his sons Antiphantes and Thymbraeus being attacked by sea serpents. The Laocoön Group has been called "the prototypical icon of human agony" in Western art. Unlike the agony often portrayed in Christian art depicting the Passion of Jesus and martyrs, the suffering shown in this statue offers no redemptive power or reward. The agony is conveyed through the contorted expressions on the faces, particularly Laocoön's bulging eyebrows, which were noted by Guillaume Duchenne de Boulogne as physiologically impossible. These expressions are mirrored in the struggling bodies, especially Laocoön's, with every part of his body shown straining. Pliny attributed the work, then in the palace of Emperor Titus, to three Greek sculptors from the island of Rhodes: Agesander, Athenodoros, and Polydorus, but he did not mention the date or patron. In style it is considered "one of the finest examples of the Hellenistic baroque" and certainly in the Greek tradition. However, its origin is uncertain, as it is not known if it is an original work or a copy of an earlier bronze sculpture.

Christopher Columbus dies.

Martin Luther ordained to the priesthood. Luther was the seminal figure of the Protestant Reformation. He is widely regarded as one of the most influential figures in Western and Christian history. He came to reject several teachings and practices of the Roman Catholic Church; in particular, he disputed the view on indulgences. Luther attempted to resolve these differences amicably, first proposing an academic discussion of the practice and efficacy of indulgences in Ninety-five Theses, which he authored in 1517. In 1520, Pope Leo X demanded that Luther renounce all of his writings, and when Luther refused to do so, excommunicated him in January 1521. Later that year, Holy Roman Emperor Charles V condemned Luther as an outlaw at the Diet of Worms. When Luther died in 1546, Pope Leo X's excommunication was still in effect. Luther taught that salvation and, consequently, eternal life are not earned by good deeds; rather, they are received only as the free gift of God's grace through the believer's faith in Jesus Christ, who is the sole redeemer from sin. Luther's theology challenged the authority and office of the pope by teaching that the Bible is the only source of divinely revealed knowledge, and opposed sacerdotalism by considering all baptized Christians to be a holy priesthood. Attempts by the Catholic Church to suppress the new protestant movement led to more than 200 years of wars — the European wars of religion.

First publication of the Waldseemüller map or Universalis Cosmographia ("Universal Cosmography") is a printed wall map of the world by German cartographer Martin Waldseemüller. It is known as the first map to use the name "America". The name America is placed on South America on the main map. As explained in Cosmographiae Introductio, the name was bestowed in honor of the Italian Amerigo Vespucci. The map is drafted on a modification of Ptolemy's second projection, expanded to accommodate the Americas and the high latitudes. A single copy of the map survives, presently housed at the Library of Congress in Washington, D.C.

Maximilian I becomes Holy Roman Emperor, a role he held until his death in 1519. He was never crowned by the Pope, as the journey to Rome was blocked by the Venetians. He proclaimed himself elected emperor in 1508 (Pope Julius II later recognized this) at Trent, thus breaking the long tradition of requiring a papal coronation for the adoption of the Imperial title. Maximilian was the only surviving son of Frederick III, Holy Roman Emperor, and Eleanor of Portugal. Since his coronation as King of the Romans in 1486, he ran a double government, or Doppelregierung (with a separate court), with his father until Frederick's death in 1493. Maximilian expanded the influence of the House of Habsburg through war and his marriage in 1477 to Mary of Burgundy, the ruler of the Burgundian State, heiress of Charles the Bold, though he also lost his family's original lands in today's Switzerland to the Swiss Confederacy. Through the marriage of his son Philip the Handsome to eventual queen Joanna of Castile in 1496, Maximilian helped to establish the Habsburg dynasty in Spain, which allowed his grandson Charles to hold the thrones of both Castile and Aragon.

Henry VIII becomes King of England. Henry is known for his six marriages and his efforts to have his first marriage (to Catherine of Aragon) annulled. His disagreement with Pope Clement VII about such an annulment led Henry to initiate the English Reformation, separating the Church of England from papal authority. He appointed himself Supreme Head of the Church of England and dissolved convents and monasteries, for which he was excommunicated by the pope. Henry brought radical changes to the Constitution of England, expanding royal power and ushering in the theory of the divine right of kings in opposition to papal supremacy. He frequently used charges of treason and heresy to quell dissent, and those accused were often executed without a formal trial using bills of attainder. He achieved many of his political aims through his chief ministers, some of whom were banished or executed when they fell out of his favor. Thomas Wolsey, Thomas More, Thomas Cromwell, and Thomas Cranmer all figured prominently in his administration.

The Constantinople earthquake occurs in the Sea of Marmara on 10 September 1509 at about 22:00. The earthquake had an estimated magnitude of 7.2 ± 0.3 on the surface-wave magnitude scale. A tsunami and 45 days of aftershocks followed the earthquake. The death toll of this earthquake is poorly known; estimates range between 1,000 and 13,000.

Luca Pacioli's De divina proportione, concerning the golden ratio, is published in Venice, with illustrations by Leonardo da Vinci. Its subject was mathematical proportions (the title refers to the golden ratio) and their applications to geometry, to visual art through perspective, and to architecture. The clarity of the written material and Leonardo's excellent diagrams helped the book to achieve an impact beyond mathematical circles, popularizing contemporary geometric concepts and images.